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Volumn 5, Issue MAY, 2014, Pages

GPER function in breast cancer: An overview

Author keywords

Breast cancer; Estrogen; Estrogen receptor; GPER; GPR30

Indexed keywords

ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTRADIOL; FULVESTRANT; G 15; G PROTEIN COUPLED RECEPTOR 30; G PROTEIN COUPLED RECEPTOR 30 ANTAGONIST; ICI 182, 780; LASOFOXIFENE; MIBE; SOMATOMEDIN C; TAMOXIFEN; UNCLASSIFIED DRUG;

EID: 84905499001     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2014.00066     Document Type: Short Survey
Times cited : (90)

References (87)
  • 1
    • 33747466839 scopus 로고    scopus 로고
    • Structure-function relationship of estrogen receptor alpha and beta: impact on human health
    • doi:10.1016/j.mam.2006.07.001
    • Ascenzi P, Bocedi A, Marino M. Structure-function relationship of estrogen receptor alpha and beta: impact on human health. Mol Aspects Med (2006) 27:299-402. doi:10.1016/j.mam.2006.07.001
    • (2006) Mol Aspects Med , vol.27 , pp. 299-402
    • Ascenzi, P.1    Bocedi, A.2    Marino, M.3
  • 2
    • 84857605169 scopus 로고    scopus 로고
    • Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
    • doi:10.1016/S0140-6736(11)60993-8
    • Davies C, Godwin J, Gray R, Clarke M, Cutter D, Darby S, et al. Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Lancet (2011) 378:771-84. doi:10.1016/S0140-6736(11)60993-8
    • (2011) Lancet , vol.378 , pp. 771-784
    • Davies, C.1    Godwin, J.2    Gray, R.3    Clarke, M.4    Cutter, D.5    Darby, S.6
  • 3
    • 77953529620 scopus 로고    scopus 로고
    • Update of the national surgical adjuvant breast and bowel project study of tamoxifen and raloxifene (STAR) P-2 trial: preventing breast cancer National surgical adjuvant breast and bowel project
    • doi:10.1158/1940-6207.CAPR-10-0076 (Phila)
    • Vogel VG, Costantino JP, Wickerham DL, Cronin WM, Cecchini RS, Atkins JN, et al. Update of the national surgical adjuvant breast and bowel project study of tamoxifen and raloxifene (STAR) P-2 trial: preventing breast cancer. National surgical adjuvant breast and bowel project. Cancer Prev Res (Phila) (2010) 3:696-706. doi:10.1158/1940-6207.CAPR-10-0076
    • (2010) Cancer Prev Res , vol.3 , pp. 696-706
    • Vogel, V.G.1    Costantino, J.P.2    Wickerham, D.L.3    Cronin, W.M.4    Cecchini, R.S.5    Atkins, J.N.6
  • 4
    • 77349090257 scopus 로고    scopus 로고
    • Lasofoxifene in postmenopausal women with osteoporosis PEARL Study Investigators
    • doi:10.1056/NEJMoa0808692
    • Cummings SR, Ensrud K, Delmas PD, LaCroix AZ, Vukicevic S, Reid DM, et al. Lasofoxifene in postmenopausal women with osteoporosis. PEARL Study Investigators. N Engl J Med (2010) 362:686-96. doi:10.1056/NEJMoa0808692
    • (2010) N Engl J Med , vol.362 , pp. 686-696
    • Cummings, S.R.1    Ensrud, K.2    Delmas, P.D.3    LaCroix, A.Z.4    Vukicevic, S.5    Reid, D.M.6
  • 6
    • 0037464769 scopus 로고    scopus 로고
    • Overview of the main outcomes in breast-cancer prevention trials
    • doi:10.1016/S0140-6736(03)12342-2
    • Cuzick J, Powles T, Veronesi U, Forbes J, Edwards R, Ashley S, et al. Overview of the main outcomes in breast-cancer prevention trials. Lancet (2003) 361:296-300. doi:10.1016/S0140-6736(03)12342-2
    • (2003) Lancet , vol.361 , pp. 296-300
    • Cuzick, J.1    Powles, T.2    Veronesi, U.3    Forbes, J.4    Edwards, R.5    Ashley, S.6
  • 7
    • 34547625250 scopus 로고    scopus 로고
    • The National Cancer Institute of Canada Clinical Trials Group MAP 3 trial: an international breast cancer prevention trial
    • doi:10.3747/co.2007.117
    • Richardson H, Johnston D, Pater J, Goss P. The National Cancer Institute of Canada Clinical Trials Group MAP.3 trial: an international breast cancer prevention trial. Curr Oncol (2007) 14:89-96. doi:10.3747/co.2007.117
    • (2007) Curr Oncol , vol.14 , pp. 89-96
    • Richardson, H.1    Johnston, D.2    Pater, J.3    Goss, P.4
  • 8
    • 84891119238 scopus 로고    scopus 로고
    • Targeted therapy for breast cancer prevention
    • doi:10.3389/fonc.2013.00250
    • den Hollander P, Savage MI, Brown PH. Targeted therapy for breast cancer prevention. Front Oncol (2013) 3:250. doi:10.3389/fonc.2013.00250
    • (2013) Front Oncol , vol.3 , pp. 250
    • Den Hollander, P.1    Savage, M.I.2    Brown, P.H.3
  • 9
    • 77951991757 scopus 로고    scopus 로고
    • Issues and updates: evaluating estrogen receptor-alpha, progesterone receptor, and HER2 in breast cancer
    • doi:10.1038/modpathol.2010.55
    • Allred DC. Issues and updates: evaluating estrogen receptor-alpha, progesterone receptor, and HER2 in breast cancer. Mod Pathol (2010) 23:S52-9. doi:10.1038/modpathol.2010.55
    • (2010) Mod Pathol , vol.23
    • Allred, D.C.1
  • 10
    • 57149142057 scopus 로고    scopus 로고
    • IGF and insulin receptor signaling in breast cancer
    • doi:10.1007/s10911-008-9099-z
    • Belfiore A, Frasca F. IGF and insulin receptor signaling in breast cancer. J Mammary Gland Biol Neoplasia (2008) 13:381-406. doi:10.1007/s10911-008-9099-z
    • (2008) J Mammary Gland Biol Neoplasia , vol.13 , pp. 381-406
    • Belfiore, A.1    Frasca, F.2
  • 11
    • 0037462733 scopus 로고    scopus 로고
    • Proximal events in signaling by plasma membrane estrogen receptors ERs associate with and regulate the production of caveolin: implications for signalling and cellular actions
    • doi:10.1074/jbc.M205692200
    • Razandi M, Pedram A, Park ST, Levin ER, Oh P, Schnitzer J. Proximal events in signaling by plasma membrane estrogen receptors ERs associate with and regulate the production of caveolin: implications for signalling and cellular actions. J Biol Chem (2003) 278:2701-12. doi:10.1074/jbc.M205692200
