Effect of Withania Somnifera on cell mediated immune responses in mice

Journal of Experimental and Clinical Cancer Research

Volumn 21, Issue 4, 2002, Pages 585-590

  Davis, L ^a   Kuttan, Giriji ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

Cell mediated immune responses; Mitogenic proliferation; Withania somnifera

Indexed keywords

CONCANAVALIN A; LIPOPOLYSACCHARIDE; MITOGENIC AGENT; PHYTOHEMAGGLUTININ; WITHANIA SOMNIFERA EXTRACT;

ANIMAL CELL; ANIMAL MODEL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; BONE MARROW CELL; CELL PROLIFERATION; CELLULAR IMMUNITY; COMPLEMENT DEPENDENT CYTOTOXICITY; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL NEOPLASM; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE TRANSFORMATION; MALE; MEDICINAL PLANT; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; THYMOCYTE; WITHANIA SOMNIFERA;

ANIMALS; CELL DIVISION; CONCANAVALIN A; IMMUNITY, CELLULAR; IMMUNOTHERAPY; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; T-LYMPHOCYTES; WITHANIA;

EID: 0036990430     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Mathew S., and Kuttan G.: Immunomodulatory and antitumour activities of Tinospora cordifolia. Fitoterapia 70: 35-42, 1999.
2. Antony S., Kuttan R., and Kuttan G.: Immunomodulatory activity of Curcumin. Immunol. Invest. 28: 291-294, 1999.
3. Kuttan G., and Kuttan R.: Immunomodulatory activity of a peptide isolated from Viscum album extract. Immunol. Invest. 21: 285-296, 1992.
4. Hersh E. In: "Immunological approaches to cancer therapeutics". E.Mihich John Wiley & Sons (eds), New York. 505, 1982.
5. Davis L., and Kuttan G.: Immunomodulatory activity of Withania somnifera. Ethanopharmacology 71: 193-200, 2000.
6. Shohat B., Gitter S., Abraham A., and Lavie D.: Antitumour activity of Withaferin A. Cancer Chemotherapy 51(5): 271-275, 1962.
7. Budiraja R.D., and Sudhir S.: Anti-inflammatory activity of Withania. J. of Scientific and Industrial Research 46: 488-490, 1988.
8. Sethi P.D., Thiagarajan A.R, and Subramanian S.S.: Evidence of antiarthritic activity of Aswagandha root powder in mice. Ind. J. of Pharmacol. 12; 165-168, 1970.
9. Davis L., and Kuttan G.: Suppressive effect of Cyclophosphamide induced toxicity by Withania somnifera extract in mice. J. of Ethanopharmacology 62: 209-214, 1998.
10. Kuttan G.: Use of Withania somnifera as an adjuvant during radition therapy. Indian J. of Exp. Biol. 34: 854-856, 1996.
11. Davis L., and Kuttan G.: Effect of Withania somnifera on cytokine production in normal and cyclophosphamide treated mice. J. Immunopharmacol & Toxicol. 21(4): 695-703, 1999.
12. Davis L., and Kuttan G.: Effect of Withania somnifera on 20-methylcholanthrene induced fibrosarcoma. J. Exp. Clin. Cancer Res. 19(2). 165-167, 2000.
13. Das H., Dutta S.K., Bhattacharya B., and Chakraborti S.K.: Antineoplastic agents from plants. Antitumour activities of Withanolid D. Indian J. Canc. Chemotherapy 7: 59-65, 1985.
14. Kim Y.B., Huh N.D., Koren H.S., and Amos D.B.: Natural Killing (NK) and antibody dependent cellular cytotoxicity (ADCC) in specific pathogen free (SPF) miniature swine and germ free piglets. I: Comparison of NK and ADCC. J. Immunol. 125(2); 755-762, 1980.
15. Gupta S.K., and Bhattacharya B.: Cytotoxicity assays. In "A handbook of practical immunology". Talwar, G.P. (eds) Vikas Publishing House, N.Delhi 328-336, 1983.
16. Greaves M., Janossy G., and Doenhoff M.: Selective triggering of human T and B lymphocyte populations in vitro by polyclonal mitogens. J. Exp. Med. 140: 1-18, 1974.