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Volumn 34, Issue 3, 2014, Pages 255-264

Genetics and epigenetics of primary biliary cirrhosis

Author keywords

genome wide association study; immune related pathways; novel drugs; primary biliary cirrhosis; sex chromosomes

Indexed keywords

I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 23; PHOSPHATIDYLINOSITOL; TUMOR NECROSIS FACTOR ALPHA; GENETIC MARKER;

EID: 84905027623     PISSN: 02728087     EISSN: 10988971     Source Type: Journal    
DOI: 10.1055/s-0034-1383725     Document Type: Article
Times cited : (44)

References (125)
  • 1
  • 2
    • 84881552070 scopus 로고    scopus 로고
    • Apotopes and innate immune system: Novel players in the primary biliary cirrhosis scenario
    • Lleo A., Invernizzi P. Apotopes and innate immune system: novel players in the primary biliary cirrhosis scenario. Dig Liver Dis: 2013; 45 8 630 636
    • (2013) Dig Liver Dis , vol.45 , Issue.8 , pp. 630-636
    • Lleo, A.1    Invernizzi, P.2
  • 3
    • 84886287502 scopus 로고    scopus 로고
    • The limitations and hidden gems of the epidemiology of primary biliary cirrhosis
    • Podda M., Selmi C., Lleo A., Moroni L., Invernizzi P. The limitations and hidden gems of the epidemiology of primary biliary cirrhosis. J Autoimmun: 2013; 46 81 87
    • (2013) J Autoimmun , vol.46 , pp. 81-87
    • Podda, M.1    Selmi, C.2    Lleo, A.3    Moroni, L.4    Invernizzi, P.5
  • 4
    • 84873304654 scopus 로고    scopus 로고
    • Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFβ receptor type II mice
    • Tsuda M., Zhang W., Yang G. X., et al. Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFβ receptor type II mice. Hepatology: 2013; 57 2 806 816
    • (2013) Hepatology , vol.57 , Issue.2 , pp. 806-816
    • Tsuda, M.1    Zhang, W.2    Yang, G.X.3
  • 5
    • 84867155919 scopus 로고    scopus 로고
    • The immunobiology of colitis and cholangitis in interleukin-23p19 and interleukin-17A deleted dominant negative form of transforming growth factor beta receptor type II mice
    • Ando Y., Yang G. X., Tsuda M., et al. The immunobiology of colitis and cholangitis in interleukin-23p19 and interleukin-17A deleted dominant negative form of transforming growth factor beta receptor type II mice. Hepatology: 2012; 56 4 1418 1426
    • (2012) Hepatology , vol.56 , Issue.4 , pp. 1418-1426
    • Ando, Y.1    Yang, G.X.2    Tsuda, M.3
  • 6
    • 67649205149 scopus 로고    scopus 로고
    • EASL Clinical Practice Guidelines: Management of cholestatic liver diseases
    • European Association for the Study of the Liver
    • European Association for the Study of the Liver EASL Clinical Practice Guidelines: management of cholestatic liver diseases. J Hepatol: 2009; 51 2 237 267
    • (2009) J Hepatol , vol.51 , Issue.2 , pp. 237-267
  • 7
    • 0037386114 scopus 로고    scopus 로고
    • Peculiar HLA polymorphisms in Italian patients with primary biliary cirrhosis
    • Invernizzi P., Battezzati P. M., Crosignani A., et al. Peculiar HLA polymorphisms in Italian patients with primary biliary cirrhosis. J Hepatol: 2003; 38 4 401 406
    • (2003) J Hepatol , vol.38 , Issue.4 , pp. 401-406
    • Invernizzi, P.1    Battezzati, P.M.2    Crosignani, A.3
  • 8
    • 58149376547 scopus 로고    scopus 로고
    • Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: A multicenter study of 664 patients and 1992 healthy controls
    • Italian PBC Genetic Study Group.
    • Invernizzi P., Selmi C., Poli F., et al. Italian PBC Genetic Study Group. Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: a multicenter study of 664 patients and 1992 healthy controls. Hepatology: 2008; 48 6 1906 1912
    • (2008) Hepatology , vol.48 , Issue.6 , pp. 1906-1912
    • Invernizzi, P.1    Selmi, C.2    Poli, F.3
  • 9
    • 33748929827 scopus 로고    scopus 로고
    • HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: A large-scale study
    • Donaldson P. T., Baragiotta A., Heneghan M. A., et al. HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale study. Hepatology: 2006; 44 3 667 674
    • (2006) Hepatology , vol.44 , Issue.3 , pp. 667-674
    • Donaldson, P.T.1    Baragiotta, A.2    Heneghan, M.A.3
  • 10
    • 79960736530 scopus 로고    scopus 로고
    • Human leukocyte antigen in primary biliary cirrhosis: An old story now reviving
    • Invernizzi P. Human leukocyte antigen in primary biliary cirrhosis: an old story now reviving. Hepatology: 2011; 54 2 714 723
    • (2011) Hepatology , vol.54 , Issue.2 , pp. 714-723
    • Invernizzi, P.1
  • 11
    • 67149095289 scopus 로고    scopus 로고
    • Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants
    • Hirschfield G. M., Liu X., Xu C., et al. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N Engl J Med: 2009; 360 24 2544 2555
    • (2009) N Engl J Med , vol.360 , Issue.24 , pp. 2544-2555
    • Hirschfield, G.M.1    Liu, X.2    Xu, C.3
  • 12
    • 77955088582 scopus 로고    scopus 로고
    • Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
    • Liu X., Invernizzi P., Lu Y., et al. Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nat Genet: 2010; 42 8 658 660
    • (2010) Nat Genet , vol.42 , Issue.8 , pp. 658-660
    • Liu, X.1    Invernizzi, P.2    Lu, Y.3
  • 13
    • 80054976037 scopus 로고    scopus 로고
    • Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis
    • UK PBC Consortium; Wellcome Trust Case Control Consortium 3.
    • Mells G. F., Floyd J. A., Morley K. I., et al. UK PBC Consortium; Wellcome Trust Case Control Consortium 3. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. Nat Genet: 2011; 43 11 1164
    • (2011) Nat Genet , vol.43 , Issue.11 , pp. 1164
    • Mells, G.F.1    Floyd, J.A.2    Morley, K.I.3
  • 14
    • 84867248201 scopus 로고    scopus 로고
    • Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population
    • Nakamura M., Nishida N., Kawashima M., et al. Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. Am J Hum Genet: 2012; 91 4 721 728
    • (2012) Am J Hum Genet , vol.91 , Issue.4 , pp. 721-728
    • Nakamura, M.1    Nishida, N.2    Kawashima, M.3
  • 15
    • 84869060864 scopus 로고    scopus 로고
    • Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants
    • Italian PBC Genetics Study Group.
