Regulation of the immune response by macrophage migration inhibitory factor: Biological and structural features

Journal of Molecular Medicine

Volumn 76, Issue 3-4, 1998, Pages 151-161

  Bernhagen, Jürgen ^a,b   Calandra, Thierry ^e   Bucala, Richard ^c,d  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF STUTTGART   (Germany)

^c ROCKEFELLER UNIVERSITY   (United States)

^d PICOWER INST FOR MEDICAL RESEARCH   (United States)

^e LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Cytokine; Glucocorticoids; Macrophage migration inhibitory factor; Molecular structure; Monocytes macrophage; Neuroendocrine; Septic shock; T cell

Indexed keywords

CYTOKINE; GLUCOCORTICOID; MACROPHAGE MIGRATION INHIBITION FACTOR;

CHEMICAL STRUCTURE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DELAYED HYPERSENSITIVITY; DRUG ACTIVITY; HUMAN; IMMUNE RESPONSE; MOUSE; NONHUMAN; RAT; REGULATORY MECHANISM; REVIEW; SEPTIC SHOCK; T LYMPHOCYTE;

ANIMALS; GLUCOCORTICOIDS; HUMANS; IMMUNITY, CELLULAR; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MACROPHAGES; PROTEIN CONFORMATION; SHOCK, SEPTIC;

EID: 0031931818     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090050204     Document Type: Review

References (56)

