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Volumn 141, Issue 16, 2014, Pages 3197-3211

Crucial requirement of ERK/MAPK signaling in respiratory tract development

Author keywords

ERK MAPK pathway; Lung agenesis; Lung morphogenesis; Mekgene function; Omphalocele; Trachea

Indexed keywords

ERK/MAPK PATHWAY; LUNG AGENESIS; LUNG MORPHOGENESIS; MEK GENE FUNCTION; OMPHALOCELE; TRACHEA;

EID: 84905484544     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.110254     Document Type: Article
Times cited : (53)

References (79)
  • 1
    • 0036830491 scopus 로고    scopus 로고
    • The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6
    • Akiyama, H., Chaboissier, M.-C., Martin, J. F., Schedl, A. andde Crombrugghe, B. (2002). The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 16, 2813-2828.
    • (2002) Genes Dev. , vol.16 , pp. 2813-2828
    • Akiyama, H.1    Chaboissier, M.-C.2    Martin, J.F.3    Schedl, A.4    de Crombrugghe, B.5
  • 3
    • 0024563729 scopus 로고
    • Pulmonary hypoplasia in infants with giant abdominal wall defects
    • Argyle, J. C. (1989). Pulmonary hypoplasia in infants with giant abdominal wall defects. Fetal Pediatr. Pathol. 9, 43-55.
    • (1989) Fetal Pediatr. Pathol. , vol.9 , pp. 43-55
    • Argyle, J.C.1
  • 4
    • 0031573797 scopus 로고    scopus 로고
    • Early postnatal lethality in Hoxa-5 mutant mice is attributable to respiratory tract defects
    • Aubin, J., Lemieux, M., Tremblay, M., Bérard, J. and Jeannotte, L. (1997). Early postnatal lethality in Hoxa-5 mutant mice is attributable to respiratory tract defects. Dev. Biol. 192, 432-445.
    • (1997) Dev. Biol. , vol.192 , pp. 432-445
    • Aubin, J.1    Lemieux, M.2    Tremblay, M.3    Bérard, J.4    Jeannotte, L.5
  • 7
    • 42549128765 scopus 로고    scopus 로고
    • R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis
    • Bell, S. M., Schreiner, C. M., Wert, S. E., Mucenski, M. L., Scott, W. J. and Whitsett, J. A. (2008). R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis. Development 135, 1049-1058.
    • (2008) Development , vol.135 , pp. 1049-1058
    • Bell, S.M.1    Schreiner, C.M.2    Wert, S.E.3    Mucenski, M.L.4    Scott, W.J.5    Whitsett, J.A.6
  • 8
    • 0031457616 scopus 로고    scopus 로고
    • Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung
    • Bellusci, S., Grindley, J., Emoto, H., Itoh, N. and Hogan, B. L. (1997). Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development 124, 4867-4878.
    • (1997) Development , vol.124 , pp. 4867-4878
    • Bellusci, S.1    Grindley, J.2    Emoto, H.3    Itoh, N.4    Hogan, B.L.5
  • 10
    • 33749389685 scopus 로고    scopus 로고
    • Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis
    • Bissonauth, V., Roy, S., Gravel, M., Guillemette, S. and Charron, J. (2006). Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis. Development 133, 3429-3440.
    • (2006) Development , vol.133 , pp. 3429-3440
    • Bissonauth, V.1    Roy, S.2    Gravel, M.3    Guillemette, S.4    Charron, J.5
  • 11
    • 84964828297 scopus 로고    scopus 로고
    • The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways
    • Boucherat, O., Chakir, J. and Jeannotte, L. (2012). The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways. Biol. Open 1, 677-691.
    • (2012) Biol. Open , vol.1 , pp. 677-691
    • Boucherat, O.1    Chakir, J.2    Jeannotte, L.3
  • 13
    • 15844417254 scopus 로고    scopus 로고
    • Tracheomalacia and tracheobronchomalacia in children and adults: An in-depth review
    • Carden, K. A., Boiselle, P. M., Waltz, D. A. and Ernst, A. (2005). Tracheomalacia and tracheobronchomalacia in children and adults: an in-depth review. Chest 127, 984-1005.