    • (2003) J Biol Chem , vol.278 , pp. 2701-2712
    • Razandi, M.1    Pedram, A.2    Park, S.T.3    Levin, E.R.4    Oh, P.5    Schnitzer, J.6
  • 12
    • 75149186664 scopus 로고    scopus 로고
    • The unfolding stories of GPR30, a new membrane bound estrogen receptor
    • doi:10.1677/JOE-09-0242
    • Maggiolini M, Picard D. The unfolding stories of GPR30, a new membrane bound estrogen receptor. J Endocrinol (2010) 204:105-14. doi:10.1677/JOE-09-0242
    • (2010) J Endocrinol , vol.204 , pp. 105-114
    • Maggiolini, M.1    Picard, D.2
  • 13
    • 0033780783 scopus 로고    scopus 로고
    • Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
    • doi:10.1210/mend.14.10.0532
    • Filardo EJ, Quinn JA, Bland KI, Frackelton AR Jr. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol (2000) 14:1649-60. doi:10.1210/mend.14.10.0532
    • (2000) Mol Endocrinol , vol.14 , pp. 1649-1660
    • Filardo, E.J.1    Quinn, J.A.2    Bland, K.I.3    Frackelton Jr., A.R.4
  • 14
    • 3042547161 scopus 로고    scopus 로고
    • The G protein coupled receptor GPR30 mediates c-fos up-regulation by 17β-estradiol and phytoestrogens in breast cancer cells
    • doi:10.1074/jbc.M403588200
    • Maggiolini M, Vivacqua A, Fasanella G, Recchia AG, Sisci D, Pezzi V, et al. The G protein coupled receptor GPR30 mediates c-fos up-regulation by 17β-estradiol and phytoestrogens in breast cancer cells. J Biol Chem (2004) 279:27008-16. doi:10.1074/jbc.M403588200
    • (2004) J Biol Chem , vol.279 , pp. 27008-27016
    • Maggiolini, M.1    Vivacqua, A.2    Fasanella, G.3    Recchia, A.G.4    Sisci, D.5    Pezzi, V.6
  • 15
    • 62049084027 scopus 로고    scopus 로고
    • Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF.
    • doi:10.1038/emboj.2008.304
    • Pandey DP, Lappano R, Albanito L, Madeo A, Maggiolini M, Picard D. Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF. EMBO J (2009) 28:523-32. doi:10.1038/emboj.2008.304
    • (2009) EMBO J , vol.28 , pp. 523-532
    • Pandey, D.P.1    Lappano, R.2    Albanito, L.3    Madeo, A.4    Maggiolini, M.5    Picard, D.6
  • 16
    • 0021348486 scopus 로고
    • Steroid-hormone receptors in breast cancer
    • doi:10.1002/1097-0142(19840201)53:3+<630::AID-CNCR2820531308>3.0.CO;2-3
    • Wittliff JL. Steroid-hormone receptors in breast cancer. Cancer (1984) 53:630-43. doi:10.1002/1097-0142(19840201)53:3+<630::AID-CNCR2820531308>3.0.CO;2-3
    • (1984) Cancer , vol.53 , pp. 630-643
    • Wittliff, J.L.1
  • 17
    • 77955771545 scopus 로고    scopus 로고
    • Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cells
    • doi:10.1007/s10549-009-0624-6
    • Ignatov A, Ignatov T, Roessner A, Costa SD, Kalinski T. Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cells. Breast Cancer Res Treat (2010) 123:87-96. doi:10.1007/s10549-009-0624-6
    • (2010) Breast Cancer Res Treat , vol.123 , pp. 87-96
    • Ignatov, A.1    Ignatov, T.2    Roessner, A.3    Costa, S.D.4    Kalinski, T.5
  • 18
    • 79959770197 scopus 로고    scopus 로고
    • G-protein-coupled estrogen receptor GPR30 and tamoxifen resistance in breast cancer
    • doi:10.1007/s10549-011-1584-1
    • Ignatov A, Ignatov T, Weissenborn C, Eggemann H, Bischoff J, Semczuk A, et al. G-protein-coupled estrogen receptor GPR30 and tamoxifen resistance in breast cancer. Breast Cancer Res Treat (2011) 128:457-66. doi:10.1007/s10549-011-1584-1
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 457-466
    • Ignatov, A.1    Ignatov, T.2    Weissenborn, C.3    Eggemann, H.4    Bischoff, J.5    Semczuk, A.6
  • 19
    • 84888259947 scopus 로고    scopus 로고
    • GPR30 as an initiator of tamoxifen resistance in hormone-dependent breast cancer
    • doi:10.1186/bcr3581
    • Mo Z, Liu M, Yang F, Luo H, Li Z, Tu G, et al. GPR30 as an initiator of tamoxifen resistance in hormone-dependent breast cancer. Breast Cancer Res (2013) 15:R114. doi:10.1186/bcr3581
    • (2013) Breast Cancer Res , vol.15
    • Mo, Z.1    Liu, M.2    Yang, F.3    Luo, H.4    Li, Z.5    Tu, G.6
  • 20
    • 0036140032 scopus 로고    scopus 로고
    • Estrogen action via the G protein-coupled receptor GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis
    • doi:10.1210/me.16.1.70
    • Filardo EJ, Quinn JA, Frackelton AR Jr, Bland KI. Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis. Mol Endocrinol (2002) 16:70-84. doi:10.1210/me.16.1.70
    • (2002) Mol Endocrinol , vol.16 , pp. 70-84
    • Filardo, E.J.1    Quinn, J.A.2    Frackelton Jr., A.R.3    Bland, K.I.4
  • 21
    • 77949568658 scopus 로고    scopus 로고
    • Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells
    • doi:10.1016/j.mce.2010.02.006
    • Lappano R, Rosano C, De Marco P, De Francesco EM, Pezzi V, Maggiolini M. Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells. Mol Cell Endocrinol (2010) 320:162-70. doi:10.1016/j.mce.2010.02.006
    • (2010) Mol Cell Endocrinol , vol.320 , pp. 162-170
    • Lappano, R.1    Rosano, C.2    De Marco, P.3    De Francesco, E.M.4    Pezzi, V.5    Maggiolini, M.6
  • 22
    • 84855767653 scopus 로고    scopus 로고
    • MIBE acts as antagonist ligand of both estrogen receptor α and GPER in breast cancer cells
    • doi:10.1186/bcr3096
    • Lappano R, Santolla MF, Pupo M, Sinicropi MS, Caruso A, Rosano C, et al. MIBE acts as antagonist ligand of both estrogen receptor α and GPER in breast cancer cells. Breast Cancer Res (2012) 14:R12. doi:10.1186/bcr3096
    • (2012) Breast Cancer Res , vol.14
    • Lappano, R.1    Santolla, M.F.2    Pupo, M.3    Sinicropi, M.S.4    Caruso, A.5    Rosano, C.6