1. Durum SK, Oppenheim JJ (1993) Proinflammatory cytokines and immunity. In: Paul W (ed) Fundamental immunology, 3rd edn. Raven, New York, pp 801-836
2. Thompson A (1993) The cytokine handbook, 2nd edn. Academic, New York
3. Bone R (1991) A critical evaluation of new agents for the treatment of sepsis. J Am Med Assoc 266:1686-1691
4. Tracey KJ, Cerami A (1993) Tumor necrosis factor: an updated view of its biology Crit Care Med 21:415-422
5. Fauci A (1996) Host factors and the pathogenesis of HIV-induced disease. Nature 384:529-534
6. Dinarello CA, Wolff SM (1993) The role of interleukin-1 in disease. New Engl J Med 328:106-113
7. Spangelo B, Gorospe WC (1995) Role of the cytokines in the neuroendocrine-immune system axis. Front Neuroendocrinol 16:1-22
8. Goldstein RA, Bowen DL, Fauci AS (1992) Adrenal corticosteroids. In: Gallin JL, Goldstein IM, Snyderman R (ed) Inflammation: basic principles and clinical correlates, vol 55, 2nd edn. Raven New York, pp 1061-1092
9. Munck A, Guyre PM, Holbrook NJ (1984) Physiological functions of glucocorticosteroids in stress and their relation to pharmacological actions. Endocrinol Rev 5:25-44
10. Bloom BR, Bennett B (1966) Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science 153:80-82
11. David JR (1966) Delayed-type hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. Proc Natl Acad Sci USA 56:72-77
12. Nathan CF, Karnovsky ML, David JR (1971) Alterations of macrophage functions by mediators from lymphocytes. J Exp Med 133:1356-1376
13. Nathan CF, Remold HG, David JR (1973) Characterization of a lymphocyte factor which alters macrophage function. J Exp Med 137:275-288
14. Thurman GB, Braude IA, Gray PW, Oldham RK, Stevenson HC (1985) MIF-like activity of natural and recombinant human interferon-gamma and their neutralization by monoclonal antibody. J Immunol 134:305-309
15. McInnes A, Rennick DM (1988) Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells. J Exp Med 167:598-611
16. Weiser WY, Temple PA, Witek-Gianotti JS, Remold HG, Clark SC, David JR (1989) Molecular cloning of cDNA encoding a human macrophage migration inhibitory factor. Proc Natl Acad Sci USA 86:7522-7526
17. David JR (1993) Erratum: important note on recombinant macrophage migration inhibition factor. J Immunol 151:1
18. David JR (1993) Corrections, immunology. Proc Natl Acad Sci USA 90:12056
19. Bernhagen, J, Calandra T, Mitchell RA, Martin SB, Tracey KJ, Voelter W, Manogue KR, Cerami A, Bucala R (1993) MIF is a pituitary-derived cytokine that potentiates endotoxemia. Nature (London) 365:756-759
20. Nishino T, Bernhagen, J, Shiiki H, Calandra T, Dohi K, Bucala R (1995) Localization of macrophage migration inhibitory factor (MIF) to secretory granules within the corticotrophic and thyrotrophic cells of the pituitary gland. Mol Med 1: 781-788
21. Tracey KJ, Beutler B, Lowry SF, Merryweather, J, Wolpe S, Milsark IW, Hariri RJ, Fahey TJ, Zentella A, Albert JD, Shiresa T, Cerami A (1988) Shock and tissue injury induced by recombinant human cachectin. Science 234:470-474
22. Calandra T, Bernhagen, J, Mitchell RA, Bucala R (1994) The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor. J Exp Med 179:1895-1902
23. Bernhagen, J, Mitchell RA, Calandra T, Voelter W, Cerami A, Bucala R (1994) Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF). Biochemistry 33:14144-14155
24. Bernhagen, J, Calandra T, Cerami A, Bucala R (1994) Macrophage migration inhibitory factor (MIF) is a neuroendocrine mediator of endotoxemia. Trends Microbiol 2:198-201
25. Bacher M, Metz CN, Calandra T, Mayer K, Chesney, J, Lohoff M, Gemsa D, Donnelly T, Bucala R (1996) An essential role for MIF in T-cell activation. Proc Natl Acad Sci USA 93: 7849-7854
26. Mikayama T, Nakano T, Gomi H, Nakagawa Y, Liu Y-C, Sato M, Iwamatsu A Ishii Y, Weiser WY, Ishizaka K (1993) Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor. Proc Natl Acad Sci USA 90:10056-10060
27. Liu Y-C, Nakano T, Elly C, Ishizaka K (1994) Requirement of posttranslational modifications for the generation of biologic activity of glycosylation-inhibiting factor. Proc Natl Acad Sci USA 91:11227-11231
28. Bernhagen J, Bacher M, Calandra T, Metz CN, Doty S, Donnelly T, Bucala R (1996) An essential role for macrophage migration inhibitory factor (MIF) in the delayed-type hypersensitivity reaction. J Exp Med 183:277-282
29. Wistow GJ, Shaughnessy MP, Lee DC, Hodin, J, Zelenka PS (1993) A macrophage migration inhibitory factor is expressed in the differentiating cells of the eye lens. Proc Natl Acad Sci USA 90:1272-1275
30. Lanahan A, Williams JB, Sanders LK, Nathans D (1992) Growth factor-induced delayed early response genes. Mol Cell Biol 12:3919-3929
31. Blocki FA, Schlievert PM, Wackett LP (1992) Rat liver protein linking chemical and immunological detoxification systems. Nature (London) 360:269-270
