메뉴 건너뛰기




Volumn 12, Issue , 2012, Pages

Autoimmune hepatitis type 2 associated with an unexpected and transient presence of primary biliary cirrhosis-specific antimitochondrial antibodies: A case study and review of the literature

Author keywords

Autoantibody; Autoimmune cholangitis; Autoimmunity; Environment; Epidemiology; Paediatric liver diseases

Indexed keywords

AUTOANTIBODY; AZATHIOPRINE; CYCLOSPORIN; CYTOCHROME P450 2D6; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; LIVER KIDNEY MICROSOMAL TYPE 1 ANTIBODY; METHYLPREDNISOLONE; MITOCHONDRION ANTIBODY; PREDNISOLONE; PREDNISONE; UNCLASSIFIED DRUG;

EID: 84864747228     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-12-92     Document Type: Article
Times cited : (23)

References (146)
  • 1
    • 33748496662 scopus 로고    scopus 로고
    • Primary biliary cirrhosis: when and why does the disease develop?
    • 10.1016/j.dld.2006.03.001, 16567309
    • Floreani A, Ostuni PA, Ferrara F, Guido M. Primary biliary cirrhosis: when and why does the disease develop?. Dig Liver Dis 2006, 38(4):272-275. 10.1016/j.dld.2006.03.001, 16567309.
    • (2006) Dig Liver Dis , vol.38 , Issue.4 , pp. 272-275
    • Floreani, A.1    Ostuni, P.A.2    Ferrara, F.3    Guido, M.4
  • 3
    • 67649205149 scopus 로고    scopus 로고
    • Management of cholestatic liver diseases
    • 10.1016/j.jhep.2009.04.009, 19501929, EASL Clinical Practice Guidelines
    • EASL Clinical Practice Guidelines management of cholestatic liver diseases. J Hepatol 2009, 51(2):237-267. 10.1016/j.jhep.2009.04.009, 19501929, EASL Clinical Practice Guidelines.
    • (2009) J Hepatol , vol.51 , Issue.2 , pp. 237-267
  • 5
    • 0028990461 scopus 로고
    • Primary biliary cirrhosis: the molecule and the mimic
    • 10.1111/j.1600-065X.1995.tb00064.x, 7590813
    • Coppel RL, Gershwin ME. Primary biliary cirrhosis: the molecule and the mimic. Immunol Rev 1995, 144:17-49. 10.1111/j.1600-065X.1995.tb00064.x, 7590813.
    • (1995) Immunol Rev , vol.144 , pp. 17-49
    • Coppel, R.L.1    Gershwin, M.E.2
  • 6
    • 84864767942 scopus 로고    scopus 로고
    • Cutting-Edge Issues in Primary Biliary Cirrhosis. Clin Rev Allergy Immunol, Selmi C
    • Folci M, Meda F. Gershwin ME 2011, Cutting-Edge Issues in Primary Biliary Cirrhosis. Clin Rev Allergy Immunol, Selmi C.
    • (2011) Gershwin ME
    • Folci, M.1    Meda, F.2
  • 7
    • 0026034491 scopus 로고
    • Primary biliary cirrhosis: paradigm or paradox for autoimmunity
    • Gershwin ME, Mackay IR. Primary biliary cirrhosis: paradigm or paradox for autoimmunity. Gastroenterology 1991, 100(3):822-833.
    • (1991) Gastroenterology , vol.100 , Issue.3 , pp. 822-833
    • Gershwin, M.E.1    Mackay, I.R.2
  • 9
    • 79551706873 scopus 로고    scopus 로고
    • Primary biliary cirrhosis: one disease with many faces
    • Hirschfield GM, Gershwin ME. Primary biliary cirrhosis: one disease with many faces. Isr Med Assoc J 2011, 13(1):55-59.
    • (2011) Isr Med Assoc J , vol.13 , Issue.1 , pp. 55-59
    • Hirschfield, G.M.1    Gershwin, M.E.2
  • 10
    • 3042774412 scopus 로고    scopus 로고
    • Is primary biliary cirrhosis a model autoimmune disease?
    • 10.1016/j.autrev.2004.04.001, 15246030
    • Ichiki Y, Shimoda S, Ishibashi H, Gershwin ME. Is primary biliary cirrhosis a model autoimmune disease?. Autoimmun Rev 2004, 3(4):331-336. 10.1016/j.autrev.2004.04.001, 15246030.
    • (2004) Autoimmun Rev , vol.3 , Issue.4 , pp. 331-336
    • Ichiki, Y.1    Shimoda, S.2    Ishibashi, H.3    Gershwin, M.E.4
  • 11
    • 77952741684 scopus 로고    scopus 로고
    • Update on primary biliary cirrhosis
    • 10.1016/j.dld.2010.02.014, 2871061, 20359968
    • Invernizzi P, Selmi C, Gershwin ME. Update on primary biliary cirrhosis. Dig Liver Dis 2010, 42(6):401-408. 10.1016/j.dld.2010.02.014, 2871061, 20359968.
    • (2010) Dig Liver Dis , vol.42 , Issue.6 , pp. 401-408
    • Invernizzi, P.1    Selmi, C.2    Gershwin, M.E.3
  • 12
    • 0032765659 scopus 로고    scopus 로고
    • Primary biliary cirrhosis once rare, now common in the United Kingdom?
    • 10.1002/hep.510300213, 10421645
    • James OF, Bhopal R, Howel D, Gray J, Burt AD, Metcalf JV. Primary biliary cirrhosis once rare, now common in the United Kingdom?. Hepatology 1999, 30(2):390-394. 10.1002/hep.510300213, 10421645.
    • (1999) Hepatology , vol.30 , Issue.2 , pp. 390-394
    • James, O.F.1    Bhopal, R.2    Howel, D.3    Gray, J.4    Burt, A.D.5    Metcalf, J.V.6
  • 13
    • 25144474552 scopus 로고    scopus 로고
    • Primary biliary cirrhosis
    • 10.1056/NEJMra043898, 16177252
    • Kaplan MM, Gershwin ME. Primary biliary cirrhosis. N Engl J Med 2005, 353(12):1261-1273. 10.1056/NEJMra043898, 16177252.
    • (2005) N Engl J Med , vol.353 , Issue.12 , pp. 1261-1273
    • Kaplan, M.M.1    Gershwin, M.E.2
  • 14
    • 0141960195 scopus 로고    scopus 로고
    • Pathogenesis of primary biliary cirrhosis
    • 10.1016/S1089-3261(03)00096-5, 14598794
    • Kita H, Nalbandian G, Keeffe EB, Coppel RL, Gershwin ME. Pathogenesis of primary biliary cirrhosis. Clin Liver Dis 2003, 7(4):821-839. 10.1016/S1089-3261(03)00096-5, 14598794.
    • (2003) Clin Liver Dis , vol.7 , Issue.4 , pp. 821-839
    • Kita, H.1    Nalbandian, G.2    Keeffe, E.B.3    Coppel, R.L.4    Gershwin, M.E.5
  • 16
    • 77649239391 scopus 로고    scopus 로고
    • Definition of human autoimmunity-autoantibodies versus autoimmune disease
    • 10.1016/j.autrev.2009.12.002, 19963079
    • Lleo A, Invernizzi P, Gao B, Podda M, Gershwin ME. Definition of human autoimmunity-autoantibodies versus autoimmune disease. Autoimmun Rev 2010, 9(5):A259-A266. 10.1016/j.autrev.2009.12.002, 19963079.
    • (2010) Autoimmun Rev , vol.9 , Issue.5
    • Lleo, A.1    Invernizzi, P.2    Gao, B.3    Podda, M.4    Gershwin, M.E.5
  • 17
    • 54349109150 scopus 로고    scopus 로고
    • Autoimmune paediatric liver disease
    • 10.3748/wjg.14.3360, 2716590, 18528933
    • Mieli-Vergani G, Vergani D. Autoimmune paediatric liver disease. World J Gastroenterol 2008, 14(21):3360-3367. 10.3748/wjg.14.3360, 2716590, 18528933.
