High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4)

Biochemical Pharmacology

Volumn 91, Issue 1, 2014, Pages 97-108

  Cheung, Leanna ^a   Flemming, Claudia L ^a   Watt, Fujiko ^a   Masada, Nanako ^b   Yu, Denise M T ^a   Huynh, Tony ^a   Conseil, Gwenaëlle ^c   Tivnan, Amanda ^a   Polinsky, Alexander ^d   Gudkov, Andrei V ^e   Munoz, Marcia A ^a   Vishvanath, Anasuya ^a   Cooper, Dermot M F ^b   Henderson, Michelle J ^a   Cole, Susan P C ^c   Fletcher, Jamie I ^a   Haber, Michelle ^a   Norris, Murray D ^a  

^a University of New South Wales   (Australia)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c QUEEN S UNIVERSITY   (Canada)

^d Tartis Aging Inc   (United States)

^e ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

ABCC4; Ceefourin; High throughput screening; MRP4 inhibitor; Multidrug resistance

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CEEFOURIN 1; CEEFOURIN 2; CEEFOURIN 3; MERCAPTOPURINE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 4; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VERLUKAST;

ARTICLE; BINDING SITE; BREAST CARCINOMA; CANCER CELL LINE; CELL MEMBRANE; CELL VIABILITY; CHEMOSENSITIZATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SENSITIZATION; FIBROBLAST; GLIOBLASTOMA; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; LIVER CELL CARCINOMA; NEUROBLASTOMA; PHARMACOPHORE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROSTATE CARCINOMA;

6-MERCAPTOPURINE (PUBCHEM CID: 667490); ABCC4; CEEFOURIN; CYCLIC AMP (PUBCHEM CID: 6076); D-LUCIFERIN (PUBCHEM CID: 6800291); ESTRADIOL 17-BETA-D-GLUCURONIDE (PUBCHEM CID: 5281887); HIGH-THROUGHPUT SCREENING; MK-571 (PUBCHEM CID: 5281888); MRP4 INHIBITOR; MULTIDRUG RESISTANCE; SN-38 (PUBCHEM CID: 104842);

ATP-BINDING CASSETTE TRANSPORTERS; BENZOTHIAZOLES; CELL LINE; DRUG RESISTANCE, MULTIPLE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; P-GLYCOPROTEIN; PYRAZOLES; PYRIMIDINES; TOXICITY TESTS; TRIAZOLES;

EID: 84905508169     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.05.023     Document Type: Article

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