  • 23
    • 84863724924 scopus 로고    scopus 로고
    • GPER mediates the Egr-1 expression induced by 17β-estradiol and 4-hydroxitamoxifen in breast and endometrial cancer cells
    • doi:10.1007/s10549-011-1901-8
    • Vivacqua A, Romeo E, De Marco P, De Francesco EM, Abonante S, Maggiolini M. GPER mediates the Egr-1 expression induced by 17β-estradiol and 4-hydroxitamoxifen in breast and endometrial cancer cells. Breast Cancer Res Treat (2012) 133:1025-35. doi:10.1007/s10549-011-1901-8
    • (2012) Breast Cancer Res Treat , vol.133 , pp. 1025-1035
    • Vivacqua, A.1    Romeo, E.2    De Marco, P.3    De Francesco, E.M.4    Abonante, S.5    Maggiolini, M.6
  • 24
    • 84873743039 scopus 로고    scopus 로고
    • Insulin-like growth factor-I regulates GPER expression and function in cancer cells
    • doi:10.1038/onc.2012.97
    • De Marco P, Bartella V, Vivacqua A, Lappano R, Santolla MF, Morcavallo A, et al. Insulin-like growth factor-I regulates GPER expression and function in cancer cells. Oncogene (2013) 32:678-88. doi:10.1038/onc.2012.97
    • (2013) Oncogene , vol.32 , pp. 678-688
    • De Marco, P.1    Bartella, V.2    Vivacqua, A.3    Lappano, R.4    Santolla, M.F.5    Morcavallo, A.6
  • 25
    • 79953227087 scopus 로고    scopus 로고
    • The G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) in breast cancer cells and cardiomyocytes
    • doi:10.1074/jbc.M110.172247
    • Recchia AG, De Francesco EM, Vivacqua A, Sisci D, Panno ML, Andò S, et al. The G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) in breast cancer cells and cardiomyocytes. J Biol Chem (2011) 286:10773-82. doi:10.1074/jbc.M110.172247
    • (2011) J Biol Chem , vol.286 , pp. 10773-10782
    • Recchia, A.G.1    De Francesco, E.M.2    Vivacqua, A.3    Sisci, D.4    Panno, M.L.5    Andò, S.6
  • 26
    • 77955024164 scopus 로고    scopus 로고
    • Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts
    • doi:10.1158/0008-5472.CAN-10-0408
    • Madeo A, Maggiolini M. Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts. Cancer Res (2010) 70:6036-46. doi:10.1158/0008-5472.CAN-10-0408
    • (2010) Cancer Res , vol.70 , pp. 6036-6046
    • Madeo, A.1    Maggiolini, M.2
  • 27
    • 84879476386 scopus 로고    scopus 로고
    • The nuclear localization signal is required for nuclear GPER translocation and function in breast cancer-associated fibroblasts (CAFs)
    • doi:10.1016/j.mce.2013.05.023
    • Pupo M, Vivacqua A, Perrotta I, Pisano A, Aquila S, Abonante S, et al. The nuclear localization signal is required for nuclear GPER translocation and function in breast cancer-associated fibroblasts (CAFs). Mol Cell Endocrinol (2013) 376:23-32. doi:10.1016/j.mce.2013.05.023
    • (2013) Mol Cell Endocrinol , vol.376 , pp. 23-32
    • Pupo, M.1    Vivacqua, A.2    Perrotta, I.3    Pisano, A.4    Aquila, S.5    Abonante, S.6
  • 28
    • 84871583000 scopus 로고    scopus 로고
    • G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17β-estradiol in cancer cells and cancer-associated fibroblasts
    • doi:10.1074/jbc.M112.417303
    • Santolla MF, Lappano R, De Marco P, Pupo M, Vivacqua A, Sisci D, et al. G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17β-estradiol in cancer cells and cancer-associated fibroblasts. J Biol Chem (2012) 287:43234-45. doi:10.1074/jbc.M112.417303
    • (2012) J Biol Chem , vol.287 , pp. 43234-43245
    • Santolla, M.F.1    Lappano, R.2    De Marco, P.3    Pupo, M.4    Vivacqua, A.5    Sisci, D.6
  • 29
    • 84899877389 scopus 로고    scopus 로고
    • GPER-mediated proliferation and estradiol production in breast cancer associated fibroblasts
    • doi:10.1530/ERC-13-0237
    • Luo H, Yang G, Yu T, Luo S, Wu C, Sun Y, et al. GPER-mediated proliferation and estradiol production in breast cancer associated fibroblasts. Endocr Relat Cancer (2014) 21(2):355-69. doi:10.1530/ERC-13-0237
    • (2014) Endocr Relat Cancer , vol.21 , Issue.2 , pp. 355-369
    • Luo, H.1    Yang, G.2    Yu, T.3    Luo, S.4    Wu, C.5    Sun, Y.6
  • 30
    • 79957620026 scopus 로고    scopus 로고
    • Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression
    • doi:10.1074/jbc.M110.195826
    • Lucki NC, Sewer MB. Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression. J Biol Chem (2011) 286:19399-409. doi:10.1074/jbc.M110.195826
    • (2011) J Biol Chem , vol.286 , pp. 19399-19409
    • Lucki, N.C.1    Sewer, M.B.2
  • 31
    • 69849105847 scopus 로고    scopus 로고
    • Tectoridin, a poor ligand of estrogen receptor alpha, exerts its estrogenic effects via an ERK-dependent pathway
    • doi:10.1007/s10059-009-0045-8
    • Kang K, Lee SB, Jung SH, Cha KH, Park WD, Sohn YC, et al. Tectoridin, a poor ligand of estrogen receptor alpha, exerts its estrogenic effects via an ERK-dependent pathway. Mol Cells (2009) 27:351-7. doi:10.1007/s10059-009-0045-8
    • (2009) Mol Cells , vol.27 , pp. 351-357
    • Kang, K.1    Lee, S.B.2    Jung, S.H.3    Cha, K.H.4    Park, W.D.5    Sohn, Y.C.6
  • 32
    • 78349309098 scopus 로고    scopus 로고
    • Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells
    • doi:10.1016/j.envpol.2010.09.004
    • Dong S, Terasaka S, Kiyama R. Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells. Environ Pollut (2011) 159:212-8. doi:10.1016/j.envpol.2010.09.004
    • (2011) Environ Pollut , vol.159 , pp. 212-218
    • Dong, S.1    Terasaka, S.2    Kiyama, R.3
  • 33
    • 84864755972 scopus 로고    scopus 로고
    • Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts
    • doi:10.1289/ehp.1104526
