메뉴 건너뛰기




Volumn 12, Issue 6, 2010, Pages 503-508

The omega-3 index: Clinical utility for therapeutic intervention

Author keywords

Docosahexaenoic acid (DHA); Eicosapentaenoic acid (EPA); Omega 3 Index

Indexed keywords

DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; LONG CHAIN FATTY ACID; OMEGA 3 FATTY ACID;

EID: 77958502858     PISSN: 15233782     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11886-010-0141-6     Document Type: Review
Times cited : (110)

References (29)
  • 1
    • 2942724415 scopus 로고    scopus 로고
    • The Omega-3 Index: A new risk factor for death from coronary heart disease?
    • DOI 10.1016/j.ypmed.2004.02.030, PII S0091743504000878
    • WS Harris C von Schacky 2004 The Omega-3 Index: a new risk factor for death from coronary heart disease? Prev Med 39 212 220 1:CAS:528: DC%2BD2cXltVCisL4%3D 10.1016/j.ypmed.2004.02.030 15208005 (Pubitemid 38797975)
    • (2004) Preventive Medicine , vol.39 , Issue.1 , pp. 212-220
    • Harris, W.S.1    Von Schacky, C.2
  • 2
    • 66349111734 scopus 로고    scopus 로고
    • Criteria for evaluation of novel markers of cardiovascular risk: A scientific statement from the American Heart Association
    • 10.1161/CIRCULATIONAHA.109.192278 19364974 This important paper provides a roadmap and rationale for the evaluation and validation of new markers for CHD
    • MA Hlatky P Greenland DK Arnett, et al. 2009 Criteria for evaluation of novel markers of cardiovascular risk: a scientific statement from the American Heart Association Circulation 119 2408 2416 10.1161/CIRCULATIONAHA.109.192278 19364974 This important paper provides a roadmap and rationale for the evaluation and validation of new markers for CHD
    • (2009) Circulation , vol.119 , pp. 2408-2416
    • Hlatky, M.A.1    Greenland, P.2    Arnett, D.K.3
  • 3
    • 31844443695 scopus 로고
    • The environment and disease: Association or causation?
    • 1:STN:280:DyaF2M%2FovVCmsw%3D%3D 14283879
    • AB Hill 1965 The environment and disease: association or causation? Proc R Soc Med 58 295 300 1:STN:280:DyaF2M%2FovVCmsw%3D%3D 14283879
    • (1965) Proc R Soc Med , vol.58 , pp. 295-300
    • Hill, A.B.1
  • 4
    • 70449508666 scopus 로고    scopus 로고
    • The omega-3 index: From biomarker to risk marker to risk factor
    • 1:CAS:528:DC%2BC3cXhtFersrrL 10.1007/s11883-009-0062-2 19852881
    • WS Harris 2009 The omega-3 index: from biomarker to risk marker to risk factor Curr Atheroscler Rep 11 411 417 1:CAS:528:DC%2BC3cXhtFersrrL 10.1007/s11883-009-0062-2 19852881
    • (2009) Curr Atheroscler Rep , vol.11 , pp. 411-417
    • Harris, W.S.1
  • 5
    • 0028855987 scopus 로고
    • Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest
    • 1:CAS:528:DyaK2MXpsl2ksL0%3D 10.1001/jama.274.17.1363
    • DS Siscovick TE Raghunathan I King, et al. 1995 Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest J Am Med Assoc 274 1363 1367 1:CAS:528:DyaK2MXpsl2ksL0%3D 10.1001/jama.274.17.1363
    • (1995) J Am Med Assoc , vol.274 , pp. 1363-1367
    • Siscovick, D.S.1    Raghunathan, T.E.2    King, I.3
  • 7
    • 40949102602 scopus 로고    scopus 로고
    • EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls
    • 10.1016/j.atherosclerosis.2007.07.042 17875307
    • RC Block WS Harris KJ Reid, et al. 2007 EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls Atherosclerosis 197 821 828 10.1016/j.atherosclerosis.2007.07.042 17875307
    • (2007) Atherosclerosis , vol.197 , pp. 821-828
    • Block, R.C.1    Harris, W.S.2    Reid, K.J.3
  • 8
    • 67649409069 scopus 로고    scopus 로고
    • The relationship between n-3 long-chain polyunsaturated fatty acids and pulse wave velocity in diabetic and non-diabetic patients under long-term hemodialysis. A horizontal study
