-
2
-
-
23844456959
-
Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells
-
Behrend L., Mohr A., Dick T., Zwacka R.M. Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells. Mol. Cell. Biol. 2005, 25(17):7758-7769.
-
(2005)
Mol. Cell. Biol.
, vol.25
, Issue.17
, pp. 7758-7769
-
-
Behrend, L.1
Mohr, A.2
Dick, T.3
Zwacka, R.M.4
-
3
-
-
84858257130
-
10 formulation improves intracellular distribution and promotes mitochondrial respiration in cultured cells
-
10 formulation improves intracellular distribution and promotes mitochondrial respiration in cultured cells. PLoS One 2012, 7(3):e33712.
-
(2012)
PLoS One
, vol.7
, Issue.3
-
-
Bergamini, C.1
Moruzzi, N.2
Sblendido, A.3
Lenaz, G.4
Fato, R.5
-
4
-
-
0026879664
-
An analysis of the role of coenzyme Q in free radical generation and as an antioxidant
-
Beyer R.E. An analysis of the role of coenzyme Q in free radical generation and as an antioxidant. Biochem. Cell Biol. 1992, 70(6):390-403.
-
(1992)
Biochem. Cell Biol.
, vol.70
, Issue.6
, pp. 390-403
-
-
Beyer, R.E.1
-
5
-
-
77955917442
-
Oxidative stress in Alzheimer disease: a possibility for prevention
-
Bonda D.J., Wang X., Perry G., Nunomura A., Tabaton M., Zhu X., Smith M.A. Oxidative stress in Alzheimer disease: a possibility for prevention. Neuropharmacology 2010, 59(4-5):290-294.
-
(2010)
Neuropharmacology
, vol.59
, Issue.4-5
, pp. 290-294
-
-
Bonda, D.J.1
Wang, X.2
Perry, G.3
Nunomura, A.4
Tabaton, M.5
Zhu, X.6
Smith, M.A.7
-
6
-
-
56549089327
-
Water-soluble composition of bioactive lipophilic compounds
-
US Patent No. 6,045,826.
-
Borowy-Borowski, H., Sikorska, M., Walker, P.R., 2000. Water-soluble composition of bioactive lipophilic compounds. US Patent No. 6,045,826.
-
(2000)
-
-
Borowy-Borowski, H.1
Sikorska, M.2
Walker, P.R.3
-
7
-
-
9444258087
-
Unique technology for solubilization and delivery of highly lipophilic bioactive molecules
-
Borowy-Borowski H., Sodja C., Docherty J., Walker P.R., Sikorska M. Unique technology for solubilization and delivery of highly lipophilic bioactive molecules. J. Drug Target. 2004, 12(7):415-424.
-
(2004)
J. Drug Target.
, vol.12
, Issue.7
, pp. 415-424
-
-
Borowy-Borowski, H.1
Sodja, C.2
Docherty, J.3
Walker, P.R.4
Sikorska, M.5
-
8
-
-
0036236006
-
The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis
-
Brunk U.T., Terman A. The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur. J. Biochem. 2002, 269:1996-2002.
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 1996-2002
-
-
Brunk, U.T.1
Terman, A.2
-
9
-
-
2342429376
-
Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species
-
Casadesus G., Smith M.A., Zhu X., Aliev G., Cash A.D., Honda K., Petersen R.B., Perry G. Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species. J. Alzheimers Dis. 2004, 6:165-169.
-
(2004)
J. Alzheimers Dis.
, vol.6
, pp. 165-169
-
-
Casadesus, G.1
Smith, M.A.2
Zhu, X.3
Aliev, G.4
Cash, A.D.5
Honda, K.6
Petersen, R.B.7
Perry, G.8
-
10
-
-
0033006576
-
Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?
-
Castellani R.J., Smith M.A., Nunomura A., Harris P.L., Perry G. Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?. Free Radic. Biol. Med. 1999, 26:1508-1512.
