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Volumn 16, Issue 9, 2014, Pages

iPCS cell modeling of inherited cardiac arrhythmias

Author keywords

Arrhythmogenic right ventricular cardiomyopathy; Cardiomyocytes; Catecholaminergic polymorphic ventricular tachycardia; Disease modeling; Induced pluripotent stem cells; Inherited cardiac arrhythmias; Long QT syndrome

Indexed keywords

CALCIUM;

EID: 84905317561     PISSN: 10928464     EISSN: 15343189     Source Type: Journal    
DOI: 10.1007/s11936-014-0331-4     Document Type: Article
Times cited : (10)

References (56)
  • 1
    • 84879482099 scopus 로고    scopus 로고
    • Transgenic models of cardiac arrhythmias and sudden death
    • doi:10.3389/fphys.2013.00060
    • Remme CA. Transgenic models of cardiac arrhythmias and sudden death. Front Physiol. 2013;4:60. doi:10.3389/fphys.2013.00060.
    • (2013) Front Physiol , vol.4 , pp. 60
    • Remme, C.A.1
  • 2
    • 43049105386 scopus 로고    scopus 로고
    • Cardiac Sodium Channel Overlap Syndromes: Different Faces of SCN5A Mutations
    • DOI 10.1016/j.tcm.2008.01.002, PII S1050173808000054
    • Remme CA, Wilde AA, Bezzina CR. Cardiac sodium channel overlap syndromes: different faces of SCN5A mutations. Trends Cardiovasc Med. 2008;18(3):78-87. doi:10.1016/j.tcm.2008.01.002. (Pubitemid 351626603)
    • (2008) Trends in Cardiovascular Medicine , vol.18 , Issue.3 , pp. 78-87
    • Remme, C.A.1    Wilde, A.A.M.2    Bezzina, C.R.3
  • 4
    • 84866491226 scopus 로고    scopus 로고
    • Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias
    • doi:10.3389/fphys.2012.00346
    • Hoekstra M, Mummery CL, Wilde AA, Bezzina CR, Verkerk AO. Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias. Front Physiol. 2012;3:346. doi:10.3389/fphys.2012.00346.
    • (2012) Front Physiol , vol.3 , pp. 346
    • Hoekstra, M.1    Mummery, C.L.2    Wilde, A.A.3    Bezzina, C.R.4    Verkerk, A.O.5
  • 5
    • 36248966518 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
    • DOI 10.1016/j.cell.2007.11.019, PII S0092867407014717
    • .•• Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131(5):861-72. Revolutionary study describing that mature somatic cells can be reprogrammed into pluripotent stem cells by introducing a set of transcription factors. (Pubitemid 350138099)
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 6
    • 33747195353 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
    • DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663-76. (Pubitemid 44233629)
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 7
    • 61949300076 scopus 로고    scopus 로고
    • Functional cardiomyocytes derived from human induced pluripotent stem cells
    • Zhang J, Wilson GF, Soerens AG, Koonce CH, Yu J, Palecek SP, et al. Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res. 2009;104(4):e30-41.
    • (2009) Circ Res , vol.104 , Issue.4
    • Zhang, J.1    Wilson, G.F.2    Soerens, A.G.3    Koonce, C.H.4    Yu, J.5    Palecek, S.P.6
  • 8
    • 70350135472 scopus 로고    scopus 로고
    • Cardiomyocyte differentiation of human induced pluripotent stem cells
    • Zwi L, Caspi O, Arbel G, Huber I, Gepstein A, Park IH, et al. Cardiomyocyte differentiation of human induced pluripotent stem cells. Circulation. 2009;120(15):1513-23.
    • (2009) Circulation , vol.120 , Issue.15 , pp. 1513-1523
    • Zwi, L.1    Caspi, O.2    Arbel, G.3    Huber, I.4    Gepstein, A.5    Park, I.H.6
  • 9
    • 77957729169 scopus 로고    scopus 로고
    • Patient-specific induced pluripotent stem-cell models for long-QT syndrome
    • The first study demonstrating that hiPSC-derived cardiomyocytes from a patient carrying inherited cardiac arrythmia can recapitulate the patient's disease phenotype
    • .•• Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flugel L, et al. Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N Engl J Med. 2010;363(15):1397-409. The first study demonstrating that hiPSC-derived cardiomyocytes from a patient carrying inherited cardiac arrythmia can recapitulate the patient's disease phenotype.