    • (2008) World J Gastroenterol , vol.14 , Issue.21 , pp. 3360-3367
    • Mieli-Vergani, G.1    Vergani, D.2
  • 21
    • 79955689227 scopus 로고    scopus 로고
    • Primary biliary cirrhosis
    • 10.1016/S0140-6736(10)61965-4, 21529926
    • Selmi C, Bowlus CL, Gershwin ME, Coppel RL. Primary biliary cirrhosis. Lancet 2011, 377(9777):1600-1609. 10.1016/S0140-6736(10)61965-4, 21529926.
    • (2011) Lancet , vol.377 , Issue.9777 , pp. 1600-1609
    • Selmi, C.1    Bowlus, C.L.2    Gershwin, M.E.3    Coppel, R.L.4
  • 24
    • 40949108859 scopus 로고    scopus 로고
    • Disease-specific autoantibodies in patients with acute liver failure: the King's College London Experience
    • author reply 1097, 10.1002/hep.22179, 18306217
    • Bernal W, Meda F, Ma Y, Bogdanos DP, Vergani D. Disease-specific autoantibodies in patients with acute liver failure: the King's College London Experience. Hepatology 2008, 47(3):1096-1097. author reply 1097, 10.1002/hep.22179, 18306217.
    • (2008) Hepatology , vol.47 , Issue.3 , pp. 1096-1097
    • Bernal, W.1    Meda, F.2    Ma, Y.3    Bogdanos, D.P.4    Vergani, D.5
  • 26
    • 0141960202 scopus 로고    scopus 로고
    • Antimitochondrial and other autoantibodies
    • vi, 10.1016/S1089-3261(03)00104-1, 14594130
    • Bogdanos DP, Baum H, Vergani D. Antimitochondrial and other autoantibodies. Clin Liver Dis 2003, 7(4):759-777. vi, 10.1016/S1089-3261(03)00104-1, 14594130.
    • (2003) Clin Liver Dis , vol.7 , Issue.4 , pp. 759-777
    • Bogdanos, D.P.1    Baum, H.2    Vergani, D.3
  • 27
    • 0030756614 scopus 로고    scopus 로고
    • A 12-year-old girl with antimitochondrial antibody-positive autoimmune hepatitis
    • 10.1016/S0168-8278(97)80093-1, 9365052
    • Gregorio GV, Portmann B, Mowat AP, Vergani D, Mieli-Vergani G. A 12-year-old girl with antimitochondrial antibody-positive autoimmune hepatitis. J Hepatol 1997, 27(4):751-754. 10.1016/S0168-8278(97)80093-1, 9365052.
    • (1997) J Hepatol , vol.27 , Issue.4 , pp. 751-754
    • Gregorio, G.V.1    Portmann, B.2    Mowat, A.P.3    Vergani, D.4    Mieli-Vergani, G.5
  • 28
    • 20244383696 scopus 로고    scopus 로고
    • Neonatal liver disease associated with placental transfer of anti-mitochondrial antibodies
    • 10.1080/0891693021000054057, 12765481
    • Hannam S, Bogdanos DP, Davies ET, Hussain MJ, Portmann BC, Mieli-Vergani G, Vergani D. Neonatal liver disease associated with placental transfer of anti-mitochondrial antibodies. Autoimmunity 2002, 35(8):545-550. 10.1080/0891693021000054057, 12765481.
    • (2002) Autoimmunity , vol.35 , Issue.8 , pp. 545-550
    • Hannam, S.1    Bogdanos, D.P.2    Davies, E.T.3    Hussain, M.J.4    Portmann, B.C.5    Mieli-Vergani, G.6    Vergani, D.7
  • 30
    • 0030988608 scopus 로고    scopus 로고
    • Ductular expression of autoantigens in primary biliary cirrhosis
    • 10.1055/s-2007-1007187, 9170196
    • Joplin R, Gershwin ME. Ductular expression of autoantigens in primary biliary cirrhosis. Semin Liver Dis 1997, 17(2):97-103. 10.1055/s-2007-1007187, 9170196.
    • (1997) Semin Liver Dis , vol.17 , Issue.2 , pp. 97-103
    • Joplin, R.1    Gershwin, M.E.2
  • 31
    • 0036246857 scopus 로고    scopus 로고
    • Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis
    • 150963, 11994412
    • Kita H, Matsumura S, He XS, Ansari AA, Lian ZX, Van de Water J, Coppel RL, Kaplan MM, Gershwin ME. Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis. J Clin Invest 2002, 109(9):1231-1240. 150963, 11994412.
    • (2002) J Clin Invest , vol.109 , Issue.9 , pp. 1231-1240
    • Kita, H.1    Matsumura, S.2    He, X.S.3    Ansari, A.A.4    Lian, Z.X.5    Van de Water, J.6    Coppel, R.L.7    Kaplan, M.M.8    Gershwin, M.E.9
  • 33
    • 0343554627 scopus 로고    scopus 로고
    • Persistence of autoantibodies against recombinant mitochondrial and nuclear pore proteins after orthotopic liver transplantation for primary biliary cirrhosis
    • 10.1006/jaut.1997.0156, 9376077
    • Mattalia A, Luttig B, Rosina F, Leung PS, Van de Water J, Bauducci M, Ciancio A, Boker KH, Worman H, Cooper RL, et al. Persistence of autoantibodies against recombinant mitochondrial and nuclear pore proteins after orthotopic liver transplantation for primary biliary cirrhosis. J Autoimmun 1997, 10(5):491-497. 10.1006/jaut.1997.0156, 9376077.
    • (1997) J Autoimmun , vol.10 , Issue.5 , pp. 491-497
    • Mattalia, A.1    Luttig, B.2    Rosina, F.3    Leung, P.S.4    Van de Water, J.5    Bauducci, M.6    Ciancio, A.7    Boker, K.H.8    Worman, H.9    Cooper, R.L.10
  • 34
    • 38049068773 scopus 로고    scopus 로고
    • Serum autoantibodies: a road map for the clinical hepatologist
    • 10.1080/08916930701619227, 18176862
    • Meda F, Zuin M, Invernizzi P, Vergani D, Selmi C. Serum autoantibodies: a road map for the clinical hepatologist. Autoimmunity 2008, 41(1):27-34. 10.1080/08916930701619227, 18176862.
    • (2008) Autoimmunity , vol.41 , Issue.1 , pp. 27-34
    • Meda, F.1    Zuin, M.2    Invernizzi, P.3    Vergani, D.4    Selmi, C.5
  • 35
    • 0031864148 scopus 로고    scopus 로고
    • Autoantibodies against subunits of pyruvate dehydrogenase and citrate synthase in a case of paediatric biliary cirrhosis
    • 10.1136/gut.42.5.753, 1727116, 9659176
    • Melegh B, Skuta G, Pajor L, Hegedus G, Sumegi B. Autoantibodies against subunits of pyruvate dehydrogenase and citrate synthase in a case of paediatric biliary cirrhosis. Gut 1998, 42(5):753-756. 10.1136/gut.42.5.753, 1727116, 9659176.
    • (1998) Gut , vol.42 , Issue.5 , pp. 753-756
    • Melegh, B.1    Skuta, G.2    Pajor, L.3    Hegedus, G.4    Sumegi, B.5
  • 36
    • 0022969590 scopus 로고
    • Positive antimitochondrial antibody but normal alkaline phosphatase: is this primary biliary cirrhosis?
    • 10.1002/hep.1840060609, 3793004
    • Mitchison HC, Bassendine MF, Hendrick A, Bennett MK, Bird G, Watson AJ, James OF. Positive antimitochondrial antibody but normal alkaline phosphatase: is this primary biliary cirrhosis?. Hepatology 1986, 6(6):1279-1284. 10.1002/hep.1840060609, 3793004.
