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Volumn 5, Issue JUL, 2014, Pages

Embryonic stem cells promoting macrophage survival and function are crucial for teratoma development

Author keywords

Angiogenesis; Apoptosis; Embryonic stem cells; Macrophages; Teratoma

Indexed keywords


EID: 84905664839     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00275     Document Type: Article
Times cited : (29)

References (80)
  • 1
    • 84863830908 scopus 로고    scopus 로고
    • Nonclinical safety strategies for stem cell therapies
    • doi:10.1016/j.taap.2012.05.007
    • Sharpe ME, Morton D, Rossi A. Nonclinical safety strategies for stem cell therapies. Toxicol Appl Pharmacol (2012) 262(3):223-31. doi:10.1016/j.taap.2012.05.007
    • (2012) Toxicol Appl Pharmacol , vol.262 , Issue.3 , pp. 223-231
    • Sharpe, M.E.1    Morton, D.2    Rossi, A.3
  • 2
    • 34247647982 scopus 로고    scopus 로고
    • Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response
    • doi:10.1096/fj.06-6769com
    • Nussbaum J, Minami E, Laflamme MA, Virag JA, Ware CB, Masino A, et al. Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response. FASEB J (2007) 21(7):1345-57. doi:10.1096/fj.06-6769com
    • (2007) FASEB J , vol.21 , Issue.7 , pp. 1345-1357
    • Nussbaum, J.1    Minami, E.2    Laflamme, M.A.3    Virag, J.A.4    Ware, C.B.5    Masino, A.6
  • 3
    • 24644519816 scopus 로고    scopus 로고
    • Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium
    • doi:10.1161/circulationaha.104.525824
    • Swijnenburg RJ, Tanaka M, Vogel H, Baker J, Kofidis T, Gunawan F, et al. Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium. Circulation (2005) 112(9 Suppl):166-72. doi:10.1161/circulationaha.104.525824
    • (2005) Circulation , vol.112 , Issue.9 SUPPL. , pp. 166-172
    • Swijnenburg, R.J.1    Tanaka, M.2    Vogel, H.3    Baker, J.4    Kofidis, T.5    Gunawan, F.6
  • 4
    • 0034101804 scopus 로고    scopus 로고
    • Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro
    • doi:10.1038/74447
    • Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol (2000) 18(4):399-404. doi:10.1038/74447
    • (2000) Nat Biotechnol , vol.18 , Issue.4 , pp. 399-404
    • Reubinoff, B.E.1    Pera, M.F.2    Fong, C.Y.3    Trounson, A.4    Bongso, A.5
  • 5
    • 62549146216 scopus 로고    scopus 로고
    • Fate of embryonic stem cell derivatives implanted into the vitreous of a slow retinal degenerative mouse model
    • doi:10.1089/scd.2008.0057
    • Chaudhry GR, Fecek C, Lai MM, Wu WC, Chang M, Vasquez A, et al. Fate of embryonic stem cell derivatives implanted into the vitreous of a slow retinal degenerative mouse model. Stem Cells Dev (2009) 18(2):247-58. doi:10.1089/scd.2008.0057
    • (2009) Stem Cells Dev , vol.18 , Issue.2 , pp. 247-258
    • Chaudhry, G.R.1    Fecek, C.2    Lai, M.M.3    Wu, W.C.4    Chang, M.5    Vasquez, A.6
  • 6
    • 84882239370 scopus 로고    scopus 로고
    • Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies
    • doi:10.1038/nm.3267
    • Lee AS, Tang C, Rao MS, Weissman IL, Wu JC. Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies. Nat Med (2013) 19(8):998-1004. doi:10.1038/nm.3267
    • (2013) Nat Med , vol.19 , Issue.8 , pp. 998-1004
    • Lee, A.S.1    Tang, C.2    Rao, M.S.3    Weissman, I.L.4    Wu, J.C.5
  • 7
    • 0037019332 scopus 로고    scopus 로고
    • Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
    • doi:10.1038/nature00900
    • Kim JH, Auerbach JM, Rodriguez-Gomez JA, Velasco I, Gavin D, Lumelsky N, et al. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature (2002) 418(6893):50-6. doi:10.1038/nature00900
    • (2002) Nature , vol.418 , Issue.6893 , pp. 50-56
    • Kim, J.H.1    Auerbach, J.M.2    Rodriguez-Gomez, J.A.3    Velasco, I.4    Gavin, D.5    Lumelsky, N.6
  • 8
    • 33646576842 scopus 로고    scopus 로고
    • Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation
    • doi:10.1111/j.1471-4159.2006.03841.x
    • Chung S, Shin BS, Hedlund E, Pruszak J, Ferree A, Kang UJ, et al. Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation. J Neurochem (2006) 97(5):1467-80. doi:10.1111/j.1471-4159.2006.03841.x
    • (2006) J Neurochem , vol.97 , Issue.5 , pp. 1467-1480
    • Chung, S.1    Shin, B.S.2    Hedlund, E.3    Pruszak, J.4    Ferree, A.5    Kang, U.J.6
  • 9
    • 33745001244 scopus 로고    scopus 로고
    • Fluorescence-activated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation
    • doi:10.1634/stemcells.2005-0137
    • Fukuda H, Takahashi J, Watanabe K, Hayashi H, Morizane A, Koyanagi M, et al. Fluorescence-activated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation. Stem Cells (2006) 24(3):763-71. doi:10.1634/stemcells.2005-0137
    • (2006) Stem Cells , vol.24 , Issue.3 , pp. 763-771
    • Fukuda, H.1    Takahashi, J.2    Watanabe, K.3    Hayashi, H.4    Morizane, A.5    Koyanagi, M.6
  • 10
    • 84895484925 scopus 로고    scopus 로고
    • Chemical ablation of tumor-initiating human pluripotent stem cells
