Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of transmembrane helix (TM) 6 and TM17 mutants of multidrug resistance protein 1 (ABCC1)

Drug Metabolism and Disposition

Volumn 37, Issue 7, 2009, Pages 1411-1420

  Maeno, Kazuma ^a,b   Nakajima, Akio ^a,c   Conseil, Gwenaëlle ^a   Rothnie, Alice ^a,d   Deeley, Roger G ^a   Cole, Susan P C ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Toyooka Public Hospital   (Japan)

^d UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

6 (4 CARBOXYPHENYLTHIO) 5 HYDROXY 7,9,11,14 ICOSATETRAENOIC ACID; APIGENIN; BENZAMIDE DERIVATIVE; ESTRADIOL; ESTRADIOL DERIVATIVE; ESTRADIOL GLUCURONIDE; ESTRONE SULFATE; GLUTATHIONE; GLUTATHIONE DISULFIDE; LEUKOTRIENE C4; LEUKOTRIENE D4; LEUKOTRIENE F4; LY 465803; MEMBRANE PROTEIN; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 1; N [3 (9 CHLORO 3 METHYL 4 OXO 4H ISOXAZOLO[4,3 C]QUINOLIN 5 YL) CYCLOHEXYLMETHYL] BENZAMIDE; PROTEIN TRANSMEMBRANE HELIX 17; PROTEIN TRANSMEMBRANE HELIX 6; S DECYL GLUTATHIONE; TOMELUKAST; UNCLASSIFIED DRUG; VERLUKAST;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; DRUG POTENCY; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG TRANSPORT; DRUG UPTAKE; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IC 50; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; SENSITIVITY ANALYSIS;

APIGENIN; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; DRUG SYNERGISM; ESTRONE; GLUTATHIONE; HELA CELLS; HUMANS; LEUKOTRIENES; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTAGENESIS, SITE-DIRECTED; MUTATION; P-GLYCOPROTEIN; PROTEIN BINDING; PROTEIN TRANSPORT; SUBSTRATE SPECIFICITY; TRITIUM;

EID: 67649398901     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.026633     Document Type: Article

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