A water soluble CoQ 10 formulation improves intracellular distribution and promotes mitochondrial respiration in cultured cells

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Bergamini, Christian ^a   Moruzzi, Noah ^a   Sblendido, Antonella ^b   Lenaz, Giorgio ^a   Fato, Romana ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b Scharper Therapeutics Medical Department   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; QTER; UBIDECARENONE; UNCLASSIFIED DRUG; 5 (6' TRIPHENYLPHOSPHONIUMHEXYL) 5,6 DIHYDRO 6 PHENYL 3,8 PHENANTHRIDINEDIAMMINE; 5-(6'-TRIPHENYLPHOSPHONIUMHEXYL)-5,6-DIHYDRO-6-PHENYL-3,8-PHENANTHRIDINEDIAMMINE; DRUG DERIVATIVE; MALONALDEHYDE; PHENANTHRIDINE DERIVATIVE; ROTENONE; SUPEROXIDE; TERT BUTYL HYDROPEROXIDE; UBIQUINONE; WATER;

ARTICLE; BIOENERGY; BREATHING RATE; CELL CULTURE; CELL GROWTH; CELL LINE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG FORMULATION; ENERGY METABOLISM; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PROTEIN CONTENT; ANIMAL; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; CELL RESPIRATION; CHEMISTRY; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRACELLULAR SPACE; METABOLISM; OXIDATION REDUCTION REACTION; RAT; SOLUBILITY; TITRIMETRY; ULTRAVIOLET SPECTROPHOTOMETRY;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; CELL RESPIRATION; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIETARY SUPPLEMENTS; HUMANS; INTRACELLULAR SPACE; MALONDIALDEHYDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHENANTHRIDINES; RATS; ROTENONE; SOLUBILITY; SPECTROPHOTOMETRY, ULTRAVIOLET; SUPEROXIDES; TERT-BUTYLHYDROPEROXIDE; TITRIMETRY; UBIQUINONE; WATER;

EID: 84858257130     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033712     Document Type: Article

References (50)