    • (2005) Chest , vol.127 , pp. 984-1005
    • Carden, K.A.1    Boiselle, P.M.2    Waltz, D.A.3    Ernst, A.4
  • 15
    • 0027943249 scopus 로고
    • Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle
    • Daksis, J. I., Lu, R. Y., Facchini, L. M., Marhin, W.W. and Penn, L. J. (1994). Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle. Oncogene 9, 3635-3645.
    • (1994) Oncogene , vol.9 , pp. 3635-3645
    • Daksis, J.I.1    Lu, R.Y.2    Facchini, L.M.3    Marhin, W.W.4    Penn, L.J.5
  • 16
    • 0033961133 scopus 로고    scopus 로고
    • An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis
    • De Moerlooze, L., Spencer-Dene, B., Revest, J. M., Hajihosseini, M., Rosewell, I. and Dickson, C. (2000). An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. Development 127, 483-492.
    • (2000) Development , vol.127 , pp. 483-492
    • De Moerlooze, L.1    Spencer-Dene, B.2    Revest, J.M.3    Hajihosseini, M.4    Rosewell, I.5    Dickson, C.6
  • 17
    • 77952999989 scopus 로고    scopus 로고
    • Explant culture of mouse embryonic whole lung, isolated epithelium, or mesenchyme under chemically defined conditions as a system to evaluate the molecular mechanism of branching morphogenesis and cellular differentiation
    • del Moral, P. M. and Warburton, D. (2010). Explant culture of mouse embryonic whole lung, isolated epithelium, or mesenchyme under chemically defined conditions as a system to evaluate the molecular mechanism of branching morphogenesis and cellular differentiation. Methods Mol. Biol. 633, 71-79.
    • (2010) Methods Mol. Biol. , vol.633 , pp. 71-79
    • del Moral, P.M.1    Warburton, D.2
  • 19
    • 46249088370 scopus 로고    scopus 로고
    • Lumi: A pipeline for processing Illumina microarray
    • Du, P., Kibbe, W. A. and Lin, S. M. (2008). lumi: a pipeline for processing Illumina microarray. Bioinformatics 24, 1547-1548.
    • (2008) Bioinformatics , vol.24 , pp. 1547-1548
    • Du, P.1    Kibbe, W.A.2    Lin, S.M.3
  • 20
    • 0036081355 scopus 로고    scopus 로고
    • Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
    • Edgar, R., Domrachev, M. and Lash, A. E. (2002). Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30, 207-210.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 207-210
    • Edgar, R.1    Domrachev, M.2    Lash, A.E.3
  • 21
    • 79955561301 scopus 로고    scopus 로고
    • Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development
    • Geng, Y., Dong, Y., Yu, M., Zhang, L., Yan, X., Sun, J., Qiao, L., Geng, H., Nakajima, M., Furuichi, T. et al. (2011). Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc. Natl. Acad. Sci. USA 108, 7058-7063.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 7058-7063
    • Geng, Y.1    Dong, Y.2    Yu, M.3    Zhang, L.4    Yan, X.5    Sun, J.6    Qiao, L.7    Geng, H.8    Nakajima, M.9    Furuichi, T.10
  • 23
    • 68349092814 scopus 로고    scopus 로고
    • Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut
    • Goss, A. M., Tian, Y., Tsukiyama, T., Cohen, E. D., Zhou, D., Lu, M. M., Yamaguchi, T. P. and Morrisey, E. E. (2009). Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev. Cell 17, 290-298.
    • (2009) Dev. Cell , vol.17 , pp. 290-298
    • Goss, A.M.1    Tian, Y.2    Tsukiyama, T.3    Cohen, E.D.4    Zhou, D.5    Lu, M.M.6    Yamaguchi, T.P.7    Morrisey, E.E.8
  • 24
    • 4644328190 scopus 로고    scopus 로고
    • Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    • Harfe, B. D., Scherz, P. J., Nissim, S., Tian, H., McMahon, A. P. and Tabin, C. J. (2004). Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 118, 517-528.