    • doi:10.1038/nprot.2014.050
    • Ben-David U, Benvenisty N. Chemical ablation of tumor-initiating human pluripotent stem cells. Nat Protoc (2014) 9(3):729-40. doi:10.1038/nprot.2014.050
    • (2014) Nat Protoc , vol.9 , Issue.3 , pp. 729-740
    • Ben-David, U.1    Benvenisty, N.2
  • 11
    • 9444265273 scopus 로고    scopus 로고
    • Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants
    • doi:10.1083/jcb.200405144
    • Bieberich E, Silva J, Wang G, Krishnamurthy K, Condie BG. Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants. J Cell Biol (2004) 167(4):723-34. doi:10.1083/jcb.200405144
    • (2004) J Cell Biol , vol.167 , Issue.4 , pp. 723-734
    • Bieberich, E.1    Silva, J.2    Wang, G.3    Krishnamurthy, K.4    Condie, B.G.5
  • 12
    • 48349106268 scopus 로고    scopus 로고
    • Selection against undifferentiated human embryonic stem cells by a cytotoxic antibody recognizing podocalyxin-like protein-1
    • doi:10.1634/stemcells.2007-0576
    • Choo AB, Tan HL, Ang SN, Fong WJ, Chin A, Lo J, et al. Selection against undifferentiated human embryonic stem cells by a cytotoxic antibody recognizing podocalyxin-like protein-1. Stem Cells (2008) 26(6):1454-63. doi:10.1634/stemcells.2007-0576
    • (2008) Stem Cells , vol.26 , Issue.6 , pp. 1454-1463
    • Choo, A.B.1    Tan, H.L.2    Ang, S.N.3    Fong, W.J.4    Chin, A.5    Lo, J.6
  • 13
    • 0038700553 scopus 로고    scopus 로고
    • Selective ablation of human embryonic stem cells expressing a "suicide" gene
    • doi:10.1634/stemcells.21-3-257
    • Schuldiner M, Itskovitz-Eldor J, Benvenisty N. Selective ablation of human embryonic stem cells expressing a "suicide" gene. Stem Cells (2003) 21(3):257-65. doi:10.1634/stemcells.21-3-257
    • (2003) Stem Cells , vol.21 , Issue.3 , pp. 257-265
    • Schuldiner, M.1    Itskovitz-Eldor, J.2    Benvenisty, N.3
  • 14
    • 80052749542 scopus 로고    scopus 로고
    • An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells
    • doi:10.1038/nbt.1947
    • Tang C, Lee AS, Volkmer JP, Sahoo D, Nag D, Mosley AR, et al. An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells. Nat Biotechnol (2011) 29(9):829-34. doi:10.1038/nbt.1947
    • (2011) Nat Biotechnol , vol.29 , Issue.9 , pp. 829-834
    • Tang, C.1    Lee, A.S.2    Volkmer, J.P.3    Sahoo, D.4    Nag, D.5    Mosley, A.R.6
  • 15
    • 84873572366 scopus 로고    scopus 로고
    • Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen
    • doi:10.1016/j.stem.2012.11.015
    • Ben-David U, Gan QF, Golan-Lev T, Arora P, Yanuka O, Oren YS, et al. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell (2013) 12(2):167-79. doi:10.1016/j.stem.2012.11.015
    • (2013) Cell Stem Cell , vol.12 , Issue.2 , pp. 167-179
    • Ben-David, U.1    Gan, Q.F.2    Golan-Lev, T.3    Arora, P.4    Yanuka, O.5    Oren, Y.S.6
  • 16
    • 84879905939 scopus 로고    scopus 로고
    • Immunologic and chemical targeting of the tight-junction protein claudin-6 eliminates tumorigenic human pluripotent stem cells
    • doi:10.1038/ncomms2992
    • Ben-David U, Nudel N, Benvenisty N. Immunologic and chemical targeting of the tight-junction protein claudin-6 eliminates tumorigenic human pluripotent stem cells. Nat Commun (2013) 4:1992. doi:10.1038/ncomms2992
    • (2013) Nat Commun , vol.4 , pp. 1992
    • Ben-David, U.1    Nudel, N.2    Benvenisty, N.3
  • 17
    • 84883386827 scopus 로고    scopus 로고
    • Inhibition of pluripotent stem cell-derived teratoma formation by small molecules
    • doi:10.1073/pnas.1303669110
    • Lee MO, Moon SH, Jeong HC, Yi JY, Lee TH, Shim SH, et al. Inhibition of pluripotent stem cell-derived teratoma formation by small molecules. Proc Natl Acad Sci U S A (2013) 110(35):E3281-90. doi:10.1073/pnas.1303669110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.35
    • Lee, M.O.1    Moon, S.H.2    Jeong, H.C.3    Yi, J.Y.4    Lee, T.H.5    Shim, S.H.6
  • 18
    • 84901332736 scopus 로고    scopus 로고
    • Knockdown of E2F2 inhibits tumorigenicity, but preserves stemness of human embryonic stem cells
    • doi:10.1089/scd.2013.0592
    • Suzuki DE, Nakahata AM, Okamoto OK. Knockdown of E2F2 inhibits tumorigenicity, but preserves stemness of human embryonic stem cells. Stem Cells Dev (2014) 23(11):1266-74. doi:10.1089/scd.2013.0592
    • (2014) Stem Cells Dev , vol.23 , Issue.11 , pp. 1266-1274
    • Suzuki, D.E.1    Nakahata, A.M.2    Okamoto, O.K.3
  • 19
    • 69249203784 scopus 로고    scopus 로고
    • Effects of cell number on teratoma formation by human embryonic stem cells
    • doi:10.4161/cc.8.16.9353
    • Lee AS, Tang C, Cao F, Xie X, van der Bogt K, Hwang A, et al. Effects of cell number on teratoma formation by human embryonic stem cells. Cell Cycle (2009) 8(16):2608-12. doi:10.4161/cc.8.16.9353
    • (2009) Cell Cycle , vol.8 , Issue.16 , pp. 2608-2612
    • Lee, A.S.1    Tang, C.2    Cao, F.3    Xie, X.4    Van der Bogt, K.5    Hwang, A.6
  • 20
    • 67349108858 scopus 로고    scopus 로고
