Water-soluble coenzyme Q10 inhibits nuclear translocation of apoptosis inducing factor and cell death caused by mitochondrial complex I inhibition

International Journal of Molecular Sciences

Volumn 15, Issue 8, 2014, Pages 13388-13400

  Li, Haining ^a,b   Chen, Guisheng ^a   Ma, Wanrui ^a   Li, Ping An Andy ^b  

^a NINGXIA MEDICAL UNIVERSITY   (China)

^b NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

Author keywords

Apoptosis; Apoptosis inducing factor; Coenzyme Q10; Mitochondrial membrane potential; Mitochondrion; Neuron; Reactive oxygen species; Rotenone; Superoxide; Ubiqunone; Water soluble coenzyme Q10

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 9; CYTOCHROME C; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; UBIDECARENONE; UBIQUINONE; WATER;

ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL LINE; CELL NUCLEUS; CHEMISTRY; DRUG EFFECTS; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE;

ANIMALS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; CASPASE 9; CELL LINE; CELL NUCLEUS; CYTOCHROMES C; ELECTRON TRANSPORT COMPLEX I; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; ROTENONE; UBIQUINONE; WATER;

EID: 84905659613     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms150813388     Document Type: Article

References (30)

1. Forno, L.S. Neuropathology of Parkinson's disease. J. Neuropathol. Exp. Neurol. 1996, 55, 259-272.
2. Schapira, A.H. Mitochondria inthe etiology and pathogenesis of Parkinson's disease. Lancet Neurol. 2008, 7, 97-109.
3. Cannon, J.R.; Tapias, V.; Na, H.M.; Honick, A.S.; Drolet, R.E.; Greenamyre, J.T. A highly reproducible rotenone model of Parkinson's disease. Neurobiol. Dis. 2009, 34, 279-290.
4. Tamilselvam, K.; Braidy, N.; Manivasagam, T.; Essa, M.M.; Prasad, N.R.; Karthikeyan, S.; Thenmozhi, A.J.; Selvaraju, S.; Guillemin, G.J. Neuroprotective effects of hesperidin, a plant flavanone, on rotenone-induced oxidative stress and apoptosis in a celluar model for Parkinson's disease. Oxid. Med. Cell. Longev. 2013, 2013, 102741
5. Radad, K.; Rausch, W.D.; Gille, G. Rotenone induces cell death in primary dopaminergic culture by increasing ROS production and inhibiting mitochondrial respiration. Neurochem. Int. 2006, 49, 379-386.
6. Reed, J.C. Mechanisms of apoptosis. Am. J. Pathol. 2000, 157, 1415-1430.
7. Papucci, L.; Schiavone, N.; Witort, E.; Donnini, M.; Lapucci, A.; Tempestini, A.; Formigli, L.; Zecchi-Orlandini, S.; Orlandini, G.; Carella, G.;et al. Coenzyme Q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radial scavenging property. J. Biol. Chem. 2003, 278, 28220-28228.
8. Kooncumcoo, P.; Sharma, S.; Porter, J.; Govitrapong, P.; Ebadi, M. Coenzyme Q10 provides neuroprotection in iron-induced apoptosis in dopaminergic neurons. J. Mol. Neurosci. 2006, 28, 125-141.
9. Park, J.; Park, H.H.; Choi, H.; Kim, Y.S.; Yu, H.J.; Lee, Y.J.; Kim, S.H.; Koh, S.H. Coenzyme Q10 protects neural stem cells against hypoxia by enhancing survival signals. Brain Res. 2012, 1478, 64-73.
10. Fetoni, A.R.; Piacentini, R.; Fiorita, A.; Paludetti, G.; Troiani, D. Water-soluble coenzyme Q10 formulation (Q-ter) promotes outer hair cell survival in a guinea pig model of noise induced hearing loss (NIHL). Brain Res. 2009, 1537, 108-116.
11. Panee, J.; Liu, W.; Nakamura, K.; Berry, M.J. The responses of HT 22 cellsto the blockade of mitochondrial complexes and potential protective effect of selenium supplementation. Int. J. Biol. Sci. 2007, 3, 335-341.
12. Kushnareva, Y.; Murphy, A.N.; Andreyev, A. Complex I-mediated reactive oxygen species generation: Modulation by cytochrome c and NAD(P)+ oxidation-reduction state. Biochem. J. 2002, 368, 545-553.
13. Li, N.; Ragheb, K.; Lawler, G.; Sturgis, J.; Rajwa, B.; Melendez, J.A.; Robinson, J.P. Mitochondrial complexes I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J. Biol. Chem. 2003, 278, 8516-8525.
