Withaferin A modulates the Spindle Assembly Checkpoint by degradation of Mad2-Cdc20 complex in colorectal cancer cell lines

Biochemical Pharmacology

Volumn 91, Issue 1, 2014, Pages 31-39

  Das, Tania ^a   Roy, Kumar Singha ^a   Chakrabarti, Tulika ^a   Mukhopadhyay, Sibabrata ^a   Roychoudhury, Susanta ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

Cdc20; Chromosome instability; Mad2; Spindle assembly checkpoint; Withaferin A

Indexed keywords

CASPASE 3; CELL CYCLE PROTEIN 20; PROTEIN MAD2; WITHAFERIN A;

ANAPHASE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE REGULATION; CELL FATE; CHROMOSOMAL INSTABILITY; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; G2 PHASE CELL CYCLE CHECKPOINT; M PHASE CELL CYCLE CHECKPOINT; PRIORITY JOURNAL; PROTEIN DEGRADATION;

CDC20; CHROMOSOME INSTABILITY; MAD2; SPINDLE ASSEMBLY CHECKPOINT; WITHAFERIN A;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CDC20 PROTEINS; CELL LINE, TUMOR; CHROMOSOME ABERRATIONS; COLORECTAL NEOPLASMS; G2 PHASE CELL CYCLE CHECKPOINTS; HCT116 CELLS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MAD2 PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; SPINDLE APPARATUS; WITHANOLIDES;

EID: 84905497126     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.06.022     Document Type: Article

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