A randomized clinical trial of the effects of supplemental calcium and vitamin D3 on the APC/β-catenin pathway in the normal mucosa of colorectal adenoma patients

Cancer Prevention Research

Volumn 5, Issue 10, 2012, Pages 1247-1256

  Ahearn, Thomas U ^a,b   Shaukat, Aasma ^c   Flanders, W Dana ^a,b   Rutherford, Robin E ^d   Bostick, Roberd M ^a,b  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC; BETA CATENIN; CALCITRIOL; CALCIUM; COLECALCIFEROL; UVOMORULIN;

ADULT; ARTICLE; COLON POLYPOSIS; COLORECTAL ADENOMA; CONTROLLED STUDY; DIET SUPPLEMENTATION; FAMILY HISTORY; FEMALE; FOLLOW UP; HUMAN; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; OBESITY; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; VITAMIN BLOOD LEVEL;

ADENOMA; ADENOMATOUS POLYPOSIS COLI PROTEIN; ADULT; AGED; BETA CATENIN; CADHERINS; CALCIUM, DIETARY; CHOLECALCIFEROL; COLORECTAL NEOPLASMS; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; INTESTINAL MUCOSA; MALE; MIDDLE AGED; PROGNOSIS; SIGNAL TRANSDUCTION;

EID: 84867364696     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-12-0292     Document Type: Article

References (41)