    • Juran B. D., Hirschfield G. M., Invernizzi P., et al. Italian PBC Genetics Study Group. Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants. Hum Mol Genet: 2012; 21 23 5209 5221
    • (2012) Hum Mol Genet , vol.21 , Issue.23 , pp. 5209-5221
    • Juran, B.D.1    Hirschfield, G.M.2    Invernizzi, P.3
  • 16
    • 84866924593 scopus 로고    scopus 로고
    • Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis
    • UK Primary Biliary Cirrhosis (PBC) Consortium; Wellcome Trust Case Control Consortium 3.
    • Liu J. Z., Almarri M. A., Gaffney D. J., et al. UK Primary Biliary Cirrhosis (PBC) Consortium; Wellcome Trust Case Control Consortium 3. Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. Nat Genet: 2012; 44 10 1137 1141
    • (2012) Nat Genet , vol.44 , Issue.10 , pp. 1137-1141
    • Liu, J.Z.1    Almarri, M.A.2    Gaffney, D.J.3
  • 17
    • 84876924156 scopus 로고    scopus 로고
    • Pathway-based analysis of primary biliary cirrhosis genome-wide association studies
    • Italian PBC Genetics Study Group.
    • Kar S. P., Seldin M. F., Chen W., et al. Italian PBC Genetics Study Group. Pathway-based analysis of primary biliary cirrhosis genome-wide association studies. Genes Immun: 2013; 14 3 179 186
    • (2013) Genes Immun , vol.14 , Issue.3 , pp. 179-186
    • Kar, S.P.1    Seldin, M.F.2    Chen, W.3
  • 18
    • 84898011122 scopus 로고    scopus 로고
    • Implications of genome-wide association studies in novel therapeutics in primary biliary cirrhosis
    • Carbone M., Lleo A., Sandford R. N., Invernizzi P. Implications of genome-wide association studies in novel therapeutics in primary biliary cirrhosis. Eur J Immunol: 2014; 44 4 945 954
    • (2014) Eur J Immunol , vol.44 , Issue.4 , pp. 945-954
    • Carbone, M.1    Lleo, A.2    Sandford, R.N.3    Invernizzi, P.4
  • 19
    • 0028200735 scopus 로고
    • Familial primary biliary cirrhosis
    • Bach N., Schaffner F. Familial primary biliary cirrhosis. J Hepatol: 1994; 20 6 698 701
    • (1994) J Hepatol , vol.20 , Issue.6 , pp. 698-701
    • Bach, N.1    Schaffner, F.2
  • 20
    • 0028965062 scopus 로고
    • Prevalence and pattern of familial disease in primary biliary cirrhosis
    • Brind A. M., Bray G. P., Portmann B. C., Williams R. Prevalence and pattern of familial disease in primary biliary cirrhosis. Gut: 1995; 36 4 615 617
    • (1995) Gut , vol.36 , Issue.4 , pp. 615-617
    • Brind, A.M.1    Bray, G.P.2    Portmann, B.C.3    Williams, R.4
  • 21
    • 0017717826 scopus 로고
    • Primary biliary cirrhosis in mother and daughter
    • Fagan E., Williams R., Cox S. Primary biliary cirrhosis in mother and daughter. BMJ: 1977; 2 6096 1195
    • (1977) BMJ , vol.2 , Issue.6096 , pp. 1195
    • Fagan, E.1    Williams, R.2    Cox, S.3
  • 22
    • 0031041624 scopus 로고    scopus 로고
    • Prevalence of familial disease in primary biliary cirrhosis in Italy
    • Floreani A., Naccarato R., Chiaramonte M. Prevalence of familial disease in primary biliary cirrhosis in Italy. J Hepatol: 1997; 26 3 737 738
    • (1997) J Hepatol , vol.26 , Issue.3 , pp. 737-738
    • Floreani, A.1    Naccarato, R.2    Chiaramonte, M.3
  • 23
    • 0018872707 scopus 로고
    • Familial occurrence of primary biliary cirrhosis associated with hypergammaglobulinemia in descendants: A family study
    • Jaup B. H., Zettergren L. S. Familial occurrence of primary biliary cirrhosis associated with hypergammaglobulinemia in descendants: a family study. Gastroenterology: 1980; 78 3 549 555
    • (1980) Gastroenterology , vol.78 , Issue.3 , pp. 549-555
    • Jaup, B.H.1    Zettergren, L.S.2
  • 24
    • 0032587434 scopus 로고    scopus 로고
    • Familial primary biliary cirrhosis reassessed: A geographically-based population study
    • Jones D. E., Watt F. E., Metcalf J. V., Bassendine M. F., James O. F. Familial primary biliary cirrhosis reassessed: a geographically-based population study. J Hepatol: 1999; 30 3 402 407
    • (1999) J Hepatol , vol.30 , Issue.3 , pp. 402-407
    • Jones, D.E.1    Watt, F.E.2    Metcalf, J.V.3    Bassendine, M.F.4    James, O.F.5
  • 25
    • 34548751132 scopus 로고    scopus 로고
    • Increased prevalence of antimitochondrial antibodies in first-degree relatives of patients with primary biliary cirrhosis
    • Lazaridis K. N., Juran B. D., Boe G. M., et al. Increased prevalence of antimitochondrial antibodies in first-degree relatives of patients with primary biliary cirrhosis. Hepatology: 2007; 46 3 785 792
    • (2007) Hepatology , vol.46 , Issue.3 , pp. 785-792
    • Lazaridis, K.N.1    Juran, B.D.2    Boe, G.M.3
  • 26
    • 0032766239 scopus 로고    scopus 로고
    • Familial primary biliary cirrhosis in Hiroshima
    • Tsuji K., Watanabe Y., Van De Water J., et al. Familial primary biliary cirrhosis in Hiroshima. J Autoimmun: 1999; 13 1 171 178
    • (1999) J Autoimmun , vol.13 , Issue.1 , pp. 171-178
    • Tsuji, K.1    Watanabe, Y.2    Van De Water, J.3
  • 28
    • 35348875366 scopus 로고    scopus 로고
    • Role of X chromosome defects in primary biliary cirrhosis
    • 03
    • Invernizzi P. Role of X chromosome defects in primary biliary cirrhosis. Hepatol Res: 2007; 37 3 03 S384 S388
    • (2007) Hepatol Res , vol.37 , Issue.3
    • Invernizzi, P.1
  • 29
    • 28444478689 scopus 로고    scopus 로고
    • Primary biliary cirrhosis in a patient with Turner syndrome