    • (2004) Cell , vol.118 , pp. 517-528
    • Harfe, B.D.1    Scherz, P.J.2    Nissim, S.3    Tian, H.4    McMahon, A.P.5    Tabin, C.J.6
  • 26
    • 70349519044 scopus 로고    scopus 로고
    • beta-Catenin promotes respiratory progenitor identity in mouse foregut
    • Harris-Johnson, K. S., Domyan, E. T., Vezina, C. M. and Sun, X. (2009). beta-Catenin promotes respiratory progenitor identity in mouse foregut. Proc. Natl. Acad. Sci. USA 106, 16287-16292.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 16287-16292
    • Harris-Johnson, K.S.1    Domyan, E.T.2    Vezina, C.M.3    Sun, X.4
  • 27
    • 0035991647 scopus 로고    scopus 로고
    • Preimplantation human embryos and embryonic stem cells showcomparable expression of stage-specific embryonic antigens
    • Henderson, J. K., Draper, J. S., Baillie, H. S., Fishel, S., Thomson, J.A., Moore, H. and Andrews, P.W. (2002). Preimplantation human embryos and embryonic stem cells showcomparable expression of stage-specific embryonic antigens. StemCells 20, 329-337.
    • (2002) StemCells , vol.20 , pp. 329-337
    • Henderson, J.K.1    Draper, J.S.2    Baillie, H.S.3    Fishel, S.4    Thomson, J.A.5    Moore, H.6    Andrews, P.W.7
  • 28
    • 84864647706 scopus 로고    scopus 로고
    • Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling
    • Hough, C., Radu, M. and Doré, J. J. E. (2012). Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling. PLoS ONE 7, e42513.
    • (2012) PLoS ONE , vol.7
    • Hough, C.1    Radu, M.2    Doré, J.J.E.3
  • 29
    • 0034067651 scopus 로고    scopus 로고
    • Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer
    • Huang, W., Zhou, X., Lefebvre, V. and de Crombrugghe, B. (2000). Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol. Cell. Biol. 20, 4149-4158.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4149-4158
    • Huang, W.1    Zhou, X.2    Lefebvre, V.3    de Crombrugghe, B.4
  • 30
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang, D. W., Sherman, B. T. and Lempicki, R. A. (2009). Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44-57.
    • (2009) Nat. Protoc. , vol.4 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 32
    • 10644264518 scopus 로고    scopus 로고
    • Lung growth for beginners
    • Kotecha, S. (2000). Lung growth for beginners. Paediatr. Respir. Rev. 1, 308-313.
    • (2000) Paediatr. Respir. Rev. , vol.1 , pp. 308-313
    • Kotecha, S.1
  • 34
    • 0029786329 scopus 로고    scopus 로고
    • Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway
    • Lavoie, J. N., L'Allemain, G., Brunet, A., Muller, R. and Pouyssegur, J. (1996). Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem. 271, 20608-20616.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20608-20616
    • Lavoie, J.N.1    L'Allemain, G.2    Brunet, A.3    Muller, R.4    Pouyssegur, J.5
  • 35
    • 34548386720 scopus 로고    scopus 로고
    • TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA
    • Lee, M.K., Pardoux, C., Hall, M. C., Lee, P. S., Warburton, D., Qing, J., Smith, S. M. and Derynck, R. (2007). TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J. 26, 3957-3967.
    • (2007) EMBO J. , vol.26 , pp. 3957-3967
    • Lee, M.K.1    Pardoux, C.2    Hall, M.C.3    Lee, P.S.4    Warburton, D.5    Qing, J.6    Smith, S.M.7    Derynck, R.8
  • 37
    • 0030730837 scopus 로고    scopus 로고
    • Alveogenesis failure in PDGF-Adeficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development
    • Lindahl, P., Karlsson, L., Hellstrom, M., Gebre-Medhin, S., Willetts, K., Heath, J. K. and Betsholtz, C. (1997). Alveogenesis failure in PDGF-Adeficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development. Development 124, 3943-3953.