    • Teratoma formation by human embryonic stem cells: evaluation of essential parameters for future safety studies
    • doi:10.1016/j.scr.2009.02.002
    • Hentze H, Soong PL, Wang ST, Phillips BW, Putti TC, Dunn NR. Teratoma formation by human embryonic stem cells: evaluation of essential parameters for future safety studies. Stem Cell Res (2009) 2(3):198-210. doi:10.1016/j.scr.2009.02.002
    • (2009) Stem Cell Res , vol.2 , Issue.3 , pp. 198-210
    • Hentze, H.1    Soong, P.L.2    Wang, S.T.3    Phillips, B.W.4    Putti, T.C.5    Dunn, N.R.6
  • 21
    • 84866564584 scopus 로고    scopus 로고
    • A scalable approach to prevent teratoma formation of human embryonic stem cells
    • doi:10.1074/jbc.M112.383810
    • Rong Z, Fu X, Wang M, Xu Y. A scalable approach to prevent teratoma formation of human embryonic stem cells. J Biol Chem (2012) 287(39):32338-45. doi:10.1074/jbc.M112.383810
    • (2012) J Biol Chem , vol.287 , Issue.39 , pp. 32338-32345
    • Rong, Z.1    Fu, X.2    Wang, M.3    Xu, Y.4
  • 23
    • 50349100425 scopus 로고    scopus 로고
    • The tumorigenicity of mouse embryonic stem cells and in vitro differentiated neuronal cells is controlled by the recipients' immune response
    • doi:10.1371/journal.pone.0002622
    • Dressel R, Schindehutte J, Kuhlmann T, Elsner L, Novota P, Baier PC, et al. The tumorigenicity of mouse embryonic stem cells and in vitro differentiated neuronal cells is controlled by the recipients' immune response. PLoS One (2008) 3(7):e2622. doi:10.1371/journal.pone.0002622
    • (2008) PLoS One , vol.3 , Issue.7
    • Dressel, R.1    Schindehutte, J.2    Kuhlmann, T.3    Elsner, L.4    Novota, P.5    Baier, P.C.6
  • 24
    • 84861855832 scopus 로고    scopus 로고
    • MIF produced by bone marrow-derived macrophages contributes to teratoma progression after embryonic stem cell transplantation
    • doi:10.1158/0008-5472.can-11-3247
    • Wang X, Chen T, Leng L, Fan J, Cao K, Duan Z, et al. MIF produced by bone marrow-derived macrophages contributes to teratoma progression after embryonic stem cell transplantation. Cancer Res (2012) 72(11):2867-78. doi:10.1158/0008-5472.can-11-3247
    • (2012) Cancer Res , vol.72 , Issue.11 , pp. 2867-2878
    • Wang, X.1    Chen, T.2    Leng, L.3    Fan, J.4    Cao, K.5    Duan, Z.6
  • 25
    • 42149099408 scopus 로고    scopus 로고
    • Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms
    • doi:10.4049/jimmunol.180.4.2011
    • Biswas SK, Sica A, Lewis CE. Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms. J Immunol (2008) 180(4):2011-7. doi:10.4049/jimmunol.180.4.2011
    • (2008) J Immunol , vol.180 , Issue.4 , pp. 2011-2017
    • Biswas, S.K.1    Sica, A.2    Lewis, C.E.3
  • 26
    • 41149164902 scopus 로고    scopus 로고
    • The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance
    • doi:10.1111/j.1600-065X.2008.00607.x
    • Allavena P, Sica A, Garlanda C, Mantovani A. The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance. Immunol Rev (2008) 222:155-61. doi:10.1111/j.1600-065X.2008.00607.x
    • (2008) Immunol Rev , vol.222 , pp. 155-161
    • Allavena, P.1    Sica, A.2    Garlanda, C.3    Mantovani, A.4
  • 27
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • doi:10.1158/0008-5472.can-05-4005
    • Lewis CE, Pollard JW. Distinct role of macrophages in different tumor microenvironments. Cancer Res (2006) 66(2):605-12. doi:10.1158/0008-5472.can-05-4005
    • (2006) Cancer Res , vol.66 , Issue.2 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 28
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • doi:10.1038/nrc1256
    • Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer (2004) 4(1):71-8. doi:10.1038/nrc1256
    • (2004) Nat Rev Cancer , vol.4 , Issue.1 , pp. 71-78
    • Pollard, J.W.1
  • 29
    • 60849118385 scopus 로고    scopus 로고
    • AIF-1 expression regulates endothelial cell activation, signal transduction, and vasculogenesis
    • doi:10.1152/ajpcell.00325.2008
    • Tian Y, Jain S, Kelemen SE, Autieri MV. AIF-1 expression regulates endothelial cell activation, signal transduction, and vasculogenesis. Am J Physiol Cell Physiol (2009) 296(2):C256-66. doi:10.1152/ajpcell.00325.2008
    • (2009) Am J Physiol Cell Physiol , vol.296 , Issue.2
    • Tian, Y.1    Jain, S.2    Kelemen, S.E.3    Autieri, M.V.4
  • 30
    • 0028111256 scopus 로고
    • Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications
    • doi:10.1016/0022-1759(94)90012-4
    • Van Rooijen N, Sanders A. Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J Immunol Methods (1994) 174(1-2):83-93. doi:10.1016/0022-1759(94)90012-4
    • (1994) J Immunol Methods , vol.174 , Issue.1-2 , pp. 83-93
    • Van Rooijen, N.1    Sanders, A.2
  • 31
    • 0004233768 scopus 로고    scopus 로고
    • Histological classification of testis tumours
    • Berlin Heidelberg: Springer-Verlag
    • Mostofi FK, Sesterhenn I. Histological classification of testis tumours. Histological Typing of Testis Tumours. Berlin Heidelberg: Springer-Verlag (1998). p. 3-5.
