Mapping and identification of the region and secondary structure required for the maturation of the nukacin ISK-1 prepeptide

Peptides

Volumn 30, Issue 8, 2009, Pages 1412-1420

  Nagao, Jun ichi ^a   Morinaga, Yoshiko ^a   Islam, Mohammad R ^a   Asaduzzaman, Sikder M ^a   Aso, Yuji ^b   Nakayama, Jiro ^a   Sonomoto, Kenji ^a,c  

^a Laboratory of Microbial Technology   (Japan)

^b Laboratory of Food Science   (Japan)

^c Bio Architecture Center   (Japan)

Author keywords

Helix; Chimeric peptide; Lantibiotics; Post translational modification

Indexed keywords

AMINO ACID; HISTIDINE; LANTIBIOTIC; MUTANT PROTEIN; NUKACIN ISK 1; PHENYLALANINE; PROTEIN PRECURSOR; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CONTROLLED STUDY; HYDROPHILICITY; HYDROPHOBICITY; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; BACTERIOCINS; CHROMATOGRAPHY, LIQUID; CIRCULAR DICHROISM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 67650569231     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2009.05.021     Document Type: Article

References (36)

1. Asaduzzaman S.M., Nagao J., Aso Y., Nakayama J., and Sonomoto K. Lysine-oriented charges trigger the membrane binding and activity of nukacin ISK-1. Appl Environ Microbiol 72 (2006) 6012-6017
2. Aso Y., Sashihara T., Nagao J., Kanemasa Y., Koga H., Hashimoto T., et al. Characterization of a gene cluster of Staphylococcus warneri ISK-1 encoding the biosynthesis of and immunity to the lantibiotic, nukacin ISK-1. Biosci Biotechnol Biochem 68 (2004) 1663-1671
3. Aso Y., Nagao J., Koga H., Okuda K., Kanemasa Y., Sashihara T., et al. Heterologous expression and functional analysis of the gene cluster for the biosynthesis of and immunity to the lantibiotic, nukacin ISK-1. J Biosci Bioeng 98 (2004) 429-436
4. Aucher W., Lacombe C., Héquet A., Frère J., and Berjeaud J.M. Influence of amino acid substitutions in the leader peptide on maturation and secretion of mesentericin Y105 by Leuconostoc mesenteroides. J Bacteriol 187 (2005) 2218-2223
5. Beck-Sickinger A.G., and Jung G. Synthesis and conformational analysis of lantibiotic leader-, pro- and pre-peptides. In: Jung G., and Sahl H.G. (Eds). Nisin and novel lantibiotics (1991), Escom, Leiden 218-230
6. Brumfitt W., Salton M.R., and Hamilton-Miller J.M. Nisin, alone and combined with peptidoglycan-modulating antibiotics: activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. J Antimicrob Chemother 50 (2002) 731-734
7. Chakicherla A., and Hansen J.N. Role of the leader and structural regions of prelantibiotic peptides as assessed by expressing nisin-subtilin chimeras in Bacillus subtilis 168, and characterization of their physical, chemical, and antimicrobial properties. J Biol Chem 270 (1995) 23533-23539
8. Chatterjee C., Paul M., Xie L., and van der Donk W.A. Biosynthesis and mode of action of lantibiotics. Chem Rev 105 (2005) 633-684
9. Chen P., Qi F., Novak J., Krull R.E., and Caufield P.W. Effect of amino acid substitutions in conserved residues in the leader peptide on biosynthesis of the lantibiotic mutacin II. FEMS Microbiol Lett 195 (2001) 139-144
10. Cotter P.D., Hill C., and Ross R.P. Bacterial lantibiotics: strategies to improve therapeutic potential. Curr Protein Pept Sci 6 (2005) 61-75
11. Cotter P.D., Deegan L.H., Lawton E.M., Draper L.A., O'Connor P.M., Hill C., et al. Complete alanine scanning of the two-component lantibiotic lacticin 3147: generating a blueprint for rational drug design. Mol Microbiol 2 (2007) 735-747
12. de Ruyter P.G., Kuipers O.P., and de Vos W.M. Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin. Appl Environ Microbiol 2 (1996) 3662-3667
13. de Vos W.M., Kuipers O.P., van der Meer J.R., and Siezen R.J. Maturation pathway of nisin and other lantibiotics: post-translationally modified antimicrobial peptides exported by Gram-positive bacteria. Mol Microbiol 7 (1995) 427-437
14. Dufour A., Hindre T., haras D., and Le Pennec J.P. The biology of lantibiotics from the lacticin 481 group is coming of age. FEMS Microbiol Rev 31 (2007) 134-167
15. Horton R.M., Hunt H.D., Ho S.N., Pullen J.K., and Pease L.R. Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene 77 (1989) 61-68