    • (2010) N Engl J Med , vol.363 , Issue.15 , pp. 1397-1409
    • Moretti, A.1    Bellin, M.2    Welling, A.3    Jung, C.B.4    Lam, J.T.5    Bott-Flugel, L.6
  • 10
    • 84865254838 scopus 로고    scopus 로고
    • Disease characterization using LQTS-specific induced pluripotent stem cells
    • doi:10.1093/cvr/cvs206
    • Egashira T, Yuasa S, Suzuki T, Aizawa Y, Yamakawa H, Matsuhashi T, et al.Disease characterization using LQTS-specific induced pluripotent stem cells. Cardiovasc Res. 2012;95(4):419-29. doi:10.1093/cvr/cvs206.
    • (2012) Cardiovasc Res , vol.95 , Issue.4 , pp. 419-429
    • Egashira, T.1    Yuasa, S.2    Suzuki, T.3    Aizawa, Y.4    Yamakawa, H.5    Matsuhashi, T.6
  • 11
    • 79952446402 scopus 로고    scopus 로고
    • Modelling the long QT syndrome with induced pluripotent stem cells
    • Pioneering study demonstrating that hiPSC-CMs derived from healthy and diseased patients could serve for drug testing ameliorating or aggravating disease phenotype, both at the single and multicellular level
    • .•• Itzhaki I, Maizels L, Huber I, Zwi-Dantsis L, Caspi O, Winterstern A, et al. Modelling the long QT syndrome with induced pluripotent stem cells. Nature. 2011;471(7337):225-9. Pioneering study demonstrating that hiPSC-CMs derived from healthy and diseased patients could serve for drug testing ameliorating or aggravating disease phenotype, both at the single and multicellular level.
    • (2011) Nature , vol.471 , Issue.7337 , pp. 225-229
    • Itzhaki, I.1    Maizels, L.2    Huber, I.3    Zwi-Dantsis, L.4    Caspi, O.5    Winterstern, A.6
  • 12
    • 84890563877 scopus 로고    scopus 로고
    • Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome
    • doi:10.1038/emboj.2013.240. Description of the use of an isogenic control line, by correcting the causative mutation, as an optimal control since it eliminates patient-specific genetic background differences between the control and the diseased cells
    • .• Bellin M, Casini S, Davis RP, D'Aniello C, Haas J, Ward-van Oostwaard D et al. Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome. EMBO J. 2013. doi:10.1038/emboj.2013.240. Description of the use of an isogenic control line, by correcting the causative mutation, as an optimal control since it eliminates patient-specific genetic background differences between the control and the diseased cells.
    • (2013) EMBO J
    • Bellin, M.1    Casini, S.2    Davis, R.P.3    D'Aniello, C.4    Haas, J.5    Ward-van Oostwaard, D.6
  • 13
    • 79954523845 scopus 로고    scopus 로고
    • Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation
    • doi:10.1093/eurheartj/ehr073
    • Matsa E, Rajamohan D, Dick E, Young L, Mellor I, Staniforth A, et al. Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. Eur Heart J. 2011;32(8):952-62. doi:10.1093/eurheartj/ehr073.
    • (2011) Eur Heart J , vol.32 , Issue.8 , pp. 952-962
    • Matsa, E.1    Rajamohan, D.2    Dick, E.3    Young, L.4    Mellor, I.5    Staniforth, A.6
  • 14
    • 84858040591 scopus 로고    scopus 로고
    • Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture
    • doi:10.1242/dmm.008409
    • Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkela E, et al. Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture. Dis Model Mech. 2012;5(2):220-30. doi:10.1242/dmm.008409.
    • (2012) Dis Model Mech , vol.5 , Issue.2 , pp. 220-230
    • Lahti, A.L.1    Kujala, V.J.2    Chapman, H.3    Koivisto, A.P.4    Pekkanen-Mattila, M.5    Kerkela, E.6
  • 15
    • 84872238836 scopus 로고    scopus 로고
    • Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics
    • doi:10.1085/jgp.201210899
    • Terrenoire C, Wang K, Tung KW, Chung WK, Pass RH, Lu JT, et al. Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics. J Gen Physiol. 2013;141(1):61-72. doi:10.1085/jgp. 201210899.