14. Sena, L.A.; Chandel, N.S. Physiological roles of mitochondrial reactive oxygen species. Mol. Cell 2012, 48, 158-167.
15. Pei, W.; Liou, A.K.; Chen, J. Two caspase-mediated apoptosis pathways induced by rotenone toxicity in cortical neuronal cells. FASEB J. 2003, 17, 520-522.
16. Green, D.R.; Reed, J.C. Mitochondrial and apoptosis. Science 1998, 281, 1309-1312.
17. Kluck, R.M.; Bossy-Wetzel, E.; Green, D.R.; Newmeyer, D.D. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science 1997, 275, 1132-1136.
18. Lee, J.H.; Won, Y.S.; Park, K.H.; Lee, M.K.; Tachibana, H.; Yamada, K.; Seo, K.I. Celastrol inhibits growth and induces apoptosis cell death in melanoma cellsvia the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling. Apoptosis 2012, 17, 1275-1286.
19. Lin, T.K.; Cheng, C.H.; Chen, S.D.; Liou, C.W.; Huang, C.R.; Chuang, Y.C. Mitochondrial dysfunction and oxidative stress promote apoptotic cell death in the striatum via cytochrome c/caspase-3 signaling cascade following chronic rotenone intoxication in rats. Int. J. Mol. Sci. 2012, 13, 8722-8739.
20. Büttner, S.; Habernig, L.; Broeskamp, F.; Ruli, D.; Vögtle, F.N.; Vlachos, M.; Macchi, F.; Küttner, V.; Carmona-Gutierrez, D.; Eisenberg, T.;et al. Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease. EMBO J. 2013, 32, 3041-3054.
21. Krantic, S.; Mechawar, N.; Reix, S.; Quirion, R. Apoptosis-inducing factor: A matter of neuron life and death. Prog. Neurobiol. 2007, 81, 179-196.
22. Li, J.; Spletter, M.L.; Johnson, D.A.; Wright, L.S.; Svendsen, C.N.; Johnson, J.A. Rotenone-induced caspase 9/3-independent and-dependent cell death in undifferentiated human neural stem cells. J. Neurochem. 2005, 92, 462-476.
23. Liang, J.M.; Yu, Y.; Wang, B.Y.; Lu, B.; Zhang, J.Z.; Zhang, H.B.; Ge, P.F. Ginsenoside Rb1 attenuates oxygen-glucose deprivation-induced apoptosis in SH-SY5Y cells via protection of mitochondrial and inhibition of AIF and cytochrome C release. Molecules 2013, 18, 12777-12792.
24. Shih, C.M.; Ko, W.C.; Wu, J.S.; Wei, Y.H.; Wang, L.F.; Cheng, H.H.; Chen, C.T. Mediating of caspase-independent apoptosis by cadmium through the mitochondrial-ROS pathway in MRC-5 fibroblasts. J. Cell. Biochem. 2004, 91, 384-397.
25. Chinta, S.J.; Rane, A.; Yadava, N.; Andersen, J.; Nicholls, D.G.; Polster, B.M. Reactive oxygen species regulation by AIF-and complex I-depleted brain mitochondria. Free Radic. Biol. Med. 2009, 46, 939-947.
26. Moon, Y.; Lee, K.H.; Park, J.-H.; Geum, D.; Kim, K. Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: Protective effect ofcoenzyme Q10. J. Neurochem. 2005, 93, 1199-11208.
27. Sandhu, J.K.; Pandey, S.; Ribecco-Lutkiewicz, M.; Monette, R.; Borowy-Borowsdi, H.; Walker, P.R.; Sikorska, M. Molecular mechanisms of glutamate neurotoxicity in mixed cultures of NT2-derived neurons and astrocytes: Protective effects of Coenzyme Q10. J. Neurosci. Res. 2003, 72, 691-703.
28. Jing, L.; Kumari, S.; Mendelev, N.; Li, P.A. Coenzyme Q10 ameliorates ultraviolet B irradiation induced cell death through inhibition of mitochondrial intrinsic cell death pathway. Int. J. Mol. Sci. 2011, 12, 8302-8315.
29. Somayajulu-Nitu, M.; Sandhu, J.K.; Cohen, J.; Sikorska, M.; Sridhar, T.S.; Matei, A.; Borowy-Borowski, H.; Pandey, S. Paraquat induces oxidative stress, neuronal loss in substantia nigra region and Parkinsonism in adult rats: Neuroprotection and amelioration of symptoms by water-soluble formulation of Coenzyme Q10. BMC Neurosci. 2009, 10, 1-12.
30. Mendelev, N.; Mehta, S.L.; Witherspoon, S.; He, Q.; Sexton, J.Z.; Li, P.A. Upregulation of human selenoprotein H in murine hippocampal neuronal cells promotes mitochondrial biogenesis and functional performance. Mitochondrion 2011, 11, 76-82.