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Volumn 9, Issue 9, 2011, Pages 997-1007

Selecting Targeted Therapies for Patients with Renal Cell Carcinoma

Author keywords

Carcinoma; Clear cell renal cell carcinoma; Genetics; Kidney neoplasms; Non clear cell renal cell carcinoma; Pathology; Renal cell; Therapy

Indexed keywords

AFLIBERCEPT; ALPHA INTERFERON; AMG 836; ANTIHYPERTENSIVE AGENT; ANTINEOPLASTIC AGENT; AXITINIB; BEVACIZUMAB; CEDIRANIB; DOVITINIB; DOXORUBICIN; ENTINOSTAT; ERLOTINIB; EVEROLIMUS; FORETINIB; GEMCITABINE; INTERLEUKIN 2; ISPINESIB; MDX 1105; MDX 1106; PANOBINOSTAT; PAZOPANIB; PERIFOSINE; RAMUCIRUMAB; RILOTUMUMAB; RX 0201; SORAFENIB; SUNITINIB; TEMSIROLIMUS; TIVOZANIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT; WARFARIN;

EID: 80052974211     PISSN: 15401405     EISSN: 15401413     Source Type: Journal    
DOI: 10.6004/jnccn.2011.0084     Document Type: Review
Times cited : (9)

References (67)
  • 2
    • 77951886671 scopus 로고    scopus 로고
    • Neoadjuvant clinical trial with sorafenib for patients with stage II or higher renal cell carcinoma
    • Cowey CL, Amin C, Pruthi RS, et al. Neoadjuvant clinical trial with sorafenib for patients with stage II or higher renal cell carcinoma. J Clin Oncol 2010;28:1502-1507.
    • (2010) J Clin Oncol , vol.28 , pp. 1502-1507
    • Cowey, C.L.1    Amin, C.2    Pruthi, R.S.3
  • 3
    • 77956642234 scopus 로고    scopus 로고
    • Prospective clinical trial of preoperative sunitinib in patients with renal cell carcinoma
    • Hellenthal NJ, Underwood W, Penetrante R, et al. Prospective clinical trial of preoperative sunitinib in patients with renal cell carcinoma. J Urol 2010;184:859-864.
    • (2010) J Urol , vol.184 , pp. 859-864
    • Hellenthal, N.J.1    Underwood, W.2    Penetrante, R.3
  • 4
    • 70249115638 scopus 로고    scopus 로고
    • Phase II presurgical feasibility study of bevacizumab in untreated patients with metastatic renal cell carcinoma
    • Jonasch E, Wood CG, Matin SF, et al. Phase II presurgical feasibility study of bevacizumab in untreated patients with metastatic renal cell carcinoma. J Clin Oncol 2009;27:4076-4081.
    • (2009) J Clin Oncol , vol.27 , pp. 4076-4081
    • Jonasch, E.1    Wood, C.G.2    Matin, S.F.3
  • 5
    • 78349249825 scopus 로고    scopus 로고
    • Feasibility and efficacy of neoadjuvant sunitinib before nephron-sparing surgery
    • Silberstein JL, Millard F, Mehrazin R, et al. Feasibility and efficacy of neoadjuvant sunitinib before nephron-sparing surgery. BJU Int 2010;106:1270-1276.
    • (2010) BJU Int , vol.106 , pp. 1270-1276
    • Silberstein, J.L.1    Millard, F.2    Mehrazin, R.3
  • 7
    • 0035934596 scopus 로고    scopus 로고
    • Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: A randomised trial
    • DOI 10.1016/S0140-6736(01)06103-7
    • Mickisch GH, Garin A, Van Poppel H, et al. Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: a randomised trial. Lancet 2001;358:966-970. (Pubitemid 32913522)
    • (2001) Lancet , vol.358 , Issue.9286 , pp. 966-970
    • Mickisch, G.H.J.1    Garin, A.2    Van Poppel, H.3    De Prijck, L.4    Sylvester, R.5
  • 8
    • 79955511505 scopus 로고    scopus 로고
    • Benefit of cytoreductive nephrectomy in metastatic RCC: Do we learn from retrospective studies and small prospective studies?
