Three observations that have changed our understanding of cyclin D1 and p27 Kip1 in cell cycle control

Genes and Cancer

Volumn 1, Issue 12, 2010, Pages 1189-1199

  Stacey, Dennis W ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell cycle; Cyclin d1; G1 phase; P27; Ras

Indexed keywords

CYCLIN D1; DNA; GLYCOGEN SYNTHASE KINASE 3; PROTEIN P27; RAS PROTEIN; SMALL INTERFERING RNA;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL PROLIFERATION; DNA SYNTHESIS; HUMAN; IMAGE ANALYSIS; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS;

EID: 79960053984     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: 10.1177/1947601911403475     Document Type: Article

References (55)

1. Sherr CJ. Mammalian G1 cyclins and cell cycle progression. Proc Assoc Am Physicians. 1995;107(2):181-6.
2. Musgrove EA. Cyclins: roles in mitogenic signaling and oncogenic transformation. Growth Factors. 2006;24(1):13-9.
3. Aktas H, Cai H, Cooper GM. Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1. Mol Cell Biol. 1997;17(7):3850-7.
4. Sherr CJ. Cancer cell cycles. Science. 1996;274(5293):1672-7.
5. Stacey DW, Hitomi M. Cell cycle studies based upon quantitative image analysis. Cytometry A. 2008;73(4):270-8.
6. Smith MR, DeGudicibus SJ, Stacey DW. Requirement for c-ras proteins during viral oncogene transformation. Nature. 1986;320(6062):540-3.
7. Mulcahy LS, Smith MR, Stacey DW. Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells. Nature. 1985;313(5999):241-3.
8. Hitomi M, Stacey DW. Cellular ras and cyclin D1 are required during different cell cycle periods in cycling NIH 3T3 cells. Mol Cell Biol. 1999;19(7):4623-32.
9. Blagosklonny MV, Pardee AB. The restriction point of the cell cycle. Cell Cycle. 2002;1(2):103-10.
10. Zetterberg A, Larsson O. Kinetic analysis of regulatory events in G1 leading to proliferation or quiescnec of Swiss 3T3 cells. Proc Natl Acad Sci U S A. 1985;82:5365-9.
11. Hitomi M, Stacey DW. Cyclin D1 production in cycling cells depends on ras in a cell-cyclespecific manner. Curr Biol. 1999;9(19):1075-84.
12. Diehl JA, Sherr CJ. A dominant-negative cyclin D1 mutant prevents nuclear import of cyclindependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase. Mol Cell Biol. 1997;17:7362-74.
13. Pagano M, Theodoras AM, Tam SW, Draetta GF. Cycling D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblassts. Genes Dev. 1994;8:1627-39.
14. Fukami-Kobayashi J, Mitsui Y. Cyclin D1 inhibits cell proliferation through binding to PCNA and cdk2. Exp Cell Res. 1999;246(2):338-47.
15. Hitomi M, Stacey DW. Cyclin D1 production in cycling cells depends on ras in a cell-cyclespecific manner. Curr Biol. 1999;9(19):1075-84.
16. Alt JR, Cleveland JL, Hannink M, Diehl JA. Phosphorylation- dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Dev. 2000;14(24):3102-14.
17. Scovassi AI, Stivala LA, Rossi L, Bianchi L, Prosperi E. Nuclear association of cyclin D1 in human fibroblasts: tight binding to nuclear structures and modulation by protein kinase inhibitors. Exp Cell Res. 1997;237(1):127-34.
18. Collecchi P, Santoni T, Gnesi E, et al. Cyclins of phases G1, S and G2/M are overexpressed in aneuploid mammary carcinomas. Cytometry. 2000;42(4):254-60.
19. Sclafani RA. Cyclin dependent kinase activating kinases. Curr Opin Cell Biol. 1996;8:788-94.
20. Lukas J, Pagano M, Staskova Z, Draetta G, Bartek J. Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene. 1994;9(3):707-18.
21. Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev. 1993;7(5):812-21.
22. Sewing A, Bürger C, Brüsselbach S, Schalk C, Lucibello FC, Müller R. Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cyclic AMP. J Cell Sci. 1993;104:545-54.
23. Matsushime H, Roussel MF, Ashmun RA, Sherr CJ. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell. 1991;65:701-13.
24. Sa G, Hitomi M, Harwalker J, Stacey A, Chen G, Stacey DW. Ras is active throughout the cell cycle, but is able to induce cyclin D1 only during G2 phase. Cell Cycle. 2002;1:50-8.
25. Diehl JA, Zindy F, Sherr CJ. Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev. 1997;11:957-72.