    • Pupo M, Pisano A, Lappano R, Santolla MF, De Francesco EM, Abonante S, et al. Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts. Environ Health Perspect (2012) 120:1177-82. doi:10.1289/ehp.1104526
    • (2012) Environ Health Perspect , vol.120 , pp. 1177-1182
    • Pupo, M.1    Pisano, A.2    Lappano, R.3    Santolla, M.F.4    De Francesco, E.M.5    Abonante, S.6
  • 34
    • 12344307170 scopus 로고    scopus 로고
    • Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells
    • doi:10.1210/en.2004-1064
    • Thomas P, Pang Y, Filardo EJ, Dong J. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology (2005) 146:624-32. doi:10.1210/en.2004-1064
    • (2005) Endocrinology , vol.146 , pp. 624-632
    • Thomas, P.1    Pang, Y.2    Filardo, E.J.3    Dong, J.4
  • 35
    • 33750992478 scopus 로고    scopus 로고
    • Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption
    • doi:10.1016/j.jsbmb.2006.09.017
    • Thomas P, Dong I. Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption. J Steroid Biochem Mol Biol (2006) 102:175-9. doi:10.1016/j.jsbmb.2006.09.017
    • (2006) J Steroid Biochem Mol Biol , vol.102 , pp. 175-179
    • Thomas, P.1    Dong, I.2
  • 37
    • 84861737062 scopus 로고    scopus 로고
    • Two novel GPER agonists induce gene expression changes and growth effects in cancer cells
    • doi:10.2174/156800912800673284
    • Lappano R, Rosano C, Santolla MF, Pupo M, De Francesco EM, De Marco P, et al. Two novel GPER agonists induce gene expression changes and growth effects in cancer cells. Curr Cancer Drug Targets (2012) 12:531-42. doi:10.2174/156800912800673284
    • (2012) Curr Cancer Drug Targets , vol.12 , pp. 531-542
    • Lappano, R.1    Rosano, C.2    Santolla, M.F.3    Pupo, M.4    De Francesco, E.M.5    De Marco, P.6
  • 38
    • 33847755409 scopus 로고    scopus 로고
    • G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells
    • doi:10.1158/0008-5472.CAN-06-2909
    • Albanito L, Madeo A, Lappano R, Vivacqua A, Rago V, Carpino A, et al. G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells. Cancer Res (2007) 67:1859-66. doi:10.1158/0008-5472.CAN-06-2909
    • (2007) Cancer Res , vol.67 , pp. 1859-1866
    • Albanito, L.1    Madeo, A.2    Lappano, R.3    Vivacqua, A.4    Rago, V.5    Carpino, A.6
  • 39
    • 76249115409 scopus 로고    scopus 로고
    • The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells
    • doi:10.1158/0008-5472.CAN-09-3068
    • Ariazi EA, Brailoiu E, Yerrum S, Shupp HA, Slifker MJ, Cunliffe HE, et al. The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells. Cancer Res (2010) 70:1184-94. doi:10.1158/0008-5472.CAN-09-3068
    • (2010) Cancer Res , vol.70 , pp. 1184-1194
    • Ariazi, E.A.1    Brailoiu, E.2    Yerrum, S.3    Shupp, H.A.4    Slifker, M.J.5    Cunliffe, H.E.6
  • 41
    • 81255160989 scopus 로고    scopus 로고
    • Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity
    • doi:10.1016/j.jsbmb.2011.07.002
    • Dennis MK, Field AS, Burai R, Ramesh C, Petrie WK, Bologa CG, et al. Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. J Steroid Biochem Mol Biol (2011) 127:358-66. doi:10.1016/j.jsbmb.2011.07.002
    • (2011) J Steroid Biochem Mol Biol , vol.127 , pp. 358-366
    • Dennis, M.K.1    Field, A.S.2    Burai, R.3    Ramesh, C.4    Petrie, W.K.5    Bologa, C.G.6
  • 42
    • 84862812872 scopus 로고    scopus 로고
    • Heregulin-β1-induced GPR30 upregulation promotes the migration and invasion potential of SkBr3 breast cancer cells via ErbB2/ErbB3-MAPK/ERK pathway
    • doi:10.1016/j.bbrc.2012.03.004
    • Ruan SQ, Wang ZH, Wang SW, Fu ZX, Xu KL, Li DB, et al. Heregulin-β1-induced GPR30 upregulation promotes the migration and invasion potential of SkBr3 breast cancer cells via ErbB2/ErbB3-MAPK/ERK pathway. Biochem Biophys Res Commun (2012) 420:385-90. doi:10.1016/j.bbrc.2012.03.004
    • (2012) Biochem Biophys Res Commun , vol.420 , pp. 385-390
    • Ruan, S.Q.1    Wang, Z.H.2    Wang, S.W.3    Fu, Z.X.4    Xu, K.L.5    Li, D.B.6
  • 43
    • 84878155024 scopus 로고    scopus 로고
    • 4-Hydroxytamoxifen-stimulated processing of cyclin E is mediated via G protein-coupled receptor 30 (GPR30) and accompanied by enhanced migration in MCF-7 breast cancer cells
    • doi:10.1016/j.tox.2013.04.012
    • Li Y, Chen Y, Zhu ZX, Liu XH, Yang L, Wan L, et al. 4-Hydroxytamoxifen-stimulated processing of cyclin E is mediated via G protein-coupled receptor 30 (GPR30) and accompanied by enhanced migration in MCF-7 breast cancer cells. Toxicology (2013) 309:61-5. doi:10.1016/j.tox.2013.04.012
    • (2013) Toxicology , vol.309 , pp. 61-65
    • Li, Y.1    Chen, Y.2    Zhu, Z.X.3    Liu, X.H.4    Yang, L.5    Wan, L.6
  • 44
    • 53249101612 scopus 로고    scopus 로고
    • The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17beta-estradiol on mouse spermatogonial GC-1 cell line
    • doi:10.1210/en.2007-1593
    • Sirianni R, Chimento A, Ruggiero C, De Luca A, Lappano R, Andò S, et al. The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17beta-estradiol on mouse spermatogonial GC-1 cell line. Endocrinology (2008) 149:5043-51. doi:10.1210/en.2007-1593
    • (2008) Endocrinology , vol.149 , pp. 5043-5051
    • Sirianni, R.1    Chimento, A.2    Ruggiero, C.3    De Luca, A.4    Lappano, R.5    Andò, S.6
  • 45
    • 70350449695 scopus 로고    scopus 로고
    • G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells
    • doi:10.1210/me.2009-0120
    • Vivacqua A, Lappano R, De Marco P, Sisci D, Aquila S, De Amicis F, et al. G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells. Mol Endocrinol (2009) 23:1815-26. doi:10.1210/me.2009-0120
    • (2009) Mol Endocrinol , vol.23 , pp. 1815-1826