    • Milkiewicz P., Heathcote J. Primary biliary cirrhosis in a patient with Turner syndrome. Can J Gastroenterol: 2005; 19 10 631 633
    • (2005) Can J Gastroenterol , vol.19 , Issue.10 , pp. 631-633
    • Milkiewicz, P.1    Heathcote, J.2
  • 30
    • 67349085696 scopus 로고    scopus 로고
    • Female predominance and X chromosome defects in autoimmune diseases
    • Invernizzi P., Pasini S., Selmi C., Gershwin M. E., Podda M. Female predominance and X chromosome defects in autoimmune diseases. J Autoimmun: 2009; 33 1 12 16
    • (2009) J Autoimmun , vol.33 , Issue.1 , pp. 12-16
    • Invernizzi, P.1    Pasini, S.2    Selmi, C.3    Gershwin, M.E.4    Podda, M.5
  • 31
    • 10744229779 scopus 로고    scopus 로고
    • Frequency of monosomy X in women with primary biliary cirrhosis
    • Invernizzi P., Miozzo M., Battezzati P. M., et al. Frequency of monosomy X in women with primary biliary cirrhosis. Lancet: 2004; 363 9408 533 535
    • (2004) Lancet , vol.363 , Issue.9408 , pp. 533-535
    • Invernizzi, P.1    Miozzo, M.2    Battezzati, P.M.3
  • 32
    • 21244456843 scopus 로고    scopus 로고
    • X chromosome monosomy: A common mechanism for autoimmune diseases
    • Invernizzi P., Miozzo M., Selmi C., et al. X chromosome monosomy: a common mechanism for autoimmune diseases. J Immunol: 2005; 175 1 575 578
    • (2005) J Immunol , vol.175 , Issue.1 , pp. 575-578
    • Invernizzi, P.1    Miozzo, M.2    Selmi, C.3
  • 35
    • 84875965690 scopus 로고    scopus 로고
    • Y chromosome loss in male patients with primary biliary cirrhosis
    • Lleo A., Oertelt-Prigione S., Bianchi I., et al. Y chromosome loss in male patients with primary biliary cirrhosis. J Autoimmun: 2013; 41 87 91
    • (2013) J Autoimmun , vol.41 , pp. 87-91
    • Lleo, A.1    Oertelt-Prigione, S.2    Bianchi, I.3
  • 36
    • 78651238248 scopus 로고    scopus 로고
    • Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis
    • Mitchell M. M., Lleo A., Zammataro L., et al. Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis. Epigenetics: 2011; 6 1 95 102
    • (2011) Epigenetics , vol.6 , Issue.1 , pp. 95-102
    • Mitchell, M.M.1    Lleo, A.2    Zammataro, L.3
  • 37
    • 84155180688 scopus 로고    scopus 로고
    • Immunoglobulin M levels inversely correlate with CD40 ligand promoter methylation in patients with primary biliary cirrhosis
    • Lleo A., Liao J., Invernizzi P., et al. Immunoglobulin M levels inversely correlate with CD40 ligand promoter methylation in patients with primary biliary cirrhosis. Hepatology: 2012; 55 1 153 160
    • (2012) Hepatology , vol.55 , Issue.1 , pp. 153-160
    • Lleo, A.1    Liao, J.2    Invernizzi, P.3
  • 38
    • 67349236051 scopus 로고    scopus 로고
    • The genetics and epigenetics of autoimmune diseases
    • Hewagama A., Richardson B. The genetics and epigenetics of autoimmune diseases. J Autoimmun: 2009; 33 1 3 11
    • (2009) J Autoimmun , vol.33 , Issue.1 , pp. 3-11
    • Hewagama, A.1    Richardson, B.2
  • 39
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr R. H., Taylor K. D., Brant S. R., et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science: 2006; 314 5804 1461 1463
    • (2006) Science , vol.314 , Issue.5804 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3
  • 40
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • Sladek R., Rocheleau G., Rung J., et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature: 2007; 445 7130 881 885
    • (2007) Nature , vol.445 , Issue.7130 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3
  • 41
    • 0030688004 scopus 로고    scopus 로고
    • Variations on a theme: Cataloging human DNA sequence variation
    • Collins F. S., Guyer M. S., Charkravarti A. Variations on a theme: cataloging human DNA sequence variation. Science: 1997; 278 5343 1580 1581
    • (1997) Science , vol.278 , Issue.5343 , pp. 1580-1581
    • Collins, F.S.1    Guyer, M.S.2    Charkravarti, A.3
  • 42
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • Hindorff L. A., Sethupathy P., Junkins H. A., et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A: 2009; 106 23 9362 9367
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.23 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3
  • 43
    • 84885830761 scopus 로고    scopus 로고
    • IL7Rα expression and upregulation by IFNβ in dendritic cell subsets is haplotype-dependent
    • McKay F. C., Hoe E., Parnell G., et al. IL7Rα expression and upregulation by IFNβ in dendritic cell subsets is haplotype-dependent. PLoS ONE: 2013; 8 10 e77508
    • (2013) PLoS ONE , vol.8 , Issue.10
    • McKay, F.C.1    Hoe, E.2    Parnell, G.3
  • 44
    • 84882640205 scopus 로고    scopus 로고
    • TGF-β cytokine signaling promotes CD8+ T cell development and low-affinity CD4+ T cell homeostasis by regulation of interleukin-7 receptor α expression
    • Ouyang W., Oh S. A., Ma Q., Bivona M. R., Zhu J., Li M. O. TGF-β cytokine signaling promotes CD8+ T cell development and low-affinity CD4+ T cell homeostasis by regulation of interleukin-7 receptor α expression. Immunity: 2013; 39 2 335 346
    • (2013) Immunity , vol.39 , Issue.2 , pp. 335-346
    • Ouyang, W.1    Oh, S.A.2    Ma, Q.3    Bivona, M.R.4    Zhu, J.5    Li, M.O.6
  • 45
    • 84863072278 scopus 로고    scopus 로고
    • Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid
