Is the omega-3 index a valid marker of intestinal membrane phospholipid EPA+DHA content?

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 91, Issue 3, 2014, Pages 87-96

  Gurzell, Eric A ^a   Wiesinger, Jason A ^a   Morkam, Christina ^a   Hemmrich, Sophia ^a   Harris, William S ^c   Fenton, Jenifer I ^a,b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c UNIVERSITY OF SOUTH DAKOTA   (United States)

Author keywords

Biomarker; Colon; Fatty acids; Intestine; Omega 3; Red blood cell

Indexed keywords

DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; FAT INTAKE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ERYTHROCYTE; FATTY ACID ANALYSIS; FATTY ACID BLOOD LEVEL; FEMALE; INTESTINE MUCOSA; LIPID COMPOSITION; MALE; METABOLIC PARAMETERS; MOUSE; NONHUMAN; OMEGA 3 INDEX; OUTCOME ASSESSMENT; PRIORITY JOURNAL; THERAPY EFFECT; TISSUE LEVEL; TREATMENT DURATION; VALIDATION STUDY; ANIMAL; CELL MEMBRANE; FAT INTAKE; INFLAMMATORY BOWEL DISEASE; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHARMACOLOGY;

MUS;

ANIMALS; CELL MEMBRANE; DIETARY FATS; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; MICE; MICE, KNOCKOUT;

EID: 84905592450     PISSN: 09523278     EISSN: 15322823     Source Type: Journal    
DOI: 10.1016/j.plefa.2014.04.001     Document Type: Article

References (35)