    • 1:CAS:528:DC%2BD1MXmsFKmsrs%3D 19473610
    • K Hamazaki Y Terashima M Itomura, et al. 2009 The relationship between n-3 long-chain polyunsaturated fatty acids and pulse wave velocity in diabetic and non-diabetic patients under long-term hemodialysis. A horizontal study Clin Nephrol 71 508 513 1:CAS:528:DC%2BD1MXmsFKmsrs%3D 19473610
    • (2009) Clin Nephrol , vol.71 , pp. 508-513
    • Hamazaki, K.1    Terashima, Y.2    Itomura, M.3
  • 9
    • 40749138171 scopus 로고    scopus 로고
    • Factors influencing EPA+DHA levels in red blood cells in Japan
    • 18396795
    • M Itomura S Fujioka K Hamazaki, et al. 2008 Factors influencing EPA+DHA levels in red blood cells in Japan In Vivo 22 131 135 18396795
    • (2008) In Vivo , vol.22 , pp. 131-135
    • Itomura, M.1    Fujioka, S.2    Hamazaki, K.3
  • 10
    • 77949273260 scopus 로고    scopus 로고
    • Fatty acid composition of plasma, erythrocytes and adipose: Their correlations and effects of age and sex
    • 1:CAS:528:DC%2BC3cXhs1amuro%3D 10.1007/s11745-010-3386-3 20094809
    • T Ogura H Takada M Okuno, et al. 2010 Fatty acid composition of plasma, erythrocytes and adipose: their correlations and effects of age and sex Lipids 45 137 144 1:CAS:528:DC%2BC3cXhs1amuro%3D 10.1007/s11745-010-3386-3 20094809
    • (2010) Lipids , vol.45 , pp. 137-144
    • Ogura, T.1    Takada, H.2    Okuno, M.3
  • 12
    • 45749105846 scopus 로고    scopus 로고
    • The omega-3 index as a risk factor for coronary heart disease
    • 1:CAS:528:DC%2BD1cXnslajs7g%3D 18541601
    • WS Harris 2008 The omega-3 index as a risk factor for coronary heart disease Am J Clin Nutr 87 1997S 2002S 1:CAS:528:DC%2BD1cXnslajs7g%3D 18541601
    • (2008) Am J Clin Nutr , vol.87
    • Harris, W.S.1
  • 13
    • 73349129719 scopus 로고    scopus 로고
    • Erythrocyte fatty acid profiles can predict acute non-fatal myocardial infarction
    • 1:CAS:528:DC%2BD1MXhsVyrtL3M 10.1017/S0007114509990298 19505347
    • Y Park J Lim J Lee SG Kim 2009 Erythrocyte fatty acid profiles can predict acute non-fatal myocardial infarction Br J Nutr 102 1355 1361 1:CAS:528:DC%2BD1MXhsVyrtL3M 10.1017/S0007114509990298 19505347
    • (2009) Br J Nutr , vol.102 , pp. 1355-1361
    • Park, Y.1    Lim, J.2    Lee, J.3    Kim, S.G.4
  • 15
    • 53049110571 scopus 로고    scopus 로고
    • Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): A randomised, double-blind, placebo-controlled trial
    • GISSI-HF investigators. 10.1016/S0140-6736(08)61239-8 18757090
    • GISSI-HF investigators L Tavazzi AP Maggioni, et al. 2008 Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial Lancet 372 1223 1230 10.1016/S0140-6736(08)61239-8 18757090
    • (2008) Lancet , vol.372 , pp. 1223-1230
    • Tavazzi, L.1    Maggioni, A.P.2
  • 17
    • 2942532780 scopus 로고    scopus 로고
    • Early modifications of fatty acid composition in plasma phospholipids, platelets and mononucleates of healthy volunteers after low doses of n-3 polyunsaturated fatty acids
    • DOI 10.1007/s00228-004-0758-8
    • D Di Stasi R Bernasconi R Marchioli, et al. 2004 Early modifications of fatty acid composition in plasma phospholipids, platelets and mononucleates of healthy volunteers after low doses of n-3 polyunsaturated fatty acids Eur J Clin Pharmacol 60 183 190 10.1007/s00228-004-0758-8 15069592 (Pubitemid 38757129)
    • (2004) European Journal of Clinical Pharmacology , vol.60 , Issue.3 , pp. 183-190
    • Di Stasi, D.1    Bernasconi, R.2    Marchioli, R.3    Marfisi, R.M.4    Rossi, G.5    Tognoni, G.6    Tacconi, M.T.7
  • 18
    • 77749292090 scopus 로고    scopus 로고