16. Ihnken L.A.F., Chatterjee C., and van der Donk W.A. In vitro reconstitution and substrate specificity of a lantibiotic protease. Biochemistry 47 (2008) 7352-7360
17. Jensen P.R., and Hammer K. Minimal requirements for exponential growth of Lactococcus lactis. Appl Environ Microbiol 59 (1993) 4363-4366
18. Jung G. Lantibiotics: a survey. In: Jung G., and Sahl H.G. (Eds). Nisin and novel lantibiotics (1991), Escom, Leiden 1-34
19. Kruszewska D., Sahl H.G., Bierbaum G., Pag U., Hynes S.O., and Ljungh A. Mersacidin eradicates methicillin-resistant Staphylococcus aureus (MRSA) in a mouse rhinitis model. J Antimicrob Chemother 54 (2004) 648-653
20. Kyte J., and Doolittle R.F. A simple method for displaying hydrophathic character of a protein. J Mol Biol 57 (1982) 105-132
21. Miller K.W., Schamber R., Chen Y., and Ray B. Production of active pediocin AcH in Escherichia coli in the absence of processing and secretion genes from the Pediococcus pap operon. Appl Environ Microbiol 64 (1998) 14-20
22. Nagao J., Aso Y., Sashihara T., Shioya K., Adachi A., Nakayama J., et al. Localization and interaction of the biosynthetic proteins for the lantibiotic, nukacin ISK-1. Biosci Biotechnol Biochem 69 (2005) 1341-1347
23. Nagao J., Harada Y., Shioya K., Aso Y., Zendo T., Nakayama J., et al. Lanthionine introduction into nukacin ISK-1 prepeptide by co-expression with the modification enzyme NukM in Escherichia coli. Biochem Biophys Res Commun 36 (2005) 507-513
24. Nagao J., Asaduzzaman S.M., Aso Y., Okuda K., Nakayama J., and Sonomoto K. Lantibiotics: Insight and foresight for new paradigm. J Biosci Bioeng 102 (2006) 139-149
25. Neis S., Bierbaum G., Josten M., Pag U., Kempter C., Jung G., et al. Effect of leader peptide mutations on biosynthesis of the lantibiotic Pep5. FEMS Microbiol Lett 149 (1997) 249-255
26. Patton G.C., Paul M., Cooper L.E., Chatterjee C., and van der Donk W.A. The importance of the leader peptide for directing lanthionine formation in lacticin 481. Biochemistry 7 (2008) 7342-7351
27. Piard J.C., Kuipers O.P., Rollema H.S., Desmazeuad M.J., and de Vos W.M. Structure, organization and expression of the lct gene for lacticin 481, a novel lantibiotic produced by Lactococcus lactis. J Biol Chem 68 (1993) 16361-16368
28. Roccantano D., Colombo G., Fioroni M., and Mark A. Mechanism by which 2,2,2-trifluoroethanol/water mixtures stabilize secondary-structure formation in peptides: A molecular dynamic study. Proc Nat Acad Sci USA 99 (2002) 12179-12184
29. Rost B., and Sander C. Combining evolutionary information and neural networks to predict protein secondary structure. Proteins 19 (1994) 55-72
30. Sambrook J., Fritsch E.F., and Maniatis T. Molecular cloning: a laboratory manual. 2nd ed. (1989), Cold Spring Harbor Laboratory Press, New York
31. Schnell N., Entian K.D., Schneider U., Götz F., Zahner H., Kellner R., and Jung G. Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings. Nature 33 (1988) 276-278
32. Scholtz J.M., Qian H., York E.J., Stewart J.M., and Baldwin R.L. Parameters of helix-coil transition theory for alanine-based peptides of varying chain lengths in water. Biopolymers 31 (1991) 1463-1470
33. Sprules T., Kawulka K.E., Gibbs A.C., Wishart D.S., and Vederas J.C. NMR solution structure of the precursor for carnobacteriocin B2, an antimicrobial peptide from Carnobacterium piscicola. Eur J Biochem 71 (2004) 1748-1756
34. van der Meer J.R., Rollema H.S., Siezen R.J., Beerthuyzen M.M., Kuipers O.P., and de Vos W.M. Influence of amino acids substitutions in the nisin leader peptide on biosynthesis and secretion of nisin by Lactococcus lactis. J Biol Chem 269 (1994) 3555-3562
35. Weil H.P., Beck-Sickinger A.G., Metzger J., Stevanovic S., Jung G., Josten M., et al. Biosynthesis of the lantibiotic Pep5. Isolation and characterization of a prepeptide containing dehydroamino acids. Eur J Biochem 94 (1990) 217-223
36. Xie L., Miller L.M., Chatterjee C., Averin O., Kelleher N.L., and van der Donk W.A. Lacticin 481: In vitro reconstitution of lantibiotic synthetase activity. Science 303 (2004) 679-681