    • (2013) J Gen Physiol , vol.141 , Issue.1 , pp. 61-72
    • Terrenoire, C.1    Wang, K.2    Tung, K.W.3    Chung, W.K.4    Pass, R.H.5    Lu, J.T.6
  • 16
    • 84887150722 scopus 로고    scopus 로고
    • Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells
    • doi:10.1016/j.ijcard.2013.08.015
    • Ma D, Wei H, Zhao Y, Lu J, Li G, Sahib NB, et al. Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells. Int J Cardiol. 2013;168(6):5277-86. doi:10.1016/j.ijcard.2013.08. 015.
    • (2013) Int J Cardiol , vol.168 , Issue.6 , pp. 5277-5286
    • Ma, D.1    Wei, H.2    Zhao, Y.3    Lu, J.4    Li, G.5    Sahib, N.B.6
  • 17
    • 79952438377 scopus 로고    scopus 로고
    • Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome
    • doi:10.1038/nature09855
    • Yazawa M, Hsueh B, Jia X, Pasca AM, Bernstein JA, Hallmayer J, et al. Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Nature. 2011;471(7337):230-4. doi:10.1038/nature09855.
    • (2011) Nature , vol.471 , Issue.7337 , pp. 230-234
    • Yazawa, M.1    Hsueh, B.2    Jia, X.3    Pasca, A.M.4    Bernstein, J.A.5    Hallmayer, J.6
  • 18
    • 84863213874 scopus 로고    scopus 로고
    • Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease
    • doi:10.1161/CIRCULATIONAHA.111.066092
    • Davis RP, Casini S, van den Berg CW, Hoekstra M, Remme CA, Dambrot C, et al. Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease. Circulation. 2012;125(25):3079-91. doi:10.1161/CIRCULATIONAHA. 111.066092.
    • (2012) Circulation , vol.125 , Issue.25 , pp. 3079-3091
    • Davis, R.P.1    Casini, S.2    Van Den Berg, C.W.3    Hoekstra, M.4    Remme, C.A.5    Dambrot, C.6
  • 19
    • 84858129398 scopus 로고    scopus 로고
    • Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia
    • Jung CB, Moretti A. Mederos y Schnitzler M, Iop L, Storch U, Bellin M et al. Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia. EMBO. Mol Med. 2012;4(3):180-91.
    • (2012) EMBO. Mol Med , vol.4 , Issue.3 , pp. 180-191
    • Jung, C.B.1    Moretti, A.2    Mederos Y Schnitzler, M.3    Iop, L.4    Storch, U.5    Bellin, M.6
  • 20
    • 83755195408 scopus 로고    scopus 로고
    • In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells
    • doi:10.1159/000335753
    • Fatima A, Xu G, Shao K, Papadopoulos S, Lehmann M, Arnaiz-Cot JJ, et al. In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells. Cell Physiol Biochem. 2011;28(4):579-92. doi:10.1159/000335753.
    • (2011) Cell Physiol Biochem , vol.28 , Issue.4 , pp. 579-592
    • Fatima, A.1    Xu, G.2    Shao, K.3    Papadopoulos, S.4    Lehmann, M.5    Arnaiz-Cot, J.J.6
  • 21
    • 84865801030 scopus 로고    scopus 로고
    • Modeling of catecholaminergic polymorphic ventricular tachycardia with patient-specific human-induced pluripotent stem cells
    • doi:10.1016/j.jacc.2012.02.066
    • Itzhaki I, Maizels L, Huber I, Gepstein A, Arbel G, Caspi O, et al. Modeling of catecholaminergic polymorphic ventricular tachycardia with patient-specific human-induced pluripotent stem cells. J Am Coll Cardiol. 2012;60(11):990-1000. doi:10.1016/j.jacc.2012.02.066.