    • (1986) Hepatology , vol.6 , Issue.6 , pp. 1279-1284
    • Mitchison, H.C.1    Bassendine, M.F.2    Hendrick, A.3    Bennett, M.K.4    Bird, G.5    Watson, A.J.6    James, O.F.7
  • 40
    • 0034927079 scopus 로고    scopus 로고
    • Detection of antimitochondrial autoantibodies in immunofluorescent AMA-negative patients with primary biliary cirrhosis using recombinant autoantigens
    • 10.1053/jhep.2001.26514, 11481607
    • Miyakawa H, Tanaka A, Kikuchi K, Matsushita M, Kitazawa E, Kawaguchi N, Fujikawa H, Gershwin ME. Detection of antimitochondrial autoantibodies in immunofluorescent AMA-negative patients with primary biliary cirrhosis using recombinant autoantigens. Hepatology 2001, 34(2):243-248. 10.1053/jhep.2001.26514, 11481607.
    • (2001) Hepatology , vol.34 , Issue.2 , pp. 243-248
    • Miyakawa, H.1    Tanaka, A.2    Kikuchi, K.3    Matsushita, M.4    Kitazawa, E.5    Kawaguchi, N.6    Fujikawa, H.7    Gershwin, M.E.8
  • 41
    • 33947366024 scopus 로고    scopus 로고
    • A sensitive bead assay for antimitochondrial antibodies: Chipping away at AMA-negative primary biliary cirrhosis
    • 10.1002/hep.21583, 17326160
    • Oertelt S, Rieger R, Selmi C, Invernizzi P, Ansari AA, Coppel RL, Podda M, Leung PS, Gershwin ME. A sensitive bead assay for antimitochondrial antibodies: Chipping away at AMA-negative primary biliary cirrhosis. Hepatology 2007, 45(3):659-665. 10.1002/hep.21583, 17326160.
    • (2007) Hepatology , vol.45 , Issue.3 , pp. 659-665
    • Oertelt, S.1    Rieger, R.2    Selmi, C.3    Invernizzi, P.4    Ansari, A.A.5    Coppel, R.L.6    Podda, M.7    Leung, P.S.8    Gershwin, M.E.9
  • 42
    • 0033063029 scopus 로고    scopus 로고
    • In situ nucleic acid detection of PDC-E2, BCOADC-E2, OGDC-E2, PDC-E1alpha, BCOADC-E1alpha, OGDC-E1, and the E3 binding protein (protein X) in primary biliary cirrhosis
    • 10.1002/hep.510300145, 10385636
    • Harada K, Sudo Y, Kono N, Ozaki S, Tsuneyama K, Gershwin ME, Nakanuma Y. In situ nucleic acid detection of PDC-E2, BCOADC-E2, OGDC-E2, PDC-E1alpha, BCOADC-E1alpha, OGDC-E1, and the E3 binding protein (protein X) in primary biliary cirrhosis. Hepatology 1999, 30(1):36-45. 10.1002/hep.510300145, 10385636.
    • (1999) Hepatology , vol.30 , Issue.1 , pp. 36-45
    • Harada, K.1    Sudo, Y.2    Kono, N.3    Ozaki, S.4    Tsuneyama, K.5    Gershwin, M.E.6    Nakanuma, Y.7
  • 45
    • 77958150189 scopus 로고    scopus 로고
    • PBC screen: an IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis
    • 10.1016/j.jaut.2010.09.005, 20932720
    • Liu H, Norman GL, Shums Z, Worman HJ, Krawitt EL, Bizzaro N, Vergani D, Bogdanos DP, Dalekos GN, Milkiewicz P, et al. PBC screen: an IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis. J Autoimmun 2010, 35(4):436-442. 10.1016/j.jaut.2010.09.005, 20932720.
    • (2010) J Autoimmun , vol.35 , Issue.4 , pp. 436-442
    • Liu, H.1    Norman, G.L.2    Shums, Z.3    Worman, H.J.4    Krawitt, E.L.5    Bizzaro, N.6    Vergani, D.7    Bogdanos, D.P.8    Dalekos, G.N.9    Milkiewicz, P.10
  • 47
    • 8744289781 scopus 로고    scopus 로고
    • Antimitochondrial antibodies and reactivity to N. aromaticivorans proteins in Icelandic patients with primary biliary cirrhosis and their relatives
    • 10.1111/j.1572-0241.2004.40397.x, 15554994
    • Olafsson S, Gudjonsson H, Selmi C, Amano K, Invernizzi P, Podda M, Gershwin ME. Antimitochondrial antibodies and reactivity to N. aromaticivorans proteins in Icelandic patients with primary biliary cirrhosis and their relatives. Am J Gastroenterol 2004, 99(11):2143-2146. 10.1111/j.1572-0241.2004.40397.x, 15554994.
    • (2004) Am J Gastroenterol , vol.99 , Issue.11 , pp. 2143-2146
    • Olafsson, S.1    Gudjonsson, H.2    Selmi, C.3    Amano, K.4    Invernizzi, P.5    Podda, M.6    Gershwin, M.E.7
  • 48
    • 4644308514 scopus 로고    scopus 로고
    • Liver autoimmune serology: a consensus statement from the committee for autoimmune serology of the International Autoimmune Hepatitis Group
    • 10.1016/j.jhep.2004.08.002, 15464251
    • Vergani D, Alvarez F, Bianchi FB, Cancado EL, Mackay IR, Manns MP, Nishioka M, Penner E. Liver autoimmune serology: a consensus statement from the committee for autoimmune serology of the International Autoimmune Hepatitis Group. J Hepatol 2004, 41(4):677-683. 10.1016/j.jhep.2004.08.002, 15464251.
    • (2004) J Hepatol , vol.41 , Issue.4 , pp. 677-683
    • Vergani, D.1    Alvarez, F.2    Bianchi, F.B.3    Cancado, E.L.4    Mackay, I.R.5    Manns, M.P.6    Nishioka, M.7    Penner, E.8
  • 49
    • 70350574604 scopus 로고    scopus 로고
    • Primary biliary cirrhosis-specific autoantibodies in patients with systemic sclerosis
    • author reply 916-917
    • Mytilinaiou MG, Bogdanos DP. Primary biliary cirrhosis-specific autoantibodies in patients with systemic sclerosis. Dig Liver Dis 2009, 41(12):916-917. author reply 916-917.
    • (2009) Dig Liver Dis , vol.41 , Issue.12 , pp. 916-917
    • Mytilinaiou, M.G.1    Bogdanos, D.P.2
  • 51
    • 34247633493 scopus 로고    scopus 로고
    • The X and why of xenobiotics in primary biliary cirrhosis
    • 1934549, 17360156
    • Rieger R, Gershwin ME. The X and why of xenobiotics in primary biliary cirrhosis. J Autoimmun 2007, 28(2-3):76-84. 1934549, 17360156.
    • (2007) J Autoimmun , vol.28 , Issue.2-3 , pp. 76-84
    • Rieger, R.1    Gershwin, M.E.2
  • 52
    • 2442473106 scopus 로고    scopus 로고
    • Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible
    • Amano K, Leung PS, Xu Q, Marik J, Quan C, Kurth MJ, Nantz MH, Ansari AA, Lam KS, Zeniya M, et al. Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible. J Immunol 2004, 172(10):6444-6452.
    • (2004) J Immunol , vol.172 , Issue.10 , pp. 6444-6452
    • Amano, K.1    Leung, P.S.2    Xu, Q.3    Marik, J.4    Quan, C.5    Kurth, M.J.6    Nantz, M.H.7    Ansari, A.A.8    Lam, K.S.9    Zeniya, M.10
  • 53
    • 0041880707 scopus 로고    scopus 로고
    • T cell immunity and primary biliary cirrhosis
    • 10.1016/S1568-9972(02)00122-2, 12848971
    • Ishibashi H, Nakamura M, Shimoda S, Gershwin ME. T cell immunity and primary biliary cirrhosis. Autoimmun Rev 2003, 2(1):19-24. 10.1016/S1568-9972(02)00122-2, 12848971.
