Dissecting the catalytic and substrate binding activity of a class II lanthipeptide synthetase BovM

Biochemical and Biophysical Research Communications

Volumn 450, Issue 2, 2014, Pages 1126-1132

  Ma, Hongchu ^a,b   Gao, Yong ^a,b   Zhao, Fangyuan ^a,b   Wang, Jian ^a,b   Teng, Kunling ^a   Zhang, Jie ^a,b   Zhong, Jin ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Dehydration; Lanthipeptide synthetase; Site directed mutagenesis; Substrate binding

Indexed keywords

LANTHIPEPTIDE SYNTHETASE BOVM; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; BINDING AFFINITY; CATALYSIS; ENZYME ACTIVITY; IN VITRO STUDY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SURFACE PLASMON RESONANCE;

DEHYDRATION; LANTHIPEPTIDE SYNTHETASE; SITE-DIRECTED MUTAGENESIS; SUBSTRATE BINDING;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BACTERIOCINS; BIOCATALYSIS; CONSERVED SEQUENCE; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; STREPTOCOCCUS BOVIS; SUBSTRATE SPECIFICITY;

EID: 84905106244     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.06.129     Document Type: Article

References (30)

1. C. Chatterjee, M. Paul, and L. Xie et al. Biosynthesis and mode of action of lantibiotics Chem. Rev. 105 2005 633 684
2. P.J. Knerr, and W.A. van der Donk Discovery, biosynthesis, and engineering of lantipeptides Annu. Rev. Biochem. 81 2012 479 505
3. J. Lubelski, W. Overkamp, and L.D. Kluskens et al. Influence of shifting positions of Ser, Thr, and Cys residues in prenisin on the efficiency of modification reactions and on the antimicrobial activities of the modified prepeptides Appl. Environ. Microbiol. 74 2008 4680 4685
4. S. Suda, A. Westerbeek, and P.M. O'Connor et al. Effect of bioengineering lacticin 3147 lanthionine bridges on specific activity and resistance to heat and proteases Chem. Biol. 17 2010 1151 1160
5. J. Dischinger, S. Basi Chipalu, and G. Bierbaum Lantibiotics: promising candidates for future applications in health care Int. J. Med. Microbiol. 304 2014 51 62
6. M.R. Levengood, C.C. Kerwood, and C. Chatterjee et al. Investigation of the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids ChemBioChem 10 2009 911 919
7. B. Li, D. Sher, and L. Kelly et al. Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria Proc. Natl. Acad. Sci. U.S.A. 107 2010 10430 10435
8. M.R. Levengood, and W.A. van der Donk Use of lantibiotic synthetases for the preparation of bioactive constrained peptides Bioorg. Med. Chem. Lett. 18 2008 3025 3028 (Pubitemid 351680395)
9. R.J. Siezen, O.P. Kuipers, and W.M. de Vos Comparison of lantibiotic gene clusters and encoded proteins Antonie Van Leeuwenhoek 69 1996 171 184 (Pubitemid 26058495)
10. L. Xie, L.M. Miller, and C. Chatterjee et al. Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity Science 303 2004 679 681 (Pubitemid 38141635)
11. M. Paul, G.C. Patton, and W.A. van der Donk Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity Biochemistry 46 2007 6268 6276 (Pubitemid 46842870)
12. P. Uguen, J.P. Le Pennec, and A. Dufour Lantibiotic biosynthesis: interactions between prelacticin 481 and its putative modification enzyme, LctM J. Bacteriol. 182 2000 5262 5266
13. C. Chatterjee, L.M. Miller, and Y.L. Leung et al. Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production J. Am. Chem. Soc. 127 2005 15332 15333 (Pubitemid 41572483)
14. Y.O. You, and W.A. van der Donk Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis Biochemistry 46 2007 5991 6000 (Pubitemid 46799161)
15. G.N. Thibodeaux, and W.A. van der Donk An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase Chem. Commun. (Camb.) 48 2012 10615 10617
16. J. Nagao, Y. Aso, and T. Sashihara et al. Localization and interaction of the biosynthetic proteins for the lantibiotic, Nukacin ISK-1 Biosci. Biotechnol. Biochem. 69 2005 1341 1347 (Pubitemid 41185218)
17. H. Xiao, X. Chen, and M. Chen et al. Bovicin HJ50, a novel lantibiotic produced by Streptococcus bovis HJ50 Microbiology 150 2004 103 108 (Pubitemid 38111475)
18. J. Zhang, Y. Feng, and K. Teng et al. Type AII lantibiotic bovicin HJ50 with a rare disulfide bond: structure, structure-activity relationships and mode of action Biochem. J. 2014
19. G. Liu, J. Zhong, and J. Ni et al. Characteristics of the bovicin HJ50 gene cluster in Streptococcus bovis HJ50 Microbiology 155 2009 584 593
20. Y. Lin, K. Teng, and L. Huan et al. Dissection of the bridging pattern of bovicin HJ50, a lantibiotic containing a characteristic disulfide bridge Microbiol. Res. 166 2011 146 154
21. J. Sambrook, and D.W. Russell Molecular Cloning: A Laboratory Manual third ed. 2001 Cold Spring Harbor Laboratory Press New York
22. J. Chiu, P.E. March, and R. Lee et al. Site-directed, ligase-independent mutagenesis (SLIM): a single-tube methodology approaching 100% efficiency in 4 h Nucleic Acids Res. 32 2004 e174
23. Y. Goto, B. Li, and J. Claesen et al. Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights PLoS Biol. 8 2010 e1000339
24. K. Meindl, T. Schmiederer, and K. Schneider et al. Labyrinthopeptins: a new class of carbacyclic lantibiotics Angew. Chem. Int. Ed. Engl. 49 2010 1151 1154
25. R. Khusainov, R. Heils, and J. Lubelski et al. Determining sites of interaction between prenisin and its modification enzymes NisB and NisC Mol. Microbiol. 82 2011 706 718
26. A. Abts, M. Montalban-Lopez, and O.P. Kuipers et al. NisC binds the FxLx motif of the nisin leader peptide Biochemistry 2013
27. A. Mavaro, A. Abts, and P.J. Bakkes et al. Substrate recognition and specificity of the NisB protein, the lantibiotic dehydratase involved in nisin biosynthesis J. Biol. Chem. 286 2011 30552 30560
28. W.M. Muller, P. Ensle, and B. Krawczyk et al. Leader peptide-directed processing of labyrinthopeptin A2 precursor peptide by the modifying enzyme LabKC Biochemistry 50 2011 8362 8373
29. G.C. Patton, M. Paul, and L.E. Cooper et al. The importance of the leader sequence for directing lanthionine formation in lacticin 481 Biochemistry 47 2008 7342 7351 (Pubitemid 351991013)
30. J. Nagao, Y. Morinaga, and M.R. Islam et al. Mapping and identification of the region and secondary structure required for the maturation of the nukacin ISK-1 prepeptide Peptides 30 2009 1412 1420