    • (1997) Development , vol.124 , pp. 3943-3953
    • Lindahl, P.1    Karlsson, L.2    Hellstrom, M.3    Gebre-Medhin, S.4    Willetts, K.5    Heath, J.K.6    Betsholtz, C.7
  • 38
    • 38349145370 scopus 로고    scopus 로고
    • Role for mitogen-activated protein kinase p38 alpha in lung epithelial branching morphogenesis
    • Liu, Y., Martinez, L., Ebine, K. and Abe, M. K. (2008). Role for mitogen-activated protein kinase p38 alpha in lung epithelial branching morphogenesis. Dev. Biol. 314, 224-235.
    • (2008) Dev. Biol. , vol.314 , pp. 224-235
    • Liu, Y.1    Martinez, L.2    Ebine, K.3    Abe, M.K.4
  • 39
    • 67650985957 scopus 로고    scopus 로고
    • Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development
    • Matsunobu, T., Torigoe, K., Ishikawa, M., de Vega, S., Kulkarni, A. B., Iwamoto, Y. and Yamada, Y. (2009). Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. Dev. Biol. 332, 325-338.
    • (2009) Dev. Biol. , vol.332 , pp. 325-338
    • Matsunobu, T.1    Torigoe, K.2    Ishikawa, M.3    de Vega, S.4    Kulkarni, A.B.5    Iwamoto, Y.6    Yamada, Y.7
  • 41
    • 44849091512 scopus 로고    scopus 로고
    • The branching programme of mouse lung development
    • Metzger, R. J., Klein, O. D., Martin, G. R. and Krasnow, M. A. (2008). The branching programme of mouse lung development. Nature 453, 745-750.
    • (2008) Nature , vol.453 , pp. 745-750
    • Metzger, R.J.1    Klein, O.D.2    Martin, G.R.3    Krasnow, M.A.4
  • 42
    • 0032532479 scopus 로고    scopus 로고
    • Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
    • Min, H., Danilenko, D. M., Scully, S. A., Bolon, B., Ring, B. D., Tarpley, J. E., DeRose, M. and Simonet, W. S. (1998). Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev. 12, 3156-3161.
    • (1998) Genes Dev. , vol.12 , pp. 3156-3161
    • Min, H.1    Danilenko, D.M.2    Scully, S.A.3    Bolon, B.4    Ring, B.D.5    Tarpley, J.E.6    DeRose, M.7    Simonet, W.S.8
  • 43
    • 74049139927 scopus 로고    scopus 로고
    • Preparing for the first breath: Genetic and cellular mechanisms in lung development
    • Morrisey, E. E. and Hogan, B. L. M. (2010). Preparing for the first breath: genetic and cellular mechanisms in lung development. Dev. Cell 18, 8-23.
    • (2010) Dev. Cell , vol.18 , pp. 8-23
    • Morrisey, E.E.1    Hogan, B.L.M.2
  • 44
    • 0031683165 scopus 로고    scopus 로고
    • Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
    • Motoyama, J., Liu, J., Mo, R., Ding, Q., Post, M. and Hui, C.-C. (1998). Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat. Genet. 20, 54-57.
    • (1998) Nat. Genet. , vol.20 , pp. 54-57
    • Motoyama, J.1    Liu, J.2    Mo, R.3    Ding, Q.4    Post, M.5    Hui, C.-C.6
  • 45
    • 0033974686 scopus 로고    scopus 로고
    • Upregulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway
    • Murakami, S., Kan, M., McKeehan, W. L. and de Crombrugghe, B. (2000). Upregulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway. Proc. Natl. Acad. Sci. USA 97, 1113-1118.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1113-1118
    • Murakami, S.1    Kan, M.2    McKeehan, W.L.3    de Crombrugghe, B.4
  • 46
    • 67650770120 scopus 로고    scopus 로고
    • Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation
    • Nadeau, V., Guillemette, S., Belanger, L.-F., Jacob, O., Roy, S. and Charron, J. (2009). Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation. Development 136, 1363-1374.