    • (2012) J Am Coll Cardiol , vol.60 , Issue.11 , pp. 990-1000
    • Itzhaki, I.1    Maizels, L.2    Huber, I.3    Gepstein, A.4    Arbel, G.5    Caspi, O.6
  • 22
    • 84866033059 scopus 로고    scopus 로고
    • Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations
    • doi:10.1371/journal.pone.0044660
    • Kujala K, Paavola J, Lahti A, Larsson K, Pekkanen-Mattila M, Viitasalo M, et al. Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations. PLoS One. 2012;7(9):e44660. doi:10.1371/journal.pone.0044660.
    • (2012) PLoS One , vol.7 , Issue.9
    • Kujala, K.1    Paavola, J.2    Lahti, A.3    Larsson, K.4    Pekkanen-Mattila, M.5    Viitasalo, M.6
  • 23
    • 84887454024 scopus 로고    scopus 로고
    • CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia
    • doi:10.1038/cddis.2013.369
    • Di Pasquale E, Lodola F, Miragoli M, Denegri M, Avelino-Cruz JE, Buonocore M, et al. CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia. Cell Death Dis. 2013;4:e843. doi:10.1038/cddis.2013.369.
    • (2013) Cell Death Dis , vol.4
    • Di Pasquale, E.1    Lodola, F.2    Miragoli, M.3    Denegri, M.4    Avelino-Cruz, J.E.5    Buonocore, M.6
  • 24
    • 84857547828 scopus 로고    scopus 로고
    • Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to beta-adrenergic stimulation
    • doi:10.1111/j.1582-4934.2011.01476.x
    • Novak A, Barad L, Zeevi-Levin N, Shick R, Shtrichman R, Lorber A, et al. Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to beta-adrenergic stimulation. J Cell Mol Med. 2012;16(3):468-82. doi:10.1111/j.1582-4934.2011.01476.x.
    • (2012) J Cell Mol Med , vol.16 , Issue.3 , pp. 468-482
    • Novak, A.1    Barad, L.2    Zeevi-Levin, N.3    Shick, R.4    Shtrichman, R.5    Lorber, A.6
  • 25
    • 84892415382 scopus 로고    scopus 로고
    • Modeling of arrhythmogenic right ventricular cardiomyopathy with human induced pluripotent stem cells
    • doi:10.1161/CIRCGENETICS.113.000188
    • Caspi O, Huber I, Gepstein A, Arbel G, Maizels L, Boulos M, et al. Modeling of arrhythmogenic right ventricular cardiomyopathy with human induced pluripotent stem cells. Circ Cardiovasc Genet. 2013;6(6):557-68. doi:10.1161/CIRCGENETICS.113.000188.
    • (2013) Circ Cardiovasc Genet , vol.6 , Issue.6 , pp. 557-568
    • Caspi, O.1    Huber, I.2    Gepstein, A.3    Arbel, G.4    Maizels, L.5    Boulos, M.6
  • 26
    • 84874741888 scopus 로고    scopus 로고
    • Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs
    • doi:10.1038/nature11799
    • Kim C, Wong J, Wen J, Wang S, Wang C, Spiering S, et al. Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs. Nature. 2013;494(7435):105-10. doi:10.1038/nature11799.
    • (2013) Nature , vol.494 , Issue.7435 , pp. 105-110
    • Kim, C.1    Wong, J.2    Wen, J.3    Wang, S.4    Wang, C.5    Spiering, S.6
  • 27
    • 84876522952 scopus 로고    scopus 로고
    • Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy
    • Ma D, Wei H, Lu J, Ho S, Zhang G, Sun X, et al. Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy. Eur Heart J 2013;34:1122-33.
    • (2013) Eur Heart J , vol.34 , pp. 1122-1133
    • Ma, D.1    Wei, H.2    Lu, J.3    Ho, S.4    Zhang, G.5    Sun, X.6
  • 29
    • 17144415220 scopus 로고    scopus 로고
    • Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing
    • DOI 10.1016/j.hrthm.2005.01.020, PII S1547527105001918
    • Tester DJ, Will ML, Haglund CM, Ackerman MJ. Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing. Heart Rhythm. 2005;2(5):507-17. doi:10.1016/j.hrthm. 2005.01.020. (Pubitemid 40521365)
    • (2005) Heart Rhythm , vol.2 , Issue.5 , pp. 507-517
    • Tester, D.J.1    Will, M.L.2    Haglund, C.M.3    Ackerman, M.J.4
  • 30
    • 70449435450 scopus 로고    scopus 로고
    • The genetic basis of long QT and short QT syndromes: A mutation update
    • doi:10.1002/humu.21106
    • Hedley PL, Jorgensen P, Schlamowitz S, Wangari R, Moolman-Smook J, Brink PA, et al. The genetic basis of long QT and short QT syndromes: a mutation update. Hum Mutat. 2009;30(11):1486-511. doi:10.1002/humu.21106.