    • Tsuda M., Moritoki Y., Lian Z. X., et al. Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid. Hepatology: 2012; 55 2 512 521
    • (2012) Hepatology , vol.55 , Issue.2 , pp. 512-521
    • Tsuda, M.1    Moritoki, Y.2    Lian, Z.X.3
  • 46
    • 0036781052 scopus 로고    scopus 로고
    • NF-kappaB regulation in the immune system
    • Li Q., Verma I. M. NF-kappaB regulation in the immune system. Nat Rev Immunol: 2002; 2 10 725 734
    • (2002) Nat Rev Immunol , vol.2 , Issue.10 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 48
    • 47249153181 scopus 로고    scopus 로고
    • CTLA-4: A key regulatory point in the control of autoimmune disease
    • Scalapino K. J., Daikh D. I. CTLA-4: a key regulatory point in the control of autoimmune disease. Immunol Rev: 2008; 223 143 155
    • (2008) Immunol Rev , vol.223 , pp. 143-155
    • Scalapino, K.J.1    Daikh, D.I.2
  • 49
    • 84873279968 scopus 로고    scopus 로고
    • Therapeutic effect of cytotoxic T lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis
    • Dhirapong A., Yang G. X., Nadler S., et al. Therapeutic effect of cytotoxic T lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis. Hepatology: 2013; 57 2 708 715
    • (2013) Hepatology , vol.57 , Issue.2 , pp. 708-715
    • Dhirapong, A.1    Yang, G.X.2    Nadler, S.3
  • 50
    • 24944498854 scopus 로고    scopus 로고
    • Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition
    • Genovese M. C., Becker J. C., Schiff M., et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition. N Engl J Med: 2005; 353 11 1114 1123
    • (2005) N Engl J Med , vol.353 , Issue.11 , pp. 1114-1123
    • Genovese, M.C.1    Becker, J.C.2    Schiff, M.3
  • 51
    • 23644455857 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: Twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial
    • Kremer J. M., Dougados M., Emery P., et al. Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial. Arthritis Rheum: 2005; 52 8 2263 2271
    • (2005) Arthritis Rheum , vol.52 , Issue.8 , pp. 2263-2271
    • Kremer, J.M.1    Dougados, M.2    Emery, P.3
  • 52
    • 0033135564 scopus 로고    scopus 로고
    • CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris
    • Abrams J. R., Lebwohl M. G., Guzzo C. A., et al. CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris. J Clin Invest: 1999; 103 9 1243 1252
    • (1999) J Clin Invest , vol.103 , Issue.9 , pp. 1243-1252
    • Abrams, J.R.1    Lebwohl, M.G.2    Guzzo, C.A.3
  • 53
    • 57749193136 scopus 로고    scopus 로고
    • Detecting shared pathogenesis from the shared genetics of immune-related diseases
    • Zhernakova A., van Diemen C. C., Wijmenga C. Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet: 2009; 10 1 43 55
    • (2009) Nat Rev Genet , vol.10 , Issue.1 , pp. 43-55
    • Zhernakova, A.1    Van Diemen, C.C.2    Wijmenga, C.3
  • 54
    • 0036246857 scopus 로고    scopus 로고
    • Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis
    • Kita H., Matsumura S., He X. S., et al. Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis. J Clin Invest: 2002; 109 9 1231 1240
    • (2002) J Clin Invest , vol.109 , Issue.9 , pp. 1231-1240
    • Kita, H.1    Matsumura, S.2    He, X.S.3
  • 55
    • 0036677420 scopus 로고    scopus 로고
    • Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
    • Becher B., Durell B. G., Noelle R. J. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J Clin Invest: 2002; 110 4 493 497
    • (2002) J Clin Invest , vol.110 , Issue.4 , pp. 493-497
    • Becher, B.1    Durell, B.G.2    Noelle, R.J.3
  • 56
    • 84857365228 scopus 로고    scopus 로고
    • Towards common denominators in primary biliary cirrhosis: The role of IL-12
    • Lleo A., Gershwin M. E., Mantovani A., Invernizzi P. Towards common denominators in primary biliary cirrhosis: the role of IL-12. J Hepatol: 2012; 56 3 731 733
    • (2012) J Hepatol , vol.56 , Issue.3 , pp. 731-733
    • Lleo, A.1    Gershwin, M.E.2    Mantovani, A.3    Invernizzi, P.4
  • 57
    • 72949093141 scopus 로고    scopus 로고
    • Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice
    • Yoshida K., Yang G. X., Zhang W., et al. Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice. Hepatology: 2009; 50 5 1494 1500
    • (2009) Hepatology , vol.50 , Issue.5 , pp. 1494-1500
    • Yoshida, K.1    Yang, G.X.2    Zhang, W.3
  • 58
    • 15444361841 scopus 로고    scopus 로고
    • Anti-interleukin-12 antibody for active Crohn's disease
    • Anti-IL-12 Crohn's Disease Study Group.
    • Mannon P. J., Fuss I. J., Mayer L., et al. Anti-IL-12 Crohn's Disease Study Group. Anti-interleukin-12 antibody for active Crohn's disease. N Engl J Med: 2005; 352 12 1276
    • (2005) N Engl J Med , vol.352 , Issue.12 , pp. 1276
    • Mannon, P.J.1    Fuss, I.J.2    Mayer, L.3
  • 59
    • 33745553245 scopus 로고    scopus 로고
    • A phase 1/2A trial of STA 5326, an oral interleukin-12/23 inhibitor, in patients with active moderate to severe Crohn's disease
    • Burakoff R., Barish C. F., Riff D., et al. A phase 1/2A trial of STA 5326, an oral interleukin-12/23 inhibitor, in patients with active moderate to severe Crohn's disease. Inflamm Bowel Dis: 2006; 12 7 558 565
    • (2006) Inflamm Bowel Dis , vol.12 , Issue.7 , pp. 558-565
    • Burakoff, R.1    Barish, C.F.2    Riff, D.3
  • 60
    • 43449111187 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
    • PHOENIX 1 study investigators.