    • (2009) Development , vol.136 , pp. 1363-1374
    • Nadeau, V.1    Guillemette, S.2    Belanger, L.-F.3    Jacob, O.4    Roy, S.5    Charron, J.6
  • 48
    • 78751507401 scopus 로고    scopus 로고
    • Conditional mutation of fibroblast growth factor receptors 1 and 2 results in an omphalocele in mice associated with disruptions in ventral body wall muscle formation
    • Nichol, P. F., Corliss, R. F., Tyrrell, J. D., Graham, B., Reeder, A. and Saijoh, Y. (2011). Conditional mutation of fibroblast growth factor receptors 1 and 2 results in an omphalocele in mice associated with disruptions in ventral body wall muscle formation. J. Pediatr. Surg. 46, 90-96.
    • (2011) J. Pediatr. Surg. , vol.46 , pp. 90-96
    • Nichol, P.F.1    Corliss, R.F.2    Tyrrell, J.D.3    Graham, B.4    Reeder, A.5    Saijoh, Y.6
  • 50
    • 75149152434 scopus 로고    scopus 로고
    • Regulation of Sox9 by Sonic Hedgehog (Shh) is essential for patterning and formation of tracheal cartilage
    • Park, J., Zhang, J. J. R., Moro, A., Kushida, M., Wegner, M. and Kim, P. C. W. (2010). Regulation of Sox9 by Sonic Hedgehog (Shh) is essential for patterning and formation of tracheal cartilage. Dev. Dyn. 239, 514-526.
    • (2010) Dev. Dyn. , vol.239 , pp. 514-526
    • Park, J.1    Zhang, J.J.R.2    Moro, A.3    Kushida, M.4    Wegner, M.5    Kim, P.C.W.6
  • 51
    • 69549090537 scopus 로고    scopus 로고
    • Multiple roles for Sox2 in the developing and adult mouse trachea
    • Que, J., Luo, X., Schwartz, R. J. and Hogan, B. L. M. (2009). Multiple roles for Sox2 in the developing and adult mouse trachea. Development 136, 1899-1907.
    • (2009) Development , vol.136 , pp. 1899-1907
    • Que, J.1    Luo, X.2    Schwartz, R.J.3    Hogan, B.L.M.4
  • 52
    • 34248597065 scopus 로고    scopus 로고
    • Differential regulation and properties of MAPKs
    • Raman, M., Chen, W. and Cobb, M. H. (2007). Differential regulation and properties of MAPKs. Oncogene 26, 3100-3112.
    • (2007) Oncogene , vol.26 , pp. 3100-3112
    • Raman, M.1    Chen, W.2    Cobb, M.H.3
  • 53
    • 49049118639 scopus 로고    scopus 로고
    • The transmembrane protein TMEM16A is required for normal development of the murine trachea
    • Rock, J. R., Futtner, C. R. and Harfe, B. D. (2008). The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev. Biol. 321, 141-149.
    • (2008) Dev. Biol. , vol.321 , pp. 141-149
    • Rock, J.R.1    Futtner, C.R.2    Harfe, B.D.3
  • 56
    • 20444481954 scopus 로고    scopus 로고
    • Oncogenic Ras blocks transforming growth factor-beta-induced cell-cycle arrest by degradation of p27 through a MEK/Erk/SKP2-dependent pathway
    • Schepers, H., Wierenga, A. T. J., Eggen, B. J. L. and Vellenga, E. (2005). Oncogenic Ras blocks transforming growth factor-beta-induced cell-cycle arrest by degradation of p27 through a MEK/Erk/SKP2-dependent pathway. Exp. Hematol. 33, 747-757.