-
(1999)
Free Radic. Biol. Med.
, vol.26
, pp. 1508-1512
-
-
Castellani, R.J.1
Smith, M.A.2
Nunomura, A.3
Harris, P.L.4
Perry, G.5
-
11
-
-
0037111170
-
Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients
-
Cecchi C., Fiorillo C., Sorbi S., Latorraca S., Nacmias B., Bagnoli S., Nassi P., Liguri G. Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients. Free Radic. Biol. Med. 2002, 33(10):1372-1379.
-
(2002)
Free Radic. Biol. Med.
, vol.33
, Issue.10
, pp. 1372-1379
-
-
Cecchi, C.1
Fiorillo, C.2
Sorbi, S.3
Latorraca, S.4
Nacmias, B.5
Bagnoli, S.6
Nassi, P.7
Liguri, G.8
-
12
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
-
Citron M., Westaway D., Xia W., Carlson G., Diehl T., Levesque G., Johnson-Wood K., Lee M., Seubert P., Davis A., Kholodenko D., Motter R., Sherrington R., Perry B., Yao H., Strome R., Lieberburg I., Rommens J., Kim S., Schenk D., Fraser P., St George Hyslop P., Selkoe D.J. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat. Med. 1997, 3(1):67-72.
-
(1997)
Nat. Med.
, vol.3
, Issue.1
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
Carlson, G.4
Diehl, T.5
Levesque, G.6
Johnson-Wood, K.7
Lee, M.8
Seubert, P.9
Davis, A.10
Kholodenko, D.11
Motter, R.12
Sherrington, R.13
Perry, B.14
Yao, H.15
Strome, R.16
Lieberburg, I.17
Rommens, J.18
Kim, S.19
Schenk, D.20
Fraser, P.21
St George Hyslop, P.22
Selkoe, D.J.23
more..
-
13
-
-
0002549377
-
The lysosome
-
de Duve C. The lysosome. Sci. Am. 1963, 208:64-72.
-
(1963)
Sci. Am.
, vol.208
, pp. 64-72
-
-
de Duve, C.1
-
15
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper B., Saftig P., Craessaerts K., Vanderstichele H., Guhde G., Annaert W., Von Figura K., Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 1998, 391:387-390.
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
Von Figura, K.7
Van Leuven, F.8
-
16
-
-
0029799910
-
Enhanced sensitivity of ubiquinone-deficient mutants of Saccharomyces cerevisiae to products of autoxidized polyunsaturated fatty acids
-
Do T.Q., Schultz J.R., Clarke C.F. Enhanced sensitivity of ubiquinone-deficient mutants of Saccharomyces cerevisiae to products of autoxidized polyunsaturated fatty acids. Proc. Natl. Acad. Sci. U. S. A. 1996, 93(15):7534-7539.
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, Issue.15
, pp. 7534-7539
-
-
Do, T.Q.1
Schultz, J.R.2
Clarke, C.F.3
-
17
-
-
0029042393
-
Biochemical, physiological and medical aspects of ubiquinone function
-
Ernster L., Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim. Biophys. Acta 1995, 127:195-204.
-
(1995)
Biochim. Biophys. Acta
, vol.127
, pp. 195-204
-
-
Ernster, L.1
Dallner, G.2
-
18
-
-
0031024594
-
Lipid peroxidation and changes in the ubiquinone content and the respiratory chain enzymes of submitochondrial particles
-
Forsmark-Andrée P., Lee C.P., Dallner G., Ernster L. Lipid peroxidation and changes in the ubiquinone content and the respiratory chain enzymes of submitochondrial particles. Free Radic. Biol. Med. 1997, 22(3):391-400.
-
(1997)
Free Radic. Biol. Med.
