Multifunctional cationic lipid-based nanoparticles facilitate endosomal escape and reduction-triggered cytosolic siRNA release

Molecular Pharmaceutics

Volumn 11, Issue 8, 2014, Pages 2734-2744

  Gujrati, Maneesh ^a   Malamas, Anthony ^a   Shin, Tesia ^a   Jin, Erlei ^a   Sun, Yunlu ^a   Lu, Zheng Rong ^a  

^a Case Western Reserve University   (United States)

Author keywords

endosomal escape; gene therapy; nanoparticle; RNA interference; siRNA

Indexed keywords

(1 AMINOETHYL)IMINOBIS[N (OLEICYLCYSTEINYL 1 AMINO ETHYL)PROPIONAMIDE]; DRUG CARRIER; GLUTATHIONE; LIPID; LUCIFERASE; NANOPARTICLE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CATION; DISULFIDE; PLASMA PROTEIN;

ARTICLE; BIOLOGICAL ACTIVITY; CONFOCAL MICROSCOPY; CORRELATIONAL STUDY; CYTOSOL; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG MECHANISM; DRUG RELEASE; ENDOSOME; GENE SILENCING; GENE THERAPY; GLIOBLASTOMA CELL LINE; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REDUCTION; ANIMAL; CHEMISTRY; DRUG EFFECTS; ERYTHROCYTE; FLUORESCENCE MICROSCOPY; HEMOLYSIS; METABOLISM; NANOTECHNOLOGY; PROCEDURES; RAT; RNA INTERFERENCE; TUMOR CELL LINE;

ANIMALS; BLOOD PROTEINS; CATIONS; CELL LINE, TUMOR; DISULFIDES; DRUG DELIVERY SYSTEMS; ENDOSOMES; ERYTHROCYTES; GENE SILENCING; GLUTATHIONE; HEMOLYSIS; HUMANS; HYDROGEN-ION CONCENTRATION; LIPIDS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; NANOTECHNOLOGY; RATS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84905459951     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400787s     Document Type: Article

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