Activation of opioid μ-receptor by sinomenine in cell and mice

Neuroscience Letters

Volumn 443, Issue 3, 2008, Pages 209-212

  Wang, Mao Hsien ^a   Chang, Cheng Kuei ^b   Cheng, Jun Hwa ^c   Wu, Hung Tsung ^c   Li, Ying Xiao ^d   Cheng, Juei Tang ^c  

^a EN CHU KONG HOSPITAL   (Taiwan)

^b MACKAY MEMORIAL HOSPITAL   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d GUANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

Author keywords

Antinociception; Mouse; Opioid receptor; Radioligand binding; Receptor phosphorylation; Sinomenine; Transfected cell

Indexed keywords

MORPHINE; MU OPIATE RECEPTOR; NALOXONAZINE; NALOXONE; SINOMENINE; TRITIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVATION; DRUG BINDING; DRUG EFFECT; DRUG INHIBITION; DRUG STRUCTURE; GENETIC TRANSFECTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TAIL FLICK TEST;

ANALGESICS, OPIOID; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; MALE; MICE; MICE, INBRED BALB C; MORPHINANS; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; PHOSPHORYLATION; PROTEIN BINDING; RECEPTORS, OPIOID, MU; TRANSFECTION;

EID: 50249107800     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.07.088     Document Type: Article

References (18)

1. Chen S.W., Mi X.J., Wang R., Wang W.J., Kong W.X., Zhang Y.J., and Li Y.L. Behavioral effects of sinomenine in murine models of anxiety. Life. Sci. 78 (2005) 232-238
2. Feng H., Yamaki K., Takano H., Inoue K., Yanagisawa R., and Yoshino S. Effect of sinomenine on collagen-induced arthritis in mice. Autoimmunity 40 (2007) 532-539
3. Johnson E.E., Christie M.J., and Connor M. The role of opioid receptor phosphorylation and trafficking in adaptations to persistent opioid treatment. Neurosignals 14 (2005) 290-302
4. Keith D.E., Murray S.R., Zaki P.A., Chu P.C., Lissin D.V., Kang L., Evans C.J., and von Zastrow M. Morphine activates opioid receptors without causing their rapid internalization. J. Biol. Chem. 271 (1996) 19021-19024
5. Kok T.W., Yue P.Y., Mak N.K., Fan T.P., Liu L., and Wong R.N. The anti-angiogenic effect of sinomenine. Angiogenesis 8 (2005) 3-12
6. Liu L., Buchner E., Beitze D., Schmidt-Weber C.B., Kaever V., Emmrich F., and Kinne R.W. Amelioration of rat experimental arthritides by treatment with the alkaloid sinomenine. Int. J. Immunopharmacol. 18 (1996) 529-543
7. Liu L., Resch K., and Kaever V. Inhibition of lymphocyte proliferation by the anti-arthritic drug sinomenine. Int. J. Immunopharmacol. 16 (1994) 685-691
8. Liu L., Riese J., Resch K., and Kaever V. Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum. Arzneimittelforschung 44 (1994) 1223-1226
9. Liu Z., Zheng J.F., Yang L.Q., Yi L., and Hu B. Effects of sinomenine on NO/nNOS system in cerebellum and spinal cord of morphine-dependent and withdrawal mice. Sheng Li Xue Bao 59 (2007) 285-292
10. Pitcher J.A., Freedman N.J., and Lefkowitz R.J. G protein-coupled receptor kinases. Annu. Rev. Biochem. 67 (1998) 653-692
11. Qian L., Xu Z., Zhang W., Wilson B., Hong J.S., and Flood P.M. Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J. Neuroinflamm. 4 (2007) 23
12. Rutherford J.M., Wang J., Xu H., Dersch C.M., Partilla J.S., Rice K.C., and Rothman R.B. Evidence for a mu-delta opioid receptor complex in CHO cells co-expressing mu and delta opioid peptide receptors. Peptides 29 (2008) 1424-1431
13. Schulz S., Mayer D., Pfeiffer M., Stumm R., Koch T., and Hollt V. Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375. EMBO J. 23 (2004) 3282-3289
14. Wang C., Mo Z., Zhu Q., and Wen L. Effect of sinamine on withdrawal symptom and neurotransmitter of morphine-dependent rats. Zhong Yao Cai 25 (2002) 337-339
15. Wang C.Y., Mo Z.X., and Tu H.H. Effect of sinomenine on morphine dependence in isolated guinea pig ileum. Di Yi Jun Yi Da Xue Xue Bao 23 (2003) 329-331
16. Webster D.E., Lu J., Chen S.N., Farnsworth N.R., and Wang Z.J. Activation of the mu-opiate receptor by Vitex agnus-castus methanol extracts: implication for its use in PMS. J. Ethnopharmacol. 106 (2006) 216-221
17. Yamasaki H. Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. Acta Med. Okayama 30 (1976) 1-20
18. Zhao Y., Li J., Yu K., Liu Y., and Chen X. Sinomenine inhibits maturation of monocyte-derived dendritic cells through blocking activation of NF-kappa B. Int. Immunopharmacol. 7 (2007) 637-645