    • (2003) Autoimmun Rev , vol.2 , Issue.1 , pp. 19-24
    • Ishibashi, H.1    Nakamura, M.2    Shimoda, S.3    Gershwin, M.E.4
  • 55
    • 43649094708 scopus 로고    scopus 로고
    • The regulatory, inflammatory, and T cell programming roles of interleukin-2 (IL-2)
    • 10.1016/j.jaut.2008.03.002, 18442895
    • Lan RY, Selmi C, Gershwin ME. The regulatory, inflammatory, and T cell programming roles of interleukin-2 (IL-2). J Autoimmun 2008, 31(1):7-12. 10.1016/j.jaut.2008.03.002, 18442895.
    • (2008) J Autoimmun , vol.31 , Issue.1 , pp. 7-12
    • Lan, R.Y.1    Selmi, C.2    Gershwin, M.E.3
  • 56
    • 0029945543 scopus 로고    scopus 로고
    • Molecular aspects and the pathological basis of primary biliary cirrhosis
    • 10.1006/jaut.1996.0015, 8738955
    • Leung PS, Van de Water J, Coppel RL, Nakanuma Y, Munoz S, Gershwin ME. Molecular aspects and the pathological basis of primary biliary cirrhosis. J Autoimmun 1996, 9(2):119-128. 10.1006/jaut.1996.0015, 8738955.
    • (1996) J Autoimmun , vol.9 , Issue.2 , pp. 119-128
    • Leung, P.S.1    Van de Water, J.2    Coppel, R.L.3    Nakanuma, Y.4    Munoz, S.5    Gershwin, M.E.6
  • 57
    • 77956627699 scopus 로고    scopus 로고
    • Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis
    • 10.1002/hep.23783, 2932809, 20568301
    • Lleo A, Bowlus CL, Yang GX, Invernizzi P, Podda M, Van de Water J, Ansari AA, Coppel RL, Worman HJ, Gores GJ, et al. Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis. Hepatology 2010, 52(3):987-998. 10.1002/hep.23783, 2932809, 20568301.
    • (2010) Hepatology , vol.52 , Issue.3 , pp. 987-998
    • Lleo, A.1    Bowlus, C.L.2    Yang, G.X.3    Invernizzi, P.4    Podda, M.5    Van de Water, J.6    Ansari, A.A.7    Coppel, R.L.8    Worman, H.J.9    Gores, G.J.10
  • 61
    • 56349147804 scopus 로고    scopus 로고
    • The consequences of apoptosis in autoimmunity
    • 10.1016/j.jaut.2008.04.009, 2637382, 18513925
    • Lleo A, Selmi C, Invernizzi P, Podda M, Gershwin ME. The consequences of apoptosis in autoimmunity. J Autoimmun 2008, 31(3):257-262. 10.1016/j.jaut.2008.04.009, 2637382, 18513925.
    • (2008) J Autoimmun , vol.31 , Issue.3 , pp. 257-262
    • Lleo, A.1    Selmi, C.2    Invernizzi, P.3    Podda, M.4    Gershwin, M.E.5
  • 62
    • 78651371502 scopus 로고    scopus 로고
    • Primary biliary cirrhosis and autoimmune hepatitis: apotopes and epitopes
    • Lleo A, Shimoda S, Ishibashi H, Gershwin ME. Primary biliary cirrhosis and autoimmune hepatitis: apotopes and epitopes. J Gastroenterol 2011, 46(Suppl 1):29-38.
    • (2011) J Gastroenterol , vol.46 , Issue.SUPPL. 1 , pp. 29-38
    • Lleo, A.1    Shimoda, S.2    Ishibashi, H.3    Gershwin, M.E.4
  • 63
    • 34249895621 scopus 로고    scopus 로고
    • Cytochrome P450IID6-specific CD8 T cell immune responses mirror disease activity in autoimmune hepatitis type 2
    • 10.1002/hep.21658, 17559153
    • Longhi MS, Hussain MJ, Bogdanos DP, Quaglia A, Mieli-Vergani G, Ma Y, Vergani D. Cytochrome P450IID6-specific CD8 T cell immune responses mirror disease activity in autoimmune hepatitis type 2. Hepatology 2007, 46(2):472-484. 10.1002/hep.21658, 17559153.
    • (2007) Hepatology , vol.46 , Issue.2 , pp. 472-484
    • Longhi, M.S.1    Hussain, M.J.2    Bogdanos, D.P.3    Quaglia, A.4    Mieli-Vergani, G.5    Ma, Y.6    Vergani, D.7
  • 64
    • 22444436491 scopus 로고    scopus 로고
    • Effect of CD4+ CD25+ regulatory T-cells on CD8 T-cell function in patients with autoimmune hepatitis
    • 10.1016/j.jaut.2005.05.001, 16298511
    • Longhi MS, Ma Y, Mitry RR, Bogdanos DP, Heneghan M, Cheeseman P, Mieli-Vergani G, Vergani D. Effect of CD4+ CD25+ regulatory T-cells on CD8 T-cell function in patients with autoimmune hepatitis. J Autoimmun 2005, 25(1):63-71. 10.1016/j.jaut.2005.05.001, 16298511.
    • (2005) J Autoimmun , vol.25 , Issue.1 , pp. 63-71
    • Longhi, M.S.1    Ma, Y.2    Mitry, R.R.3    Bogdanos, D.P.4    Heneghan, M.5    Cheeseman, P.6    Mieli-Vergani, G.7    Vergani, D.8
  • 65
    • 0028355710 scopus 로고
    • Activation of autoreactive T-cell clones from NZB.H-2bm12 mice
    • 10.1006/jaut.1994.1021, 7916904
    • Naiki M, Yoshida SH, Ansari AA, Bill J, Gershwin ME. Activation of autoreactive T-cell clones from NZB.H-2bm12 mice. J Autoimmun 1994, 7(3):275-290. 10.1006/jaut.1994.1021, 7916904.
    • (1994) J Autoimmun , vol.7 , Issue.3 , pp. 275-290
    • Naiki, M.1    Yoshida, S.H.2    Ansari, A.A.3    Bill, J.4    Gershwin, M.E.5
  • 66
    • 79959549320 scopus 로고    scopus 로고
    • Epithelial cell specificity and apotope recognition by serum autoantibodies in primary biliary cirrhosis
    • 10.1002/hep.24355, 3125447, 21488079
    • Rong G, Zhong R, Lleo A, Leung PS, Bowlus CL, Yang GX, Yang CY, Coppel RL, Ansari AA, Cuebas DA, et al. Epithelial cell specificity and apotope recognition by serum autoantibodies in primary biliary cirrhosis. Hepatology 2011, 54(1):196-203. 10.1002/hep.24355, 3125447, 21488079.
    • (2011) Hepatology , vol.54 , Issue.1 , pp. 196-203
    • Rong, G.1    Zhong, R.2    Lleo, A.3    Leung, P.S.4    Bowlus, C.L.5    Yang, G.X.6    Yang, C.Y.7    Coppel, R.L.8    Ansari, A.A.9    Cuebas, D.A.10
  • 68
    • 0034456203 scopus 로고    scopus 로고
    • Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: searching for a mimic
    • 10.1006/jaut.2000.0390, 10936028
    • Sasaki M, Ansari A, Pumford N, van de Water J, Leung PS, Humphries KM, Szweda LI, Nakanuma Y, Roche TE, Coppel RL, et al. Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: searching for a mimic. J Autoimmun 2000, 15(1):51-60. 10.1006/jaut.2000.0390, 10936028.
