Coenzyme Q10 protects neural stem cells against hypoxia by enhancing survival signals

Brain Research

Volumn 1478, Issue , 2012, Pages 64-73

  Park, Jinse ^a,b   Park, Hyun Hee ^a   Choi, Hojin ^a   Seo Kim, Young ^a   Yu, Hyun Jeung ^c   Lee, Kyu Yong ^a   Joo Lee, Young ^a   Hyun Kim, Seung ^a   Koh, Seong Ho ^a,d  

^a Hanyang University Guri Hospital   (South Korea)

^b Inje University College of Medicine   (South Korea)

^c Bundang Jesaeng Hospital   (South Korea)

^d Hanyang University   (South Korea)

Author keywords

Coenzyme Q10; Hypoxia; Neural stem cells; Neuroprotection

Indexed keywords

CASPASE 3; FREE RADICAL; GLYCOGEN SYNTHASE KINASE 3; PROTEIN BCL 2; PROTEIN KINASE B; UBIDECARENONE;

ANIMAL CELL; ARTICLE; BRAIN HYPOXIA; CELL VIABILITY; EMBRYO; ENZYME PHOSPHORYLATION; INTRACELLULAR SIGNALING; NEURAL STEM CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY;

ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; FREE RADICALS; IN SITU NICK-END LABELING; NEURAL STEM CELLS; RATS; REPERFUSION INJURY; SIGNAL TRANSDUCTION; UBIQUINONE;

EID: 84866503493     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.08.025     Document Type: Article

References (28)