    • Relation between blood and atrial fatty acids in patients undergoing cardiac bypass surgery
    • 1:CAS:528:DC%2BC3cXisFyntLg%3D 10.3945/ajcn.2009.28302 20089730 RBC EPA+DHA levels were shown to correlate highly with human myocardial EPA+DHA content, indicating that the former is a valid surrogate marker for the latter
    • RG Metcalf LG Cleland RA Gibson, et al. 2010 Relation between blood and atrial fatty acids in patients undergoing cardiac bypass surgery Am J Clin Nutr 91 528 534 1:CAS:528:DC%2BC3cXisFyntLg%3D 10.3945/ajcn.2009.28302 20089730 RBC EPA+DHA levels were shown to correlate highly with human myocardial EPA+DHA content, indicating that the former is a valid surrogate marker for the latter
    • (2010) Am J Clin Nutr , vol.91 , pp. 528-534
    • Metcalf, R.G.1    Cleland, L.G.2    Gibson, R.A.3
  • 19
    • 54949108563 scopus 로고    scopus 로고
    • Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects
    • 1:CAS:528:DC%2BD1cXhtlOgtL3L 18841286
    • MK Larson JH Ashmore KA Harris, et al. 2008 Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects Thromb Haemost 100 634 641 1:CAS:528:DC%2BD1cXhtlOgtL3L 18841286
    • (2008) Thromb Haemost , vol.100 , pp. 634-641
    • Larson, M.K.1    Ashmore, J.H.2    Harris, K.A.3
  • 20
    • 70350712230 scopus 로고    scopus 로고
    • Omega-3 augmentation of sertraline in treatment of depression in patients with coronary heart disease: A randomized controlled trial
    • 1:CAS:528:DC%2BD1MXhtlams7nN 10.1001/jama.2009.1487 19843899
    • RM Carney KE Freedland EH Rubin, et al. 2009 Omega-3 augmentation of sertraline in treatment of depression in patients with coronary heart disease: a randomized controlled trial JAMA 302 1651 1657 1:CAS:528:DC%2BD1MXhtlams7nN 10.1001/jama.2009.1487 19843899
    • (2009) JAMA , vol.302 , pp. 1651-1657
    • Carney, R.M.1    Freedland, K.E.2    Rubin, E.H.3
  • 21
    • 51349141189 scopus 로고    scopus 로고
    • Stearidonic acid-enriched soybean oil increased the omega-3 index, an emerging cardiovascular risk marker
    • 1:CAS:528:DC%2BD1cXhtVOntL3F 10.1007/s11745-008-3215-0 18683001
    • WS Harris SL Lemke SN Hansen, et al. 2008 Stearidonic acid-enriched soybean oil increased the omega-3 index, an emerging cardiovascular risk marker Lipids 43 805 811 1:CAS:528:DC%2BD1cXhtVOntL3F 10.1007/s11745-008-3215-0 18683001
    • (2008) Lipids , vol.43 , pp. 805-811
    • Harris, W.S.1    Lemke, S.L.2    Hansen, S.N.3
  • 22
    • 64649093352 scopus 로고    scopus 로고
    • Determinants of blood cell omega-3 fatty acid content
    • 1:CAS:528:DC%2BD1MXhtFaqu74%3D 10.2174/1875318300801010001 19953197
    • RC Block WS Harris JV Pottala 2008 Determinants of blood cell omega-3 fatty acid content Open Biomark J 1 1 6 1:CAS:528:DC%2BD1MXhtFaqu74%3D 10.2174/1875318300801010001 19953197
    • (2008) Open Biomark J , vol.1 , pp. 1-6
    • Block, R.C.1    Harris, W.S.2    Pottala, J.V.3
  • 23
    • 0030711745 scopus 로고    scopus 로고
    • Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: An 18-month controlled study
    • 1:CAS:528:DyaK2sXntFCntbY%3D 9374124
    • MB Katan JP Deslypere AP van Birgelen, et al. 1997 Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study J Lipid Res 38 2012 2022 1:CAS:528:DyaK2sXntFCntbY%3D 9374124
    • (1997) J Lipid Res , vol.38 , pp. 2012-2022
    • Katan, M.B.1    Deslypere, J.P.2    Van Birgelen, A.P.3
  • 24
    • 74249118054 scopus 로고    scopus 로고
    • Biological variability of blood omega-3 biomarkers
    • 10.1016/j.clinbiochem.2009.08.016 19733159 The within-person stability of the Omega-3 Index, total plasma, and plasma phospholipid EPA+DHA was assessed in 20 volunteers tested weekly for 6 weeks. The variability of the Omega-3 Index was about one third of that of the other two markers
