Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells

FASEB Journal

Volumn 21, Issue 2, 2007, Pages 543-550

  Yang, Yizeng ^a   Goldstein, Bree G ^a   Nakagawa, Hiroshi ^a   Katz, Jonathan P ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Keratinocytes; Proliferation

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 5; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; DOWNSTREAM PROCESSING; EPITHELIUM CELL; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SQUAMOUS EPITHELIUM; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PROTEIN BINDING; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSFECTION;

EID: 33846819952     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-6694com     Document Type: Article

References (40)

1. Karam, S. M. (1999) Lineage commitment and maturation of epithelial cells in the gut. Front. Biosci. 4, D286-298
2. Al Yassin, T. M., and Toner, P. G. (1977) Fine structure of squamous epithelium and submucosal glands of human 0esophagus. J. Anat. 123, 705-721
3. Seery, J. P. (2002) Stem cells of the oesophageal epithelium. J. Cell Sci. 115, 1783-1789
4. Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M., and Fuchs, E. (2004) Defining the epithelial stem cell niche in skin. Science 303, 359-363
5. Katz, J. P., and Kaestner, K. H. (2002) Cellular and molecular mechanisms of carcinogenesis. Gastroenterol. Clin. North. Am. 31, 379-394
6. Fuchs, E., Tumbar, T., and Guasch, G. (2004) Socializing with the neighbors: stem cells and their niche. Cell 116, 769-778
7. Kaczynski, J., Cook, T., and Urrutia, R. (2003) Sp1- and Krüppel-like transcription factors. Genome. Biol. 4, 206
8. Bieker, J. J. (2001) Krüppel-like factors: three fingers in many pies. J. Biol. Chem. 276, 34355-34358
9. Ohnishi, S., Laub, F., Matsumoto, N., Asaka, M., Ramirez, F., Yoshida, T., and Terada, M. (2000) Developmental expression of the mouse gene coding for the Krüppel-like transcription factor KLF5. Dev. Dyn. 217, 421-429
10. Conkright, M. D., Wani, M. A., Anderson, K. P., and Lingrel, J. B. (1999) A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells. Nucleic Acids Res. 27, 1263-1270
11. Sun, R., Chen, X., and Yang, V. W. (2001) Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation. J. Biol. Chem. 276, 6897-6900
12. Nandan, M. O., Yoon, H. S., Zhao, W., Ouko, L. A., Chanchevalap, S., and Yang, V. W. (2004) Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras. Oncogene 23, 3404-3413
13. Nandan, M. O., Chanchevalap, S., Dalton, W. B., and Yang, V. W. (2005) Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation. FEBS Lett. 579, 4757-4762
14. Chen, C., Benjamin, M. S., Sun, X., Otto, K. B., Guo, P., Dong, X. Y., Bao, Y., Zhou, Z., Cheng, X., Simons, J. W., and Dong, J. T. (2006) KLF5 promotes cell proliferation and tumorigenesis through gene regulation in the TSU-Pr1 human bladder cancer cell line. Int. J. Cancer. 118, 1346-1355
15. Bateman, N. W., Tan, D., Pestell, R. G., Black, J. D., and Black, A. R. (2004) Intestinal tumor progression is associated with altered function of KLF5. J. Biol. Chem. 279, 12093-12101
16. Chen, C., Bhalala, H. V., Qiao, H., and Dong, J. T. (2002) A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer. Oncogene 21, 6567-6572
17. Chen, C., Bhalala, H. V., Vessella, R. L., and Dong, J. T. (2003) KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer. Prostate 55, 81-88
18. Yang, Y., Goldstein, B. G., Chao, H. H., and Katz, J. P. (2005) KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells. Cancer Biol. Ther. 4, 1216-1221
19. Shindo, T., et al. (2002) Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat. Med. 8, 856-863
20. Oishi, Y., et al. (2005) Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell. Metab. 1, 27-39