1. Turner D., Steinhart A.H., Griffiths A.M. Omega 3 fatty acids (fish oil) for maintenance of remission in ulcerative colitis. Cochrane Database Syst. Rev. 2007, CD006443.
2. Hou J.K., Abraham B., El-Serag H. Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. Am. J. Gastroenterol. 2011, 106:563-573.
3. Gil A. Polyunsaturated fatty acids and inflammatory diseases. Biomed. Pharmacother. 2002, 56:388-396.
4. Chapkin R.S., Davidson L.A., Ly L., Weeks B.R., Lupton J.R., McMurray D.N. Immunomodulatory effects of (n-3) fatty acids: putative link to inflammation and colon cancer. J. Nutr. 2007, 137:200S-204S.
5. Matsunaga H., Hokari R., Kurihara C., Okada Y., Takebayashi K., Okudaira K., Watanabe C., Komoto S., Nakamura M., Tsuzuki Y., Kawaguchi A., Nagao S., Itoh K., Miura S. Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts. Inflammatory Bowel Dis. 2008, 14:1348-1357.
6. Ghosh S., DeCoffe D., Brown K., Rajendiran E., Estaki M., Dai C., Yip A., Gibson D.L. Fish oil attenuates omega-6 polyunsaturated fatty acid-induced dysbiosis and infectious colitis but impairs LPS dephosphorylation activity causing sepsis. PLoS One 2013, 8:e55468.
7. Turk H.F., Monk J.M., Fan Y.Y., Callaway E.S., Weeks B., Chapkin R.S. Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing. Am. J. Physiol. Cell Physiol. 2013, 304:C905-917.
8. Woodworth H.L., McCaskey S.J., Duriancik D.M., Clinthorne J.F., Langohr I.M., Gardner E.M., Fenton J.I. Dietary fish oil alters T lymphocyte cell populations and exacerbates disease in a mouse model of inflammatory colitis. Cancer Res. 2010, 70:7960-7969.
9. Harris W.S., Von Schacky C. The Omega-3 Index: a new risk factor for death from coronary heart disease?. Prevent. med. 2004, 39:212-220.
10. Harris W.S., Varvel S.A., Pottala J.V., Warnick G.R., McConnell J.P. Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: Implications for clinical utility. J. Clin. Lipidol. 2013.
11. Harris W.S. The omega-3 index: clinical utility for therapeutic intervention. Curr. Cardiol. Rep. 2010, 12:503-508.
12. Harris W.S., Sands S.A., Windsor S.L., Ali H.A., Stevens T.L., Magalski A., Porter C.B., Borkon A.M. Omega-3 fatty acids in cardiac biopsies from heart transplantation patients-correlation with erythrocytes and response to supplementation. Circulation 2004, 110:1645-1649.
13. Kris-Etherton P.M., Harris W.S., Appel L.J., Nutrition C. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Arterioscler. thromb. vasc. Biology 2003, 23:e20-30.
14. Rose H.G., Oklander M. Improved procedure for extraction of lipids from human erythrocytes. J. Lipid Res. 1965, 6:428. (&).
15. Lydic T.A., Renis R., Busik J.V., Reid G.E. Analysis of retina and erythrocyte glycerophospholipid alterations in a rat model of type 1 diabetes. Jala-J. Lab. Autom. 2009, 14:383-399.
16. Agren J.J., Julkunen A., Penttila I. Rapid separation of serum-lipids for fatty-acid analysis by a single aminopropyl column. J. Lipid Res. 1992, 33:1871-1876.
17. Bondia-Pons I., Morera-Pons S., Castellote A.I., Lopez-Sabater M.C. Determination of phospholipid fatty acids in biological samples by solid-phase extraction and fast gas chromatography. J. Chromatogr. A 2006, 1116:204-208.
18. Burdge G.C., Wright P., Jones A.E., Wootton S.A. A method for separation of phosphatidylcholine, triacylglycerol, non-esterified fatty acids and cholesterol esters from plasma by solid-phase extraction. Br. J. Nutr. 2000, 84:781-787.
19. Aarsetoey H., Aarsetoey R., Lindner T., Staines H., Harris W.S., Nilsen D.W.T. Low levels of the omega-3 index are associated with sudden cardiac arrest and remain stable in survivors in the subacute phase. Lipids 2011, 46:151-161.
20. von Schacky C. The omega-3 index as a risk factor for cardiovascular diseases. Prostaglandins Other Lipid Mediators 2011, 96:94-98.
21. Turner D., Shah P.S., Steinhart A.H., Zlotkin S., Griffiths A.M. Maintenance of remission in inflammatory bowel disease using omega-3 fatty acids (fish oil): a systematic review and meta-analyses. Inflamm. Bowel Dis. 2011, 17:336-345.
22. Arnold C., Markovic M., Blossey K., Wallukat G., Fischer R., Dechend R., Konkel A., von Schacky C., Luft F.C., Muller D.N., Rothe M., Schunck W.H. Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of omega-3 fatty acids. J Biol. Chem. 2010, 285:32720-32733.
23. Min/+) mice. J. Nutr. 2000, 130:1153-1158.
24. Oikarinen S.I., Pajari A.M., Salminen I., Heinonen S.M., Adlercreutz H., Mutanen M. Effects of a flaxseed mixture and plant oils rich in alpha-linolenic acid on the adenoma formation in multiple intestinal neoplasia (Min) mice. Br. J. Nutr. 2005, 94:510-518.
25. Alvheim A.R., Malde M.K., Osei-Hyiaman D., Lin Y.H., Pawlosky R.J., Madsen L., Kristiansen K., Froyland L., Hibbeln J.R. Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity. Obesity (Silver Spring) 2012, 20:1984-1994.
26. Acar N., Berdeaux O., Gregoire S., Cabaret S., Martine L., Gain P., Thuret G., Creuzot-Garcher C.P., Bron A.M., Bretillon L. Lipid composition of the human eye: are red blood cells a good mirror of retinal and optic nerve fatty acids?. PloS one 2012, 7:e35102.
27. Metcalf R.G., James M.J., Gibson R.A., Edwards J.R., Stubberfield J., Stuklis R., Roberts-Thomson K., Young G.D., Cleland L.G. Effects of fish-oil supplementation on myocardial fatty acids in humans. Am. J. Clin. Nutr. 2007, 85:1222-1228.
28. Flock M.R., Skulas-Ray A.C., Harris W.S., Etherton T.D., Fleming J.A., Kris-Etherton P.M. Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: a dose-response randomized controlled trial. J. Am. Heart Assoc. 2013, 2:e000513.
29. Metcalf R.G., Cleland L.G., Gibson R.A., Roberts-Thomson K.C., Edwards J.R., Sanders P., Stuklis R., James M.J., Young G.D. Relation between blood and atrial fatty acids in patients undergoing cardiac bypass surgery. Am. J. Clin. Nutr. 2010, 91:528-534.
30. Carver J.D., Benford V.J., Han B., Cantor A.B. The relationship between age and the fatty acid composition of cerebral cortex and erythrocytes in human subjects. Brain res. Bull. 2001, 56:79-85.
31. Rix T.A., Joensen A.M., Riahi S., Lundbye-Christensen S., Overvad K., Schmidt E.B. Marine n-3 fatty acids in adipose tissue and development of atrial fibrillation: a Danish cohort study. Heart 2013, 99:1519-1524.
32. Courtney E.D., Matthews S., Finlayson C., Di Pierro D., Belluzzi A., Roda E., Kang J.Y., Leicester R.J. Eicosapentaenoic acid (EPA) reduces crypt cell proliferation and increases apoptosis in normal colonic mucosa in subjects with a history of colorectal adenomas. International journal of colorectal disease 2007, 22:765-776.
33. Esteve M., Navarro E., Klaassen J., Abad-Lacruz A., Gonzalez-Huix F., Cabre E., Ramos E., Condom E., Fernandez-Banares F., Pastor C., Humbert P., Marti-Rague J., Gassull M.A. Plasma and mucosal fatty acid pattern in colectomized ulcerative colitis patients. Dig. Dis. Sci. 1998, 43:1071-1078.
34. Sen A., Ren J., Ruffin M.T., Turgeon D.K., Brenner D.E., Sidahmed E., Rapai M.E., Cornellier M.L., Djuric Z. Relationships between serum and colon concentrations of carotenoids and fatty acids in randomized dietary intervention trial. Cancer Prev. Res. (Phila) 2013, 6:558-565.
35. Fernandez-Banares F., Esteve M., Navarro E., Cabre E., Boix J., Abad-Lacruz A., Klaassen J., Planas R., Humbert P., Pastor C., Gassull M.A. Changes of the mucosal n3 and n6 fatty acid status occur early in the colorectal adenoma-carcinoma sequence. Gut 1996, 38:254-259.