    • Vivacqua, A.1    Lappano, R.2    De Marco, P.3    Sisci, D.4    Aquila, S.5    De Amicis, F.6
  • 46
    • 84889786238 scopus 로고    scopus 로고
    • GPER activates notch signaling in breast cancer cells and cancer-associated fibroblasts (CAFs)
    • doi:10.1016/j.biocel.2013.11.011
    • Pupo M, Pisano A, Abonante S, Maggiolini M, Musti AM. GPER activates notch signaling in breast cancer cells and cancer-associated fibroblasts (CAFs). Int J Biochem Cell Biol (2014) 46:56-67. doi:10.1016/j.biocel.2013.11.011
    • (2014) Int J Biochem Cell Biol , vol.46 , pp. 56-67
    • Pupo, M.1    Pisano, A.2    Abonante, S.3    Maggiolini, M.4    Musti, A.M.5
  • 47
    • 84881522450 scopus 로고    scopus 로고
    • 17β-estradiol promotes the invasion and migration of nuclear estrogen receptor-negative breast cancer cells through cross-talk between GPER1 and CXCR1
    • doi:10.1016/j.jsbmb.2013.07.011
    • Jiang QF, Wu TT, Yang JY, Dong CR, Wang N, Liu XH, et al. 17β-estradiol promotes the invasion and migration of nuclear estrogen receptor-negative breast cancer cells through cross-talk between GPER1 and CXCR1. J Steroid Biochem Mol Biol (2013) 138:314-24. doi:10.1016/j.jsbmb.2013.07.011
    • (2013) J Steroid Biochem Mol Biol , vol.138 , pp. 314-324
    • Jiang, Q.F.1    Wu, T.T.2    Yang, J.Y.3    Dong, C.R.4    Wang, N.5    Liu, X.H.6
  • 48
    • 84856248591 scopus 로고    scopus 로고
    • Alternate estrogen receptors promote invasion of inflammatory breast cancer cells via non-genomic signaling
    • doi:10.1371/journal.pone.0030725
    • Ohshiro K, Schwartz AM, Levine PH, Kumar R. Alternate estrogen receptors promote invasion of inflammatory breast cancer cells via non-genomic signaling. PLoS One (2012) 7:e30725. doi:10.1371/journal.pone.0030725
    • (2012) PLoS One , vol.7
    • Ohshiro, K.1    Schwartz, A.M.2    Levine, P.H.3    Kumar, R.4
  • 49
    • 84894053614 scopus 로고    scopus 로고
    • Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis
    • doi:10.1016/j.taap.2014.01.005
    • Chen Y, Li Z, He Y, Shang D, Pan J, Wang H, et al. Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol (2014) 275(2):176-81. doi:10.1016/j.taap.2014.01.005
    • (2014) Toxicol Appl Pharmacol , vol.275 , Issue.2 , pp. 176-181
    • Chen, Y.1    Li, Z.2    He, Y.3    Shang, D.4    Pan, J.5    Wang, H.6
  • 50
    • 84867007536 scopus 로고    scopus 로고
    • Disruption of 3D MCF-12A breast cell cultures by estrogens-an in vitro model for ER-mediated changes indicative of hormonal carcinogenesis
    • doi:10.1371/journal.pone.0045767
    • Marchese S, Silva E. Disruption of 3D MCF-12A breast cell cultures by estrogens-an in vitro model for ER-mediated changes indicative of hormonal carcinogenesis. PLoS One (2012) 7(10):e45767. doi:10.1371/journal.pone.0045767
    • (2012) PLoS One , vol.7 , Issue.10
    • Marchese, S.1    Silva, E.2
  • 51
    • 84900437591 scopus 로고    scopus 로고
    • GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast
    • doi:10.1007/s12672-014-0174-1
    • Scaling AL, Prossnitz ER, Hathaway HJ. GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast. Horm Cancer (2014). doi:10.1007/s12672-014-0174-1
    • (2014) Horm Cancer
    • Scaling, A.L.1    Prossnitz, E.R.2    Hathaway, H.J.3
  • 52
    • 84881449433 scopus 로고    scopus 로고
    • HIF-1α/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs)
    • doi:10.1186/bcr3458
    • De Francesco EM, Lappano R, Santolla MF, Marsico S, Caruso A, Maggiolini M. HIF-1α/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs). Breast Cancer Res (2013) 15:R64. doi:10.1186/bcr3458
    • (2013) Breast Cancer Res , vol.15
    • De Francesco, E.M.1    Lappano, R.2    Santolla, M.F.3    Marsico, S.4    Caruso, A.5    Maggiolini, M.6
  • 53
    • 84861610903 scopus 로고    scopus 로고
    • Regulation of HRG-β1-induced proliferation, migration and invasion of MCF-7 cells by upregulation of GPR30 expression
    • doi:10.3892/mmr.2012.874
    • Ruan SQ, Wang SW, Wang ZH, Zhang SZ. Regulation of HRG-β1-induced proliferation, migration and invasion of MCF-7 cells by upregulation of GPR30 expression. Mol Med Rep (2012) 6:131-8. doi:10.3892/mmr.2012.874
    • (2012) Mol Med Rep , vol.6 , pp. 131-138
    • Ruan, S.Q.1    Wang, S.W.2    Wang, Z.H.3    Zhang, S.Z.4
  • 54
    • 47949111993 scopus 로고    scopus 로고
    • Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells
    • doi:10.1210/en.2008-0117
    • Albanito L, Sisci D, Aquila S, Brunelli E, Vivacqua A, Madeo A, et al. Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells. Endocrinology (2008) 149:3799-808. doi:10.1210/en.2008-0117
    • (2008) Endocrinology , vol.149 , pp. 3799-3808
    • Albanito, L.1    Sisci, D.2    Aquila, S.3    Brunelli, E.4    Vivacqua, A.5    Madeo, A.6
  • 56
    • 78650845707 scopus 로고    scopus 로고
    • G protein-coupled receptors: novel targets for drug discovery in cancer
    • doi:10.1038/nrd3320
    • Lappano R, Maggiolini M. G protein-coupled receptors: novel targets for drug discovery in cancer. Nat Rev Drug Discov (2011) 10:47-60. doi:10.1038/nrd3320
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 47-60
    • Lappano, R.1    Maggiolini, M.2
  • 57
    • 0031282001 scopus 로고    scopus 로고
    • Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer
    • doi:10.1006/geno.1997.4972
    • Carmeci C, Thompson DA, Ring HZ, Francke U, Weigel RJ. Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer. Genomics (1997) 45:607-17. doi:10.1006/geno.1997.4972
    • (1997) Genomics , vol.45 , pp. 607-617
    • Carmeci, C.1    Thompson, D.A.2    Ring, H.Z.3    Francke, U.4    Weigel, R.J.5
  • 58
    • 14844343093 scopus 로고    scopus 로고