    • Escudier B. Benefit of cytoreductive nephrectomy in metastatic RCC: do we learn from retrospective studies and small prospective studies? Ann Oncol 2011;22:995-996.
    • (2011) Ann Oncol , vol.22 , pp. 995-996
    • Escudier, B.1
  • 10
    • 0036138580 scopus 로고    scopus 로고
    • Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
    • DOI 10.1200/JCO.20.1.289
    • Motzer RJ, Bacik J, Murphy BA, et al. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002;20:289-296. (Pubitemid 34032623)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.1 , pp. 289-296
    • Motzer, R.J.1    Bacik, J.2    Murphy, B.A.3    Russo, P.4    Mazumdar, M.5
  • 11
    • 67651201656 scopus 로고    scopus 로고
    • Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: An expanded-access trial
    • Gore ME, Szczylik C, Porta C, et al. Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial. Lancet Oncol 2009;10:757-763.
    • (2009) Lancet Oncol , vol.10 , pp. 757-763
    • Gore, M.E.1    Szczylik, C.2    Porta, C.3
  • 13
    • 0345098465 scopus 로고    scopus 로고
    • Scoring Algorithm to Predict Survival after Nephrectomy and Immunotherapy in Patients with Metastatic Renal Cell Carcinoma: A Stratification Tool for Prospective Clinical Trials
    • DOI 10.1002/cncr.11851
    • Leibovich BC, Han KR, Bui MH, et al. Scoring algorithm to predict survival after nephrectomy and immunotherapy in patients with metastatic renal cell carcinoma: a stratification tool for prospective clinical trials. Cancer 2003;98:2566-2575. (Pubitemid 37509519)
    • (2003) Cancer , vol.98 , Issue.12 , pp. 2566-2575
    • Leibovich, B.C.1    Han, K.-R.2    Bui, M.H.T.3    Pantuck, A.J.4    Dorey, F.J.5    Figlin, R.A.6    Belldegrun, A.7
  • 14
    • 78650630648 scopus 로고    scopus 로고
    • The high-dose aldesleukin (HD IL-2) "SELECT" trial in patients with metastatic renal cell carcinoma (mRCC)
    • [abstract] Abstract 4514
    • McDermott DF, Ghebremichael MS, Signoretti S, et al. The high-dose aldesleukin (HD IL-2) "SELECT" trial in patients with metastatic renal cell carcinoma (mRCC) [abstract]. J Clin Oncol 2010;28(Suppl 1):Abstract 4514.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL. 1
    • McDermott, D.F.1    Ghebremichael, M.S.2    Signoretti, S.3
  • 15
    • 63649158633 scopus 로고    scopus 로고
    • Retrospective analysis of the safety and efficacy of interleukin-2 after prior VEGF-targeted therapy in patients with advanced renal cell carcinoma
    • Cho DC, Puzanov I, Regan MM, et al. Retrospective analysis of the safety and efficacy of interleukin-2 after prior VEGF-targeted therapy in patients with advanced renal cell carcinoma. J Immunother 2009;32:181-185.
    • (2009) J Immunother , vol.32 , pp. 181-185
    • Cho, D.C.1    Puzanov, I.2    Regan, M.M.3
  • 16
    • 35548931472 scopus 로고    scopus 로고
    • Randomized phase II trial of first-line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: Final results
    • [abstract] Abstract 5025
    • Szczylik C, Demkow T, Staehler M, et al. Randomized phase II trial of first-line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: final results [abstract]. J Clin Oncol 2007;25(Suppl 1):Abstract 5025.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 1
    • Szczylik, C.1    Demkow, T.2    Staehler, M.3
  • 17
    • 79955728914 scopus 로고    scopus 로고
    • Randomized phase II multicenter study of the efficacy and safety of sunitinib on the 4/2 versus continuous dosing schedule as first-line therapy of metastatic renal cell carcinoma: Renal EFFECT Trial
    • [abstract] Abstract LBA308
    • Motzer RJ, Hutson TE, Olsen MR, et al. Randomized phase II multicenter study of the efficacy and safety of sunitinib on the 4/2 versus continuous dosing schedule as first-line therapy of metastatic renal cell carcinoma: renal EFFECT Trial [abstract]. J Clin Oncol 2011;29(Suppl 7):Abstract LBA308.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 7
    • Motzer, R.J.1    Hutson, T.E.2    Olsen, M.R.3
  • 18
    • 80052406632 scopus 로고    scopus 로고
    • Efficacy and toxicity of sunitinib in patients with metastatic renal cell carcinoma with severe renal impairment or on haemodialysis
    • in press
    • Josephs D, Hutson TE, Cowey CL, et al. Efficacy and toxicity of sunitinib in patients with metastatic renal cell carcinoma with severe renal impairment or on haemodialysis. BJU Int, in press.