    • Leonardi C. L., Kimball A. B., Papp K. A., et al. PHOENIX 1 study investigators. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet: 2008; 371 9625 1665 1674
    • (2008) Lancet , vol.371 , Issue.9625 , pp. 1665-1674
    • Leonardi, C.L.1    Kimball, A.B.2    Papp, K.A.3
  • 61
    • 79951955543 scopus 로고    scopus 로고
    • Activation of the PI3K pathway increases TLR-induced TNF-α and IL-6 but reduces IL-1β production in mast cells
    • Hochdörfer T., Kuhny M., Zorn C. N., et al. Activation of the PI3K pathway increases TLR-induced TNF-α and IL-6 but reduces IL-1β production in mast cells. Cell Signal: 2011; 23 5 866 875
    • (2011) Cell Signal , vol.23 , Issue.5 , pp. 866-875
    • Hochdörfer, T.1    Kuhny, M.2    Zorn, C.N.3
  • 62
    • 33744913842 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells
    • Frey R. S., Gao X., Javaid K., Siddiqui S. S., Rahman A., Malik A. B. Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells. J Biol Chem: 2006; 281 23 16128 16138
    • (2006) J Biol Chem , vol.281 , Issue.23 , pp. 16128-16138
    • Frey, R.S.1    Gao, X.2    Javaid, K.3    Siddiqui, S.S.4    Rahman, A.5    Malik, A.B.6
  • 63
    • 0037374815 scopus 로고    scopus 로고
    • The role of PI3K in immune cells
    • Koyasu S. The role of PI3K in immune cells. Nat Immunol: 2003; 4 4 313 319
    • (2003) Nat Immunol , vol.4 , Issue.4 , pp. 313-319
    • Koyasu, S.1
  • 64
    • 51949085076 scopus 로고    scopus 로고
    • Hedgehog: Functions and mechanisms
    • Varjosalo M., Taipale J. Hedgehog: functions and mechanisms. Genes Dev: 2008; 22 18 2454 2472
    • (2008) Genes Dev , vol.22 , Issue.18 , pp. 2454-2472
    • Varjosalo, M.1    Taipale, J.2
  • 65
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • Ingham P. W., McMahon A. P. Hedgehog signaling in animal development: paradigms and principles. Genes Dev: 2001; 15 23 3059 3087
    • (2001) Genes Dev , vol.15 , Issue.23 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 66
    • 0035257660 scopus 로고    scopus 로고
    • Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
    • Bhardwaj G., Murdoch B., Wu D., et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol: 2001; 2 2 172 180
    • (2001) Nat Immunol , vol.2 , Issue.2 , pp. 172-180
    • Bhardwaj, G.1    Murdoch, B.2    Wu, D.3
  • 67
    • 34248669615 scopus 로고    scopus 로고
    • Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis
    • Jung Y., McCall S. J., Li Y. X., Diehl A. M. Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis. Hepatology: 2007; 45 5 1091 1096
    • (2007) Hepatology , vol.45 , Issue.5 , pp. 1091-1096
    • Jung, Y.1    McCall, S.J.2    Li, Y.X.3    Diehl, A.M.4
  • 68
    • 50249151525 scopus 로고    scopus 로고
    • The hedgehog pathway regulates remodelling responses to biliary obstruction in rats
    • Omenetti A., Popov Y., Jung Y., et al. The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. Gut: 2008; 57 9 1275 1282
    • (2008) Gut , vol.57 , Issue.9 , pp. 1275-1282
    • Omenetti, A.1    Popov, Y.2    Jung, Y.3
  • 69
    • 68949194359 scopus 로고    scopus 로고
    • Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production
    • Omenetti A., Syn W. K., Jung Y., et al. Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production. Hepatology: 2009; 50 2 518 527
    • (2009) Hepatology , vol.50 , Issue.2 , pp. 518-527
    • Omenetti, A.1    Syn, W.K.2    Jung, Y.3
  • 70
    • 61949261267 scopus 로고    scopus 로고
    • Inflammatory pathways in liver homeostasis and liver injury
    • Tacke F., Luedde T., Trautwein C. Inflammatory pathways in liver homeostasis and liver injury. Clin Rev Allergy Immunol: 2009; 36 1 4 12
    • (2009) Clin Rev Allergy Immunol , vol.36 , Issue.1 , pp. 4-12
    • Tacke, F.1    Luedde, T.2    Trautwein, C.3
  • 71
    • 0035936797 scopus 로고    scopus 로고
    • The TNF and TNF receptor superfamilies: Integrating mammalian biology
    • Locksley R. M., Killeen N., Lenardo M. J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell: 2001; 104 4 487 501
    • (2001) Cell , vol.104 , Issue.4 , pp. 487-501
    • Locksley, R.M.1    Killeen, N.2    Lenardo, M.J.3
  • 72
    • 1642570212 scopus 로고    scopus 로고
    • Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons
    • Del Villar K., Miller C. A. Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons. Proc Natl Acad Sci U S A: 2004; 101 12 4210 4215
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.12 , pp. 4210-4215
    • Del Villar, K.1    Miller, C.A.2
  • 73
    • 85088340344 scopus 로고    scopus 로고
    • Variants of DENND1B associated with asthma in children
    • Sleiman P. M., Flory J., Imielinski M., et al. Variants of DENND1B associated with asthma in children. N Engl J Med: 2012; 366 7 672
    • (2012) N Engl J Med , vol.366 , Issue.7 , pp. 672
    • Sleiman, P.M.1    Flory, J.2    Imielinski, M.3
  • 74
    • 0036094259 scopus 로고    scopus 로고
    • Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis
    • Kitamura K., Nakamoto Y., Akiyama M., et al. Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis. Lab Invest: 2002; 82 5 571 583
    • (2002) Lab Invest , vol.82 , Issue.5 , pp. 571-583
    • Kitamura, K.1    Nakamoto, Y.2    Akiyama, M.3
  • 75
    • 77956627699 scopus 로고    scopus 로고
    • Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis
    • Lleo A., Bowlus C. L., Yang G. X., et al. Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis. Hepatology: 2010; 52 3 987 998
    • (2010) Hepatology , vol.52 , Issue.3 , pp. 987-998
    • Lleo, A.1    Bowlus, C.L.2    Yang, G.X.3
  • 76
    • 0036226760 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and transforming growth factor-beta reflect severity of liver damage in primary biliary cirrhosis
    • Neuman M., Angulo P., Malkiewicz I., et al. Tumor necrosis factor-alpha and transforming growth factor-beta reflect severity of liver damage in primary biliary cirrhosis. J Gastroenterol Hepatol: 2002; 17 2 196 202
    • (2002) J Gastroenterol Hepatol , vol.17 , Issue.2 , pp. 196-202
    • Neuman, M.1    Angulo, P.2    Malkiewicz, I.3