32. Nishihara, J, Kuriyama T, Nishino H, Ishibashi T, Sakai M, Nishi S (1993) Purification and characterization of human macrophage migration inhibitory factor: evidence for specific binding to glutathione and formation of subunit structure. Biochem Mol Biol Int 31:841-850
33. Pearson W R (1994) MIF proteins are not glutathione transferase homologs. Protein Sci 3:525-527
34. Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Nishihara, J, Sakai M (1996) Crystal structure of the macrophage migration inhibitory factor from rat liver. Nat Struct Biol 3:259-266
35. Rosengren E, Bucala, R, Åman P, Jacobsson L, Odh G, Metz CN, Rorsman H (1996) The immunoregulatory mediator macrophage migration inhibitory factor (MIF) catalyzes a tautomerization reaction. Mol Med 2:143-149
36. Calandra T, Bernhagen J, Metz CN, Spiegel L, Bacher M, Donnelly T, Cerami A, Bucala R (1995) MIF as a glucocorticoid-induced modulator of cytokine production. Nature (London) 377:68-71
37. Paralkar V, Wistow G (1994) Cloning of the human gene for macrophage migration inhibitory factor (MIF). Genomics 19: 48-51
38. Mitchell RA, Bacher M, Bernhagen, J, Pushkarskaya T, Seldin M, Bucala R (1995) Cloning and characterization of the gene for mouse MIF. J Immunol 154:3863-3870
39. Bozza M, Kolakowski LF, Jenkins NA, Gilbert DJ, Copeland NG, David JR, Gerard C (1995) Structural characterization and chromosomal localization of the mouse macrophage migration inhibitory factor gene and pseudogenes. Genomics 27:412-419
40. Kozak CA, Adamson MC, Buckler CE, Segovia L, Paralkar V, Wistow G (1995) Genomic cloning of mouse MIF and genetic mapping of the human and mouse expressed gene and nine mouse pseudogenes. Genomics 27:405-411
41. Galat A, Riviere S, Bouet F (1993) Purification of macrophage migration inhibitory factor (MIF) from bovine brain cytosol FEBS Lett 319:233-236
42. Zeng F-Y, Weiser WY, Kratzin H, Stahl B, Karas M, Gabius H-J (1993) The major binding protein of the interferon antagonist sarcolectin in human placenta is a macrophage migration inhibitory factor. Arch Biochem Biophys 303:74-80
43. Sun H-W, Bernhagen, J, Bucala, R, Lolis E (1996) Crystal structure at 2.6 Å resolution of human macrophage migration inhibitory factor. Proc Natl Acad Sci USA 93:5191-5196
44. Kato Y, Muto T, Tomura T, Tsumura H, Watarai H, Mikayama T, Ishizaka I, Kuroki R (1996) The crystal structure of human glycosylation-inhibiting factor is a trimeric barrel with three 6-stranded β-sheets. Proc Natl Acad Sci USA 93:3007-3010
45. Sugimoto H, Suzuki M, Nakagawa A, Tanaka I, Nishihara J (1996) Crystal structure of macrophage migration inhibitory factor from human lymphocyte at 2.1 Å resolution. FEBS Lett 389:145-148
46. Mühlhahn P, Bernhagen, J, Czisch M, Georgescu, J, Renner C, Ross A, Bucala, R, Holak T (1996) NMR characterization of structure, backbone dynamics, and glutathione binding of human macrophage migration inhibitory factor (MIF). Protein Sci 5:2095-2103
47. Bacher M, Meinhardt A, Lan HY, Mu W, Metz CN, Chesney JA, Calandra T, Gemsa D, Donnelly T, Atkins RC, Bucala R (1997) Migration inhibitory factor expression in experimentally induced endotoxemia. Am J Pathol 150:235-246
48. Waeber G, Calandra T, Roduit, R, Haefliger JA, Bonny C, Thompson, N, Thorens B, Temler E, Meinhardt A, Bacher M, Metz CN, Nicod P, Bucala, R (1997) Insulin secretion regulated by the glucose-dependent production of islet β cell macrophage migration inhibitory factor. Proc Natl Acad Sci USA (in press)
49. Lan HY, Mu W, Yang, N, Meinhardt A, Nikolic-Paterson DJ, Ng YY, Bacher M, Atkins RC, Bucala R (1996) De novo renal expression of macrophage migration inhibitory factor during the development of rat crescentic glomerulonephritis. Am J Pathol 149:1119-1127
50. Nishibori M, Nakaya, N, Tahara A, Kawabata M, Mori S, Saeki K (1996) Presence of macrophage migration inhibitory factor (MIF) in ependyma. astrocytes, and neurons in the brain. Neurosci Lett 213:193-196
51. Suzuki H, Kanagawa H, Nishihara J (1996) Evidence for the presence of macrophage migration inhibitory factor in murine reproductive organs and early embryos. Immunology Lett 51: 141-147
52. Meinhardt A, Bacher M, McFarlane JR, Metz CN, Seitz J, Hedger MP, Dekretser DM, Bucala R (1996) Macrophage migration inhibitory factor production by Leydig cells. Endocrinology 137:5090-5095
53. Subramanya HS, Roper DI, Dauter Z, Dodson EJ, Davies GJ, Wilson KS, Wigley DB (1996) Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases. Biochemistry 35: 792-802
54. Schreiber SL, Crabtree G R (1992) The mechanism of action of cyclosporin A and FK506. Immunol Today 13:136-142
55. Sherry B, Yarlett, N, Strupp A, Cerami A (1992) Identification of cyclophilin as a pro-inflammatory secretory product of lipopolysaccharide-activated macrophages. Proc Natl Acad Sci USA 89:3511-3515
56. Donnelly SC, Haslett C, Reid PT, Grant IS, Wallace W AH, Metz CN, Bruce LJ, Bucala R (1997) Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Nat Med 3:320-323