Design, synthesis, and anticancer activity of novel berberine derivatives prepared via CuAAC "click" chemistry as potential anticancer agents

Drug Design, Development and Therapy

Volumn 8, Issue , 2014, Pages 1047-1059

  Jin, Xin ^a,b   Yan, Tian Hua ^c   Yan, Lan ^a   Li, Qian ^d   Wang, Rui Lian ^a   Hu, Zhen Lin ^a   Jiang, Yuan Ying ^a   Sun, Qing Yan ^a   Cao, Yong Bing ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

^d Diakite Biological Technology Co Ltd   (China)

Author keywords

Anticancer; Berberine; Click chemistry; Structure activity relationship

Indexed keywords

9 O (PROPYNE) BERBERINE CHLORIDE; 9 O [1 (2 BENZONITRILE) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (2 BROMOBENZYL) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (2 CHLOROBENZYL) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (2 FLUOROBENZYL) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (2 METHYLBENZYL) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (3 BROMOBENZYL) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (3 CHLOROBENZYL) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (3 FLUOROBENZYL) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (3 METHOXYBENZYL) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (4 BENZONITRILE) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (4 BROMOBENZYL) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (4 CHLOROBENZYL) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (4 FLUOROBENZYL) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (4 METHOXYBENZYL) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (4 METHYL FORMATE BENZYL) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (4 METHYLBENZYL) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (4 NITROBENZYL) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 (4 TERT BUTYLBENZYL) 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 [3 (TRIFLUOROMETHOXY)BENZYL] 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1 [4 (TRIFLUOROMETHOXY)BENZYL] 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1[3 (TRIFLUOROMETHOXY)BENZYL] 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [1[4 (TRIFLUOROMETHOXY)BENZYL] 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [4 (TRIFLUOROMETHOXY)BENZYL 4 ETHYL 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; 9 O [4 ETHYL (1 BENZYL) 1H 1,2,3 TRIAZOLE] BERBERINE CHLORIDE; ANTINEOPLASTIC AGENT; AZIDE; BERBERINE DERIVATIVE; COPPER; UNCLASSIFIED DRUG; UNINDEXED DRUG; BERBERINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CLICK CHEMISTRY; CYCLOADDITION; CYTOTOXICITY; DRUG DESIGN; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY; HUMAN; IC 50; MASS SPECTROMETRY; MCF 7 CELL LINE; PANCREAS CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; THIN LAYER CHROMATOGRAPHY; UMBILICAL VEIN ENDOTHELIAL CELL; BREAST NEOPLASMS; CHEMISTRY; COMPARATIVE STUDY; FEMALE; IC50; LIVER NEOPLASMS; PANCREATIC NEOPLASMS; PATHOLOGY; PROCEDURES; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BERBERINE; BREAST NEOPLASMS; CELL LINE, TUMOR; CLICK CHEMISTRY; DRUG DESIGN; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS; MCF-7 CELLS; PANCREATIC NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84905665478     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S63228     Document Type: Article

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