  • 77
    • 67349248095 scopus 로고    scopus 로고
    • X-linked primary immunodeficiencies as a bridge to better understanding X-chromosome related autoimmunity
    • Pessach I. M., Notarangelo L. D. X-linked primary immunodeficiencies as a bridge to better understanding X-chromosome related autoimmunity. J Autoimmun: 2009; 33 1 17 24
    • (2009) J Autoimmun , vol.33 , Issue.1 , pp. 17-24
    • Pessach, I.M.1    Notarangelo, L.D.2
  • 81
    • 84858750418 scopus 로고    scopus 로고
    • Twin studies in autoimmune disease: Genetics, gender and environment
    • Bogdanos D. P., Smyk D. S., Rigopoulou E. I., et al. Twin studies in autoimmune disease: genetics, gender and environment. J Autoimmun: 2012; 38 2-3 J156 J169
    • (2012) J Autoimmun , vol.38 , Issue.23
    • Bogdanos, D.P.1    Smyk, D.S.2    Rigopoulou, E.I.3
  • 82
    • 84864747228 scopus 로고    scopus 로고
    • Autoimmune hepatitis type 2 associated with an unexpected and transient presence of primary biliary cirrhosis-specific antimitochondrial antibodies: A case study and review of the literature
    • Invernizzi P., Alessio M. G., Smyk D. S., et al. Autoimmune hepatitis type 2 associated with an unexpected and transient presence of primary biliary cirrhosis-specific antimitochondrial antibodies: a case study and review of the literature. BMC Gastroenterol: 2012; 12 92
    • (2012) BMC Gastroenterol , vol.12 , pp. 92
    • Invernizzi, P.1    Alessio, M.G.2    Smyk, D.S.3
  • 83
    • 82455162799 scopus 로고    scopus 로고
    • Immunopathogenesis of primary biliary cirrhosis: An old wives' tale
    • Smyk D. S., Rigopoulou E. I., Lleo A., et al. Immunopathogenesis of primary biliary cirrhosis: an old wives' tale. Immun Ageing: 2011; 8 1 12
    • (2011) Immun Ageing , vol.8 , Issue.1 , pp. 12
    • Smyk, D.S.1    Rigopoulou, E.I.2    Lleo, A.3
  • 84
    • 84862275352 scopus 로고    scopus 로고
    • Sex differences associated with primary biliary cirrhosis
    • Smyk D. S., Rigopoulou E. I., Pares A., et al. Sex differences associated with primary biliary cirrhosis. Clin Dev Immunol: 2012; 2012 610504
    • (2012) Clin Dev Immunol , vol.2012 , pp. 610504
    • Smyk, D.S.1    Rigopoulou, E.I.2    Pares, A.3
  • 88
    • 34548303660 scopus 로고    scopus 로고
    • Preferential X chromosome loss but random inactivation characterize primary biliary cirrhosis
    • Miozzo M., Selmi C., Gentilin B., et al. Preferential X chromosome loss but random inactivation characterize primary biliary cirrhosis. Hepatology: 2007; 46 2 456 462
    • (2007) Hepatology , vol.46 , Issue.2 , pp. 456-462
    • Miozzo, M.1    Selmi, C.2    Gentilin, B.3
  • 89
    • 84858753281 scopus 로고    scopus 로고
    • Increased loss of the y chromosome in peripheral blood cells in male patients with autoimmune thyroiditis
    • Persani L., Bonomi M., Lleo A., et al. Increased loss of the Y chromosome in peripheral blood cells in male patients with autoimmune thyroiditis. J Autoimmun: 2012; 38 2-3 J193 J196
    • (2012) J Autoimmun , vol.38 , Issue.23
    • Persani, L.1    Bonomi, M.2    Lleo, A.3
  • 90
    • 0035874130 scopus 로고    scopus 로고
    • The human y chromosome: Function, evolution and disease
    • Quintana-Murci L., Krausz C., McElreavey K. The human Y chromosome: function, evolution and disease. Forensic Sci Int: 2001; 118 2-3 169 181
    • (2001) Forensic Sci Int , vol.118 , Issue.23 , pp. 169-181
    • Quintana-Murci, L.1    Krausz, C.2    McElreavey, K.3
  • 91
    • 79954414352 scopus 로고    scopus 로고
    • Nuclear localization of pyruvate dehydrogenase complex-E2 (PDC-E2), a mitochondrial enzyme, and its role in signal transducer and activator of transcription 5 (STAT5)-dependent gene transcription
    • Chueh F. Y., Leong K. F., Cronk R. J., Venkitachalam S., Pabich S., Yu C. L. Nuclear localization of pyruvate dehydrogenase complex-E2 (PDC-E2), a mitochondrial enzyme, and its role in signal transducer and activator of transcription 5 (STAT5)-dependent gene transcription. Cell Signal: 2011; 23 7 1170 1178
    • (2011) Cell Signal , vol.23 , Issue.7 , pp. 1170-1178
    • Chueh, F.Y.1    Leong, K.F.2    Cronk, R.J.3    Venkitachalam, S.4    Pabich, S.5    Yu, C.L.6
  • 92
    • 77957228169 scopus 로고    scopus 로고
    • Cellular sources and immune functions of interleukin-9
    • Noelle R. J., Nowak E. C. Cellular sources and immune functions of interleukin-9. Nat Rev Immunol: 2010; 10 10 683 687
    • (2010) Nat Rev Immunol , vol.10 , Issue.10 , pp. 683-687
    • Noelle, R.J.1    Nowak, E.C.2
  • 93
    • 0025990513 scopus 로고
    • Selective autoantibody production by Yaa+ B cells in autoimmune Yaa(+)-Yaa- bone marrow chimeric mice
    • Merino R., Fossati L., Lacour M., Izui S. Selective autoantibody production by Yaa+ B cells in autoimmune Yaa(+)-Yaa- bone marrow chimeric mice. J Exp Med: 1991; 174 5 1023 1029
    • (1991) J Exp Med , vol.174 , Issue.5 , pp. 1023-1029
    • Merino, R.1    Fossati, L.2    Lacour, M.3    Izui, S.4
  • 94
    • 33745617886 scopus 로고    scopus 로고
    • A Tlr7 translocation accelerates systemic autoimmunity in murine lupus
    • Subramanian S., Tus K., Li Q. Z., et al. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci U S A: 2006; 103 26 9970 9975
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.26 , pp. 9970-9975
    • Subramanian, S.1    Tus, K.2    Li, Q.Z.3
  • 95
    • 50549086761 scopus 로고    scopus 로고
    • Yaa autoimmune phenotypes are conferred by overexpression of TLR7
    • Fairhurst A. M., Hwang S. H., Wang A., et al. Yaa autoimmune phenotypes are conferred by overexpression of TLR7. Eur J Immunol: 2008; 38 7 1971 1978
    • (2008) Eur J Immunol , vol.38 , Issue.7 , pp. 1971-1978
    • Fairhurst, A.M.1    Hwang, S.H.2    Wang, A.3
  • 96
    • 49049120579 scopus 로고    scopus 로고
    • Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus
    • Santiago-Raber M. L., Kikuchi S., Borel P., et al. Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus. J Immunol: 2008; 181 2 1556 1562
    • (2008) J Immunol , vol.181 , Issue.2 , pp. 1556-1562