    • (1998) Histological Typing of Testis Tumours , pp. 3-5
    • Mostofi, F.K.1    Sesterhenn, I.2
  • 32
    • 0033591231 scopus 로고    scopus 로고
    • Roles of the mitogen-activated protein kinase family in macrophage responses to colony stimulating factor-1 addition and withdrawal
    • doi:10.1074/jbc.274.21.15127
    • Jaworowski A, Wilson NJ, Christy E, Byrne R, Hamilton JA. Roles of the mitogen-activated protein kinase family in macrophage responses to colony stimulating factor-1 addition and withdrawal. J Biol Chem (1999) 274(21):15127-33. doi:10.1074/jbc.274.21.15127
    • (1999) J Biol Chem , vol.274 , Issue.21 , pp. 15127-15133
    • Jaworowski, A.1    Wilson, N.J.2    Christy, E.3    Byrne, R.4    Hamilton, J.A.5
  • 33
    • 0042090272 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein inhibits macrophage apoptosis by blocking ceramide generation, thereby maintaining protein kinase B activation and Bcl-XL levels
    • doi:10.1074/jbc.M209179200
    • Hundal RS, Gomez-Munoz A, Kong JY, Salh BS, Marotta A, Duronio V, et al. Oxidized low density lipoprotein inhibits macrophage apoptosis by blocking ceramide generation, thereby maintaining protein kinase B activation and Bcl-XL levels. J Biol Chem (2003) 278(27):24399-408. doi:10.1074/jbc.M209179200
    • (2003) J Biol Chem , vol.278 , Issue.27 , pp. 24399-24408
    • Hundal, R.S.1    Gomez-Munoz, A.2    Kong, J.Y.3    Salh, B.S.4    Marotta, A.5    Duronio, V.6
  • 34
    • 44049092407 scopus 로고    scopus 로고
    • Discovery of a cytokine and its receptor by functional screening of the extracellular proteome
    • doi:10.1126/science.1154370
    • Lin H, Lee E, Hestir K, Leo C, Huang M, Bosch E, et al. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science (2008) 320(5877):807-11. doi:10.1126/science.1154370
    • (2008) Science , vol.320 , Issue.5877 , pp. 807-811
    • Lin, H.1    Lee, E.2    Hestir, K.3    Leo, C.4    Huang, M.5    Bosch, E.6
  • 35
    • 0033543563 scopus 로고    scopus 로고
    • Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B
    • doi:10.1074/jbc.274.37.26393
    • Kelley TW, Graham MM, Doseff AI, Pomerantz RW, Lau SM, Ostrowski MC, et al. Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. J Biol Chem (1999) 274(37):26393-8. doi:10.1074/jbc.274.37.26393
    • (1999) J Biol Chem , vol.274 , Issue.37 , pp. 26393-26398
    • Kelley, T.W.1    Graham, M.M.2    Doseff, A.I.3    Pomerantz, R.W.4    Lau, S.M.5    Ostrowski, M.C.6
  • 36
    • 0036884413 scopus 로고    scopus 로고
    • Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves phosphatidylinositol 3-kinase and reactive oxygen species in human monocytes
    • doi:10.4049/jimmunol.169.11.6427
    • Bhatt NY, Kelley TW, Khramtsov VV, Wang Y, Lam GK, Clanton TL, et al. Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves phosphatidylinositol 3-kinase and reactive oxygen species in human monocytes. J Immunol (2002) 169(11):6427-34. doi:10.4049/jimmunol.169.11.6427
    • (2002) J Immunol , vol.169 , Issue.11 , pp. 6427-6434
    • Bhatt, N.Y.1    Kelley, T.W.2    Khramtsov, V.V.3    Wang, Y.4    Lam, G.K.5    Clanton, T.L.6
  • 37
    • 33846075802 scopus 로고    scopus 로고
    • The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival
    • doi:10.1165/rcmb.2006-0165OC
    • Wang Y, Zeigler MM, Lam GK, Hunter MG, Eubank TD, Khramtsov VV, et al. The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival. Am J Respir Cell Mol Biol (2007) 36(1):68-77. doi:10.1165/rcmb.2006-0165OC
    • (2007) Am J Respir Cell Mol Biol , vol.36 , Issue.1 , pp. 68-77
    • Wang, Y.1    Zeigler, M.M.2    Lam, G.K.3    Hunter, M.G.4    Eubank, T.D.5    Khramtsov, V.V.6
  • 38
    • 84886434204 scopus 로고    scopus 로고
    • Modulation of macrophage phenotype by cell shape
    • doi:10.1073/pnas.1308887110
    • McWhorter FY, Wang T, Nguyen P, Chung T, Liu WF. Modulation of macrophage phenotype by cell shape. Proc Natl Acad Sci U S A (2013) 110(43):17253-8. doi:10.1073/pnas.1308887110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.43 , pp. 17253-17258
    • McWhorter, F.Y.1    Wang, T.2    Nguyen, P.3    Chung, T.4    Liu, W.F.5
  • 39
    • 33645991795 scopus 로고    scopus 로고
    • Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy
