Calcium intake and colorectal cancer risk: Dose-response meta-analysis of prospective observational studies

International Journal of Cancer

Volumn 135, Issue 8, 2014, Pages 1940-1948

  Keum, Nana ^a   Aune, Dagfinn ^b,c   Greenwood, Darren C ^d   Ju, Woong ^e   Giovannucci, Edward L ^a,f  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF LEEDS   (United Kingdom)

^e Ewha Womans University   (South Korea)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

calcium supplements; colorectal cancer; dietary calcium; dose response; meta analysis

Indexed keywords

CALCIUM; VITAMIN D;

ARTICLE; CALCIUM INTAKE; CANCER RISK; COLORECTAL CANCER; DIET SUPPLEMENTATION; DIETARY INTAKE; HUMAN; OBSERVATIONAL STUDY; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK REDUCTION; SYSTEMATIC REVIEW; VITAMIN INTAKE;

CALCIUM SUPPLEMENTS; COLORECTAL CANCER; DIETARY CALCIUM; DOSE-RESPONSE; META-ANALYSIS;

ANTICARCINOGENIC AGENTS; CALCIUM; COLORECTAL NEOPLASMS; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; OBSERVATIONAL STUDY AS TOPIC; PROSPECTIVE STUDIES; RISK;

EID: 84905736387     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28840     Document Type: Article

References (51)