    • Santiago-Raber, M.L.1    Kikuchi, S.2    Borel, P.3
  • 97
    • 81355142141 scopus 로고    scopus 로고
    • Non-coding RNAs in human disease
    • Esteller M. Non-coding RNAs in human disease. Nat Rev Genet: 2011; 12 12 861 874
    • (2011) Nat Rev Genet , vol.12 , Issue.12 , pp. 861-874
    • Esteller, M.1
  • 98
    • 84875936395 scopus 로고    scopus 로고
    • FOXP3: Genetic and epigenetic implications for autoimmunity
    • Katoh H., Zheng P., Liu Y. FOXP3: genetic and epigenetic implications for autoimmunity. J Autoimmun: 2013; 41 72 78
    • (2013) J Autoimmun , vol.41 , pp. 72-78
    • Katoh, H.1    Zheng, P.2    Liu, Y.3
  • 99
    • 84875934940 scopus 로고    scopus 로고
    • The critical importance of epigenetics in autoimmunity
    • Lu Q. The critical importance of epigenetics in autoimmunity. J Autoimmun: 2013; 41 1 5
    • (2013) J Autoimmun , vol.41 , pp. 1-5
    • Lu, Q.1
  • 100
    • 84875950918 scopus 로고    scopus 로고
    • Epigenetic considerations and the clinical reevaluation of the overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis
    • Wang Q., Selmi C., Zhou X., et al. Epigenetic considerations and the clinical reevaluation of the overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis. J Autoimmun: 2013; 41 140 145
    • (2013) J Autoimmun , vol.41 , pp. 140-145
    • Wang, Q.1    Selmi, C.2    Zhou, X.3
  • 101
    • 4143103585 scopus 로고    scopus 로고
    • Primary biliary cirrhosis in monozygotic and dizygotic twins: Genetics, epigenetics, and environment
    • Selmi C., Mayo M. J., Bach N., et al. Primary biliary cirrhosis in monozygotic and dizygotic twins: genetics, epigenetics, and environment. Gastroenterology: 2004; 127 2 485 492
    • (2004) Gastroenterology , vol.127 , Issue.2 , pp. 485-492
    • Selmi, C.1    Mayo, M.J.2    Bach, N.3
  • 102
    • 84894379923 scopus 로고    scopus 로고
    • The emerging role of epigenetics in rheumatic diseases
    • Gay S., Wilson A. G. The emerging role of epigenetics in rheumatic diseases. Rheumatology (Oxford): 2014; 53 3 406 414
    • (2014) Rheumatology (Oxford) , vol.53 , Issue.3 , pp. 406-414
    • Gay, S.1    Wilson, A.G.2
  • 103
    • 84884352609 scopus 로고    scopus 로고
    • Rethinking mechanisms of autoimmune pathogenesis
    • Pillai S. Rethinking mechanisms of autoimmune pathogenesis. J Autoimmun: 2013; 45 97 103
    • (2013) J Autoimmun , vol.45 , pp. 97-103
    • Pillai, S.1
  • 104
    • 84861483169 scopus 로고    scopus 로고
    • Genes, epigenetic regulation and environmental factors: Which is the most relevant in developing autoimmune diseases
    • Costenbader K. H., Gay S., Alarcón-Riquelme M. E., Iaccarino L., Doria A. Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases? Autoimmun Rev: 2012; 11 8 604 609
    • (2012) Autoimmun Rev , vol.11 , Issue.8 , pp. 604-609
    • Costenbader, K.H.1    Gay, S.2    Alarcón-Riquelme, M.E.3    Iaccarino, L.4    Doria, A.5
  • 105
    • 84897930527 scopus 로고    scopus 로고
    • Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis
    • Selmi C., Cavaciocchi F., Lleo A., et al. Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis. Front Immunol: 2014; 5 128
    • (2014) Front Immunol , vol.5 , pp. 128
    • Selmi, C.1    Cavaciocchi, F.2    Lleo, A.3
  • 106
    • 15244353967 scopus 로고    scopus 로고
    • X-inactivation profile reveals extensive variability in X-linked gene expression in females
    • Carrel L., Willard H. F. X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature: 2005; 434 7031 400 404
    • (2005) Nature , vol.434 , Issue.7031 , pp. 400-404
    • Carrel, L.1    Willard, H.F.2
  • 107
    • 18544413131 scopus 로고    scopus 로고
    • Skewed X chromosome inactivation in blood cells of women with scleroderma
    • Ozbalkan Z., BagiŚlar S., Kiraz S., et al. Skewed X chromosome inactivation in blood cells of women with scleroderma. Arthritis Rheum: 2005; 52 5 1564 1570
    • (2005) Arthritis Rheum , vol.52 , Issue.5 , pp. 1564-1570
    • Ozbalkan, Z.1    Bagiślar, S.2    Kiraz, S.3
  • 108
    • 27744454481 scopus 로고    scopus 로고
    • High frequency of skewed X-chromosome inactivation in females with autoimmune thyroid disease: A possible explanation for the female predisposition to thyroid autoimmunity
    • Brix T. H., Knudsen G. P., Kristiansen M., Kyvik K. O., Orstavik K. H., Hegedüs L. High frequency of skewed X-chromosome inactivation in females with autoimmune thyroid disease: a possible explanation for the female predisposition to thyroid autoimmunity. J Clin Endocrinol Metab: 2005; 90 11 5949 5953
    • (2005) J Clin Endocrinol Metab , vol.90 , Issue.11 , pp. 5949-5953
    • Brix, T.H.1    Knudsen, G.P.2    Kristiansen, M.3    Kyvik, K.O.4    Orstavik, K.H.5    Hegedüs, L.6
  • 109
    • 49349096392 scopus 로고    scopus 로고
    • Skewed X-chromosome inactivation in scleroderma
    • Uz E., Loubiere L. S., Gadi V. K., et al. Skewed X-chromosome inactivation in scleroderma. Clin Rev Allergy Immunol: 2008; 34 03 352 355
    • (2008) Clin Rev Allergy Immunol , vol.34 , Issue.3 , pp. 352-355
    • Uz, E.1    Loubiere, L.S.2    Gadi, V.K.3
  • 110
    • 49349084347 scopus 로고    scopus 로고
    • X chromosome inactivation and female predisposition to autoimmunity
    • Ozcelik T. X chromosome inactivation and female predisposition to autoimmunity. Clin Rev Allergy Immunol: 2008; 34 03 348 351
    • (2008) Clin Rev Allergy Immunol , vol.34 , Issue.3 , pp. 348-351
    • Ozcelik, T.1
  • 111
    • 0031770766 scopus 로고    scopus 로고
    • Analysis of CD40 ligand gene mutations in patients with primary biliary cirrhosis
    • Higuchi M., Horiuchi T., Kojima T., et al. Analysis of CD40 ligand gene mutations in patients with primary biliary cirrhosis. Scand J Clin Lab Invest: 1998; 58 5 429 432
    • (1998) Scand J Clin Lab Invest , vol.58 , Issue.5 , pp. 429-432
    • Higuchi, M.1    Horiuchi, T.2    Kojima, T.3
  • 112
    • 34247277666 scopus 로고    scopus 로고
    • Foxp3 in control of the regulatory T cell lineage
    • Zheng Y., Rudensky A. Y. Foxp3 in control of the regulatory T cell lineage. Nat Immunol: 2007; 8 5 457 462