, vol.22
, Issue.3
, pp. 391-400
-
-
Forsmark-Andrée, P.1
Lee, C.P.2
Dallner, G.3
Ernster, L.4
-
19
-
-
79961194820
-
Autophagy impairment induces premature senescence in primary human fibroblasts
-
Kang H.T., Lee K.B., Kim S.Y., Choi H.R., Park S.C. Autophagy impairment induces premature senescence in primary human fibroblasts. PLoS One 2011, 6(8):e23367.
-
(2011)
PLoS One
, vol.6
, Issue.8
-
-
Kang, H.T.1
Lee, K.B.2
Kim, S.Y.3
Choi, H.R.4
Park, S.C.5
-
20
-
-
77953913051
-
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
-
Lee J.H., Yu W.H., Kumar A., Lee S., Mohan P.S., Peterhoff C.M., Wolfe D.M., Martinez-Vicente M., Massey A.C., Sovak G., Uchiyama Y., Westaway D., Cuervo A.M., Nixon R.A. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 2010, 141(7):1146-1158.
-
(2010)
Cell
, vol.141
, Issue.7
, pp. 1146-1158
-
-
Lee, J.H.1
Yu, W.H.2
Kumar, A.3
Lee, S.4
Mohan, P.S.5
Peterhoff, C.M.6
Wolfe, D.M.7
Martinez-Vicente, M.8
Massey, A.C.9
Sovak, G.10
Uchiyama, Y.11
Westaway, D.12
Cuervo, A.M.13
Nixon, R.A.14
-
21
-
-
84555195856
-
Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling
-
Lee J., Giordano S., Zhang J. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem. J. 2012, 441(2):523-540.
-
(2012)
Biochem. J.
, vol.441
, Issue.2
, pp. 523-540
-
-
Lee, J.1
Giordano, S.2
Zhang, J.3
-
22
-
-
34147193472
-
Cell biology: autophagy and cancer
-
Levine B. Cell biology: autophagy and cancer. Nature 2007, 446(7137):745-747.
-
(2007)
Nature
, vol.446
, Issue.7137
, pp. 745-747
-
-
Levine, B.1
-
23
-
-
0032555066
-
Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects
-
Matthews R.T., Yang L., Browne S., Baik M., Beal M.F. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc. Natl. Acad. Sci. U. S. A. 1998, 95(15):8892-8897.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, Issue.15
, pp. 8892-8897
-
-
Matthews, R.T.1
Yang, L.2
Browne, S.3
Baik, M.4
Beal, M.F.5
-
25
-
-
0032189159
-
Copper/zinc ratio and systemic oxidant load: effect of aging and aging-related degenerative diseases
-
Mezzetti A., Pierdomenico S.D., Costantini F., Romano F., De Cesare D., Cuccurullo F., Imbastaro T., Riario-Sforza G., Di Giacomo F., Zuliani G., Fellin R. Copper/zinc ratio and systemic oxidant load: effect of aging and aging-related degenerative diseases. Free Radic. Biol. Med. 1998, 25(6):676-681.
-
(1998)
Free Radic. Biol. Med.
, vol.25
, Issue.6
, pp. 676-681
-
-
Mezzetti, A.1
Pierdomenico, S.D.2
Costantini, F.3
Romano, F.4
De Cesare, D.5
Cuccurullo, F.6
Imbastaro, T.7
Riario-Sforza, G.8
Di Giacomo, F.9
Zuliani, G.10
Fellin, R.11
-
26
-
-
71749121998
-
Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
-
Moreira P.I., Carvalho C., Zhu X., Smith M.A., Perry G. Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology. Biochim. Biophys. Acta 2010, 1802(1):2-10.
-
(2010)
Biochim. Biophys. Acta
, vol.1802
, Issue.1
, pp. 2-10
-
-
Moreira, P.I.1
Carvalho, C.2
Zhu, X.3
Smith, M.A.4
Perry, G.5
-
27
-
-
28244440298
-
Chronically increased oxidative stress in fibroblasts from Alzheimer's disease patients causes early senescence and renders resistance to apoptosis by oxidative stress
-
Naderi J., Lopez C., Pandey S. Chronically increased oxidative stress in fibroblasts from Alzheimer's disease patients causes early senescence and renders resistance to apoptosis by oxidative stress. Mech. Ageing Dev. 2006, 127(1):25-35.