26. Guo Y, Harwalkar J, Stacey DW, Hitomi M. Destabilization of cyclin D1 message plays a critical role in cell cycle exit upon mitogen withdrawal. Oncogene. 2005;24(6):1032-42.
27. Guo Y, Stacey DW, Hitomi M. Post-transcriptional regulation of cyclin D1 expression during G2 phase. Oncogene. 2002;21(49):7545-56.
28. Guo Y, Yang K, Harwalkar J, et al. Phosphorylation of cyclin D1 at Thr 286 during S phase leads to its proteasomal degradation and allows efficient DNA synthesis. Oncogene. 2005;24(16):2599-612.
29. Diehl JA, Cheng M, Roussel MF, Sherr CJ. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 1998;12:3499-511.
30. Woodgett JR, Plyte SE, Pulverer BJ, Mitchell JA, Hughes K. Roles of glycogen synthase kinase-3 in signal transduction. Biochem Soc Transactions. 1993;21:905-7.
31. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 1995;378(6559):785-9.
32. Yang K, Guo Y, Stacey WC, et al. Glycogen synthase kinase 3 has a limited role in cell cycle regulation of cyclin D1 levels. BMC Cell Biol. 2006;7:33.
33. Shechter D, Costanzo V, Gautier J. ATR and ATM regulate the timing of DNA replication origin firing. Nat Cell Biol. 2004;6:648-55.
34. Jirmanova L, Bulavin DV, Fornace AJ, Jr. Inhibition of the ATR/Chk1 pathway induces a p38- dependent S-phase delay in mouse embryonic stem cells. Cell Cycle. 2005;4(10):1428-34.
35. Sorensen CS, Syljuasen RG, Lukas J, Bartek J. ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. Cell Cycle. 2004;3(7):941-5.
36. Hitomi M, Yang K, Stacey AW, Stacey DW. Phosphorylation of cyclin D1 regulated by ATM or ATR controls cell cycle progression. Mol Cell Biol. 2008;28(17):5478-93.
37. Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 2001;15(17):2177-96.
38. Shiloh Y. The ATM-mediated DNA-damage response: taking shape. Trends Biochem Sci. 2006;31(7):402-10.
39. Falck J, Petrini JH, Williams BR, Lukas J, Bartek J. The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat Genet. 2002;30(3):290-4.
40. McKinnon PJ. ATM and ataxia telangiectasia. EMBO Rep. 2004;5(8):772-6.
41. Vincent I, Rosado M, Davies P. Mitotic mechanisms in Alzheimer's disease? J Cell Biol. 1996;132(3):413-25.
42. Bhaskar K, Miller M, Chludzinski A, Herrup K, Zagorski M, Lamb BT. The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events. Mol Neurodegener. 2009;4:14.
43. Herrup K, Neve R, Ackerman SL, Copani A. Divide and die: cell cycle events as triggers of nerve cell death. J Neurosci. 2004;24(42):9232-9.
44. Hitomi M, Stacey DW. The checkpoint kinase ATM protects against stress-induced elevation of cyclin D1 and potential cell death in neurons. Cytometry A. 2010;77(6):524-33.
45. Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999;13(12):1501-12.
46. Blain SW. Switching cyclin D-Cdk4 kinase activity on and off. Cell Cycle. 2008;7(7):892-8.
47. Cheng M, Olivier P, Diehl JA, et al. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J. 1999;18(6):1571-83.
48. Bagui TK, Mohapatra S, Haura E, Pledger WJ. P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes. Mol Cell Biol. 2003;23(20):7285-90.
49. Sa G, Stacey DW. P27 expression is regulated by separate signaling pathways, downstream of Ras, in each cell cycle phase. Exp Cell Res. 2004;300(2):427-39.
50. Han EK, Sgambato A, Jiang W, et al. Stable overexpression of cyclin D1 in a human mammary epithelial cell line prolongs the S-phase and inhibits growth. Oncogene. 1995;10(5):953-61.
51. Sa G, Guo Y, Stacey DW. The regulation of S phase initiation by p27Kip1 in NIH3T3 cells. Cell Cycle. 2005;4:618-27.
52. Zetterberg A, Larsson O, Wiman KG. What is the restriction point? Curr Opin Cell Biol. 1995;7(6):835-42.
53. Hitomi M, Yang K, Guo Y, Fretthold J, Harwalkar J, Stacey DW. p27Kip1 and cyclin dependent kinase 2 regulate passage through the restriction point. Cell Cycle. 2006;5(19):2281-9.
54. Coats S, Flanagan M, Nourse J, Roberts JM. Requirement of p27kip1 for restriction point control of the fibroblast cell cycle. Science. 1996; 272:877-80.
55. Stacey DW. Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells. Curr Opin Cell Biol. 2003;15(2):158-63.