    • BJU Int
    • Josephs, D.1    Hutson, T.E.2    Cowey, C.L.3
  • 19
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
    • Sternberg CN, Davis ID, Mardiak J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol 2010;28:1061-1068.
    • (2010) J Clin Oncol , vol.28 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3
  • 20
    • 75749090050 scopus 로고    scopus 로고
    • Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma
    • Hutson TE, Davis ID, Machiels JP, et al. Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma. J Clin Oncol 2010;28:475-480.
    • (2010) J Clin Oncol , vol.28 , pp. 475-480
    • Hutson, T.E.1    Davis, I.D.2    Machiels, J.P.3
  • 21
    • 56749161699 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
    • Rini BI, Halabi S, Rosenberg JE, et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol 2008;26:5422-5428.
    • (2008) J Clin Oncol , vol.26 , pp. 5422-5428
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3
  • 23
    • 48749092867 scopus 로고    scopus 로고
    • First-line bevacizumab combined with reduced dose interferon-alpha2a is active in patients with metastatic renal cell carcinoma
    • Melichar B, Koralewski P, Ravaud A, et al. First-line bevacizumab combined with reduced dose interferon-alpha2a is active in patients with metastatic renal cell carcinoma. Ann Oncol 2008;19:1470-1476.
    • (2008) Ann Oncol , vol.19 , pp. 1470-1476
    • Melichar, B.1    Koralewski, P.2    Ravaud, A.3
  • 24
    • 0033514050 scopus 로고    scopus 로고
    • Interferon-alpha and survival in metastatic renal carcinoma: Early results of a randomised controlled trial
    • Medical Research Council Renal Cancer Collaborators
    • Interferon-alpha and survival in metastatic renal carcinoma: early results of a randomised controlled trial. Medical Research Council Renal Cancer Collaborators. Lancet 1999;353:14-17.
    • (1999) Lancet , vol.353 , pp. 14-17
  • 30
    • 77956227464 scopus 로고    scopus 로고
    • Phase 3 trial of everolimus for metastatic renal cell carcinoma: Final results and analysis of prognostic factors
    • Motzer RJ, Escudier B, Oudard S, et al. Phase 3 trial of everolimus for metastatic renal cell carcinoma: final results and analysis of prognostic factors. Cancer 2010;116:4256-4265.
    • (2010) Cancer , vol.116 , pp. 4256-4265
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 31
    • 70349388719 scopus 로고    scopus 로고
    • Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma
    • Rini BI, Wilding G, Hudes G, et al. Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma. J Clin Oncol 2009;27:4462-4468.