    • A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    • doi:10.1126/science.1106943
    • Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science (2005) 307:1625-30. doi:10.1126/science.1106943
    • (2005) Science , vol.307 , pp. 1625-1630
    • Revankar, C.M.1    Cimino, D.F.2    Sklar, L.A.3    Arterburn, J.B.4    Prossnitz, E.R.5
  • 59
    • 33751272253 scopus 로고    scopus 로고
    • Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopathologic determinants of tumor progression
    • doi:10.1158/1078-0432.CCR-06-0860
    • Filardo EJ, Graeber CT, Quinn JA, Resnick MB, Giri D, DeLellis RA, et al. Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopathologic determinants of tumor progression. Clin Cancer Res (2006) 12:6359-66. doi:10.1158/1078-0432.CCR-06-0860
    • (2006) Clin Cancer Res , vol.12 , pp. 6359-6366
    • Filardo, E.J.1    Graeber, C.T.2    Quinn, J.A.3    Resnick, M.B.4    Giri, D.5    DeLellis, R.A.6
  • 60
    • 84900480955 scopus 로고    scopus 로고
    • Lack of G protein-coupled estrogen receptor (GPER) in the plasma membrane is associated with excellent long-term prognosis in breast cancer
    • doi:10.1007/s10549-014-2936-4
    • Sjöström M, Hartman L, Grabau D, Fornander T, Malmström P, Nordenskjöld B, et al. Lack of G protein-coupled estrogen receptor (GPER) in the plasma membrane is associated with excellent long-term prognosis in breast cancer. Breast Cancer Res Treat (2014) 145:61-71. doi:10.1007/s10549-014-2936-4
    • (2014) Breast Cancer Res Treat , vol.145 , pp. 61-71
    • Sjöström, M.1    Hartman, L.2    Grabau, D.3    Fornander, T.4    Malmström, P.5    Nordenskjöld, B.6
  • 61
    • 33748923143 scopus 로고    scopus 로고
    • 17Beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30
    • doi:10.1124/mol.106.026344
    • Vivacqua A, Bonofiglio D, Albanito L, Madeo A, Rago V, Carpino A, et al. 17Beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30. Mol Pharmacol (2006) 70:1414-23. doi:10.1124/mol.106.026344
    • (2006) Mol Pharmacol , vol.70 , pp. 1414-1423
    • Vivacqua, A.1    Bonofiglio, D.2    Albanito, L.3    Madeo, A.4    Rago, V.5    Carpino, A.6
  • 62
    • 33344461590 scopus 로고    scopus 로고
    • The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells
    • doi:10.1210/me.2005-0280
    • Vivacqua A, Bonofiglio D, Recchia AG, Musti AM, Picard D, Andò S, et al. The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells. Mol Endocrinol (2006) 20:631-46. doi:10.1210/me.2005-0280
    • (2006) Mol Endocrinol , vol.20 , pp. 631-646
    • Vivacqua, A.1    Bonofiglio, D.2    Recchia, A.G.3    Musti, A.M.4    Picard, D.5    Andò, S.6
  • 63
    • 84901506348 scopus 로고    scopus 로고
    • G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth
    • doi:10.1155/2013/472720
    • Petrie WK, Dennis MK, Hu C, Dai D, Arterburn JB, Smith HO, et al. G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth. Obstet Gynecol Int (2013) 2013:472720. doi:10.1155/2013/472720
    • (2013) Obstet Gynecol Int , vol.2013 , pp. 472720
    • Petrie, W.K.1    Dennis, M.K.2    Hu, C.3    Dai, D.4    Arterburn, J.B.5    Smith, H.O.6
  • 64
    • 70349169955 scopus 로고    scopus 로고
    • ERalpha-negative and triple negative breast cancer: molecular features and potential therapeutic approaches
    • doi:10.1016/j.bbcan.2009.06.003
    • Chen JQ, Russo J. ERalpha-negative and triple negative breast cancer: molecular features and potential therapeutic approaches. Biochim Biophys Acta (2009) 1796:162-75. doi:10.1016/j.bbcan.2009.06.003
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 162-175
    • Chen, J.Q.1    Russo, J.2
  • 65
    • 34547661993 scopus 로고    scopus 로고
    • Triple-negative breast cancer: clinical features and patterns of recurrence
    • doi:10.1158/1078-0432.CCR-06-3045
    • Dent R, Trudeau M, Pritchard KI, Hanna WM, Kahn HK, Sawka CA, et al. Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res (2007) 13:4429-34. doi:10.1158/1078-0432.CCR-06-3045
    • (2007) Clin Cancer Res , vol.13 , pp. 4429-4434
    • Dent, R.1    Trudeau, M.2    Pritchard, K.I.3    Hanna, W.M.4    Kahn, H.K.5    Sawka, C.A.6
  • 67
    • 84863984601 scopus 로고    scopus 로고
    • Inactivation of GPR30 reduces growth of triple-negative breast cancer cells: possible application in targeted therapy
    • doi:10.1007/s10549-012-1968-x
    • Girgert R, Emons G, Gründker C. Inactivation of GPR30 reduces growth of triple-negative breast cancer cells: possible application in targeted therapy. Breast Cancer Res Treat (2012) 134:199-205. doi:10.1007/s10549-012-1968-x
    • (2012) Breast Cancer Res Treat , vol.134 , pp. 199-205
    • Girgert, R.1    Emons, G.2    Gründker, C.3
  • 68
    • 84886698168 scopus 로고    scopus 로고
    • Biology of the estrogen receptor, GPR30, in triple negative breast cancer
    • doi:10.1016/j.amjsurg.2013.07.014
    • Steiman J, Peralta EA, Louis S, Kamel O. Biology of the estrogen receptor, GPR30, in triple negative breast cancer. Am J Surg (2013) 206:698-703. doi:10.1016/j.amjsurg.2013.07.014
    • (2013) Am J Surg , vol.206 , pp. 698-703
    • Steiman, J.1    Peralta, E.A.2    Louis, S.3    Kamel, O.4
  • 69
    • 34347238583 scopus 로고    scopus 로고
    • Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane
    • doi:10.1210/en.2006-1605
    • Filardo EJ, Quinn J, Pang Y, Graeber C, Shaw S, Dong J, et al. Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane. Endocrinology (2007) 148:3236-45. doi:10.1210/en.2006-1605
    • (2007) Endocrinology , vol.148 , pp. 3236-3245
    • Filardo, E.J.1    Quinn, J.2    Pang, Y.3    Graeber, C.4    Shaw, S.5    Dong, J.6