    • doi:10.1016/j.ejca.2006.01.003
    • Sica A, Schioppa T, Mantovani A, Allavena P. Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer (2006) 42(6):717-27. doi:10.1016/j.ejca.2006.01.003
    • (2006) Eur J Cancer , vol.42 , Issue.6 , pp. 717-727
    • Sica, A.1    Schioppa, T.2    Mantovani, A.3    Allavena, P.4
  • 40
    • 33845524204 scopus 로고    scopus 로고
    • Role of tumor-associated macrophages in tumor progression and invasion
    • doi:10.1007/s10555-006-9001-7
    • Mantovani A, Schioppa T, Porta C, Allavena P, Sica A. Role of tumor-associated macrophages in tumor progression and invasion. Cancer Metastasis Rev (2006) 25(3):315-22. doi:10.1007/s10555-006-9001-7
    • (2006) Cancer Metastasis Rev , vol.25 , Issue.3 , pp. 315-322
    • Mantovani, A.1    Schioppa, T.2    Porta, C.3    Allavena, P.4    Sica, A.5
  • 41
    • 18744376552 scopus 로고    scopus 로고
    • Mouse aortic ring assay: a new approach of the molecular genetics of angiogenesis
    • doi:10.1251/bpo30
    • Masson VV, Devy L, Grignet-Debrus C, Bernt S, Bajou K, Blacher S, et al. Mouse aortic ring assay: a new approach of the molecular genetics of angiogenesis. Biol Proced Online (2002) 4:24-31. doi:10.1251/bpo30
    • (2002) Biol Proced Online , vol.4 , pp. 24-31
    • Masson, V.V.1    Devy, L.2    Grignet-Debrus, C.3    Bernt, S.4    Bajou, K.5    Blacher, S.6
  • 42
    • 54049091124 scopus 로고    scopus 로고
    • The angiogenic response of the aorta to injury and inflammatory cytokines requires macrophages
    • doi:10.4049/jimmunol.181.8.5711
    • Gelati M, Aplin AC, Fogel E, Smith KD, Nicosia RF. The angiogenic response of the aorta to injury and inflammatory cytokines requires macrophages. J Immunol (2008) 181(8):5711-9. doi:10.4049/jimmunol.181.8.5711
    • (2008) J Immunol , vol.181 , Issue.8 , pp. 5711-5719
    • Gelati, M.1    Aplin, A.C.2    Fogel, E.3    Smith, K.D.4    Nicosia, R.F.5
  • 43
    • 68749109536 scopus 로고    scopus 로고
    • A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    • doi:10.1371/journal.pone.0006562
    • Qian B, Deng Y, Im JH, Muschel RJ, Zou Y, Li J, et al. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One (2009) 4(8):e6562. doi:10.1371/journal.pone.0006562
    • (2009) PLoS One , vol.4 , Issue.8
    • Qian, B.1    Deng, Y.2    Im, J.H.3    Muschel, R.J.4    Zou, Y.5    Li, J.6
  • 44
    • 0034028817 scopus 로고    scopus 로고
    • Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
    • doi:10.1128/MCB.20.11.4106-4114.2000
    • Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, Sher A, et al. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol (2000) 20(11):4106-14. doi:10.1128/MCB.20.11.4106-4114.2000
    • (2000) Mol Cell Biol , vol.20 , Issue.11 , pp. 4106-4114
    • Jung, S.1    Aliberti, J.2    Graemmel, P.3    Sunshine, M.J.4    Kreutzberg, G.W.5    Sher, A.6
  • 45
    • 76249095169 scopus 로고    scopus 로고
    • Development of monocytes, macrophages, and dendritic cells
    • doi:10.1126/science.1178331
    • Geissmann F, Manz MG, Jung S, Sieweke MH, Merad M, Ley K. Development of monocytes, macrophages, and dendritic cells. Science (2010) 327(5966):656-61. doi:10.1126/science.1178331
    • (2010) Science , vol.327 , Issue.5966 , pp. 656-661
    • Geissmann, F.1    Manz, M.G.2    Jung, S.3    Sieweke, M.H.4    Merad, M.5    Ley, K.6
  • 46
    • 0000172885 scopus 로고
    • Identification and subcellular localization of proteins that are rapidly phosphorylated in tyrosine in response to colony-stimulating factor 1
    • doi:10.1073/pnas.85.21.8062
    • Sengupta A, Liu WK, Yeung YG, Yeung DC, Frackelton AR Jr, Stanley ER. Identification and subcellular localization of proteins that are rapidly phosphorylated in tyrosine in response to colony-stimulating factor 1. Proc Natl Acad Sci U S A (1988) 85(21):8062-6. doi:10.1073/pnas.85.21.8062
    • (1988) Proc Natl Acad Sci U S A , vol.85 , Issue.21 , pp. 8062-8066
    • Sengupta, A.1    Liu, W.K.2    Yeung, Y.G.3    Yeung, D.C.4    Frackelton Jr., A.R.5    Stanley, E.R.6
  • 47
    • 0030768744 scopus 로고    scopus 로고
    • CSF-1 signal transduction
    • Hamilton JA. CSF-1 signal transduction. J Leukoc Biol (1997) 62(2):145-55.
