Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: Implications for clinical utility

Journal of Clinical Lipidology

Volumn 7, Issue 5, 2013, Pages 433-440

  Harris, William S ^a,b,c   Varvel, Stephen A ^a   Pottala, James V ^b,c   Warnick, G Russell ^a   McConnell, Joseph P ^a  

^a Health Diagnostic Laboratory Inc   (United States)

^b OmegaQuant Analytics   (United States)

^c UNIVERSITY OF SOUTH DAKOTA   (United States)

Author keywords

Biomarker; Biovariability; Erythrocytes; n 3 Fatty acids; Plasma

Indexed keywords

DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID;

ADULT; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CLINICAL ARTICLE; ERYTHROCYTE; FEMALE; HUMAN; MALE; MEAL; MICROCAPSULE; PLASMA; PRIORITY JOURNAL;

BIOMARKER; BIOVARIABILITY; ERYTHROCYTES; N-3 FATTY ACIDS; PLASMA;

ADULT; BLOOD CHEMICAL ANALYSIS; DOCOSAHEXAENOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; EICOSAPENTAENOIC ACID; ERYTHROCYTES; FEMALE; FISH OILS; HUMANS; MALE; PLASMA;

EID: 84885020744     PISSN: 19332874     EISSN: 18764789     Source Type: Journal    
DOI: 10.1016/j.jacl.2013.05.001     Document Type: Article

References (61)