1. Spindler M, Beal MF, Henchcliffe C, (2009) Coenzyme Q10 effects in neurodegenerative disease. Neuropsychiatr Dis Treat 5: 597-610.
2. Geromel V, Rotig A, Munnich A, Rustin P, (2002) Coenzyme Q10 depletion is comparatively less detrimental to human cultured skin fibroblasts than respiratory chain complex deficiencies. Free Radic Res 36: 375-379.
3. Groneberg DA, Kindermann B, Althammer M, Klapper M, Vormann J, et al. (2005) Coenzyme Q10 affects expression of genes involved in cell signalling, metabolism and transport in human CaCo-2 cells. Int J Biochem Cell Biol 37: 1208-1218.
4. Schmelzer C, Lindner I, Rimbach G, Niklowitz P, Menke T, et al. (2008) Functions of coenzyme Q10 in inflammation and gene expression. Biofactors 32: 179-183.
5. Zhang Y, Aberg F, Appelkvist EL, Dallner G, Ernster L, (1995) Uptake of dietary coenzyme Q supplement is limited in rats. J Nutr 125: 446-453.
6. Silver MA, Langsjoen PH, Szabo S, Patil H, Zelinger A, (2004) Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction. Am J Cardiol 94: 1306-1310.
7. Di Giovanni S, Mirabella M, Spinazzola A, Crociani P, Silvestri G, et al. (2001) Coenzyme Q10 reverses pathological phenotype and reduces apoptosis in familial CoQ10 deficiency. Neurology 57: 515-518.
8. Kumar A, Kaur H, Devi P, Mohan V, (2009) Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. Pharmacol Ther 124: 259-268.
9. Hamilton SJ, Chew GT, Watts GF, (2009) Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. Diabetes Care 32: 810-812.
10. Henchcliffe C, Beal MF, (2008) Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Pract Neurol 4: 600-609.
11. Sharma S, Kheradpezhou M, Shavali S, El Refaey H, Eken J, et al. (2004) Neuroprotective actions of coenzyme Q10 in Parkinson's disease. Methods Enzymol 382: 488-509.
12. Shults CW, Haas R, (2005) Clinical trials of coenzyme Q10 in neurological disorders. Biofactors 25: 117-126.
13. Yang X, Dai G, Li G, Yang ES, (2009) Coenzyme Q10 reduces beta-amyloid plaque in an APP/PS1 transgenic mouse model of Alzheimer's disease. J Mol Neurosci 41: 110-113.
14. Huntington Study Group (2001) A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology 57: 397-404.
15. Storch A, Jost WH, Vieregge P, Spiegel J, Greulich W, et al. (2007) Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease. Arch Neurol 64: 938-944.
16. Kaufmann P, Thompson JL, Levy G, Buchsbaum R, Shefner J, et al. (2009) Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III. Ann Neurol 66: 235-244.
17. Young JM, Florkowski CM, Molyneux SL, McEwan RG, Frampton CM, et al. (2007) Effect of coenzyme Q(10) supplementation on simvastatin-induced myalgia. Am J Cardiol 100: 1400-1403.
18. Bhagavan HN, Chopra RK, (2007) Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion 7 (Suppl): S78-88.
19. Beg S, Javed S, Kohli K, (2010) Bioavailability enhancement of coenzyme Q10: an extensive review of patents. Recent Pat Drug Deliv Formul 4: 245-255.
20. Balakrishnan P, Lee BJ, Oh DH, Kim JO, Lee YI, et al. (2009) Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems. Int J Pharm 374: 66-72.
21. Villalba JM, Parrado C, Santos-Gonzalez M, Alcain FJ, (2010) Therapeutic use of coenzyme Q10 and coenzyme Q10-related compounds and formulations. Expert Opin Investig Drugs 19: 535-554.
22. Overvad K, Diamant B, Holm L, Holmer G, Mortensen SA, et al. (1999) Coenzyme Q10 in health and disease. Eur J Clin Nutr 53: 764-770.
23. Ibrahim WH, Bhagavan HN, Chopra RK, Chow CK, (2000) Dietary coenzyme Q10 and vitamin E alter the status of these compounds in rat tissues and mitochondria. J Nutr 130: 2343-2348.
24. Lenaz G, Samori B, Fato R, Battino M, Parenti Castelli G, et al. (1992) Localization and preferred orientations of ubiquinone homologs in model bilayers. Biochem Cell Biol 70: 504-514.
25. Cornell BA, Keniry MA, Post A, Robertson RN, Weir LE, et al. (1987) Location and activity of ubiquinone 10 and ubiquinone analogues in model and biological membranes. Biochemistry 26: 7702-7707.
26. Bentinger M, Dallner G, Chojnacki T, Swiezewska E, (2003) Distribution and breakdown of labeled coenzyme Q10 in rat. Free Radic Biol Med 34: 563-575.
27. Santos-Ocana C, Do TQ, Padilla S, Navas P, Clarke CF, (2002) Uptake of exogenous coenzyme Q and transport to mitochondria is required for bc1 complex stability in yeast coq mutants. J Biol Chem 277: 10973-10981.