    • (2009) Hum Mutat , vol.30 , Issue.11 , pp. 1486-1511
    • Hedley, P.L.1    Jorgensen, P.2    Schlamowitz, S.3    Wangari, R.4    Moolman-Smook, J.5    Brink, P.A.6
  • 31
    • 84893923275 scopus 로고    scopus 로고
    • New iPSC for old long QT syndrome modeling: Putting the evidence into perspective
    • doi:10.1177/1535370213514000
    • Li G, Cheng G, Wu J, Ma S, Sun C. New iPSC for old long QT syndrome modeling: Putting the evidence into perspective. Exp Biol Med (Maywood). 2014;239(2):131-40. doi:10.1177/1535370213514000.
    • (2014) Exp Biol Med (Maywood) , vol.239 , Issue.2 , pp. 131-140
    • Li, G.1    Cheng, G.2    Wu, J.3    Ma, S.4    Sun, C.5
  • 32
    • 0032831603 scopus 로고    scopus 로고
    • Sinus node function and ventricular repolarization during exercise stress test in long QT syndrome patients with KvLQT1 and HERG potassium channel defects
    • DOI 10.1016/S0735-1097(99)00255-7, PII S0735109799002557
    • Swan H, Viitasalo M, Piippo K, Laitinen P, Kontula K, Toivonen L. Sinus node function and ventricular repolarization during exercise stress test in long QT syndrome patients with KvLQT1 and HERG potassium channel defects. J Am Coll Cardiol. 1999;34(3):823-9. (Pubitemid 29436190)
    • (1999) Journal of the American College of Cardiology , vol.34 , Issue.3 , pp. 823-829
    • Swan, H.1    Viitasalo, M.2    Piippo, K.3    Laitinen, P.4    Kontula, K.5    Toivonen, L.6
  • 33
    • 84863915312 scopus 로고    scopus 로고
    • Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel
    • doi:10.1073/pnas.1205266109
    • Zhang H, Zou B, Yu H, Moretti A, Wang X, Yan W, et al. Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel. Proc Natl Acad Sci U S A. 2012;109(29):11866-71. doi:10.1073/pnas.1205266109.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.29 , pp. 11866-11871
    • Zhang, H.1    Zou, B.2    Yu, H.3    Moretti, A.4    Wang, X.5    Yan, W.6
  • 34
    • 80053574096 scopus 로고    scopus 로고
    • Cardiomyocytes obtained from induced pluripotent stem cells with long-QT syndrome 3 recapitulate typical disease-specific features in vitro
    • doi:10.1161/CIRCRESAHA.111.243139
    • Malan D, Friedrichs S, Fleischmann BK, Sasse P. Cardiomyocytes obtained from induced pluripotent stem cells with long-QT syndrome 3 recapitulate typical disease-specific features in vitro. Circ Res. 2011;109(8):841-7. doi:10.1161/CIRCRESAHA.111.243139.
    • (2011) Circ Res , vol.109 , Issue.8 , pp. 841-847
    • Malan, D.1    Friedrichs, S.2    Fleischmann, B.K.3    Sasse, P.4
  • 35
    • 33750825834 scopus 로고    scopus 로고
    • Multiple effects of KPQ deletion mutation on gating of human cardiac Na + channels expressed in mammalian cells
    • Chandra R, Starmer CF, Grant AO. Multiple effects of KPQ deletion mutation on gating of human cardiac Na + channels expressed in mammalian cells. Am J Physiol. 1998;274(5 Pt 2):H1643-54.