    • (2007) Nat Immunol , vol.8 , Issue.5 , pp. 457-462
    • Zheng, Y.1    Rudensky, A.Y.2
  • 113
    • 67349240835 scopus 로고    scopus 로고
    • Primary biliary cirrhosis is associated with altered hepatic microRNA expression
    • Padgett K. A., Lan R. Y., Leung P. C., et al. Primary biliary cirrhosis is associated with altered hepatic microRNA expression. J Autoimmun: 2009; 32 3-4 246 253
    • (2009) J Autoimmun , vol.32 , Issue.34 , pp. 246-253
    • Padgett, K.A.1    Lan, R.Y.2    Leung, P.C.3
  • 114
    • 84874372441 scopus 로고    scopus 로고
    • Analysis of altered microRNA expression profiles in peripheral blood mononuclear cells from patients with primary biliary cirrhosis
    • Qin B., Huang F., Liang Y., Yang Z., Zhong R. Analysis of altered microRNA expression profiles in peripheral blood mononuclear cells from patients with primary biliary cirrhosis. J Gastroenterol Hepatol: 2013; 28 3 543 550
    • (2013) J Gastroenterol Hepatol , vol.28 , Issue.3 , pp. 543-550
    • Qin, B.1    Huang, F.2    Liang, Y.3    Yang, Z.4    Zhong, R.5
  • 115
    • 84864376260 scopus 로고    scopus 로고
    • Up-regulation of microRNA 506 leads to decreased Cl-/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis
    • Banales J. M., Sáez E., Uriz M., et al. Up-regulation of microRNA 506 leads to decreased Cl-/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis. Hepatology: 2012; 56 2 687 697
    • (2012) Hepatology , vol.56 , Issue.2 , pp. 687-697
    • Banales, J.M.1    Sáez, E.2    Uriz, M.3
  • 116
    • 84875917033 scopus 로고    scopus 로고
    • Overexpression of microRNA-21 is associated with elevated pro-inflammatory cytokines in dominant-negative TGF-β receptor type II mouse
    • Ando Y., Yang G. X., Kenny T. P., et al. Overexpression of microRNA-21 is associated with elevated pro-inflammatory cytokines in dominant-negative TGF-β receptor type II mouse. J Autoimmun: 2013; 41 111 119
    • (2013) J Autoimmun , vol.41 , pp. 111-119
    • Ando, Y.1    Yang, G.X.2    Kenny, T.P.3
  • 117
    • 84878919588 scopus 로고    scopus 로고
    • Distinct microRNAs expression profile in primary biliary cirrhosis and evaluation of miR 505-3p and miR197-3p as novel biomarkers
    • Ninomiya M., Kondo Y., Funayama R., et al. Distinct microRNAs expression profile in primary biliary cirrhosis and evaluation of miR 505-3p and miR197-3p as novel biomarkers. PLoS ONE: 2013; 8 6 e66086
    • (2013) PLoS ONE , vol.8 , Issue.6
    • Ninomiya, M.1    Kondo, Y.2    Funayama, R.3
  • 118
    • 84898539921 scopus 로고    scopus 로고
    • Abnormal expression of miR-let-7b in primary biliary cirrhosis and its clinical significance
    • Qian C., Chen S. X., Ren C. L., Zhong R. Q., Deng A. M., Qin Q. [Abnormal expression of miR-let-7b in primary biliary cirrhosis and its clinical significance]. Zhonghua Gan Zang Bing Za Zhi: 2013; 21 7 533 536
    • (2013) Zhonghua Gan Zang Bing Za Zhi , vol.21 , Issue.7 , pp. 533-536
    • Qian, C.1    Chen, S.X.2    Ren, C.L.3    Zhong, R.Q.4    Deng, A.M.5    Qin, Q.6
  • 119
    • 77955087537 scopus 로고    scopus 로고
    • Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis
    • Hirschfield G. M., Liu X., Han Y., et al. Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis. Nat Genet: 2010; 42 8 655 657
    • (2010) Nat Genet , vol.42 , Issue.8 , pp. 655-657
    • Hirschfield, G.M.1    Liu, X.2    Han, Y.3
  • 120
    • 84878725018 scopus 로고    scopus 로고
    • Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
    • UK-PSCSC Consortium; International IBD Genetics Consortium; International PSC Study Group.
    • Liu J. Z., Hov J. R., Folseraas T., et al. UK-PSCSC Consortium; International IBD Genetics Consortium; International PSC Study Group. Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis. Nat Genet: 2013; 45 6 670 675
    • (2013) Nat Genet , vol.45 , Issue.6 , pp. 670-675
    • Liu, J.Z.1    Hov, J.R.2    Folseraas, T.3
  • 121
    • 4444332045 scopus 로고    scopus 로고
    • Rapid clearance of psoriatic skin lesions induced by topical cyclopamine. A preliminary proof of concept study
    • TaŚ S., Avci O. Rapid clearance of psoriatic skin lesions induced by topical cyclopamine. A preliminary proof of concept study. Dermatology: 2004; 209 2 126 131
    • (2004) Dermatology , vol.209 , Issue.2 , pp. 126-131
    • Taś, S.1    Avci, O.2
  • 122
    • 0142041982 scopus 로고    scopus 로고
    • Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases
    • Feldmann M., Maini R. N. Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat Med: 2003; 9 10 1245 1250
    • (2003) Nat Med , vol.9 , Issue.10 , pp. 1245-1250
    • Feldmann, M.1    Maini, R.N.2
  • 123
    • 33144469246 scopus 로고    scopus 로고
    • First update of the international ASAS consensus statement for the use of anti-TNF agents in patients with ankylosing spondylitis
    • ASAS Working Group
    • Braun J., Davis J., Dougados M., Sieper J., van der Linden S., van der Heijde D. ASAS Working Group First update of the international ASAS consensus statement for the use of anti-TNF agents in patients with ankylosing spondylitis. Ann Rheum Dis: 2006; 65 3 316 320
    • (2006) Ann Rheum Dis , vol.65 , Issue.3 , pp. 316-320
    • Braun, J.1    Davis, J.2    Dougados, M.3    Sieper, J.4    Van Der Linden, S.5    Van Der Heijde, D.6
  • 124
    • 34548494602 scopus 로고    scopus 로고
    • Biologic therapies in psoriasis: A new therapeutic approach
    • Gisondi P., Girolomoni G. Biologic therapies in psoriasis: a new therapeutic approach. Autoimmun Rev: 2007; 6 8 515 519
    • (2007) Autoimmun Rev , vol.6 , Issue.8 , pp. 515-519
    • Gisondi, P.1    Girolomoni, G.2
  • 125
    • 62949219864 scopus 로고    scopus 로고
    • Biological therapies for inflammatory bowel diseases
    • Rutgeerts P., Vermeire S., Van Assche G. Biological therapies for inflammatory bowel diseases. Gastroenterology: 2009; 136 4 1182 1197
    • (2009) Gastroenterology , vol.136 , Issue.4 , pp. 1182-1197
    • Rutgeerts, P.1    Vermeire, S.2    Van Assche, G.3


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