1. W.S. Harris, and C. von Schacky The omega-3 index: a new risk factor for death from coronary heart disease? Prev Med 39 2004 212 220
2. D.S. Siscovick, T.E. Raghunathan, and I. King Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest J Am Med Assoc 274 1995 1363 1367
3. W.S. Harris, S.A. Sands, and S.L. Windsor Omega-3 fatty acids in cardiac biopsies from heart transplant patients: correlation with erythrocytes and response to supplementation Circulation 110 2004 1645 1649
4. R.G. Metcalf, L.G. Cleland, and R.A. Gibson Relation between blood and atrial fatty acids in patients undergoing cardiac bypass surgery Am J Clin Nutr 91 2010 528 534
5. W.S. Harris, and R.M. Thomas Biological variability of blood omega-3 biomarkers Clin Biochem 43 2010 338 340
6. M.H. Davidson, J. Johnson, M.W. Rooney, M.L. Kyle, and D.F. Kling A novel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3-acid ethyl esters: the ECLIPSE (Epanova compared to Lovaza in a pharmacokinetic single-dose evaluation) study J Clin Lipidol 6 2012 573 584
7. N. Brossard, M. Croset, and S. Normand Human plasma albumin transports [13c]docosahexaenoic acid in two lipid forms to blood cells J Lipid Res 38 1997 1571 1582
8. W.S. Harris, J.V. Pottala, R.S. Vasan, M.G. Larson, and S.J. Robins Changes in erythrocyte membrane trans and marine fatty acids between 1999 and 2006 in older Americans J Nutr 142 2012 1297 1303
9. H. Akaike Information theory as an extension of the maximum likelihood principal B. Petrov, F. Csaki, Second International Symposium of Information Theory and Control 1973 Akademia Kiado Budapest 267 281
10. M.B. Katan, J.P. Deslypere, A.P. van Birgelen, M. Penders, and M. Zegwaard Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study J Lipid Res 38 1997 2012 2022
11. W.S. Harris, J.V. Pottala, S.A. Sands, and P.G. Jones Comparison of the effects of fish and fish-oil capsules on the n 3 fatty acid content of blood cells and plasma phospholipids Am J Clin Nutr 86 2007 1621 1625
12. L. Hodson, C.M. Skeaff, and B.A. Fielding Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake Prog Lipid Res 47 2008 348 380
13. N. Yanagisawa, K. Shimada, and T. Miyazaki Polyunsaturated fatty acid levels of serum and red blood cells in apparently healthy Japanese subjects living in an urban area J Atheroscler Thromb 17 2010 285 294
14. P. Rise, S. Eligini, S. Ghezzi, S. Colli, and C. Galli Fatty acid composition of plasma, blood cells and whole blood: relevance for the assessment of the fatty acid status in humans Prostaglandins Leukot Essent Fatty Acids 76 2007 363 369
15. L.M. Browning, C.G. Walker, and A.P. Mander Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish Am J Clin Nutr 96 2012 748 758
16. E.C. Rizos, E.E. Ntzani, E. Bika, M.S. Kostapanos, and M.S. Elisaf Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis JAMA 308 2012 1024 1033
17. S.M. Kwak, S.K. Myung, Y.J. Lee, and H.G. Seo Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials Arch Intern Med 172 2012 686 694
18. Q. Sun, J. Ma, H. Campos, S.E. Hankinson, and F.B. Hu Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in us women Am J Clin Nutr 86 2007 74 81
19. J. Zheng, T. Huang, Y. Yu, X. Hu, B. Yang, and D. Li Fish consumption and CHD mortality: an updated meta-analysis of seventeen cohort studies Public Health Nutr 15 2012 725 737
20. P. Xun, B. Qin, and Y. Song Fish consumption and risk of stroke and its subtypes: accumulative evidence from a meta-analysis of prospective cohort studies Eur J Clin Nutr 66 2012 1199 1207
21. C.M. Albert, H. Campos, and M.J. Stampfer Blood levels of long-chain n-3 fatty acids and the risk of sudden death N Engl J Med 346 2002 1113 1118
22. W.S. Harris The omega-3 index: from biomarker to risk marker to risk factor Curr Atheroscler Rep 11 2009 411 417
23. A.C. Salisbury, W.S. Harris, A.P. Amin, K.J. Reid, J.H. O'Keefe Jr., and J.A. Spertus Relation between red blood cell omega-3 fatty acid index and bleeding during acute myocardial infarction Am J Cardiol 109 2012 13 18
24. W.S. Harris, K.F. Kennedy, J.H. O'Keefe Jr., and J.A. Spertus Red blood cell fatty acid levels improve GRACE score prediction of 2-yr mortality in patients with myocardial infarction Int J Cardiol 168 2013 53 59
25. G.C. Shearer, J.V. Pottala, J.A. Spertus, and W.S. Harris Red blood cell fatty acid patterns and acute coronary syndrome PLoS ONE 4 2009 e5444
26. W.S. Harris, J.V. Pottala, S.M. Lacey, R.S. Vasan, M.G. Larson, and S.J. Robins Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study Atherosclerosis 225 2012 425 431
27. J.B. Ladesich, J.V. Pottala, A. Romaker, and W.S. Harris Membrane level of omega-3 docosahexaenoic acid is associated with severity of obstructive sleep apnea J Clin Sleep Med 7 2011 391 396
28. J.V. Pottala, S. Garg, B.E. Cohen, M.A. Whooley, and W.S. Harris Blood eicosapentaenoic and docosahexaenoic acids predict all-cause mortality in patients with stable coronary heart disease: the Heart and Soul study Circ Cardiovasc Qual Outcomes 3 2010 406 412
29. R.C. Block, W.S. Harris, K.J. Reid, and J.A. Spertus Omega-6 and trans fatty acids in blood cell membranes: a risk factor for acute coronary syndromes? Am Heart J 156 2008 1117 1123
30. R.C. Block, W.S. Harris, K.J. Reid, S.A. Sands, and J.A. Spertus EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls Atherosclerosis 197 2007 821 828
31. Y.J. Kim, D.W. Jeong, and J.G. Lee Omega-3 index and smoking in patients with acute ST-elevation myocardial infarction taking statins: a case-control study in Korea Lipids Health Dis 11 2012 43
32. Y. Park, J. Lim, J. Lee, and S.G. Kim Erythrocyte fatty acid profiles can predict acute non-fatal myocardial infarction Br J Nutr 102 2009 1355 1361
33. Y. Park, S. Park, and H. Yi Low level of n-3 polyunsaturated fatty acids in erythrocytes is a risk factor for both acute ischemic and hemorrhagic stroke in Koreans Nutr Res 29 2009 825 830