-
(2006)
Mech. Ageing Dev.
, vol.127
, Issue.1
, pp. 25-35
-
-
Naderi, J.1
Lopez, C.2
Pandey, S.3
-
28
-
-
33745851187
-
10 inhibits Bax-induced destabilization of mitochondria in mammalian cells
-
10 inhibits Bax-induced destabilization of mitochondria in mammalian cells. Apoptosis 2006, 11(8):1359-1369.
-
(2006)
Apoptosis
, vol.11
, Issue.8
, pp. 1359-1369
-
-
Naderi, J.1
Somayajulu-Nitu, M.2
Mukerji, A.3
Sharda, P.4
Sikorska, M.5
Borowy-Borowski, H.6
Antonsson, B.7
Pandey, S.8
-
29
-
-
14844303381
-
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study
-
Nixon R.A., Wegiel J., Kumar A., Yu W.H., Peterhoff C., Cataldo A., Cuervo A.M. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J. Neuropathol. Exp. Neurol. 2005, 64:113-122.
-
(2005)
J. Neuropathol. Exp. Neurol.
, vol.64
, pp. 113-122
-
-
Nixon, R.A.1
Wegiel, J.2
Kumar, A.3
Yu, W.H.4
Peterhoff, C.5
Cataldo, A.6
Cuervo, A.M.7
-
30
-
-
0028364948
-
Relations between tocopherol depletion and coenzyme Q during lipid peroxidation in rat liver mitochondria
-
Noack H., Kube U., Augustin W. Relations between tocopherol depletion and coenzyme Q during lipid peroxidation in rat liver mitochondria. Free Radic. Res. 1994, 20(6):375-386.
-
(1994)
Free Radic. Res.
, vol.20
, Issue.6
, pp. 375-386
-
-
Noack, H.1
Kube, U.2
Augustin, W.3
-
31
-
-
0038320062
-
10
-
10. J. Neurosci. Res. 2003, 72(6):691-703.
-
(2003)
J. Neurosci. Res.
, vol.72
, Issue.6
, pp. 691-703
-
-
Sandhu, J.K.1
Pandey, S.2
Ribecco-Lutkiewicz, M.3
Monette, R.4
Borowy-Borowski, H.5
Walker, P.R.6
Sikorska, M.7
-
32
-
-
66249141245
-
Age, neuropathology, and dementia
-
Savva G.M., Wharton S.B., Ince P.G., Forster G., Matthews F.E., Brayne C. Age, neuropathology, and dementia. N. Engl. J. Med. 2009, 360(22):2302-2309.
-
(2009)
N. Engl. J. Med.
, vol.360
, Issue.22
, pp. 2302-2309
-
-
Savva, G.M.1
Wharton, S.B.2
Ince, P.G.3
Forster, G.4
Matthews, F.E.5
Brayne, C.6
-
33
-
-
33644653041
-
Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice
-
Schuessel K., Frey C., Jourdan C., Keil U., Weber C.C., Müller-Spahn F., Müller W.E., Eckert A. Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice. Free Radic. Biol. Med. 2006, 40(5):850-862.
-
(2006)
Free Radic. Biol. Med.
, vol.40
, Issue.5
, pp. 850-862
-
-
Schuessel, K.1
Frey, C.2
Jourdan, C.3
Keil, U.4
Weber, C.C.5
Müller-Spahn, F.6
Müller, W.E.7
Eckert, A.8
-
34
-
-
0030885482
-
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
-
Smith M.A., Harris P.L., Sayre L.M., Perry G. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc. Natl. Acad. Sci. 1997, 94:9866-9868.
-
(1997)
Proc. Natl. Acad. Sci.