    • (1997) J Leukoc Biol , vol.62 , Issue.2 , pp. 145-155
    • Hamilton, J.A.1
  • 48
    • 84888063933 scopus 로고    scopus 로고
    • Beyond stem cells: self-renewal of differentiated macrophages
    • doi:10.1126/science.1242974
    • Sieweke MH, Allen JE. Beyond stem cells: self-renewal of differentiated macrophages. Science (2013) 342(6161):1242974. doi:10.1126/science.1242974
    • (2013) Science , vol.342 , Issue.6161 , pp. 1242974
    • Sieweke, M.H.1    Allen, J.E.2
  • 49
    • 77957115690 scopus 로고    scopus 로고
    • Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells
    • doi:10.1189/jlb.1209822
    • Wei S, Nandi S, Chitu V, Yeung YG, Yu W, Huang M, et al. Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. J Leukoc Biol (2010) 88(3):495-505. doi:10.1189/jlb.1209822
    • (2010) J Leukoc Biol , vol.88 , Issue.3 , pp. 495-505
    • Wei, S.1    Nandi, S.2    Chitu, V.3    Yeung, Y.G.4    Yu, W.5    Huang, M.6
  • 51
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • doi:10.1016/j.it.2004.09.015
    • Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol (2004) 25(12):677-86. doi:10.1016/j.it.2004.09.015
    • (2004) Trends Immunol , vol.25 , Issue.12 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 52
    • 38449102676 scopus 로고    scopus 로고
    • Macrophage activation and polarization
    • doi:10.2741/2692
    • Martinez FO, Sica A, Mantovani A, Locati M. Macrophage activation and polarization. Front Biosci (2008) 13:453-61. doi:10.2741/2692
    • (2008) Front Biosci , vol.13 , pp. 453-461
    • Martinez, F.O.1    Sica, A.2    Mantovani, A.3    Locati, M.4
  • 53
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • doi:10.1038/nri978
    • Gordon S. Alternative activation of macrophages. Nat Rev Immunol (2003) 3(1):23-35. doi:10.1038/nri978
    • (2003) Nat Rev Immunol , vol.3 , Issue.1 , pp. 23-35
    • Gordon, S.1
  • 54
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: mechanism and functions
    • doi:10.1016/j.immuni.2010.05.007
    • Gordon S, Martinez FO. Alternative activation of macrophages: mechanism and functions. Immunity (2010) 32(5):593-604. doi:10.1016/j.immuni.2010.05.007
    • (2010) Immunity , vol.32 , Issue.5 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 55
    • 33344460032 scopus 로고    scopus 로고
    • A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation)
    • doi:10.1182/blood-2005-01-0428
    • Biswas SK, Gangi L, Paul S, Schioppa T, Saccani A, Sironi M, et al. A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation). Blood (2006) 107(5):2112-22. doi:10.1182/blood-2005-01-0428
    • (2006) Blood , vol.107 , Issue.5 , pp. 2112-2122
    • Biswas, S.K.1    Gangi, L.2    Paul, S.3    Schioppa, T.4    Saccani, A.5    Sironi, M.6
  • 56
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: in vivo veritas
    • doi:10.1172/jci59643
    • Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest (2012) 122(3):787-95. doi:10.1172/jci59643
    • (2012) J Clin Invest , vol.122 , Issue.3 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 57
    • 34248172324 scopus 로고    scopus 로고
    • Altered macrophage differentiation and immune dysfunction in tumor development
    • doi:10.1172/jci31422
    • Sica A, Bronte V. Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest (2007) 117(5):1155-66. doi:10.1172/jci31422
    • (2007) J Clin Invest , vol.117 , Issue.5 , pp. 1155-1166
    • Sica, A.1    Bronte, V.2
  • 58
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages: an immunologic functional perspective
    • doi:10.1146/annurev.immunol.021908.132532
    • Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol (2009) 27:451-83. doi:10.1146/annurev.immunol.021908.132532
    • (2009) Annu Rev Immunol , vol.27 , pp. 451-483
    • Martinez, F.O.1    Helming, L.2    Gordon, S.3
  • 59
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
    • doi:10.1038/ni.1937
    • Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol (2010) 11(10):889-96. doi:10.1038/ni.1937
    • (2010) Nat Immunol , vol.11 , Issue.10 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 60
    • 34548798765 scopus 로고    scopus 로고
    • Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2
    • doi:10.1158/0008-5472.can-07-1684
    • Lewis CE, De Palma M, Naldini L. Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2. Cancer Res (2007) 67(18):8429-32. doi:10.1158/0008-5472.can-07-1684
    • (2007) Cancer Res , vol.67 , Issue.18 , pp. 8429-8432
    • Lewis, C.E.1    De Palma, M.2    Naldini, L.3
  • 61
    • 3042526264 scopus 로고    scopus 로고
    • Dual functional roles of Tie-2/angiopoietin in TNF-alpha-mediated angiogenesis
    • doi:10.1152/ajpheart.01058.2003
    • Chen JX, Chen Y, DeBusk L, Lin W, Lin PC. Dual functional roles of Tie-2/angiopoietin in TNF-alpha-mediated angiogenesis. Am J Physiol Heart Circ Physiol (2004) 287(1):H187-95. doi:10.1152/ajpheart.01058.2003