    • (2000) J Autoimmun , vol.15 , Issue.1 , pp. 51-60
    • Sasaki, M.1    Ansari, A.2    Pumford, N.3    van de Water, J.4    Leung, P.S.5    Humphries, K.M.6    Szweda, L.I.7    Nakanuma, Y.8    Roche, T.E.9    Coppel, R.L.10
  • 69
    • 84864768947 scopus 로고    scopus 로고
    • Immune-mediated bile duct injury: The case of primary biliary cirrhosis
    • 10.4291/wjgp.v1.i4.118, 3097954, 21607152
    • Selmi C, Affronti A, Ferrari L, Invernizzi P. Immune-mediated bile duct injury: The case of primary biliary cirrhosis. World J Gastrointest Pathophysiol 2010, 1(4):118-128. 10.4291/wjgp.v1.i4.118, 3097954, 21607152.
    • (2010) World J Gastrointest Pathophysiol , vol.1 , Issue.4 , pp. 118-128
    • Selmi, C.1    Affronti, A.2    Ferrari, L.3    Invernizzi, P.4
  • 71
    • 78651064512 scopus 로고    scopus 로고
    • The autoimmunity of primary biliary cirrhosis and the clonal selection theory
    • 10.1038/icb.2010.126, 3017230, 20975735
    • Selmi C, Mackay IR, Gershwin ME. The autoimmunity of primary biliary cirrhosis and the clonal selection theory. Immunol Cell Biol 2011, 89(1):70-80. 10.1038/icb.2010.126, 3017230, 20975735.
    • (2011) Immunol Cell Biol , vol.89 , Issue.1 , pp. 70-80
    • Selmi, C.1    Mackay, I.R.2    Gershwin, M.E.3
  • 72
    • 4143106857 scopus 로고    scopus 로고
    • Lack of immunological or molecular evidence for a role of mouse mammary tumor retrovirus in primary biliary cirrhosis
    • 10.1053/j.gastro.2004.05.033, 15300582
    • Selmi C, Ross SR, Ansari AA, Invernizzi P, Podda M, Coppel RL, Gershwin ME. Lack of immunological or molecular evidence for a role of mouse mammary tumor retrovirus in primary biliary cirrhosis. Gastroenterology 2004, 127(2):493-501. 10.1053/j.gastro.2004.05.033, 15300582.
    • (2004) Gastroenterology , vol.127 , Issue.2 , pp. 493-501
    • Selmi, C.1    Ross, S.R.2    Ansari, A.A.3    Invernizzi, P.4    Podda, M.5    Coppel, R.L.6    Gershwin, M.E.7
  • 73
    • 79953762710 scopus 로고    scopus 로고
    • Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis
    • 10.1002/hep.24194, 3077894, 21400555
    • Shimoda S, Harada K, Niiro H, Shirabe K, Taketomi A, Maehara Y, Tsuneyama K, Nakanuma Y, Leung P, Ansari AA, et al. Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis. Hepatology 2011, 53(4):1270-1281. 10.1002/hep.24194, 3077894, 21400555.
    • (2011) Hepatology , vol.53 , Issue.4 , pp. 1270-1281
    • Shimoda, S.1    Harada, K.2    Niiro, H.3    Shirabe, K.4    Taketomi, A.5    Maehara, Y.6    Tsuneyama, K.7    Nakanuma, Y.8    Leung, P.9    Ansari, A.A.10
  • 74
    • 33746542732 scopus 로고    scopus 로고
    • Autoreactive T-cell responses in primary biliary cirrhosis are proinflammatory whereas those of controls are regulatory
    • 10.1053/j.gastro.2006.05.056, 16890612
    • Shimoda S, Ishikawa F, Kamihira T, Komori A, Niiro H, Baba E, Harada K, Isse K, Nakanuma Y, Ishibashi H, et al. Autoreactive T-cell responses in primary biliary cirrhosis are proinflammatory whereas those of controls are regulatory. Gastroenterology 2006, 131(2):606-618. 10.1053/j.gastro.2006.05.056, 16890612.
    • (2006) Gastroenterology , vol.131 , Issue.2 , pp. 606-618
    • Shimoda, S.1    Ishikawa, F.2    Kamihira, T.3    Komori, A.4    Niiro, H.5    Baba, E.6    Harada, K.7    Isse, K.8    Nakanuma, Y.9    Ishibashi, H.10
  • 75
    • 50549091821 scopus 로고    scopus 로고
    • CD4 T-cell autoreactivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis
    • 10.1016/j.jaut.2008.05.003, 18644699
    • Shimoda S, Miyakawa H, Nakamura M, Ishibashi H, Kikuchi K, Kita H, Niiro H, Arinobu Y, Ono N, Mackay IR, et al. CD4 T-cell autoreactivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis. J Autoimmun 2008, 31(2):110-115. 10.1016/j.jaut.2008.05.003, 18644699.
    • (2008) J Autoimmun , vol.31 , Issue.2 , pp. 110-115
    • Shimoda, S.1    Miyakawa, H.2    Nakamura, M.3    Ishibashi, H.4    Kikuchi, K.5    Kita, H.6    Niiro, H.7    Arinobu, Y.8    Ono, N.9    Mackay, I.R.10
  • 76
    • 56749133320 scopus 로고    scopus 로고
    • The autoimmunologist: geoepidemiology, a new center of gravity, and prime time for autoimmunity
    • 10.1016/j.jaut.2008.08.004, 18838248
    • Shoenfeld Y, Selmi C, Zimlichman E, Gershwin ME. The autoimmunologist: geoepidemiology, a new center of gravity, and prime time for autoimmunity. J Autoimmun 2008, 31(4):325-330. 10.1016/j.jaut.2008.08.004, 18838248.
    • (2008) J Autoimmun , vol.31 , Issue.4 , pp. 325-330
    • Shoenfeld, Y.1    Selmi, C.2    Zimlichman, E.3    Gershwin, M.E.4
  • 77
    • 0035422204 scopus 로고    scopus 로고
    • Genomic analysis of differentially expressed genes in liver and biliary epithelial cells of patients with primary biliary cirrhosis
    • 10.1006/jaut.2001.0522, 11488641
    • Tanaka A, Leung PS, Kenny TP, Au-Young J, Prindiville T, Coppel RL, Ansari AA, Gershwin ME. Genomic analysis of differentially expressed genes in liver and biliary epithelial cells of patients with primary biliary cirrhosis. J Autoimmun 2001, 17(1):89-98. 10.1006/jaut.2001.0522, 11488641.
    • (2001) J Autoimmun , vol.17 , Issue.1 , pp. 89-98
    • Tanaka, A.1    Leung, P.S.2    Kenny, T.P.3    Au-Young, J.4    Prindiville, T.5    Coppel, R.L.6    Ansari, A.A.7    Gershwin, M.E.8
  • 79
    • 0026356011 scopus 로고
    • The identification and cloning of the murine genes encoding the liver specific F alloantigens
    • 10.1016/0896-8411(91)90049-I, 1667467
    • Teuber SS, Coppel RL, Ansari AA, Leung PS, Neve R, Mackay IR, Gershwin ME. The identification and cloning of the murine genes encoding the liver specific F alloantigens. J Autoimmun 1991, 4(6):857-870. 10.1016/0896-8411(91)90049-I, 1667467.
    • (1991) J Autoimmun , vol.4 , Issue.6 , pp. 857-870
    • Teuber, S.S.1    Coppel, R.L.2    Ansari, A.A.3    Leung, P.S.4    Neve, R.5    Mackay, I.R.6    Gershwin, M.E.7
  • 81
    • 0141532278 scopus 로고    scopus 로고
    • Myeloperoxidase-positive inflammatory cells participate in bile duct damage in primary biliary cirrhosis through nitric oxide-mediated reactions
    • Wu CT, Eiserich JP, Ansari AA, Coppel RL, Balasubramanian S, Bowlus CL, Gershwin ME, Van De Water J. Myeloperoxidase-positive inflammatory cells participate in bile duct damage in primary biliary cirrhosis through nitric oxide-mediated reactions. Hepatology 2003, 38(4):1018-1025.