    • (2005) Exp. Hematol. , vol.33 , pp. 747-757
    • Schepers, H.1    Wierenga, A.T.J.2    Eggen, B.J.L.3    Vellenga, E.4
  • 57
    • 34047129136 scopus 로고    scopus 로고
    • Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and raf-induced hyperplasia
    • Scholl, F.A., Dumesic, P. A., Barragan, D.I., Harada, K., Bissonauth, V., Charron, J. and Khavari, P. A. (2007). Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and raf-induced hyperplasia. Dev. Cell 12, 615-629.
    • (2007) Dev. Cell , vol.12 , pp. 615-629
    • Scholl, F.A.1    Dumesic, P.A.2    Barragan, D.I.3    Harada, K.4    Bissonauth, V.5    Charron, J.6    Khavari, P.A.7
  • 59
    • 13444310931 scopus 로고    scopus 로고
    • Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung
    • Serls, A. E., Doherty, S., Parvatiyar, P., Wells, J. M. and Deutsch, G. H. (2005). Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development 132, 35-47.
    • (2005) Development , vol.132 , pp. 35-47
    • Serls, A.E.1    Doherty, S.2    Parvatiyar, P.3    Wells, J.M.4    Deutsch, G.H.5
  • 60
    • 33750530166 scopus 로고    scopus 로고
    • Igf-I extends the chondrogenic potential of human articular chondrocytes in vitro: Molecular association between Sox9 and Erk1/2
    • Shakibaei, M., Seifarth, C., John, T., Rahmanzadeh, M. and Mobasheri, A. (2006). Igf-I extends the chondrogenic potential of human articular chondrocytes in vitro: molecular association between Sox9 and Erk1/2. Biochem. Pharmacol. 72, 1382-1395.
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 1382-1395
    • Shakibaei, M.1    Seifarth, C.2    John, T.3    Rahmanzadeh, M.4    Mobasheri, A.5
  • 61
    • 47649126492 scopus 로고    scopus 로고
    • Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth
    • Simmons, D. G., Natale, D. R. C., Begay, V., Hughes, M., Leutz, A. and Cross, J.C. (2008). Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth. Development 135, 2083-2091.
    • (2008) Development , vol.135 , pp. 2083-2091
    • Simmons, D.G.1    Natale, D.R.C.2    Begay, V.3    Hughes, M.4    Leutz, A.5    Cross, J.C.6
  • 62
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • Article3
    • Smyth, G. K. (2004). Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 3, Article3.
    • (2004) Stat. Appl. Genet. Mol. Biol. , vol.3
    • Smyth, G.K.1
  • 63
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain
    • Soriano, P. (1999). Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21, 70-71.
    • (1999) Nat. Genet. , vol.21 , pp. 70-71
    • Soriano, P.1
  • 64
    • 79960053984 scopus 로고    scopus 로고
    • Three observations that have changed our understanding of Cyclin D1 and p27Kip1 in cell cycle control
    • Stacey, D. W. (2010). Three observations that have changed our understanding of Cyclin D1 and p27Kip1 in cell cycle control. Genes Cancer 1, 1189-1199.
    • (2010) Genes Cancer , vol.1 , pp. 1189-1199
    • Stacey, D.W.1
  • 67
    • 79960487665 scopus 로고    scopus 로고
    • Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape
    • Tang, N., Marshall, W. F., McMahon, M., Metzger, R. J. and Martin, G. R. (2011). Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape. Science 333, 342-345.
    • (2011) Science , vol.333 , pp. 342-345
    • Tang, N.1    Marshall, W.F.2    McMahon, M.3    Metzger, R.J.4    Martin, G.R.5
  • 69
    • 77953387301 scopus 로고    scopus 로고
    • Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation
    • Voisin, L., Saba-El-Leil, M. K., Julien, C., Fremin, C. and Meloche, S. (2010). Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation. Mol. Cell. Biol. 30, 2918-2932.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 2918-2932
    • Voisin, L.1    Saba-El-Leil, M.K.2    Julien, C.3    Fremin, C.4    Meloche, S.5
  • 70
    • 84883237460 scopus 로고    scopus 로고
    • Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors
    • Volckaert, T., Campbell, A., Dill, E., Li, C., Minoo, P. and De Langhe, S. (2013). Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors. Development 140, 3731-3742.