    • (2004) Am J Physiol Heart Circ Physiol , vol.287 , Issue.1
    • Chen, J.X.1    Chen, Y.2    DeBusk, L.3    Lin, W.4    Lin, P.C.5
  • 62
    • 80055009377 scopus 로고    scopus 로고
    • Proangiogenic Tie2(+) macrophages infiltrate human and murine endometriotic lesions and dictate their growth in a mouse model of the disease
    • doi:10.1016/j.ajpath.2011.07.029
    • Capobianco A, Monno A, Cottone L, Venneri MA, Biziato D, Di Puppo F, et al. Proangiogenic Tie2(+) macrophages infiltrate human and murine endometriotic lesions and dictate their growth in a mouse model of the disease. Am J Pathol (2011) 179(5):2651-9. doi:10.1016/j.ajpath.2011.07.029
    • (2011) Am J Pathol , vol.179 , Issue.5 , pp. 2651-2659
    • Capobianco, A.1    Monno, A.2    Cottone, L.3    Venneri, M.A.4    Biziato, D.5    Di Puppo, F.6
  • 63
    • 24944587964 scopus 로고    scopus 로고
    • Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
    • doi:10.1016/j.ccr.2005.08.002
    • De Palma M, Venneri MA, Galli R, Sergi Sergi L, Politi LS, Sampaolesi M, et al. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell (2005) 8(3):211-26. doi:10.1016/j.ccr.2005.08.002
    • (2005) Cancer Cell , vol.8 , Issue.3 , pp. 211-226
    • De Palma, M.1    Venneri, M.A.2    Galli, R.3    Sergi Sergi, L.4    Politi, L.S.5    Sampaolesi, M.6
  • 64
    • 79953750307 scopus 로고    scopus 로고
    • Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells
    • doi:10.1016/j.ccr.2011.02.005
    • Mazzieri R, Pucci F, Moi D, Zonari E, Ranghetti A, Berti A, et al. Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. Cancer Cell (2011) 19(4):512-26. doi:10.1016/j.ccr.2011.02.005
    • (2011) Cancer Cell , vol.19 , Issue.4 , pp. 512-526
    • Mazzieri, R.1    Pucci, F.2    Moi, D.3    Zonari, E.4    Ranghetti, A.5    Berti, A.6
  • 65
    • 0031931818 scopus 로고    scopus 로고
    • Regulation of the immune response by macrophage migration inhibitory factor: biological and structural features
    • doi:10.1007/s001090050204
    • Bernhagen J, Calandra T, Bucala R. Regulation of the immune response by macrophage migration inhibitory factor: biological and structural features. J Mol Med (Berl) (1998) 76(3-4):151-61. doi:10.1007/s001090050204
    • (1998) J Mol Med (Berl) , vol.76 , Issue.3-4 , pp. 151-161
    • Bernhagen, J.1    Calandra, T.2    Bucala, R.3
  • 66
    • 0029143676 scopus 로고
    • MIF as a glucocorticoid-induced modulator of cytokine production
    • doi:10.1038/377068a0
    • Calandra T, Bernhagen J, Metz CN, Spiegel LA, Bacher M, Donnelly T, et al. MIF as a glucocorticoid-induced modulator of cytokine production. Nature (1995) 377(6544):68-71. doi:10.1038/377068a0
    • (1995) Nature , vol.377 , Issue.6544 , pp. 68-71
    • Calandra, T.1    Bernhagen, J.2    Metz, C.N.3    Spiegel, L.A.4    Bacher, M.5    Donnelly, T.6
  • 67
    • 0031052013 scopus 로고    scopus 로고
    • Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome
    • doi:10.1038/nm0397-320
    • Donnelly SC, Haslett C, Reid PT, Grant IS, Wallace WA, Metz CN, et al. Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Nat Med (1997) 3(3):320-3. doi:10.1038/nm0397-320
    • (1997) Nat Med , vol.3 , Issue.3 , pp. 320-323
    • Donnelly, S.C.1    Haslett, C.2    Reid, P.T.3    Grant, I.S.4    Wallace, W.A.5    Metz, C.N.6
  • 68
    • 0037039308 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response
    • doi:10.1073/pnas.012511599
    • Mitchell RA, Liao H, Chesney J, Fingerle-Rowson G, Baugh J, David J, et al. Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response. Proc Natl Acad Sci U S A (2002) 99(1):345-50. doi:10.1073/pnas.012511599
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.1 , pp. 345-350
    • Mitchell, R.A.1    Liao, H.2    Chesney, J.3    Fingerle-Rowson, G.4    Baugh, J.5    David, J.6
  • 69
    • 36749070996 scopus 로고    scopus 로고
    • Mechanism of action of certolizumab pegol (CDP870): in vitro comparison with other anti-tumor necrosis factor alpha agents
    • doi:10.1002/ibd.20225
    • Nesbitt A, Fossati G, Bergin M, Stephens P, Stephens S, Foulkes R, et al. Mechanism of action of certolizumab pegol (CDP870): in vitro comparison with other anti-tumor necrosis factor alpha agents. Inflamm Bowel Dis (2007) 13(11):1323-32. doi:10.1002/ibd.20225
    • (2007) Inflamm Bowel Dis , vol.13 , Issue.11 , pp. 1323-1332
    • Nesbitt, A.1    Fossati, G.2    Bergin, M.3    Stephens, P.4    Stephens, S.5    Foulkes, R.6
  • 70
    • 84872529636 scopus 로고    scopus 로고
    • Anti-tumour strategies aiming to target tumour-associated macrophages
    • doi:10.1111/imm.12023
    • Tang X, Mo C, Wang Y, Wei D, Xiao H. Anti-tumour strategies aiming to target tumour-associated macrophages. Immunology (2013) 138(2):93-104. doi:10.1111/imm.12023
    • (2013) Immunology , vol.138 , Issue.2 , pp. 93-104