    • (2003) Hepatology , vol.38 , Issue.4 , pp. 1018-1025
    • Wu, C.T.1    Eiserich, J.P.2    Ansari, A.A.3    Coppel, R.L.4    Balasubramanian, S.5    Bowlus, C.L.6    Gershwin, M.E.7    Van De Water, J.8
  • 82
    • 79952223723 scopus 로고    scopus 로고
    • Innate immunity and primary biliary cirrhosis: activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosis
    • 10.1002/hep.24113, 3076334, 21374662
    • Wu SJ, Yang YH, Tsuneyama K, Leung PS, Illarionov P, Gershwin ME, Chuang YH. Innate immunity and primary biliary cirrhosis: activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosis. Hepatology 2011, 53(3):915-925. 10.1002/hep.24113, 3076334, 21374662.
    • (2011) Hepatology , vol.53 , Issue.3 , pp. 915-925
    • Wu, S.J.1    Yang, Y.H.2    Tsuneyama, K.3    Leung, P.S.4    Illarionov, P.5    Gershwin, M.E.6    Chuang, Y.H.7
  • 83
    • 0032697569 scopus 로고    scopus 로고
    • Anti-pyruvate dehydrogenase autoantibodies in extrahepatic disorders
    • 10.1016/S0168-8278(99)80302-X, 10580598
    • Zamfir O, Briaud I, Dubel L, Ballot E, Johanet C. Anti-pyruvate dehydrogenase autoantibodies in extrahepatic disorders. J Hepatol 1999, 31(5):964-965. 10.1016/S0168-8278(99)80302-X, 10580598.
    • (1999) J Hepatol , vol.31 , Issue.5 , pp. 964-965
    • Zamfir, O.1    Briaud, I.2    Dubel, L.3    Ballot, E.4    Johanet, C.5
  • 84
    • 80052662284 scopus 로고    scopus 로고
    • T cell clonal expansions detected in patients with primary biliary cirrhosis express CX3CR1
    • 10.1016/j.jaut.2011.05.009, 21636249
    • Zhang W, Ono Y, Miyamura Y, Bowlus CL, Gershwin ME, Maverakis E. T cell clonal expansions detected in patients with primary biliary cirrhosis express CX3CR1. J Autoimmun 2011, 37(2):71-78. 10.1016/j.jaut.2011.05.009, 21636249.
    • (2011) J Autoimmun , vol.37 , Issue.2 , pp. 71-78
    • Zhang, W.1    Ono, Y.2    Miyamura, Y.3    Bowlus, C.L.4    Gershwin, M.E.5    Maverakis, E.6
  • 85
    • 18144383173 scopus 로고    scopus 로고
    • From bases to basis: linking genetics to causation in primary biliary cirrhosis
    • 10.1016/S1542-3565(04)00678-0, 15880308
    • Invernizzi P, Selmi C, Mackay IR, Podda M, Gershwin ME. From bases to basis: linking genetics to causation in primary biliary cirrhosis. Clin Gastroenterol Hepatol 2005, 3(5):401-410. 10.1016/S1542-3565(04)00678-0, 15880308.
    • (2005) Clin Gastroenterol Hepatol , vol.3 , Issue.5 , pp. 401-410
    • Invernizzi, P.1    Selmi, C.2    Mackay, I.R.3    Podda, M.4    Gershwin, M.E.5
  • 87
    • 79955634917 scopus 로고    scopus 로고
    • Progress in the genetics of primary biliary cirrhosis
    • 10.1055/s-0031-1276644, 21538281
    • Hirschfield GM, Invernizzi P. Progress in the genetics of primary biliary cirrhosis. Semin Liver Dis 2011, 31(2):147-156. 10.1055/s-0031-1276644, 21538281.
    • (2011) Semin Liver Dis , vol.31 , Issue.2 , pp. 147-156
    • Hirschfield, G.M.1    Invernizzi, P.2
  • 88
    • 67349226871 scopus 로고    scopus 로고
    • Future directions in genetic for autoimmune diseases
    • 10.1016/j.jaut.2009.03.001, 19410428
    • Invernizzi P. Future directions in genetic for autoimmune diseases. J Autoimmun 2009, 33(1):1-2. 10.1016/j.jaut.2009.03.001, 19410428.
    • (2009) J Autoimmun , vol.33 , Issue.1 , pp. 1-2
    • Invernizzi, P.1
  • 89
    • 84864774463 scopus 로고    scopus 로고
    • HLA in primary biliary cirrhosis: An old story now reviving
    • Invernizzi P. HLA in primary biliary cirrhosis: An old story now reviving. Hepatology 2011,
    • (2011) Hepatology
    • Invernizzi, P.1
  • 91
    • 53049092302 scopus 로고    scopus 로고
    • The genetic basis of primary biliary cirrhosis: premises, not promises
    • 10.1053/j.gastro.2008.08.020, 2629658, 18773895
    • Invernizzi P, Gershwin ME. The genetic basis of primary biliary cirrhosis: premises, not promises. Gastroenterology 2008, 135(4):1044-1047. 10.1053/j.gastro.2008.08.020, 2629658, 18773895.
    • (2008) Gastroenterology , vol.135 , Issue.4 , pp. 1044-1047
    • Invernizzi, P.1    Gershwin, M.E.2
  • 92
    • 71649102108 scopus 로고    scopus 로고
    • The genetics of human autoimmune disease
    • Invernizzi P, Gershwin ME. The genetics of human autoimmune disease. J Autoimmun 2009, 33(3-4):290-299.
    • (2009) J Autoimmun , vol.33 , Issue.3-4 , pp. 290-299
    • Invernizzi, P.1    Gershwin, M.E.2
  • 96
    • 67349085696 scopus 로고    scopus 로고
    • Female predominance and X chromosome defects in autoimmune diseases
    • 10.1016/j.jaut.2009.03.005, 19356902
    • Invernizzi P, Pasini S, Selmi C, Gershwin ME, Podda M. Female predominance and X chromosome defects in autoimmune diseases. J Autoimmun 2009, 33(1):12-16. 10.1016/j.jaut.2009.03.005, 19356902.
    • (2009) J Autoimmun , vol.33 , Issue.1 , pp. 12-16
    • Invernizzi, P.1    Pasini, S.2    Selmi, C.3    Gershwin, M.E.4    Podda, M.5
  • 97
    • 58149376547 scopus 로고    scopus 로고
    • Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: a multicenter study of 664 patients and 1992 healthy controls
    • 10.1002/hep.22567, 2592501, 19003916
    • Invernizzi P, Selmi C, Poli F, Frison S, Floreani A, Alvaro D, Almasio P, Rosina F, Marzioni M, Fabris L, et al. Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: a multicenter study of 664 patients and 1992 healthy controls. Hepatology 2008, 48(6):1906-1912. 10.1002/hep.22567, 2592501, 19003916.
    • (2008) Hepatology , vol.48 , Issue.6 , pp. 1906-1912
    • Invernizzi, P.1    Selmi, C.2    Poli, F.3    Frison, S.4    Floreani, A.5    Alvaro, D.6    Almasio, P.7    Rosina, F.8    Marzioni, M.9    Fabris, L.10
  • 98
    • 20144363210 scopus 로고    scopus 로고
    • Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis
    • 10.1016/j.jaut.2005.03.002, 15878652
    • Kikuchi K, Lian ZX, Kimura Y, Selmi C, Yang GX, Gordon SC, Invernizzi P, Podda M, Coppel RL, Ansari AA, et al. Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis. J Autoimmun 2005, 24(4):347-352. 10.1016/j.jaut.2005.03.002, 15878652.
    • (2005) J Autoimmun , vol.24 , Issue.4 , pp. 347-352
    • Kikuchi, K.1    Lian, Z.X.2    Kimura, Y.3    Selmi, C.4    Yang, G.X.5    Gordon, S.C.6    Invernizzi, P.7    Podda, M.8    Coppel, R.L.9    Ansari, A.A.10
  • 99
    • 19944427556 scopus 로고    scopus 로고
    • Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis
    • 10.1002/hep.20516, 15690482
    • Kimura Y, Selmi C, Leung PS, Mao TK, Schauer J, Watnik M, Kuriyama S, Nishioka M, Ansari AA, Coppel RL, et al. Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis. Hepatology 2005, 41(1):55-63. 10.1002/hep.20516, 15690482.