    • (2013) Development , vol.140 , pp. 3731-3742
    • Volckaert, T.1    Campbell, A.2    Dill, E.3    Li, C.4    Minoo, P.5    De Langhe, S.6
  • 72
    • 0033933136 scopus 로고    scopus 로고
    • Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis
    • Weaver, M., Dunn, N. R. and Hogan, B. L. (2000). Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis. Development 127, 2695-2704.
    • (2000) Development , vol.127 , pp. 2695-2704
    • Weaver, M.1    Dunn, N.R.2    Hogan, B.L.3
  • 73
    • 0032169781 scopus 로고    scopus 로고
    • Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasia
    • Wunderle, V. M., Critcher, R., Hastie, N., Goodfellow, P. N. and Schedl, A. (1998). Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasia. Proc. Natl. Acad. Sci. USA 95, 10649-10654.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10649-10654
    • Wunderle, V.M.1    Critcher, R.2    Hastie, N.3    Goodfellow, P.N.4    Schedl, A.5
  • 74
    • 79959896031 scopus 로고    scopus 로고
    • The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility
    • Yamashita, S., Tai, P., Charron, J., Ko, C. and Ascoli, M. (2011). The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility. Mol. Endocrinol. 25, 1211-1222.
    • (2011) Mol. Endocrinol. , vol.25 , pp. 1211-1222
    • Yamashita, S.1    Tai, P.2    Charron, J.3    Ko, C.4    Ascoli, M.5
  • 76
    • 33846819952 scopus 로고    scopus 로고
    • Kruppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells
    • Yang, Y., Goldstein, B. G., Nakagawa, H. and Katz, J. P. (2007). Kruppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells. FASEB J. 21, 543-550.
    • (2007) FASEB J. , vol.21 , pp. 543-550
    • Yang, Y.1    Goldstein, B.G.2    Nakagawa, H.3    Katz, J.P.4
  • 77
    • 79960154778 scopus 로고    scopus 로고
    • Mesothelial-and epithelial-derived FGF9 have distinct functions in the regulation of lung development
    • Yin, Y., Wang, F. and Ornitz, D. M. (2011). Mesothelial-and epithelial-derived FGF9 have distinct functions in the regulation of lung development. Development 138, 3169-3177.
    • (2011) Development , vol.138 , pp. 3169-3177
    • Yin, Y.1    Wang, F.2    Ornitz, D.M.3
  • 78
    • 77954470662 scopus 로고    scopus 로고
    • Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema
    • Yoshida, T., Mett, I., Bhunia, A.K., Bowman, J., Perez, M., Zhang, L., Gandjeva, A., Zhen, L. J., Chukwueke, U., Mao, T. et al. (2010). Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nat. Med. 16, 767-773.
    • (2010) Nat. Med. , vol.16 , pp. 767-773
    • Yoshida, T.1    Mett, I.2    Bhunia, A.K.3    Bowman, J.4    Perez, M.5    Zhang, L.6    Gandjeva, A.7    Zhen, L.J.8    Chukwueke, U.9    Mao, T.10
  • 79
    • 0038782306 scopus 로고    scopus 로고
    • Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
    • Yu, K., Xu, J., Liu, Z., Sosic, D., Shao, J., Olson, E. N., Towler, D. A. and Ornitz, D. M. (2003). Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development 130, 3063-3074.
    • (2003) Development , vol.130 , pp. 3063-3074
    • Yu, K.1    Xu, J.2    Liu, Z.3    Sosic, D.4    Shao, J.5    Olson, E.N.6    Towler, D.A.7    Ornitz, D.M.8


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