    • Tang, X.1    Mo, C.2    Wang, Y.3    Wei, D.4    Xiao, H.5
  • 71
    • 84857618521 scopus 로고    scopus 로고
    • Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling
    • doi:10.1182/blood-2011-09-379214
    • Hume DA, MacDonald KP. Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. Blood (2012) 119(8):1810-20. doi:10.1182/blood-2011-09-379214
    • (2012) Blood , vol.119 , Issue.8 , pp. 1810-1820
    • Hume, D.A.1    MacDonald, K.P.2
  • 72
    • 84887481716 scopus 로고    scopus 로고
    • CSF-1R inhibition alters macrophage polarization and blocks glioma progression
    • doi:10.1038/nm.3337
    • Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med (2013) 19(10):1264-72. doi:10.1038/nm.3337
    • (2013) Nat Med , vol.19 , Issue.10 , pp. 1264-1272
    • Pyonteck, S.M.1    Akkari, L.2    Schuhmacher, A.J.3    Bowman, R.L.4    Sevenich, L.5    Quail, D.F.6
  • 73
    • 84878652051 scopus 로고    scopus 로고
    • PI3K and MEK inhibitor combinations: examining the evidence in selected tumor types
    • doi:10.1007/s00280-013-2121-1
    • Britten CD. PI3K and MEK inhibitor combinations: examining the evidence in selected tumor types. Cancer Chemother Pharmacol (2013) 71(6):1395-409. doi:10.1007/s00280-013-2121-1
    • (2013) Cancer Chemother Pharmacol , vol.71 , Issue.6 , pp. 1395-1409
    • Britten, C.D.1
  • 74
    • 84871370178 scopus 로고    scopus 로고
    • Alternative dosing of dual PI3K and MEK inhibition in cancer therapy
    • doi:10.1186/1471-2407-12-612
    • Jokinen E, Laurila N, Koivunen JP. Alternative dosing of dual PI3K and MEK inhibition in cancer therapy. BMC Cancer (2012) 12:612. doi:10.1186/1471-2407-12-612
    • (2012) BMC Cancer , vol.12 , pp. 612
    • Jokinen, E.1    Laurila, N.2    Koivunen, J.P.3
  • 75
    • 84892405979 scopus 로고    scopus 로고
    • The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing mice
    • doi:10.1371/journal.pone.0081763
    • Haagensen EJ, Thomas HD, Wilson I, Harnor SJ, Payne SL, Rennison T, et al. The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing mice. PLoS One (2013) 8(12):e81763. doi:10.1371/journal.pone.0081763
    • (2013) PLoS One , vol.8 , Issue.12
    • Haagensen, E.J.1    Thomas, H.D.2    Wilson, I.3    Harnor, S.J.4    Payne, S.L.5    Rennison, T.6
  • 76
    • 79953201225 scopus 로고    scopus 로고
    • Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling
    • doi:10.1042/bst0390674
    • Welham MJ, Kingham E, Sanchez-Ripoll Y, Kumpfmueller B, Storm M, Bone H. Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling. Biochem Soc Trans (2011) 39(2):674-8. doi:10.1042/bst0390674
    • (2011) Biochem Soc Trans , vol.39 , Issue.2 , pp. 674-678
    • Welham, M.J.1    Kingham, E.2    Sanchez-Ripoll, Y.3    Kumpfmueller, B.4    Storm, M.5    Bone, H.6
  • 77
    • 84885062308 scopus 로고    scopus 로고
    • Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival
    • doi:10.1073/pnas.1312197110
    • Cieslewicz M, Tang J, Yu JL, Cao H, Zavaljevski M, Motoyama K, et al. Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival. Proc Natl Acad Sci U S A (2013) 110(40):15919-24. doi:10.1073/pnas.1312197110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.40 , pp. 15919-15924
    • Cieslewicz, M.1    Tang, J.2    Yu, J.L.3    Cao, H.4    Zavaljevski, M.5    Motoyama, K.6
  • 78
    • 17144398046 scopus 로고    scopus 로고
    • Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection
    • doi:10.1158/0008-5472.can-04-4262
    • Guiducci C, Vicari AP, Sangaletti S, Trinchieri G, Colombo MP. Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection. Cancer Res (2005) 65(8):3437-46. doi:10.1158/0008-5472.can-04-4262
    • (2005) Cancer Res , vol.65 , Issue.8 , pp. 3437-3446
    • Guiducci, C.1    Vicari, A.P.2    Sangaletti, S.3    Trinchieri, G.4    Colombo, M.P.5
  • 79
    • 84893429662 scopus 로고    scopus 로고
    • Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors
    • doi:10.1016/j.bbcan.2013.12.005
    • Siveen KS, Sikka S, Surana R, Dai X, Zhang J, Kumar AP, et al. Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. Biochim Biophys Acta (2014) 1845(2):136-54. doi:10.1016/j.bbcan.2013.12.005
    • (2014) Biochim Biophys Acta , vol.1845 , Issue.2 , pp. 136-154
    • Siveen, K.S.1    Sikka, S.2    Surana, R.3    Dai, X.4    Zhang, J.5    Kumar, A.P.6
  • 80
    • 77956199358 scopus 로고    scopus 로고
    • Stat3 activation is limiting for reprogramming to ground state pluripotency
    • doi:10.1016/j.stem.2010.06.022
    • Yang J, van Oosten AL, Theunissen TW, Guo G, Silva JC, Smith A. Stat3 activation is limiting for reprogramming to ground state pluripotency. Cell Stem Cell (2010) 7(3):319-28. doi:10.1016/j.stem.2010.06.022
    • (2010) Cell Stem Cell , vol.7 , Issue.3 , pp. 319-328
    • Yang, J.1    Van Oosten, A.L.2    Theunissen, T.W.3    Guo, G.4    Silva, J.C.5    Smith, A.6


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