  • 70
    • 79951987933 scopus 로고    scopus 로고
    • G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments
    • doi:10.1124/mol.110.069500
    • Sandén C, Broselid S, Cornmark L, Andersson K, Daszkiewicz-Nilsson J, Mårtensson UE, et al. G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments. Mol Pharmacol (2011) 79:400-10. doi:10.1124/mol.110.069500
    • (2011) Mol Pharmacol , vol.79 , pp. 400-410
    • Sandén, C.1    Broselid, S.2    Cornmark, L.3    Andersson, K.4    Daszkiewicz-Nilsson, J.5    Mårtensson, U.E.6
  • 71
    • 33749054116 scopus 로고    scopus 로고
    • G-protein-coupled receptors signalling at the cell nucleus: an emerging paradigm
    • doi:10.1139/y05-127
    • Gobeil F, Fortier A, Zhu T, Bossolasco M, Leduc M, Grandbois M, et al. G-protein-coupled receptors signalling at the cell nucleus: an emerging paradigm. Can J Physiol Pharmacol (2006) 84:287-97. doi:10.1139/y05-127
    • (2006) Can J Physiol Pharmacol , vol.84 , pp. 287-297
    • Gobeil, F.1    Fortier, A.2    Zhu, T.3    Bossolasco, M.4    Leduc, M.5    Grandbois, M.6
  • 72
    • 79959358168 scopus 로고    scopus 로고
    • Intracellular α2C-adrenoceptors: storage depot, stunted development or signaling domain?
    • doi:10.1016/j.bbamcr.2011.05.006
    • Chotani MA, Flavahan NA. Intracellular α2C-adrenoceptors: storage depot, stunted development or signaling domain? Biochim Biophys Acta (2011) 1813:1495-503. doi:10.1016/j.bbamcr.2011.05.006
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 1495-1503
    • Chotani, M.A.1    Flavahan, N.A.2
  • 73
    • 84881253920 scopus 로고    scopus 로고
    • Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55
    • doi:10.1074/jbc.M113.456178
    • Yu J, Deliu E, Zhang XQ, Hoffman NE, Carter RL, Grisanti LA, et al. Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55. J Biol Chem (2013) 288:22481-92. doi:10.1074/jbc.M113.456178
    • (2013) J Biol Chem , vol.288 , pp. 22481-22492
    • Yu, J.1    Deliu, E.2    Zhang, X.Q.3    Hoffman, N.E.4    Carter, R.L.5    Grisanti, L.A.6
  • 74
    • 84897379667 scopus 로고    scopus 로고
    • The G protein-coupled estrogen receptor (GPER) is expressed in two different subcellular localizations reflecting distinct tumor properties in breast cancer
    • doi:10.1371/journal.pone.0083296
    • Samartzis EP, Noske A, Meisel A, Varga Z, Fink D, Imesch P. The G protein-coupled estrogen receptor (GPER) is expressed in two different subcellular localizations reflecting distinct tumor properties in breast cancer. PLoS One (2014) 9:e83296. doi:10.1371/journal.pone.0083296
    • (2014) PLoS One , vol.9
    • Samartzis, E.P.1    Noske, A.2    Meisel, A.3    Varga, Z.4    Fink, D.5    Imesch, P.6
  • 75
    • 84897607740 scopus 로고    scopus 로고
    • Oleuropein and hydroxytyrosol activate GPER/GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells
    • doi:10.1002/mnfr.201300323
    • Chimento A, Casaburi I, Rosano C, Avena P, De Luca A, Campana C, et al. Oleuropein and hydroxytyrosol activate GPER/GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells. Mol Nutr Food Res (2013) 58(3):478-89. doi:10.1002/mnfr.201300323
    • (2013) Mol Nutr Food Res , vol.58 , Issue.3 , pp. 478-489
    • Chimento, A.1    Casaburi, I.2    Rosano, C.3    Avena, P.4    De Luca, A.5    Campana, C.6
  • 76
    • 84877088406 scopus 로고    scopus 로고
    • G protein-coupled estrogen receptor is apoptotic and correlates with increased distant disease-free survival of estrogen receptor-positive breast cancer patients
    • doi:10.1158/1078-0432.CCR-12-2376
    • Broselid S, Cheng B, Sjöström M, Lövgren K, Klug-De Santiago HL, Belting M, et al. G protein-coupled estrogen receptor is apoptotic and correlates with increased distant disease-free survival of estrogen receptor-positive breast cancer patients. Clin Cancer Res (2013) 19:1681-92. doi:10.1158/1078-0432.CCR-12-2376
    • (2013) Clin Cancer Res , vol.19 , pp. 1681-1692
    • Broselid, S.1    Cheng, B.2    Sjöström, M.3    Lövgren, K.4    Klug-De Santiago, H.L.5    Belting, M.6
  • 77
    • 84901587405 scopus 로고    scopus 로고
    • GPER functions as a tumor suppressor in triple-negative breast cancer cells
    • doi:10.1007/s00432-014-1620-8
    • Weißenborn C, Ignatov T, Ochel HJ, Costa SD, Zenclussen AC, Ignatova Z, et al. GPER functions as a tumor suppressor in triple-negative breast cancer cells. J Cancer Res Clin Oncol (2014) 140(5):713-23. doi:10.1007/s00432-014-1620-8
    • (2014) J Cancer Res Clin Oncol , vol.140 , Issue.5 , pp. 713-723
    • Weißenborn, C.1    Ignatov, T.2    Ochel, H.J.3    Costa, S.D.4    Zenclussen, A.C.5    Ignatova, Z.6
  • 78
    • 84899477541 scopus 로고    scopus 로고
    • GPER functions as a tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells
    • doi:10.1007/s00432-014-1598-2
    • Weißenborn C, Ignatov T, Poehlmann A, Wege AK, Costa SD, Zenclussen AC, et al. GPER functions as a tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells. J Cancer Res Clin Oncol (2014) 140(4):663-71. doi:10.1007/s00432-014-1598-2
    • (2014) J Cancer Res Clin Oncol , vol.140 , Issue.4 , pp. 663-671
    • Weißenborn, C.1    Ignatov, T.2    Poehlmann, A.3    Wege, A.K.4    Costa, S.D.5    Zenclussen, A.C.6
  • 79
    • 84868010705 scopus 로고    scopus 로고
    • The putative G-protein coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian and breast cancer cells in a GPER-independent manner
    • Wang C, Lv X, Jiang C, Davis JS. The putative G-protein coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian and breast cancer cells in a GPER-independent manner. Am J Transl Res (2012) 4:390-402.
