Generation of reactive oxygen species by a novel berberine-bile acid analog mediates apoptosis in hepatocarcinoma SMMC-7721 cells

Biochemical and Biophysical Research Communications

Volumn 433, Issue 4, 2013, Pages 432-437

  Li, Qingyong ^a   Zhang, Li ^a   Zu, Yuangang ^a   Liu, Tianyu ^a   Zhang, Baoyou ^a   He, Wuna ^a  

^a NORTHEAST FORESTRY UNIVERSITY   (China)

Author keywords

A novel berberine bile acid analog; Apoptosis; Reactive oxygen species; SMMC 7721

Indexed keywords

ACETYLCYSTEINE; APOPTOSIS INDUCING FACTOR; BERBERINE DERIVATIVE; BILE ACID; CALCIUM; CASPASE 3; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CANCER CELL CULTURE; CELL CYCLE PHASE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSOL; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN TRANSPORT;

ACETYLCYSTEINE; ACTIVE TRANSPORT, CELL NUCLEUS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BERBERINE; BILE ACIDS AND SALTS; CALCIUM; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; CYTOSOL; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 84876489258     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.02.104     Document Type: Article

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