1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010;60:277-300.
2. World Cancer Research Fund/American Institute for Cancer Research. Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective. Washington, DC: AICR; 2007.
3. Ferlay J, Shin H-R, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893 -917.
4. Potter JD. Colorectal cancer: molecules and populations. J Natl Cancer Inst 1999;91:916-32. (Pubitemid 29272518)
5. Goss KH, Groden J. Biology of the adenomatous polyposis coli tumor suppressor. J Clin Oncol 2000;18:1967-79. (Pubitemid 30261936)
6. Markowitz SD, Bertagnolli MM. Molecular basis of colorectal cancer.N Engl J Med 2009;361:2449-60.
7. Willert K, Jones KA. Wnt signaling: is the party in the nucleus? Genes Dev 2006;20:1394-404. (Pubitemid 43830647)
8. Ahearn TU, Shaukat A, Flanders WD, Seabrook ME, Bostick RM. Markers of the APC/β-catenin signaling pathway as potential treatable, preneoplastic biomarkers of risk for colorectal neoplasms. Cancer Epidemiol Biomarkers Prev 2012;21:969-79.
9. Bostick RM, Goodman M, Sidelnikov E. Calcium and vitamin D. New York: Springer Science + Business Media, LLC; 2009.
10. Grau MV, Baron JA, Sandler RS, Haile RW, Beach ML, Church TR, et al. Vitamin D, calcium supplementation, and colorectal adenomas: results of a randomized trial. J Natl Cancer Inst 2003;95:1765-71. (Pubitemid 38008899)
11. Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, et al. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Am J Prev Med 2007;32:210-6. (Pubitemid 46223622)
12. Fedirko V, Bostick RM, Goodman M, Flanders WD, Gross MD. Blood 25-hydroxyvitamin D3 concentrations and incident sporadic colorectal adenoma risk: a pooled case-control study. Am J Epidemiol 2010:172:489-500.
13. Yang K, Kurihara N, Fan K, Newmark H, Rigas B, Bancroft L, et al. Dietary induction of colonic tumors in a mouse model of sporadic colon cancer. Cancer Res 2008;68:7803-10.
14. Umar S, Morris AP, Kourouma F, Sellin JH. Dietary pectin and calcium inhibit colonic proliferation in vivo by differing mechanisms. Cell Prolif 2003;36:361-75. (Pubitemid 37500136)
15. Bhagavathula N, Hanosh AW, Nerusu KC, Appelman H, Chakrabarty S, Varani J. Regulation of E-cadherin and β-catenin by Ca2+ in colon carcinoma is dependent on calcium-sensing receptor expression and function. Int J Cancer 2007;121:1455-62. (Pubitemid 47328703)
16. Chakrabarty S, Radjendirane V, Appelman H, Varani J. Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of {beta}-catenin/TCF activation. Cancer Res 2003;63:67-71. (Pubitemid 36070421)
17. Chakrabarty S, Wang H, Canaff L, Hendy GN, Appelman H, Varani J. Calcium sensing receptor in human colon carcinoma: interaction with Ca2+ and 1,25-dihydroxyvitamin D3. Cancer Res 2005;65:493-8.
18. Fedirko V, Bostick RM, Flanders WD, Long Q, Shaukat A, Rutherford RE, et al. Effects of vitamin D and calcium supplementation on markers of apoptosis in normal colon mucosa: a randomized, double-blind, Placebo-controlled clinical trial. Cancer Prev Res 2009;2:213-23.
19. Liu G, Hu X, Chakrabarty S. Vitamin D mediates its action in human colon carcinoma cells in a calcium-sensing receptor-dependent manner: downregulates malignant cell behavior and the expression of thymidylate synthase and survivin and promotes cellular sensitivity to 5-FU. Int J Cancer 2010;126:631-9.
20. Bostick RM, Fosdick L, Lillemoe TJ, Overn P, Wood JR, Grambsch P, et al. Methodological findings and considerations in measuring colorectal epithelial cell proliferation in humans. Cancer Epidemiol Biomarkers Prev 1997;6:931-42. (Pubitemid 27481642)
21. Hollis BW. Quantitation of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D by radioimmunoassay using radioiodinated tracers. Methods Enzymol 1997;282:174-86. (Pubitemid 27412774)
22. Hollis BW, Kamerud JQ, Kurkowski A, Beaulieu J, Napoli JL. Quantification of circulating 1,25-dihydroxyvitamin D by radioimmunoassay with 125I-labeled tracer. Clin Chem 1996;42:586-92.
23. Elzagheid A, Algars A, Bendardaf R, Lamlum H, Ristamaki R, Collan Y, et al. E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome. World J Gastroenterol 2006;12:4304-9. (Pubitemid 44194521)
24. Schafer JL. Analysis of incomplete multivariate data. New York: Chapman and Hall/CRC; 1997.
25. Iwamoto M, Ahnen DJ, Franklin WA, Maltzman TH. Expression of β-catenin and full-length APC protein in normal and neoplastic colonic tissues. Carcinogenesis 2000;21:1935-40.
26. Day RM, Hao X, Ilyas M, Daszak P, Talbot IC, Forbes A. Changes in the expression of syndecan-1 in the colorectal adenoma-carcinoma sequence. Virchows Archiv 1999;434:121-5. (Pubitemid 29184989)
27. Pap Z, Pavái Z, Dénes L, Kovalszky I, Jung J. An immunohistochemical study of colon adenomas and carcinomas: E-cadherin, Syndecan-1, Ets-1. Pathol Oncol Res. 2009;15:579-87.
28. Mi B, Wang X, Bai Y, Gong W, Geng Y, Wang J, et al. Beta-catenin expression is altered in dysplastic and nondysplastic aberrant crypt foci of human colon. Appl Immunohistochem Mol Morphol 2009;17:294-300.
29. Palmer HG, Gonzalez-Sancho JM, Espada J, Berciano MT, Puig I, Baulida J, et al. Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling. J Cell Biol 2001;154:369-88.
30. Murillo G, Mehta RG. Chemoprevention of chemically-induced mammary and colon carcinogenesis by 1α-hydroxyvitamin D5. J Steroid Biochem Mol Biol 2005;97:129-36. (Pubitemid 41546222)
31. Yu W, Cline M, Maxwell LG, Berrigan D, Rodriguez G, Warri A, et al. Dietary vitamin D exposure prevents obesity-induced increase in endometrial cancer in Pten+/- mice. Cancer Prev Res 2010;3:1246-58.
32. Liu Z, Choi S-W, Crott JW, Keyes MK, Jang H, Smith DE, et al. Mild depletion of dietary folate combined with other B vitamins alters multiple components of the Wnt pathway in mouse colon. J Nutr 2007;137:2701-8. (Pubitemid 350255301)
33. Liu Z, Ciappio ED, Crott JW, Brooks RS, Nesvet J, Smith DE, et al. Combined inadequacies of multiple B vitamins amplify colonic Wnt signaling and promote intestinal tumorigenesis in BAT-LacZxApc1638N mice. FASEB J 2011;25:3136-45.
34. Park J-I, Venteicher AS, Hong JY, Choi J, Jun S, Shkreli M, et al. Telomerase modulates Wnt signalling by association with target gene chromatin. Nature 2009;460:66-72.
35. van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, et al. The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 2002;111:241-50. (Pubitemid 35292444)
36. Fedirko V, Bostick RM, Flanders WD, Long Q, Sidelnikov E, Shaukat A, et al. Effects of vitamin D and calcium on proliferation and differentiation in normal colon mucosa: a randomized clinical trial. Cancer Epidemiol Biomarkers Prev 2009;18:2933-41.
37. Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 2007;85:1586-91. (Pubitemid 46890428)
38. Pence BC, Buddingh F. Inhibition of dietary fat-promoted colon carcinogenesis in rats by supplemental calcium or vitamin D3. Carcinogenesis 1988;9:187-90. (Pubitemid 18023180)
39. Ahearn TU, McCullough ML, Flanders WD, Long Q, Sidelnikov E, Fedirko V, et al. A randomized clinical trial of the effects of supplemental calcium and vitamin D3 on markers of their metabolism in normal mucosa of colorectal adenoma patients. Cancer Res 2011;71:413- 23.
40. Sidelnikov E, Bostick RM, Flanders WD, Long Q, Fedirko V, Shaukat A, et al. Effects of calcium and vitamin D on MLH1 and MSH2 expression in rectal mucosa of sporadic colorectal adenoma patients. Cancer Epidemiol Biomarkers Prev 2010;19:1022-32.
41. Fedirko V, Bostick RM, Long Q, Flanders WD, McCullough ML, Sidelnikov E, et al. Effects of supplemental vitamin D and calcium on oxidative DNA damage marker in normal colorectal mucosa: a randomized clinical trial. Cancer Epidemiol Biomarkers Prev 2010;19:280-91.