    • (2009) J Clin Oncol , vol.27 , pp. 4462-4468
    • Rini, B.I.1    Wilding, G.2    Hudes, G.3
  • 32
    • 35549007093 scopus 로고    scopus 로고
    • Axitinib (AG-013736; AG) in patients (pts) with metastatic renal cell cancer (RCC) refractory to sorafenib
    • [abstract] Abstract 5032
    • Rini BI, Wilding GT, Hudes G, et al. Axitinib (AG-013736; AG) in patients (pts) with metastatic renal cell cancer (RCC) refractory to sorafenib [abstract]. J Clin Oncol 2007;25(Suppl 1):Abstract 5032.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 1
    • Rini, B.I.1    Wilding, G.T.2    Hudes, G.3
  • 33
    • 0036286212 scopus 로고    scopus 로고
    • Biological significance of c-met over expression in papillary renal cell carcinoma
    • Sweeney P, El-Naggar AK, Lin SH, et al. Biological significance of c-met over expression in papillary renal cell carcinoma. J Urol 2002;168:51-55. (Pubitemid 34640783)
    • (2002) Journal of Urology , vol.168 , Issue.1 , pp. 51-55
    • Sweeney, P.1    El-Naggar, A.K.2    Lin, S.-H.3    Pisters, L.L.4
  • 34
    • 84856550225 scopus 로고    scopus 로고
    • Phase II trial of sunitinib in patients with metastatic non-clear cell renal cell carcinoma
    • in press
    • Molina AM, Feldman DR, Ginsberg MS, et al. Phase II trial of sunitinib in patients with metastatic non-clear cell renal cell carcinoma. Invest New Drugs, in press.
    • Invest New Drugs
    • Molina, A.M.1    Feldman, D.R.2    Ginsberg, M.S.3
  • 36
    • 77957984795 scopus 로고    scopus 로고
    • First-line sunitinib in type I and II papillary renal cell carcinoma (PRCC): SUPAP, a phase II study of the French Genito-Urinary Group (GETUG) and the Group of Early Phase trials (GEP)
    • [abstract]. Abstract 5146
    • Ravaud A, Oudard S, Gravis-Mescam G, et al. First-line sunitinib in type I and II papillary renal cell carcinoma (PRCC): SUPAP, a phase II study of the French Genito-Urinary Group (GETUG) and the Group of Early Phase trials (GEP) [abstract]. J Clin Oncol 2009;27(Suppl 1):Abstract 5146.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. 1
    • Ravaud, A.1    Oudard, S.2    Gravis-Mescam, G.3
  • 37
    • 67651056360 scopus 로고    scopus 로고
    • Effect of temsirolimus versus interferon-alpha on outcome of patients with advanced renal cell carcinoma of different tumor histologies
    • Dutcher JP, De Souza P, McDermott D, et al. Effect of temsirolimus versus interferon-alpha on outcome of patients with advanced renal cell carcinoma of different tumor histologies. Med Oncol 2009;26:202-209.
    • (2009) Med Oncol , vol.26 , pp. 202-209
    • Dutcher, J.P.1    De Souza, P.2    McDermott, D.3
  • 38
    • 73349085260 scopus 로고    scopus 로고
    • Phase II study of erlotinib in patients with locally advanced or metastatic papillary histology renal cell cancer: SWOG S0317
    • Gordon MS, Hussey M, Nagle RB, et al. Phase II study of erlotinib in patients with locally advanced or metastatic papillary histology renal cell cancer: SWOG S0317. J Clin Oncol 2009;27:5788-5793.
    • (2009) J Clin Oncol , vol.27 , pp. 5788-5793
    • Gordon, M.S.1    Hussey, M.2    Nagle, R.B.3
  • 39
    • 4844231761 scopus 로고    scopus 로고
    • Active chemotherapy for sarcomatoid and rapidly progressing renal cell carcinoma
    • DOI 10.1002/cncr.20541
    • Nanus DM, Garino A, Milowsky MI, et al. Active chemotherapy for sarcomatoid and rapidly progressing renal cell carcinoma. Cancer 2004;101:1545-1551. (Pubitemid 39318900)
    • (2004) Cancer , vol.101 , Issue.7 , pp. 1545-1551
    • Nanus, D.M.1    Garino, A.2    Milowsky, M.I.3    Larkin, M.4    Dutcher, J.P.5
  • 40
    • 84866274288 scopus 로고    scopus 로고
    • A phase II trial of doxorubicin and gemcitabine in renal cell carcinoma with sarcomatoid features: ECOG 8802
    • in press
    • Haas N, Lin X, Manola J, et al. A phase II trial of doxorubicin and gemcitabine in renal cell carcinoma with sarcomatoid features: ECOG 8802. Med Oncol, in press.