    • WS Harris RM Thomas 2009 Biological variability of blood omega-3 biomarkers Clin Biochem 43 338 340 10.1016/j.clinbiochem.2009.08.016 19733159 The within-person stability of the Omega-3 Index, total plasma, and plasma phospholipid EPA+DHA was assessed in 20 volunteers tested weekly for 6 weeks. The variability of the Omega-3 Index was about one third of that of the other two markers
    • (2009) Clin Biochem , vol.43 , pp. 338-340
    • Harris, W.S.1    Thomas, R.M.2
  • 25
    • 74549184608 scopus 로고    scopus 로고
    • Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease
    • 1:CAS:528:DC%2BC3cXptFShsA%3D%3D 10.1001/jama.2009.2008 20085953 This is the first study to describe an inverse association between blood levels of EPA+DHA and the rate of "cellular aging." The latter was assessed by measuring the change in leukocyte telomere length in over 600 patients with stable CHD over a 5-year period of time
    • R Farzaneh-Far J Lin ES Epel, et al. 2010 Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease JAMA 303 250 257 1:CAS:528:DC%2BC3cXptFShsA%3D%3D 10.1001/jama.2009.2008 20085953 This is the first study to describe an inverse association between blood levels of EPA+DHA and the rate of "cellular aging." The latter was assessed by measuring the change in leukocyte telomere length in over 600 patients with stable CHD over a 5-year period of time
    • (2010) JAMA , vol.303 , pp. 250-257
    • Farzaneh-Far, R.1    Lin, J.2    Epel, E.S.3
  • 26
    • 60449109369 scopus 로고    scopus 로고
    • Association between omega-3 fatty acids and depressive symptoms among patients with established coronary artery disease: Data from the Heart and Soul Study
    • 10.1159/000203118 19223688
    • S Ali SK Garg BE Cohen, et al. 2009 Association between omega-3 fatty acids and depressive symptoms among patients with established coronary artery disease: data from the Heart and Soul Study Psychother Psychosom 78 125 127 10.1159/000203118 19223688
    • (2009) Psychother Psychosom , vol.78 , pp. 125-127
    • Ali, S.1    Garg, S.K.2    Cohen, B.E.3
  • 27
    • 48149091259 scopus 로고    scopus 로고
    • Low levels of cellular omega-3 increase the risk of ventricular fibrillation during the acute ischaemic phase of a myocardial infarction
    • 1:CAS:528:DC%2BD1cXpt1GqsLw%3D 10.1016/j.resuscitation.2008.04.007 18556107
    • H Aarsetoy V Ponitz OB Nilsen, et al. 2008 Low levels of cellular omega-3 increase the risk of ventricular fibrillation during the acute ischaemic phase of a myocardial infarction Resuscitation 78 258 264 1:CAS:528: DC%2BD1cXpt1GqsLw%3D 10.1016/j.resuscitation.2008.04.007 18556107
    • (2008) Resuscitation , vol.78 , pp. 258-264
    • Aarsetoy, H.1    Ponitz, V.2    Nilsen, O.B.3
  • 28
    • 77956932832 scopus 로고    scopus 로고
    • Effects of a convenience drink fortified with n-3 fatty acids on the n-3 index
    • Apr 27:1-8 [Epub ahead of print]
    • Kohler A, Bittner D, Low A, von Schacky C: Effects of a convenience drink fortified with n-3 fatty acids on the n-3 index. Br J Nutr 2010 Apr 27:1-8 [Epub ahead of print].
    • (2010) Br J Nutr
    • Kohler, A.1    Bittner, D.2    Low, A.3    Von Schacky, C.4
  • 29
    • 0002673687 scopus 로고
    • Lipid metabolism and ischemic heart disease in Greenland eskimos
    • 1:CAS:528:DyaL3MXivFajsQ%3D%3D
    • HO Bang J Dyerberg 1980 Lipid metabolism and ischemic heart disease in Greenland eskimos Adv Nutr Res 3 1 22 1:CAS:528:DyaL3MXivFajsQ%3D%3D
    • (1980) Adv Nutr Res , vol.3 , pp. 1-22
    • Bang, H.O.1    Dyerberg, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.