28. Geromel V, Darin N, Chretien D, Benit P, DeLonlay P, et al. (2002) Coenzyme Q(10) and idebenone in the therapy of respiratory chain diseases: rationale and comparative benefits. Mol Genet Metab 77: 21-30.
29. Lopez LC, Quinzii CM, Area E, Naini A, Rahman S, et al. (2010) Treatment of CoQ(10) deficient fibroblasts with ubiquinone, CoQ analogs, and vitamin C: time- and compound-dependent effects. PLoS One 5: e11897.
30. Somayajulu M, McCarthy S, Hung M, Sikorska M, Borowy-Borowski H, et al. (2005) Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. Neurobiol Dis 18: 618-627.
31. Fernandez-Ayala DJ, Lopez-Lluch G, Garcia-Valdes M, Arroyo A, Navas P, (2005) Specificity of coenzyme Q10 for a balanced function of respiratory chain and endogenous ubiquinone biosynthesis in human cells. Biochim Biophys Acta 1706: 174-183.
32. Hackenbrock CR, Chazotte B, Gupte SS, (1986) The random collision model and a critical assessment of diffusion and collision in mitochondrial electron transport. J Bioenerg Biomembr 18: 331-368.
33. Schagger H, (2002) Respiratory chain supercomplexes of mitochondria and bacteria. Biochim Biophys Acta 1555: 154-159.
34. Lenaz G, Genova ML, (2009) Mobility and function of coenzyme Q (ubiquinone) in the mitochondrial respiratory chain. Biochim Biophys Acta 1787: 563-573.
35. Carli F, Corvi Mora P, Canal T, (2003) Co-grinding process for the preparation of a ternary composition. European patent office. Wipo website. Available: http://www.wipo.int/patentscope/search/en/WO2003097012. Accessed 2012 Feb 23.
36. Corvi Mora P, Canal T, Ruzzier F, (2008) Composition containing micronutrients with improved anti-oxidant activity and the use thereof. Wipo website. Available: http://www.wipo.int/patentscope/search/en/WO2007009997. Accessed 2012 Feb 23.
37. Somayajulu-Nitu M, Sandhu JK, Cohen J, Sikorska M, Sridhar TS, et al. (2009) Paraquat induces oxidative stress, neuronal loss in substantia nigra region and parkinsonism in adult rats: neuroprotection and amelioration of symptoms by water-soluble formulation of coenzyme Q10. BMC Neurosci 10: 88.
38. McCarthy S, Somayajulu M, Sikorska M, Borowy-Borowski H, Pandey S, (2004) Paraquat induces oxidative stress and neuronal cell death; neuroprotection by water-soluble Coenzyme Q10. Toxicol Appl Pharmacol 201: 21-31.
39. Fetoni AR, Piacentini R, Fiorita A, Paludetti G, Troiani D, (2009) Water-soluble Coenzyme Q10 formulation (Q-ter) promotes outer hair cell survival in a guinea pig model of noise induced hearing loss (NIHL). Brain Res 1257: 108-116.
40. Xu J, Seo AY, Vorobyeva DA, Carter CS, Anton SD, et al. (2010) Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats. PLoS One 5: e10572.
41. Fumagalli S, Fattirolli F, Guarducci L, Cellai T, Baldasseroni S, et al. (2011) Coenzyme Q10 terclatrate and creatine in chronic heart failure: a randomized, placebo-controlled, double-blind study. Clin Cardiol 34: 211-217.
42. Lauro GM, Di Lorenzo N, Grossi M, Maleci A, Guidetti B, (1986) Prostaglandin E2 as an immunomodulating factor released in vitro by human glioma cells. Acta Neuropathol 69: 278-282.
43. Gorman A, McCarthy J, Finucane D, Reville W, (1996) Morphological assessment of apoptosis. In: Cotter TG, Martin SJ, editors. Techniques in Apoptosis, A Users Guide pp. 6-7.
44. Chomyn A, (1996) Platelet-mediated transformation of human mitochondrial DNA-less cells. Methods Enzymol 264: 334-339.
45. Takada M, Ikenoya S, Yuzuriha T, Katayama K, (1984) Simultaneous determination of reduced and oxidized ubiquinones. Methods Enzymol 105: 147-155.
46. Chomyn A, (1996) In vivo labeling and analysis of human mitochondrial translation products. Methods Enzymol 264: 197-211.
47. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ, (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.
48. Strehler BL, (1963) Adenosine-5V-triphosphate and creatine phosphate, determination with luciferase. Methods of enzymatic analysis pp. 559-572.
49. Napolitano MJ, Shain DH, (2005) Quantitating adenylate nucleotides in diverse organisms. J Biochem Biophys Methods 63: 69-77.
50. Buege JA, Aust SD, (1978) Microsomal lipid peroxidation. Methods Enzymol 52: 302-310.