    • (2005) Hepatology , vol.41 , Issue.1 , pp. 55-63
    • Kimura, Y.1    Selmi, C.2    Leung, P.S.3    Mao, T.K.4    Schauer, J.5    Watnik, M.6    Kuriyama, S.7    Nishioka, M.8    Ansari, A.A.9    Coppel, R.L.10
  • 100
    • 77955088582 scopus 로고    scopus 로고
    • Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
    • 10.1038/ng.627, 3150510, 20639880
    • Liu X, Invernizzi P, Lu Y, Kosoy R, Bianchi I, Podda M, Xu C, Xie G, Macciardi F, Selmi C, et al. Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nat Genet 2010, 42(8):658-660. 10.1038/ng.627, 3150510, 20639880.
    • (2010) Nat Genet , vol.42 , Issue.8 , pp. 658-660
    • Liu, X.1    Invernizzi, P.2    Lu, Y.3    Kosoy, R.4    Bianchi, I.5    Podda, M.6    Xu, C.7    Xie, G.8    Macciardi, F.9    Selmi, C.10
  • 102
    • 78651238248 scopus 로고    scopus 로고
    • Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis
    • 10.4161/epi.6.1.13405, 3029486,3029486, 20864813
    • Mitchell MM, Lleo A, Zammataro L, Mayo MJ, Invernizzi P, Bach N, Shimoda S, Gordon S, Podda M, Gershwin ME, et al. Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis. Epigenetics 2011, 6(1):95-102. 10.4161/epi.6.1.13405, 3029486,3029486, 20864813.
    • (2011) Epigenetics , vol.6 , Issue.1 , pp. 95-102
    • Mitchell, M.M.1    Lleo, A.2    Zammataro, L.3    Mayo, M.J.4    Invernizzi, P.5    Bach, N.6    Shimoda, S.7    Gordon, S.8    Podda, M.9    Gershwin, M.E.10
  • 104
    • 24044442553 scopus 로고    scopus 로고
    • Genes and goals: an approach to microarray analysis in autoimmunity
    • 10.1016/j.autrev.2005.05.004, 16137606
    • Oertelt S, Selmi C, Invernizzi P, Podda M, Gershwin ME. Genes and goals: an approach to microarray analysis in autoimmunity. Autoimmun Rev 2005, 4(7):414-422. 10.1016/j.autrev.2005.05.004, 16137606.
    • (2005) Autoimmun Rev , vol.4 , Issue.7 , pp. 414-422
    • Oertelt, S.1    Selmi, C.2    Invernizzi, P.3    Podda, M.4    Gershwin, M.E.5
  • 106
    • 24344502234 scopus 로고    scopus 로고
    • Genetics and geoepidemiology of primary biliary cirrhosis: following the footprints to disease etiology
    • 10.1055/s-2005-916319, 16143943
    • Selmi C, Invernizzi P, Zuin M, Podda M, Gershwin ME. Genetics and geoepidemiology of primary biliary cirrhosis: following the footprints to disease etiology. Semin Liver Dis 2005, 25(3):265-280. 10.1055/s-2005-916319, 16143943.
    • (2005) Semin Liver Dis , vol.25 , Issue.3 , pp. 265-280
    • Selmi, C.1    Invernizzi, P.2    Zuin, M.3    Podda, M.4    Gershwin, M.E.5
  • 107
    • 27844477306 scopus 로고    scopus 로고
    • Genes and (auto)immunity in primary biliary cirrhosis
    • 10.1038/sj.gene.6364248, 16034472
    • Selmi C, Invernizzi P, Zuin M, Podda M, Seldin MF, Gershwin ME. Genes and (auto)immunity in primary biliary cirrhosis. Genes Immun 2005, 6(7):543-556. 10.1038/sj.gene.6364248, 16034472.
    • (2005) Genes Immun , vol.6 , Issue.7 , pp. 543-556
    • Selmi, C.1    Invernizzi, P.2    Zuin, M.3    Podda, M.4    Seldin, M.F.5    Gershwin, M.E.6
  • 108
  • 110
    • 79958769177 scopus 로고    scopus 로고
    • Replicated association of 17q12-21 with susceptibility of primary biliary cirrhosis in a Japanese cohort
    • 10.1111/j.1399-0039.2011.01684.x, 21506939
    • Tanaka A, Invernizzi P, Ohira H, Kikuchi K, Nezu S, Kosoy R, Seldin MF, Gershwin ME, Takikawa H. Replicated association of 17q12-21 with susceptibility of primary biliary cirrhosis in a Japanese cohort. Tissue Antigens 2011, 78(1):65-68. 10.1111/j.1399-0039.2011.01684.x, 21506939.
    • (2011) Tissue Antigens , vol.78 , Issue.1 , pp. 65-68
    • Tanaka, A.1    Invernizzi, P.2    Ohira, H.3    Kikuchi, K.4    Nezu, S.5    Kosoy, R.6    Seldin, M.F.7    Gershwin, M.E.8    Takikawa, H.9
  • 111
    • 67349255018 scopus 로고    scopus 로고
    • Vitamin D receptor polymorphisms are associated with increased susceptibility to primary biliary cirrhosis in Japanese and Italian populations
    • 10.1016/j.jhep.2009.01.015, 19376604
    • Tanaka A, Nezu S, Uegaki S, Kikuchi K, Shibuya A, Miyakawa H, Takahashi S, Bianchi I, Zermiani P, Podda M, et al. Vitamin D receptor polymorphisms are associated with increased susceptibility to primary biliary cirrhosis in Japanese and Italian populations. J Hepatol 2009, 50(6):1202-1209. 10.1016/j.jhep.2009.01.015, 19376604.
    • (2009) J Hepatol , vol.50 , Issue.6 , pp. 1202-1209
    • Tanaka, A.1    Nezu, S.2    Uegaki, S.3    Kikuchi, K.4    Shibuya, A.5    Miyakawa, H.6    Takahashi, S.7    Bianchi, I.8    Zermiani, P.9    Podda, M.10
  • 112
    • 1242269935 scopus 로고    scopus 로고
    • Autoimmunity and environmental factors in the pathogenesis of primary biliary cirrhosis
    • 10.1080/07853890310018467, 15000349
    • Kita H, He XS, Gershwin ME. Autoimmunity and environmental factors in the pathogenesis of primary biliary cirrhosis. Ann Med 2004, 36(1):72-80. 10.1080/07853890310018467, 15000349.
    • (2004) Ann Med , vol.36 , Issue.1 , pp. 72-80
    • Kita, H.1    He, X.S.2    Gershwin, M.E.3
  • 114
    • 3042626975 scopus 로고    scopus 로고
    • Bacteria and human autoimmunity: the case of primary biliary cirrhosis
    • 10.1097/01.bor.0000130538.76808.c2, 15201604
    • Selmi C, Gershwin ME. Bacteria and human autoimmunity: the case of primary biliary cirrhosis. Curr Opin Rheumatol 2004, 16(4):406-410. 10.1097/01.bor.0000130538.76808.c2, 15201604.
    • (2004) Curr Opin Rheumatol , vol.16 , Issue.4 , pp. 406-410
    • Selmi, C.1    Gershwin, M.E.2
  • 115
  • 116
    • 0027319044 scopus 로고
    • Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2
    • 10.1172/JCI116504, 443329, 8514873
    • Van de Water J, Turchany J, Leung PS, Lake J, Munoz S, Surh CD, Coppel R, Ansari A, Nakanuma Y, Gershwin ME. Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2. J Clin Invest 1993, 91(6):2653-2664. 10.1172/JCI116504, 443329, 8514873.