1. Aune D, Lau R, Chan DS, et al. Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort studies. Ann Oncol 2012; 23: 37-45.
2. Cho E, Smith-Warner SA, Spiegelman D, et al. Dairy foods, calcium, and colorectal cancer: a pooled analysis of 10 cohort studies. J Natl Cancer Inst 2004; 96: 1015-22.
3. Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2008; 127: 2893-917.
4. Wargovich MJ, Eng VW, Newmark HL,. Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium. Cancer Lett 1984; 23: 253-8.
5. Newmark HL, Wargovich MJ, Bruce WR,. Colon cancer and dietary fat, phosphate, and calcium: a hypothesis. J Natl Cancer Inst 1984; 72: 1323-5.
6. Lamprecht SA, Lipkin M,. Cellular mechanisms of calcium and vitamin D in the inhibition of colorectal carcinogenesis. Ann NY Acad Sci 2001; 952: 73-87.
7. Buset M, Lipkin M, Winawer S, et al. Inhibition of human colonic epithelial cell proliferation in vivo and in vitro by calcium. Cancer Res 1986; 46: 5426-30.
8. Touvier M, Chan DS, Lau R, et al. Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 2011; 20: 1003-16.
9. Giovannucci E,. The epidemiology of vitamin D and colorectal cancer: recent findings. Curr Opin Gastroenterol 2006; 22: 24-9.
10. Parodi PW,. Cows' milk fat components as potential anticarcinogenic agents. J Nutr 1997; 127: 1055-60.
11. Hague A, Paraskeva C,. The short-chain fatty acid butyrate induces apoptosis in colorectal tumour cell lines. Eur J Cancer Prev 1995; 4: 359-64.
12. Garland CF, Garland FC,. Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol 1980; 9: 227-31.
13. Ahearn TU, Shaukat A, Flanders WD, et al. A randomized clinical trial of the effects of supplemental calcium and vitamin D3 on the APC/beta-catenin pathway in the normal mucosa of colorectal adenoma patients. Cancer Prev Res (Phila) 2012; 5: 1247-56.
14. Huncharek M, Muscat J, Kupelnick B,. Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies. Nutr Cancer 2009; 61: 47-69.
15. Bristow SM, Bolland MJ, Maclennan GS, et al. Calcium supplements and cancer risk: a meta-analysis of randomised controlled trials. Br J Nutr 2013; 110: 1384-93.
16. World Cancer Research Fund/American Institute for Cancer Research. Food, nutrition, physical activity, and the prevention of colorectal cancer. Continuous Update Project Report Summary. 2011.
17. Allen LH,. Calcium bioavailability and absorption: a review. Am J Clin Nutr 1982; 35: 783-808.
18. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA 2000; 283: 2008-12.
19. Wu K, Willett WC, Fuchs CS, et al. Calcium intake and risk of colon cancer in women and men. J Natl Cancer Inst 2002; 94: 437-46.
20. Kato I, Akhmedkhanov A, Koenig K, et al. Prospective study of diet and female colorectal cancer: the New York University Women's Health Study. Nutr Cancer 1997; 28: 276-81.
21. Greenland S, Longnecker MP,. Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol 1992; 135: 1301-9.
22. Bagnardi V, Zambon A, Quatto P, et al. Flexible meta-regression functions for modeling aggregate dose-response data, with an application to alcohol and mortality. Am J Epidemiol 2004; 159: 1077-86.
23. Higgins JP, Thompson SG,. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21: 1539-58.
24. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315: 629-34.
25. Begg CB, Mazumdar M,. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994; 50: 1088-101.
26. Sellers TA, Bazyk AE, Bostick RM, et al. Diet and risk of colon cancer in a large prospective study of older women: an analysis stratified on family history (Iowa, United States). Cancer Causes Control 1998; 9: 357-67.
27. Flood A, Peters U, Chatterjee N, et al. Calcium from diet and supplements is associated with reduced risk of colorectal cancer in a prospective cohort of women. Cancer Epidemiol Biomarkers Prev 2005; 14: 126-32.
28. Gaard M, Tretli S, Loken EB,. Dietary factors and risk of colon cancer: a prospective study of 50,535 young Norwegian men and women. Eur J Cancer Prev 1996; 5: 445-54.
29. Larsson SC, Bergkvist L, Rutegard J, et al. Calcium and dairy food intakes are inversely associated with colorectal cancer risk in the Cohort of Swedish Men. Am J Clin Nutr 2006; 83: 667-73; quiz 728-9.
30. Lin J, Zhang SM, Cook NR, et al. Intakes of calcium and vitamin D and risk of colorectal cancer in women. Am J Epidemiol 2005; 161: 755-64.
31. McCullough ML, Robertson AS, Rodriguez C, et al. Calcium, vitamin D, dairy products, and risk of colorectal cancer in the Cancer Prevention Study II Nutrition Cohort (United States). Cancer Causes Control 2003; 14: 1-12.
32. Park Y, Leitzmann MF, Subar AF, et al. Dairy food, calcium, and risk of cancer in the NIH-AARP Diet and Health Study. Arch Intern Med 2009; 169: 391-401.
33. Park SY, Murphy SP, Wilkens LR, et al. Calcium and vitamin D intake and risk of colorectal cancer: the Multiethnic Cohort Study. Am J Epidemiol 2007; 165: 784-93.
34. Ishihara J, Inoue M, Iwasaki M, et al. Dietary calcium, vitamin D, and the risk of colorectal cancer. Am J Clin Nutr 2008; 88: 1576-83.
35. Jarvinen R, Knekt P, Hakulinen T, et al. Prospective study on milk products, calcium and cancers of the colon and rectum. Eur J Clin Nutr 2001; 55: 1000-7.
36. Kampman E, Goldbohm RA, van den Brandt PA, et al. Fermented dairy products, calcium, and colorectal cancer in The Netherlands Cohort Study. Cancer Res 1994; 54: 3186-90.
37. Kesse E, Boutron-Ruault MC, Norat T, et al. Dietary calcium, phosphorus, vitamin D, dairy products and the risk of colorectal adenoma and cancer among French women of the E3N-EPIC prospective study. Int J Cancer 2005; 117: 137-44.
38. Shin A, Li H, Shu XO, et al. Dietary intake of calcium, fiber and other micronutrients in relation to colorectal cancer risk: results from the Shanghai Women's Health Study. Int J Cancer 2006; 119: 2938-42.
39. Zheng W, Anderson KE, Kushi LH, et al. A prospective cohort study of intake of calcium, vitamin D, and other micronutrients in relation to incidence of rectal cancer among postmenopausal women. Cancer Epidemiol Biomarkers Prev 1998; 7: 221-5.
40. Pietinen P, Malila N, Virtanen M, et al. Diet and risk of colorectal cancer in a cohort of Finnish men. Cancer Causes Control 1999; 10: 387-96.
41. Key TJ, Appleby PN, Masset G, et al. Vitamins, minerals, essential fatty acids and colorectal cancer risk in the United Kingdom Dietary Cohort Consortium. Int J Cancer 2011; 131: E320-E325.
42. Li K, Kaaks R, Linseisen J, et al. Dietary calcium and magnesium intake in relation to cancer incidence and mortality in a German prospective cohort (EPIC-Heidelberg). Cancer Causes Control 2011; 22: 1375-82.
43. Terry P, Baron JA, Bergkvist L, et al. Dietary calcium and vitamin D intake and risk of colorectal cancer: a prospective cohort study in women. Nutr Cancer 2002; 43: 39-46.
44. Freedman LS, Schatzkin A, Midthune D, et al. Dealing with dietary measurement error in nutritional cohort studies. J Natl Cancer Inst 2011; 103: 1086-92.
45. Winawer SJ,. Natural history of colorectal cancer. Am J Med 1999; 106: 3S-6S; discussion 50S-1S.
46. Carroll C, Cooper K, Papaioannou D, et al. Supplemental calcium in the chemoprevention of colorectal cancer: a systematic review and meta-analysis. Clin Ther 2010; 32: 789-803.
47. Wallace K, Baron JA, Cole BF, et al. Effect of calcium supplementation on the risk of large bowel polyps. J Natl Cancer Inst 2004; 96: 921-5.
48. Mangano KM, Walsh SJ, Insogna KL, et al. Calcium intake in the United States from dietary and supplemental sources across adult age groups: new estimates from the National Health and Nutrition Examination Survey 2003-2006. J Am Diet Assoc 2011; 111: 687-95.
49. Willett WC,. Dietary fats and coronary heart disease. J Intern Med 2012; 272: 13-24.
50. Ludwig DS, Willett WC,. Three daily servings of reduced-fat milk: an evidence-based recommendation? JAMA Pediatr 2013; 167: 788-9.
51. Melnik BC, John SM, Schmitz G,. Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth. Nutr J 2013; 12: 103.