34. Y. Park, S.H. Oh, and M.Y. Rhee Association between 24-hour ambulatory blood pressure and erythrocyte n-3 polyunsaturated fatty acids in Korean subjects with hypertension Nutr Res 30 2010 807 814
35. T.C. Baghai, G. Varallo-Bedarida, and C. Born Major depressive disorder is associated with cardiovascular risk factors and low omega-3 index J Clin Psychiatry 72 2010 1242 1247
36. B. Moyers, R. Farzaneh-Far, W.S. Harris, S. Garg, B. Na, and M.A. Whooley Relation of whole blood n-3 fatty acid levels to exercise parameters in patients with stable coronary artery disease (from the Heart and Soul study) Am J Cardiol 107 2011 1149 1154
37. R. Farzaneh-Far, J. Lin, E.S. Epel, W.S. Harris, E.H. Blackburn, and M.A. Whooley Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease JAMA 303 2010 250 257
38. S. Ali, S.K. Garg, B.E. Cohen, P. Bhave, W.S. Harris, and M.A. Whooley Association between omega-3 fatty acids and depressive symptoms among patients with established coronary artery disease: data from the Heart and Soul study Psychother Psychosom 78 2009 125 127
39. R. Farzaneh-Far, W.S. Harris, S. Garg, B. Na, and M.A. Whooley Inverse association of erythrocyte n-3 fatty acid levels with inflammatory biomarkers in patients with stable coronary artery disease: the Heart and Soul study Atherosclerosis 205 2009 538 543
40. Y. Wang, M.A. Crawford, and J. Chen Fish consumption, blood docosahexaenoic acid and chronic diseases in Chinese rural populations Comp Biochem Physiol A Mol Integr Physiol 136 2003 127 140
41. C. Viviani Anselmi, C. Ferreri, and V. Novelli Fatty acid percentage in erythrocyte membranes of atrial flutter/fibrillation patients and controls J Interv Card Electrophysiol 27 2010 95 99
42. A.A. Puca, P. Andrew, and V. Novelli Fatty acid profile of erythrocyte membranes as possible biomarker of longevity Rejuvenation Res 11 2008 63 72
43. C.M. Milte, N. Parletta, J.D. Buckley, A.M. Coates, R.M. Young, and P.R. Howe Eicosapentaenoic and docosahexaenoic acids, cognition, and behavior in children with attention-deficit/hyperactivity disorder: a randomized controlled trial Nutrition 28 2012 670 677
44. K. Kuriki, K. Hirose, and K. Wakai Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese Int J Cancer 121 2007 377 385
45. C.R. Ritch, C.B. Brendler, R.L. Wan, K.E. Pickett, and M.H. Sokoloff Relationship of erythrocyte membrane polyunsaturated fatty acids and prostate-specific antigen levels in Jamaican men BJU Int 93 2004 1211 1215
46. C.C. Chiu, S. Frangou, and C.J. Chang Associations between n-3 PUFA concentrations and cognitive function after recovery from late-life depression Am J Clin Nutr 95 2012 420 427
47. B. Heude, P. Ducimetiere, and C. Berr Cognitive decline and fatty acid composition of erythrocyte membranes-the EVA Study Am J Clin Nutr 77 2003 803 808
48. M. Watari, K. Hamazaki, T. Hirata, T. Hamazaki, and Y. Okubo Hostility of drug-free patients with schizophrenia and n-3 polyunsaturated fatty acid levels in red blood cells Psychiatry Res 177 2010 22 26
49. I. Swenne, A. Rosling, S. Tengblad, and B. Vessby Omega-3 polyunsaturated essential fatty acids are associated with depression in adolescents with eating disorders and weight loss Acta Paediatr 100 2011 1610 1615
50. E. Cyhlarova, J.G. Bell, J.R. Dick, E.E. Mackinlay, J.F. Stein, and A.J. Richardson Membrane fatty acids, reading and spelling in dyslexic and non-dyslexic adults Eur Neuropsychopharmacol 17 2007 116 121
51. T. Nakamura, A. Azuma, T. Kuribayashi, H. Sugihara, S. Okuda, and M. Nakagawa Serum fatty acid levels, dietary style and coronary heart disease in three neighbouring areas in Japan: the Kumihama study Br J Nutr 89 2003 267 272
52. A. Nogi, J. Yang, and L. Li Plasma n-3 polyunsaturated fatty acid and cardiovascular disease risk factors in Japanese, Korean and Mongolian workers J Occup Health 49 2007 205 216
53. E. Oda, K. Hatada, K. Katoh, M. Kodama, Y. Nakamura, and Y. Aizawa A case-control pilot study on n-3 polyunsaturated fatty acid as a negative risk factor for myocardial infarction Int Heart J 46 2005 583 591
54. A. Sekikawa, J.D. Curb, H. Ueshima ERA JUMP (Electron-Beam Tomography, Risk Factor Assessment Among Japanese and U.S. Men in the Post-World War II Birth Cohort) Study Group Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese-American, and white men: a cross-sectional study J Am Coll Cardiol 52 2008 417 424
55. E.N. Siguel, and R.H. Lerman Altered fatty acid metabolism in patients with angiographically documented coronary artery disease Metabolism 43 1994 982 993
56. M. Ueeda, T. Doumei, and Y. Takaya Serum n-3 polyunsaturated fatty acid levels correlate with the extent of coronary plaques and calcifications in patients with acute myocardial infarction Circ J 72 2008 1836 1843
57. L. Ferrucci, A. Cherubini, and S. Bandinelli Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers J Clin Endocrinol Metab 91 2006 439 446
58. Q. Sun, J. Ma, and H. Campos Blood concentrations of individual long-chain n-3 fatty acids and risk of nonfatal myocardial infarction Am J Clin Nutr 88 2008 216 223
59. D. Mozaffarian, R.N. Lemaitre, and I.B. King Plasma phospholipid long-chain omega-3 fatty acids and total and cause-specific mortality in older adults: a cohort study Ann Intern Med 158 2013 515 525
60. W.S. Harris, C. von Schacky, and Y. Park Standardizing methods for assessing omega-3 fatty acid biostatus R.K. McNamara, The Omega-3 Fatty Acid Deficiency Syndrome: Opportunities for Disease Prevention 2013 Nova Science Publishers, Inc Hauppauge, NY 385 398
61. C. Bocking, W.A. Nockher, M. Schreiner, H. Renz, and P.I. Pfefferle Development and validation of a combined method for the biomonitoring of omega-3/-6 fatty acids and conjugated linoleic acids in different matrices from human and nutritional sources Clin Chem Lab Med 48 2010 1757 1763