, vol.94
, pp. 9866-9868
-
-
Smith, M.A.1
Harris, P.L.2
Sayre, L.M.3
Perry, G.4
-
35
-
-
14744287295
-
10
-
10. Neurobiol. Dis. 2005, 18(3):618-627.
-
(2005)
Neurobiol. Dis.
, vol.18
, Issue.3
, pp. 618-627
-
-
Somayajulu, M.1
McCarthy, S.2
Hung, M.3
Sikorska, M.4
Borowy-Borowski, H.5
Pandey, S.6
-
36
-
-
68949203496
-
10
-
10. BMC Neurosci. 2009, 10:88.
-
(2009)
BMC Neurosci.
, vol.10
, pp. 88
-
-
Somayajulu-Nitu, M.1
Sandhu, J.K.2
Cohen, J.3
Sikorska, M.4
Sridhar, T.S.5
Matei, A.6
Borowy-Borowski, H.7
Pandey, S.8
-
37
-
-
70350012316
-
Regional brain metabolism with cytochrome c oxidase histochemistry in aPS1/A246E mouse model of autosomal dominant Alzheimer's disease: correlations with behavior and oxidative stress
-
Strazielle C., Jazi R., Verdier Y., Qian S., Lalonde R. Regional brain metabolism with cytochrome c oxidase histochemistry in aPS1/A246E mouse model of autosomal dominant Alzheimer's disease: correlations with behavior and oxidative stress. Neurochem. Int. 2009, 55(8):806-814.
-
(2009)
Neurochem. Int.
, vol.55
, Issue.8
, pp. 806-814
-
-
Strazielle, C.1
Jazi, R.2
Verdier, Y.3
Qian, S.4
Lalonde, R.5
-
38
-
-
0033732110
-
Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
-
Toussaint O., Medrano E.E., von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp. Gerontol. 2000, 35(8):927-945.
-
(2000)
Exp. Gerontol.
, vol.35
, Issue.8
, pp. 927-945
-
-
Toussaint, O.1
Medrano, E.E.2
von Zglinicki, T.3
-
39
-
-
84869147050
-
Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation
-
Wang R.C., Wei Y., An Z., Zou Z., Xiao G., Bhagat G., White M., Reichelt J., Levine B. Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science 2012, 338(6109):956-959.
-
(2012)
Science
, vol.338
, Issue.6109
, pp. 956-959
-
-
Wang, R.C.1
Wei, Y.2
An, Z.3
Zou, Z.4
Xiao, G.5
Bhagat, G.6
White, M.7
Reichelt, J.8
Levine, B.9
-
40
-
-
0031593675
-
Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells
-
Yamamoto A., Tagawa Y., Yoshimori T., Moriyama Y., Masaki R., Tashiro Y. Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct. Funct. 1998, 23:33-42.
-
(1998)
Cell Struct. Funct.
, vol.23
, pp. 33-42
-
-
Yamamoto, A.1
Tagawa, Y.2
Yoshimori, T.3
Moriyama, Y.4
Masaki, R.5
Tashiro, Y.6
-
41
-
-
34548356689
-
Causes of oxidative stress in Alzheimer disease
-
Zhu X., Su B., Wang X., Smith M.A., Perry G. Causes of oxidative stress in Alzheimer disease. Cell. Mol. Life Sci. 2007, 64(17):2202-2210.
-
(2007)
Cell. Mol. Life Sci.
, vol.64
, Issue.17
, pp. 2202-2210
-
-
Zhu, X.1
Su, B.2
Wang, X.3
Smith, M.A.4
Perry, G.5
-
42
-
-
84877972142
-
Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease
-
Zhu X., Perry G., Smith M.A., Wang X. Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J. Alzheimers Dis. 2013, 33(1):S253-S262.
-
(2013)
J. Alzheimers Dis.
, vol.33
, Issue.1
-
-
Zhu, X.1
Perry, G.2
Smith, M.A.3
Wang, X.4
|