    • (1998) Am J Physiol , vol.274 , Issue.5 PART 2
    • Chandra, R.1    Starmer, C.F.2    Grant, A.O.3
  • 36
    • 60149107033 scopus 로고    scopus 로고
    • In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes
    • doi:10.1089/scd.2007.0280
    • Caspi O, Itzhaki I, Kehat I, Gepstein A, Arbel G, Huber I, et al. In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes. Stem Cells Dev. 2009;18(1):161-72. doi:10.1089/scd.2007.0280.
    • (2009) Stem Cells Dev , vol.18 , Issue.1 , pp. 161-172
    • Caspi, O.1    Itzhaki, I.2    Kehat, I.3    Gepstein, A.4    Arbel, G.5    Huber, I.6
  • 37
    • 84876526111 scopus 로고    scopus 로고
    • Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity
    • doi:10.1161/CIRCULATIONAHA.113.001883
    • Liang P, Lan F, Lee AS, Gong T, Sanchez-Freire V, Wang Y, et al. Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation. 2013;127(16):1677-91. doi:10.1161/CIRCULATIONAHA.113.001883.
    • (2013) Circulation , vol.127 , Issue.16 , pp. 1677-1691
    • Liang, P.1    Lan, F.2    Lee, A.S.3    Gong, T.4    Sanchez-Freire, V.5    Wang, Y.6
  • 38
    • 58149464807 scopus 로고    scopus 로고
    • Molecular basis of catecholaminergic polymorphic ventricular tachycardia
    • doi:10.1016/j.hrthm.2008.09.013
    • Gyorke S. Molecular basis of catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm. 2009;6(1):123-9. doi:10.1016/j.hrthm.2008.09.013.
    • (2009) Heart Rhythm , vol.6 , Issue.1 , pp. 123-129
    • Gyorke, S.1
  • 39
    • 57049108713 scopus 로고    scopus 로고
    • Catecholaminergic polymorphic ventricular tachycardia from bedside to bench and beyond
    • doi:10.1016/j.cpcardiol.2008.09.002
    • Katz G, Arad M, Eldar M. Catecholaminergic polymorphic ventricular tachycardia from bedside to bench and beyond. Curr Probl Cardiol. 2009;34(1):9-43. doi:10.1016/j.cpcardiol.2008.09.002.
    • (2009) Curr Probl Cardiol , vol.34 , Issue.1 , pp. 9-43
    • Katz, G.1    Arad, M.2    Eldar, M.3
  • 40
    • 0038124349 scopus 로고    scopus 로고
    • A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in bedouin families from Israel
    • Eldar M, Pras E, Lahat H. Amissensemutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel. Cold Spring Harb Symp Quant Biol. 2002;67:333-7. (Pubitemid 36775528)
    • (2002) Cold Spring Harbor Symposia on Quantitative Biology , vol.67 , pp. 333-337
    • Eldar, M.1    Pras, E.2    Lahat, H.3
  • 42
    • 84880513096 scopus 로고    scopus 로고
    • Ca2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPSCM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-afflicted subjects
    • doi:10.1016/j.ceca.2013.04.004
    • Zhang XH, Haviland S, Wei H, Saric T, Fatima A, Hescheler J, et al. Ca2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPSCM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-afflicted subjects. Cell Calcium. 2013;54(2):57-70. doi:10.1016/j.ceca. 2013.04.004.
    • (2013) Cell Calcium , vol.54 , Issue.2 , pp. 57-70
    • Zhang, X.H.1    Haviland, S.2    Wei, H.3    Saric, T.4    Fatima, A.5    Hescheler, J.6
  • 43
    • 38949159633 scopus 로고    scopus 로고
    • Arrhythmogenic right ventricular cardiomyopathy/dysplasia
    • doi:10.1186/1750-1172-2-45
    • Thiene G, Corrado D, Basso C. Arrhythmogenic right ventricular cardiomyopathy/dysplasia. Orphanet J Rare Dis. 2007;2:45. doi:10.1186/1750-1172- 2-45.