    • (2012) Am J Transl Res , vol.4 , pp. 390-402
    • Wang, C.1    Lv, X.2    Jiang, C.3    Davis, J.S.4
  • 80
    • 84887456860 scopus 로고    scopus 로고
    • The G-protein-coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian cancer cells by blocking tubulin polymerization
    • doi:10.1038/cddis.2013.397
    • Wang C, Lv X, He C, Hua G, Tsai MY, Davis JS. The G-protein-coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian cancer cells by blocking tubulin polymerization. Cell Death Dis (2013) 4:e869. doi:10.1038/cddis.2013.397
    • (2013) Cell Death Dis , vol.4
    • Wang, C.1    Lv, X.2    He, C.3    Hua, G.4    Tsai, M.Y.5    Davis, J.S.6
  • 81
    • 63849242931 scopus 로고    scopus 로고
    • Expression pattern of G protein-coupled receptor 30 in LacZ reporter mice
    • doi:10.1210/en.2008-1488
    • Isensee J, Meoli L, Zazzu V, Nabzdyk C, Witt H, Soewarto D, et al. Expression pattern of G protein-coupled receptor 30 in LacZ reporter mice. Endocrinology (2009) 150:1722-30. doi:10.1210/en.2008-1488
    • (2009) Endocrinology , vol.150 , pp. 1722-1730
    • Isensee, J.1    Meoli, L.2    Zazzu, V.3    Nabzdyk, C.4    Witt, H.5    Soewarto, D.6
  • 82
    • 58149512521 scopus 로고    scopus 로고
    • GPR30 does not mediate estrogenic responses in reproductive organs in mice
    • doi:10.1095/biolreprod.108.071175
    • Otto C, Fuchs I, Kauselmann G, Kern H, Zevnik B, Andreasen P, et al. GPR30 does not mediate estrogenic responses in reproductive organs in mice. Biol Reprod (2009) 80:34-41. doi:10.1095/biolreprod.108.071175
    • (2009) Biol Reprod , vol.80 , pp. 34-41
    • Otto, C.1    Fuchs, I.2    Kauselmann, G.3    Kern, H.4    Zevnik, B.5    Andreasen, P.6
  • 83
    • 79960133918 scopus 로고    scopus 로고
    • Involvement of epidermal growth factor receptor signaling in estrogen inhibition of oocyte maturation mediated through the G-protein-coupled estrogen receptor (GPER) in zebrafish (Danio rerio)
    • doi:10.1095/biolreprod.110.088765
    • Peyton C, Thomas P. Involvement of epidermal growth factor receptor signaling in estrogen inhibition of oocyte maturation mediated through the G-protein-coupled estrogen receptor (GPER) in zebrafish (Danio rerio). Biol Reprod (2011) 85:42-50. doi:10.1095/biolreprod.110.088765
    • (2011) Biol Reprod , vol.85 , pp. 42-50
    • Peyton, C.1    Thomas, P.2
  • 84
    • 46349096631 scopus 로고    scopus 로고
    • Estrogen signaling characteristics of Atlantic croaker G-protein-coupled receptor 30 (GPR30) and evidence it is involved in maintenance of oocyte meiotic arrest
    • doi:10.1210/en.2007-1663
    • Pang Y, Dong J, Thomas P. Estrogen signaling characteristics of Atlantic croaker G-protein-coupled receptor 30 (GPR30) and evidence it is involved in maintenance of oocyte meiotic arrest. Endocrinology (2008) 149:3410-26. doi:10.1210/en.2007-1663
    • (2008) Endocrinology , vol.149 , pp. 3410-3426
    • Pang, Y.1    Dong, J.2    Thomas, P.3
  • 85
    • 77949570772 scopus 로고    scopus 로고
    • 17 Beta-estradiol activates rapid signaling pathways involved in rat pachytene spermatocytes apoptosis through GPR30 and ER alpha
    • doi:10.1016/j.mce.2010.01.035
    • Chimento A, Sirianni R, Delalande C, Silandre D, Bois C, Andò S, et al. 17 Beta-estradiol activates rapid signaling pathways involved in rat pachytene spermatocytes apoptosis through GPR30 and ER alpha. Mol Cell Endocrinol (2010) 320:136-44. doi:10.1016/j.mce.2010.01.035
    • (2010) Mol Cell Endocrinol , vol.320 , pp. 136-144
    • Chimento, A.1    Sirianni, R.2    Delalande, C.3    Silandre, D.4    Bois, C.5    Andò, S.6
  • 86
    • 80053329514 scopus 로고    scopus 로고
    • GPER and ESRs are expressed in rat round spermatids and mediate oestrogen-dependent rapid pathways modulating expression of cyclin B1 and Bax
    • doi:10.1111/j.1365-2605.2010.01100.x
    • Chimento A, Sirianni R, Zolea F, Bois C, Delalande C, Andò S, et al. GPER and ESRs are expressed in rat round spermatids and mediate oestrogen-dependent rapid pathways modulating expression of cyclin B1 and Bax. Int J Androl (2011) 34:420-9. doi:10.1111/j.1365-2605.2010.01100.x
    • (2011) Int J Androl , vol.34 , pp. 420-429
    • Chimento, A.1    Sirianni, R.2    Zolea, F.3    Bois, C.4    Delalande, C.5    Andò, S.6
  • 87
    • 50449104180 scopus 로고    scopus 로고
    • G-protein-coupled receptor 30 expression is required for estrogen stimulation of primordial follicle formation in the hamster ovary
    • doi:10.1210/en.2008-0441
    • Wang C, Prossnitz ER, Roy SK. G-protein-coupled receptor 30 expression is required for estrogen stimulation of primordial follicle formation in the hamster ovary. Endocrinology (2008) 149:4452-61. doi:10.1210/en.2008-0441
    • (2008) Endocrinology , vol.149 , pp. 4452-4461
    • Wang, C.1    Prossnitz, E.R.2    Roy, S.K.3


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