21. Usui, S., Sugimoto, N., Takuwa, N., Sakagami, S., Takata, S., Kaneko, S., and Takuwa, Y. (2004) Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Krüppel-like factor 5. J. Biol. Chem. 279, 12300-12311
22. Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103, 211-225
23. Chang, L., and Karin, M. (2001) Mammalian MAP kinase signalling cascades. Nature 410, 37-40
24. Andl, C. D., Mizushima, T., Nakagawa, H., Oyama, K., Harada, H., Chruma, K., Herlyn, M., and Rustgi, A. K. (2003) Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo. J. Biol. Chem. 278, 1824-1830
25. Calabro, A., Orsini, B., Renzi, D., Papi, L., Surrenti, E., Amorosi, A., Herbst, H., Milani, S., and Surrenti, C. (1997) Expression of epidermal growth factor, transforming growth factor-alpha and their receptor in the human oesophagus. Histochem. J. 29, 745-758
26. Harada, H., et al. (2003) Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation. Mol. Cancer Res. 1, 729-738
27. Sogawa, K., Imataka, H., Yamasaki, Y., Kusume, H., Abe, H., and Fujii-Kuriyama, Y. (1993) cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. Nucleic Acids Res. 21, 1527-1532
28. Johnson, G. L., and Lapadat, R. (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298, 1911-1912
29. Schlessinger, J. (2004) Common and distinct elements in cellular signaling via EGF and FGF receptors. Science 306, 1506-1507
30. Dikic, I. (2003) Mechanisms controlling EGF receptor endocytosis and degradation. Biochem. Soc. Trans. 31, 1178-1181
31. Ohlstein, B., Kai, T., Decotto, E., and Spradling, A. (2004) The stem cell niche: theme and variations. Curr. Opin. Cell Biol. 16, 693-699
32. Fujiwara, Y., Higuchi, K., Takashima, T., Hamaguchi, M., Watanabe, T., Tominaga, K., Oshitani, N., Matsumoto, T., and Arakawa, T. (2002) Increased expression of epidermal growth factor receptors in basal cell hyperplasia of the oesophagus after acid reflux oesophagitis in rats. Aliment. Pharmacol. Ther. 16. Suppl. 2, 52-58
33. Mandard, A. M., Hainaut, P., and Hollstein, M. (2000) Genetic steps in the development of squamous cell carcinoma of the esophagus. Mutat. Res. 462, 335-342
34. Takaoka, M., Harada, H., Andl, C. D., Oyama, K., Naomoto, Y., Dempsey, K. L., Klein-Szanto, A. J., El-Deiry, W. S., Grimberg, A., and Nakagawa, H. (2004) Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3. Cancer Res. 64, 7711-7723
35. Goessel, G., Quante, M., Hahn, W. C., Harada, H., Heeg, S., Suliman, Y., Doebele, M., von Werder, A., Fulda, C., Nakagawa, H., Rustgi, A. K., Blum, H. E., and Opitz, O. G. (2005) Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis. Proc. Natl. Acad. Sci. U. S. A. 102, 15599-15604
36. Moro, L., Venturino, M., Bozzo, C., Silengo, L., Altruda, F., Beguinot, L., Tarone, G., and Defilippi, P. (1998) Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival. EMBO J. 17, 6622-6632
37. Sonnenberg, A., Calafat, J., Janssen, H., Daams, H., van der Raaij-Helmer, L. M., Falcioni, R., Kennel, S. J., Aplin, J. D., Baker, J., Loizidou, M., and et al. (1991) Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion. J. Cell Biol. 113, 907-917
38. Pandey, P. K., Udayakumar, T. S., Lin, X., Sharma, D., Shapiro, P. S., and Fondell, J. D. (2005) Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation. Mol. Cell. Biol. 25, 10695-10710
39. Chen, C., Sun, X., Guo, P., Dong, X. Y., Sethi, P., Cheng, X., Zhou, J., Ling, J., Simons, J. W., Lingrel, J. B., and Dong, J. T. (2005) Human Krüppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells. J. Biol. Chem. 280, 41553-41561
40. Chen, C., Sun, X., Ran, Q., Wilkinson, K. D., Murphy, T. J., Simons, J. W., and Dong, J. T. (2005) Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. Oncogene 24, 3319-3327