    • (2007) Orphanet J Rare Dis , vol.2 , pp. 45
    • Thiene, G.1    Corrado, D.2    Basso, C.3
  • 44
    • 84859111164 scopus 로고    scopus 로고
    • Pathophysiology of arrhythmogenic cardiomyopathy
    • doi:10.1038/nrcardio.2011.173
    • Basso C, Bauce B, Corrado D, Thiene G. Pathophysiology of arrhythmogenic cardiomyopathy. Nat Rev Cardiol. 2012;9(4):223-33. doi:10.1038/nrcardio.2011. 173.
    • (2012) Nat Rev Cardiol , vol.9 , Issue.4 , pp. 223-233
    • Basso, C.1    Bauce, B.2    Corrado, D.3    Thiene, G.4
  • 45
    • 84865221010 scopus 로고    scopus 로고
    • Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency
    • doi:10.1093/cvr/cvs218
    • Cerrone M, Noorman M, Lin X, Chkourko H, Liang FX, van der Nagel R, et al. Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency. Cardiovasc Res. 2012;95(4):460-8. doi:10.1093/cvr/cvs218.
    • (2012) Cardiovasc Res , vol.95 , Issue.4 , pp. 460-468
    • Cerrone, M.1    Noorman, M.2    Lin, X.3    Chkourko, H.4    Liang, F.X.5    Van Der Nagel, R.6
  • 46
    • 80054935074 scopus 로고    scopus 로고
    • Cardiomyocytes derived from human embryonic and induced pluripotent stem cells: Comparative ultrastructure
    • doi:10.1111/j.1582-4934.2011.01417.x
    • Gherghiceanu M, Barad L, Novak A, Reiter I, Itskovitz-Eldor J, Binah O, et al. Cardiomyocytes derived from human embryonic and induced pluripotent stem cells: comparative ultrastructure. J Cell Mol Med. 2011;15(11):2539-51. doi:10.1111/j.1582-4934.2011.01417.x.
    • (2011) J Cell Mol Med , vol.15 , Issue.11 , pp. 2539-2551
    • Gherghiceanu, M.1    Barad, L.2    Novak, A.3    Reiter, I.4    Itskovitz-Eldor, J.5    Binah, O.6
  • 47
    • 84880227000 scopus 로고    scopus 로고
    • Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells
    • doi:10.1089/scd.2012.0490
    • Lundy SD, Zhu WZ, Regnier M, Laflamme MA. Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells. Stem Cells Dev. 2013;22(14):1991-2002. doi:10.1089/scd.2012.0490.
    • (2013) Stem Cells Dev , vol.22 , Issue.14 , pp. 1991-2002
    • Lundy, S.D.1    Zhu, W.Z.2    Regnier, M.3    Laflamme, M.A.4
  • 48
    • 84876322089 scopus 로고    scopus 로고
    • Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes
    • doi:10.1161/CIRCEP.111.973420
    • Lieu DK, Fu JD, Chiamvimonvat N, Tung KC, McNerney GP, Huser T, et al. Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes. Circ Arrhythm Electrophysiol. 2013;6(1):191-201. doi:10.1161/CIRCEP.111.973420.
    • (2013) Circ Arrhythm Electrophysiol , vol.6 , Issue.1 , pp. 191-201
    • Lieu, D.K.1    Fu, J.D.2    Chiamvimonvat, N.3    Tung, K.C.4    McNerney, G.P.5    Huser, T.6
  • 49
    • 84889805480 scopus 로고    scopus 로고
    • Electronic "expression" of the inward rectifier in cardiocytes derived from human-induced pluripotent stem cells
    • doi:S1547-5271(13)01071-0
    • Bett GC, Kaplan AD, Lis A, Cimato TR, Tzanakakis ES, Zhou Q et al. Electronic "expression" of the inward rectifier in cardiocytes derived from human-induced pluripotent stem cells. Heart Rhythm. 2013. doi:S1547-5271(13)01071-0.
    • (2013) Heart Rhythm
    • Bett, G.C.1    Kaplan, A.D.2    Lis, A.3    Cimato, T.R.4    Tzanakakis, E.S.5    Zhou, Q.6
  • 50
    • 84887913513 scopus 로고    scopus 로고
    • Electrophysiological integration and action potential properties of transplanted cardiomyocytes derived from induced pluripotent stem cells
    • doi:cvt213
    • Halbach M, Peinkofer G, Baumgartner S, Maass M, Wiedey M, Neef K et al. Electrophysiological integration and action potential properties of transplanted cardiomyocytes derived from induced pluripotent stem cells. Cardiovasc Res. 2013. doi:cvt213.
