Type AII lantibiotic bovicin HJ50 with a rare disulfide bond: Structure, structure-activity relationships and mode of action

Biochemical Journal

Volumn 461, Issue 3, 2014, Pages 497-508

  Zhang, Jie ^a,b   Feng, Yingang ^c,d   Teng, Kunling ^a   Lin, Yuheng ^a,e   Gao, Yong ^a   Wang, Jinfeng ^c   Zhong, Jin ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c INSTITUTE OF BIOPHYSICS   (China)

^d QINGDAO INSTITUTE OF BIOENERGY AND BIOPROCESS TECHNOLOGY   (China)

^e University of Georgia   (United States)

Author keywords

Antimicrobial mechanism; Disulfide bond; Pore forming activity; Structure activity relationship; Three dimensional structure; Type AII lantibiotic

Indexed keywords

ASPARTIC ACID; BOVICIN HJ 50; LANTIBIOTIC; LYSINE; PEPTIDOGLYCAN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIMICROBIAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; DISULFIDE BOND; FLOW CYTOMETRY; FLUORESCENCE SPECTROSCOPY; HETERONUCLEAR SINGLE QUANTUM COHERENCE; MEMBRANE POTENTIAL; PHOSPHOLIPID VESICLE; PRIORITY JOURNAL; PROTEIN BINDING; PROTON NUCLEAR MAGNETIC RESONANCE; RIGIDITY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; ASPARTIC ACID; BACTERIOCINS; CELL MEMBRANE; CONSERVED SEQUENCE; CYSTINE; ENTEROCOCCUS; LIPOSOMES; LYSINE; MEMBRANE POTENTIALS; MICROCOCCUS LUTEUS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PROTEIN CONFORMATION; PROTEIN PRECURSORS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES;

EID: 84904132570     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20131524     Document Type: Article

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