    • Med Oncol
    • Haas, N.1    Lin, X.2    Manola, J.3
  • 41
    • 84655165029 scopus 로고    scopus 로고
    • Long-term survival of patients with sarcomatoid renal cell cancer treated with chemotherapy
    • in press
    • Dutcher JP, Nanus D. Long-term survival of patients with sarcomatoid renal cell cancer treated with chemotherapy. Med Oncol, in press.
    • Med Oncol
    • Dutcher, J.P.1    Nanus, D.2
  • 42
    • 58249094490 scopus 로고    scopus 로고
    • Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy
    • Golshayan AR, George S, Heng DY, et al. Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. J Clin Oncol 2009;27:235-241.
    • (2009) J Clin Oncol , vol.27 , pp. 235-241
    • Golshayan, A.R.1    George, S.2    Heng, D.Y.3
  • 43
    • 84870807820 scopus 로고    scopus 로고
    • Sarcomatoid-variant renal cell carcinoma: Treatment outcome and survival in advanced disease
    • in press
    • Molina AM, Tickoo SK, Ishill N, et al. Sarcomatoid-variant renal cell carcinoma: treatment outcome and survival in advanced disease. Am J Clin Oncol, in press.
    • Am J Clin Oncol
    • Molina, A.M.1    Tickoo, S.K.2    Ishill, N.3
  • 44
    • 0036142183 scopus 로고    scopus 로고
    • Active chemotherapy for collecting duct carcinoma of the kidney: A case report and review of the literature
    • DOI 10.1002/cncr.10204
    • Milowsky MI, Rosmarin A, Tickoo SK, et al. Active chemotherapy for collecting duct carcinoma of the kidney: a case report and review of the literature. Cancer 2002;94:111-116. (Pubitemid 34049048)
    • (2002) Cancer , vol.94 , Issue.1 , pp. 111-116
    • Milowsky, M.I.1    Rosmarin, A.2    Tickoo, S.K.3    Papanicolaou, N.4    Nanus, D.M.5
  • 48
    • 50549095129 scopus 로고    scopus 로고
    • High-dose-intensity MVAC for advanced renal medullary carcinoma: Report of three cases and literature review
    • Rathmell WK, Monk JP. High-dose-intensity MVAC for advanced renal medullary carcinoma: report of three cases and literature review. Urology 2008;72:659-663.
    • (2008) Urology , vol.72 , pp. 659-663
    • Rathmell, W.K.1    Monk, J.P.2
  • 49
    • 77958537003 scopus 로고    scopus 로고
    • Complete response to carboplatin, gemcitabine, and paclitaxel in a patient with advanced metastatic renal medullary carcinoma
    • Walsh A, Kelly DR, Vaid YN, et al. Complete response to carboplatin, gemcitabine, and paclitaxel in a patient with advanced metastatic renal medullary carcinoma. Pediatr Blood Cancer 2010;55:1217-1220.
    • (2010) Pediatr Blood Cancer , vol.55 , pp. 1217-1220
    • Walsh, A.1    Kelly, D.R.2    Vaid, Y.N.3
  • 50
    • 37849001813 scopus 로고    scopus 로고
    • Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma
    • Choueiri TK, Plantade A, Elson P, et al. Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. J Clin Oncol 2008;26:127-131.
    • (2008) J Clin Oncol , vol.26 , pp. 127-131
    • Choueiri, T.K.1    Plantade, A.2    Elson, P.3
  • 51
    • 79952751962 scopus 로고    scopus 로고
    • Chromophobe renal cell carcinoma with prolonged response to sequential sunitinib and everolimus
    • Larkin JM, Fisher RA, Pickering LM, et al. Chromophobe renal cell carcinoma with prolonged response to sequential sunitinib and everolimus. J Clin Oncol 2011;29:e241-242.