    • (2013) Cardiovasc Res
    • Halbach, M.1    Peinkofer, G.2    Baumgartner, S.3    Maass, M.4    Wiedey, M.5    Neef, K.6
  • 51
    • 84855390254 scopus 로고    scopus 로고
    • Concise review: Genomic stability of human induced pluripotent stem cells
    • doi:10.1002/stem.705
    • Martins-Taylor K, Xu RH. Concise review: Genomic stability of human induced pluripotent stem cells. Stem Cells. 2012;30(1):22-7. doi:10.1002/stem.705.
    • (2012) Stem Cells , vol.30 , Issue.1 , pp. 22-27
    • Martins-Taylor, K.1    Xu, R.H.2
  • 52
    • 79960836456 scopus 로고    scopus 로고
    • Genetic engineering of human pluripotent cells using TALE nucleases
    • doi:10.1038/nbt.1927
    • Hockemeyer D, Wang H, Kiani S, Lai CS, Gao Q, Cassady JP, et al. Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol. 2011;29(8):731-4. doi:10.1038/nbt.1927.
    • (2011) Nat Biotechnol , vol.29 , Issue.8 , pp. 731-734
    • Hockemeyer, D.1    Wang, H.2    Kiani, S.3    Lai, C.S.4    Gao, Q.5    Cassady, J.P.6
  • 53
    • 84875618956 scopus 로고    scopus 로고
    • Efficient TALEN construction and evaluation methods for human cell and animal applications
    • doi:10.1111/gtc.12037
    • Sakuma T, Hosoi S, Woltjen K, Suzuki K, Kashiwagi K, Wada H, et al. Efficient TALEN construction and evaluation methods for human cell and animal applications. Genes Cells. 2013;18(4):315-26. doi:10.1111/gtc.12037.
    • (2013) Genes Cells , vol.18 , Issue.4 , pp. 315-326
    • Sakuma, T.1    Hosoi, S.2    Woltjen, K.3    Suzuki, K.4    Kashiwagi, K.5    Wada, H.6
  • 54
    • 85039734432 scopus 로고    scopus 로고
    • Development of a Mouse ESC Reporter Line to Isolate Purkinje-Like Cardiac Conduction System Cells
    • doi:10.1016/j.hrthm.2013.09.036
    • Maass K, Lu J, See F, D'Souza S, Fishman GI. Development of a Mouse ESC Reporter Line to Isolate Purkinje-Like Cardiac Conduction System Cells. Heart Rhythm. 2013;10(11):1748. doi:10.1016/j.hrthm.2013.09.036.
    • (2013) Heart Rhythm , vol.10 , Issue.11 , pp. 1748
    • Maass, K.1    Lu, J.2    See, F.3    D'Souza, S.4    Fishman, G.I.5
  • 55
    • 84863560929 scopus 로고    scopus 로고
    • Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling
    • doi:10.1073/pnas.1200250109
    • Lian X, Hsiao C, Wilson G, Zhu K, Hazeltine LB, Azarin SM, et al. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc Natl Acad Sci U S A. 2012;109(27):E1848-57. doi:10.1073/pnas.1200250109.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.27
    • Lian, X.1    Hsiao, C.2    Wilson, G.3    Zhu, K.4    Hazeltine, L.B.5    Azarin, S.M.6
  • 56
    • 84872016692 scopus 로고    scopus 로고
    • Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/beta-catenin signaling under fully defined conditions
    • doi:10.1038/nprot.2012.150
    • Lian X, Zhang J, Azarin SM, Zhu K, Hazeltine LB, Bao X, et al. Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/beta-catenin signaling under fully defined conditions. Nat Protoc. 2013;8(1):162-75. doi:10.1038/nprot.2012.150.
    • (2013) Nat Protoc , vol.8 , Issue.1 , pp. 162-175
    • Lian, X.1    Zhang, J.2    Azarin, S.M.3    Zhu, K.4    Hazeltine, L.B.5    Bao, X.6


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