1. A.A. Abd-El-Fattah, M.M. El-Sawalhi, E.R. Rashed, and M.A. El-Ghazaly Possible role of vitamin E, coenzyme Q10 and rutin in protection against cerebral ischemia/reperfusion injury in irradiated rats Int. J. Radiat. Biol. 86 2010 1070 1078
2. M.F. Beal Coenzyme Q10 administration and its potential for treatment of neurodegenerative diseases Biofactors 9 1999 261 266
3. B.R. Broughton, D.C. Reutens, and C.G. Sobey Apoptotic mechanisms after cerebral ischemia Stroke 40 2009 e331 e339
4. A. Chojnacki, and S. Weiss Production of neurons, astrocytes and oligodendrocytes from mammalian CNS stem cells Nat. Protoc. 3 2008 935 940
5. H. Chung, S. Seo, M. Moon, and S. Park Phosphatidylinositol-3-kinase/Akt/ glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells J. Endocrinol. 198 2008 511 521
6. D.S. Currle, J.S. Hu, A. Kolski-Andreaco, and E.S. Monuki Culture of mouse neural stem cell precursors J. Vis. Exp. 2007 152
7. C. Fleury, B. Mignotte, and J.L. Vayssiere Mitochondrial reactive oxygen species in cell death signaling Biochimie 84 2002 131 141
8. P. Grieb, M.S. Ryba, J. Sawicki, and S.J. Chrapusta Oral coenzyme Q10 administration prevents the development of ischemic brain lesions in a rabbit model of symptomatic vasospasm Acta Neuropathol. 94 1997 363 368
9. Q. Jiang, Z. Gu, G. Zhang, and G. Jing Diphosphorylation and involvement of extracellular signal-regulated kinases (ERK1/2) in glutamate-induced apoptotic-like death in cultured rat cortical neurons Brain Res. 857 2000 71 77
10. K. Jin, Y. Sun, L. Xie, A. Peel, X.O. Mao, S. Batteur, and D.A. Greenberg Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum Mol. Cell Neurosci. 24 2003 171 189
11. T. Kallur, V. Darsalia, O. Lindvall, and Z. Kokaia Human fetal cortical and striatal neural stem cells generate region-specific neurons in vitro and differentiate extensively to neurons after intrastriatal transplantation in neonatal rats J. Neurosci. Res. 84 2006 1630 1644
12. Y.J. Lee, H.H. Park, S.H. Koh, N.Y. Choi, and K.Y. Lee Amlodipine besylate and amlodipine camsylate prevent cortical neuronal cell death induced by oxidative stress J Neurochem 119 2011 1262 1270
13. Y.J. Lee, K.H. Park, H.H. Park, Y.J. Kim, K.Y. Lee, S.H. Kim, and S.H. Koh Cilnidipine mediates a neuroprotective effect by scavenging free radicals and activating the phosphatidylinositol 3-kinase pathway J. Neurochem. 111 2009 90 100
14. C. Li, R. Issa, P. Kumar, I.N. Hampson, J.M. Lopez-Novoa, C. Bernabeu, and S. Kumar CD105 prevents apoptosis in hypoxic endothelial cells J. Cell Sci. 116 2003 2677 2685
15. H.J. Lin, X. Wang, K.M. Shaffer, C.Y. Sasaki, and W. Ma Characterization of H2O2-induced acute apoptosis in cultured neural stem/progenitor cells FEBS Lett. 570 2004 102 106
16. R.T. Matthews, L. Yang, S. Browne, M. Baik, and M.F. Beal Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects Proc. Natl. Acad. Sci. U S A 95 1998 8892 8897
17. D. Nakayama, T. Matsuyama, H. Ishibashi-Ueda, T. Nakagomi, Y. Kasahara, H. Hirose, A. Kikuchi-Taura, D.M. Stern, H. Mori, and A. Taguchi Injury-induced neural stem/progenitor cells in post-stroke human cerebral cortex Eur. J. Neurosci. 31 2010 90 98
18. R.P. Ostrowski Effect of coenzyme Q10 (CoQ10) on superoxide dismutase activity in ET-1 and ET-3 experimental models of cerebral ischemia in the rat Folia. Neuropathol. 37 1999 247 251
19. J. Pan, Q. Chang, X. Wang, Y. Son, Z. Zhang, G. Chen, J. Luo, Y. Bi, F. Chen, and X. Shi Reactive oxygen species-activated Akt/ASK1/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells Chem. Res. Toxicol. 23 2010 568 577
20. C.W. Shults, D. Oakes, K. Kieburtz, M.F. Beal, R. Haas, S. Plumb, J.L. Juncos, J. Nutt, I. Shoulson, J. Carter, K. Kompoliti, J.S. Perlmutter, S. Reich, M. Stern, R.L. Watts, R. Kurlan, E. Molho, M. Harrison, and M. Lew Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline Arch. Neurol. 59 2002 1541 1550
21. C.W. Shults, and R. Haas Clinical trials of coenzyme Q10 in neurological disorders Biofactors 25 2005 117 126
22. M. Somayajulu, S. McCarthy, M. Hung, M. Sikorska, H. Borowy-Borowski, and S. Pandey Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10 Neurobiol. Dis. 18 2005 618 627
23. M. Spindler, M.F. Beal, and C. Henchcliffe Coenzyme Q10 effects in neurodegenerative disease Neuropsychiatr. Dis. Treat. 5 2009 597 610
24. L. Studer, V. Tabar, and R.D. McKay Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats Nat. Neurosci. 1 1998 290 295
25. K.C. Walls, A.P. Ghosh, M.E. Ballestas, B.J. Klocke, and K.A. Roth bcl-2/Adenovirus E1B 19-kd interacting protein 3 (BNIP3) regulates hypoxia-induced neural precursor cell death J. Neuropathol. Exp. Neurol. 68 2009 1326 1338
26. S. Willaime-Morawek, and D. van der Kooy Cortex- and striatum-derived neural stem cells produce distinct progeny in the olfactory bulb and striatum Eur. J. Neurosci. 27 2008 2354 2362
27. L. Yang, N.Y. Calingasan, E.J. Wille, K. Cormier, K. Smith, R.J. Ferrante, and M.F. Beal Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases J. Neurochem. 109 2009 1427 1439
28. Y. Zhao, Z. Xiao, Y. Gao, B. Chen, J. Zhang, and J. Dai Insulin rescues ES cell-derived neural progenitor cells from apoptosis by differential regulation of Akt and ERK pathways Neurosci. Lett. 429 2007 49 54