    • (2011) J Clin Oncol , vol.29
    • Larkin, J.M.1    Fisher, R.A.2    Pickering, L.M.3
  • 52
    • 65949118243 scopus 로고    scopus 로고
    • Combination targeted therapy in advanced renal cell carcinoma
    • Sosman J, Puzanov I. Combination targeted therapy in advanced renal cell carcinoma. Cancer 2009;115:2368-2375.
    • (2009) Cancer , vol.115 , pp. 2368-2375
    • Sosman, J.1    Puzanov, I.2
  • 53
    • 63049093371 scopus 로고    scopus 로고
    • Phase I trial of bevacizumab plus escalated doses of sunitinib in patients with metastatic renal cell carcinoma
    • Feldman DR, Baum MS, Ginsberg MS, et al. Phase I trial of bevacizumab plus escalated doses of sunitinib in patients with metastatic renal cell carcinoma. J Clin Oncol 2009;27:1432-1439.
    • (2009) J Clin Oncol , vol.27 , pp. 1432-1439
    • Feldman, D.R.1    Baum, M.S.2    Ginsberg, M.S.3
  • 54
    • 79960374758 scopus 로고    scopus 로고
    • Phase I trial sunitinib plus everolimus in patients with metastatic renal cell carcinoma (mRCC)
    • [abstract]. Abstract 311
    • Molina AM, Feldman DR, Ginsberg MS, et al. Phase I trial sunitinib plus everolimus in patients with metastatic renal cell carcinoma (mRCC) [abstract]. J Clin Oncol 2011;29(Suppl 7):Abstract 311.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 7
    • Molina, A.M.1    Feldman, D.R.2    Ginsberg, M.S.3
  • 55
    • 65249102843 scopus 로고    scopus 로고
    • Phase I study combining treatment with temsirolimus and sunitinib malate in patients with advanced renal cell carcinoma
    • Patel PH, Senico PL, Curiel RE, et al. Phase I study combining treatment with temsirolimus and sunitinib malate in patients with advanced renal cell carcinoma. Clin Genitourin Cancer 2009;7:24-27.
    • (2009) Clin Genitourin Cancer , vol.7 , pp. 24-27
    • Patel, P.H.1    Senico, P.L.2    Curiel, R.E.3
  • 56
    • 77958452678 scopus 로고    scopus 로고
    • Can the combination of temsirolimus and bevacizumab improve the treatment of metastatic renal cell carcinoma (mRCC)? Results of the randomized TORAVA phase II trial
    • [abstract]. Abstract 4516
    • Escudier BJ, Negrier S, Gravis G, et al. Can the combination of temsirolimus and bevacizumab improve the treatment of metastatic renal cell carcinoma (mRCC)? Results of the randomized TORAVA phase II trial [abstract]. J Clin Oncol 2010;28:Abstract 4516.
    • (2010) J Clin Oncol , pp. 28
    • Escudier, B.J.1    Negrier, S.2    Gravis, G.3
  • 57
    • 80052999789 scopus 로고    scopus 로고
    • Cessation of VEGF-targeted therapy in patients with metastatic renal cell carcinoma (mRCC): Feasibility and clinical outcome
    • [abstract]. Abstract 307
    • Sadeghi S, Albiges L, Wood LS, et al. Cessation of VEGF-targeted therapy in patients with metastatic renal cell carcinoma (mRCC): feasibility and clinical outcome [abstract]. J Clin Oncol 2011;29(Suppl 7):Abstract 307.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 7
    • Sadeghi, S.1    Albiges, L.2    Wood, L.S.3
  • 58
    • 79952784860 scopus 로고    scopus 로고
    • NCCN Task Force Report: Optimizing treatment of advanced renal cell carcinoma with molecular targeted therapy
    • Hudes GR, Carducci MA, Choueiri TK, et al. NCCN Task Force Report: optimizing treatment of advanced renal cell carcinoma with molecular targeted therapy. J Natl Compr Cancer Netw 2011;9:S1-29.
    • (2011) J Natl Compr Cancer Netw , vol.9
    • Hudes, G.R.1    Carducci, M.A.2    Choueiri, T.K.3
  • 60
    • 70349329441 scopus 로고    scopus 로고
    • Novel antiangiogenic agents in the treatment of refractory renal cell carcinoma
    • Sonpavde G, Hutson TE. Novel antiangiogenic agents in the treatment of refractory renal cell carcinoma. Clin Genitourin Cancer 2008;6(Suppl 1):S29-36.
