Design and evaluation of new pH-sensitive amphiphilic cationic lipids for siRNA delivery

Journal of Controlled Release

Volumn 171, Issue 3, 2013, Pages 296-307

  Malamas, Anthony S ^a   Gujrati, Maneesh ^a   Kummitha, China M ^a   Xu, Rongzuo ^a   Lu, Zheng Rong ^a  

^a Case Western Reserve University   (United States)

Author keywords

Cationic lipid; Endosomal escape; PH sensitive amphiphilicity; SiRNA delivery

Indexed keywords

AMINES; AMINO ACIDS; CELLS; CYTOLOGY; DISEASES; HYDROPHOBICITY; LIPOSOMES; MOLECULAR BIOLOGY; PH SENSORS; RNA; SYNTHESIS (CHEMICAL);

AMPHIPHILICITY; CATIONIC LIPIDS; DEGREE OF UNSATURATIONS; DESIGN AND EVALUATIONS; ENDOSOMAL ESCAPES; HUMAN COLON CANCER CELLS; SIRNA DELIVERY; SMALL INTERFERING RNA (SIRNA);

GENE THERAPY;

AMINE; AMINO ACID; HISTIDINE; LIPID; LIPOFECTAMINE; LUCIFERASE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; CHO CELL; COLON CANCER; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG SCREENING; ENCAPSULATION; GENE SILENCING; GENETIC TRANSFECTION; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; MEMBRANE DAMAGE; NONHUMAN; PH; PRIORITY JOURNAL; SCREENING; SOLID; ZETA POTENTIAL;

CATIONIC LIPID; ENDOSOMAL ESCAPE; PH-SENSITIVE AMPHIPHILICITY; SIRNA DELIVERY;

ANIMALS; CATIONS; CELL LINE, TUMOR; CELL SURVIVAL; CHO CELLS; CRICETULUS; DRUG CARRIERS; GREEN FLUORESCENT PROTEINS; HUMANS; HYDROGEN-ION CONCENTRATION; LIPIDS; LUCIFERASES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SURFACE-ACTIVE AGENTS; TRANSFECTION;

EID: 84892944324     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.06.019     Document Type: Article

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