    • (2008) Clin Genitourin Cancer , vol.6 , Issue.SUPPL. 1
    • Sonpavde, G.1    Hutson, T.E.2
  • 61
    • 80052735494 scopus 로고    scopus 로고
    • Activity of tivozanib (AV-951) in patients (Pts) with different histologic subtypes of renal cell carcinoma (RCC)
    • [abstract] Abstract 327
    • Bhargava P, Esteves B, Al-Adhami M, et al. Activity of tivozanib (AV-951) in patients (Pts) with different histologic subtypes of renal cell carcinoma (RCC) [abstract]. J Clin Oncol 2011;29(Suppl 7):Abstract 327.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 7
    • Bhargava, P.1    Esteves, B.2    Al-Adhami, M.3
  • 63
    • 70349379206 scopus 로고    scopus 로고
    • Phase I/II trial of CCI 779 and bevacizumab in advanced renal cell carcinoma (RCC): Safety and activity in RTKI refractory RCC patients
    • [abstract] Abstract 5039
    • Merchan JR, Pitot HC, Qin R, et al. Phase I/II trial of CCI 779 and bevacizumab in advanced renal cell carcinoma (RCC): safety and activity in RTKI refractory RCC patients [abstract]. J Clin Oncol 2009;27(Suppl 1):Abstract 5039.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. 1
    • Merchan, J.R.1    Pitot, H.C.2    Qin, R.3
  • 64
    • 77952301116 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab and everolimus in patients with advanced renal cell carcinoma
    • Hainsworth JD, Spigel DR, Burris HA III. Phase II trial of bevacizumab and everolimus in patients with advanced renal cell carcinoma. J Clin Oncol 2010;28:2131-2136.
    • (2010) J Clin Oncol , vol.28 , pp. 2131-2136
    • Hainsworth, J.D.1    Spigel, D.R.2    Burris III, H.A.3
  • 65
    • 55349098735 scopus 로고    scopus 로고
    • Updated results of phase I trial of sorafenib (S) and bevacizumab (B) in patients with metastatic renal cell cancer (mRCC)
    • [abstract]. Abstract 5011
    • Sosman JA, Flaherty KT, Atkins MB, et al. Updated results of phase I trial of sorafenib (S) and bevacizumab (B) in patients with metastatic renal cell cancer (mRCC) [abstract]. J Clin Oncol 2008;26(Suppl 1):Abstract 5011.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL. 1
    • Sosman, J.A.1    Flaherty, K.T.2    Atkins, M.B.3
  • 66
    • 36849031075 scopus 로고    scopus 로고
    • A phase I, pharmacokinetic and pharmacodynamic study of sorafenib (S), a multi-targeted kinase inhibitor in combination with temsirolimus (T), an mTOR inhibitor in patients with advanced solid malignancies
    • [abstract]. Abstract 3512
    • Patnaik A, Ricart A, Cooper J, et al. A phase I, pharmacokinetic and pharmacodynamic study of sorafenib (S), a multi-targeted kinase inhibitor in combination with temsirolimus (T), an mTOR inhibitor in patients with advanced solid malignancies [abstract]. J Clin Oncol 2007;25(Suppl 1):Abstract 3512.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 1
    • Patnaik, A.1    Ricart, A.2    Cooper, J.3
  • 67
    • 77955095539 scopus 로고    scopus 로고
    • A phase I study of everolimus plus sorafenib in patients with metastatic renal cell carcinoma (mRCC)
    • [abstract]. Abstract e16056
    • Cen P, Daleiden A, Doshi G, et al. A phase I study of everolimus plus sorafenib in patients with metastatic renal cell carcinoma (mRCC) [abstract]. J Clin Oncol 2009;27(Suppl 1):Abstract e16056.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. 1
    • Cen, P.1    Daleiden, A.2    Doshi, G.3


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