    • (1993) J Clin Invest , vol.91 , Issue.6 , pp. 2653-2664
    • Van de Water, J.1    Turchany, J.2    Leung, P.S.3    Lake, J.4    Munoz, S.5    Surh, C.D.6    Coppel, R.7    Ansari, A.8    Nakanuma, Y.9    Gershwin, M.E.10
  • 118
    • 79951661765 scopus 로고    scopus 로고
    • PBC triggers in water reservoirs, coal mining areas and waste disposal sites: from Newcastle to New York
    • Smyk D, Mytilinaiou MG, Rigopoulou EI, Bogdanos DP. PBC triggers in water reservoirs, coal mining areas and waste disposal sites: from Newcastle to New York. Dis Markers 2010, 29(6):337-344.
    • (2010) Dis Markers , vol.29 , Issue.6 , pp. 337-344
    • Smyk, D.1    Mytilinaiou, M.G.2    Rigopoulou, E.I.3    Bogdanos, D.P.4
  • 120
    • 48449098497 scopus 로고    scopus 로고
    • Primary biliary cirrhosis following Lactobacillus vaccination for recurrent vaginitis
    • 10.1016/j.jhep.2008.05.022, 18644655
    • Bogdanos D, Pusl T, Rust C, Vergani D, Beuers U. Primary biliary cirrhosis following Lactobacillus vaccination for recurrent vaginitis. J Hepatol 2008, 49(3):466-473. 10.1016/j.jhep.2008.05.022, 18644655.
    • (2008) J Hepatol , vol.49 , Issue.3 , pp. 466-473
    • Bogdanos, D.1    Pusl, T.2    Rust, C.3    Vergani, D.4    Beuers, U.5
  • 121
    • 1542389147 scopus 로고    scopus 로고
    • Association between the primary biliary cirrhosis specific anti-sp100 antibodies and recurrent urinary tract infection
    • 10.1016/S1590-8658(03)00466-3, 14674671
    • Bogdanos DP, Baum H, Butler P, Rigopoulou EI, Davies ET, Ma Y, Burroughs AK, Vergani D. Association between the primary biliary cirrhosis specific anti-sp100 antibodies and recurrent urinary tract infection. Dig Liver Dis 2003, 35(11):801-805. 10.1016/S1590-8658(03)00466-3, 14674671.
    • (2003) Dig Liver Dis , vol.35 , Issue.11 , pp. 801-805
    • Bogdanos, D.P.1    Baum, H.2    Butler, P.3    Rigopoulou, E.I.4    Davies, E.T.5    Ma, Y.6    Burroughs, A.K.7    Vergani, D.8
  • 122
    • 0346689993 scopus 로고    scopus 로고
    • Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis
    • 10.1016/S0168-8278(03)00501-4, 14672611
    • Bogdanos DP, Baum H, Grasso A, Okamoto M, Butler P, Ma Y, Rigopoulou E, Montalto P, Davies ET, Burroughs AK, et al. Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis. J Hepatol 2004, 40(1):31-39. 10.1016/S0168-8278(03)00501-4, 14672611.
    • (2004) J Hepatol , vol.40 , Issue.1 , pp. 31-39
    • Bogdanos, D.P.1    Baum, H.2    Grasso, A.3    Okamoto, M.4    Butler, P.5    Ma, Y.6    Rigopoulou, E.7    Montalto, P.8    Davies, E.T.9    Burroughs, A.K.10
  • 123
    • 6344228782 scopus 로고    scopus 로고
    • Extensive homology between the major immunodominant mitochondrial antigen in primary biliary cirrhosis and Helicobacter pylori does not lead to immunological cross-reactivity
    • 10.1080/00365520410003236, 15513338
    • Bogdanos DP, Baum H, Gunsar F, Arioli D, Polymeros D, Ma Y, Burroughs AK, Vergani D. Extensive homology between the major immunodominant mitochondrial antigen in primary biliary cirrhosis and Helicobacter pylori does not lead to immunological cross-reactivity. Scand J Gastroenterol 2004, 39(10):981-987. 10.1080/00365520410003236, 15513338.
    • (2004) Scand J Gastroenterol , vol.39 , Issue.10 , pp. 981-987
    • Bogdanos, D.P.1    Baum, H.2    Gunsar, F.3    Arioli, D.4    Polymeros, D.5    Ma, Y.6    Burroughs, A.K.7    Vergani, D.8
  • 124
    • 23044467085 scopus 로고    scopus 로고
    • Primary biliary cirrhosis is characterized by IgG3 antibodies cross-reactive with the major mitochondrial autoepitope and its Lactobacillus mimic
    • 10.1002/hep.20788, 16025495
    • Bogdanos DP, Baum H, Okamoto M, Montalto P, Sharma UC, Rigopoulou EI, Vlachogiannakos J, Ma Y, Burroughs AK, Vergani D. Primary biliary cirrhosis is characterized by IgG3 antibodies cross-reactive with the major mitochondrial autoepitope and its Lactobacillus mimic. Hepatology 2005, 42(2):458-465. 10.1002/hep.20788, 16025495.
    • (2005) Hepatology , vol.42 , Issue.2 , pp. 458-465
    • Bogdanos, D.P.1    Baum, H.2    Okamoto, M.3    Montalto, P.4    Sharma, U.C.5    Rigopoulou, E.I.6    Vlachogiannakos, J.7    Ma, Y.8    Burroughs, A.K.9    Vergani, D.10
  • 125
    • 0036126558 scopus 로고    scopus 로고
    • Antibodies against homologous microbial caseinolytic proteases P characterise primary biliary cirrhosis
    • 10.1016/S0168-8278(01)00252-5, 11804659
    • Bogdanos DP, Baum H, Sharma UC, Grasso A, Ma Y, Burroughs AK, Vergani D. Antibodies against homologous microbial caseinolytic proteases P characterise primary biliary cirrhosis. J Hepatol 2002, 36(1):14-21. 10.1016/S0168-8278(01)00252-5, 11804659.
    • (2002) J Hepatol , vol.36 , Issue.1 , pp. 14-21
    • Bogdanos, D.P.1    Baum, H.2    Sharma, U.C.3    Grasso, A.4    Ma, Y.5    Burroughs, A.K.6    Vergani, D.7
  • 126
    • 79951629112 scopus 로고    scopus 로고
    • The role of E. coli infection in the pathogenesis of primary biliary cirrhosis.
    • Bogdanos DP, Baum H, Vergani D, Burroughs AK. The role of E. coli infection in the pathogenesis of primary biliary cirrhosis. Dis Markers 2010, 29(6):301-311.
    • (2010) Dis Markers , vol.29 , Issue.6 , pp. 301-311
    • Bogdanos, D.P.1    Baum, H.2    Vergani, D.3    Burroughs, A.K.4
  • 127
    • 33748485365 scopus 로고    scopus 로고
    • Borrelia Burgdorferi: a new self-mimicking trigger in primary biliary cirrhosis
    • author reply 782-783, 10.1016/j.dld.2006.05.010, 16870516
    • Bogdanos DP, Koutsoumpas A, Baum H, Vergani D. Borrelia Burgdorferi: a new self-mimicking trigger in primary biliary cirrhosis. Dig Liver Dis 2006, 38(10):781-782. author reply 782-783, 10.1016/j.dld.2006.05.010, 16870516.
    • (2006) Dig Liver Dis , vol.38 , Issue.10 , pp. 781-782
    • Bogdanos, D.P.1    Koutsoumpas, A.2    Baum, H.3    Vergani, D.4
  • 128
    • 2142711248 scopus 로고    scopus 로고
    • Disease-specific cross-reactivity between mimicking peptides of heat shock protein of Mycobacterium gordonae and dominant epitope of E2 subunit of pyruvate dehydrogenase is common in Spanish but not British patients with primary biliary cirrhosis
    • 10.1016/j.jaut.2004.03.002, 15120760
    • Bogdanos DP, Pares A, Baum H, Caballeria L, Rigopoulou EI, Ma Y, Burroughs AK, Rodes J, Vergani D. Disease-specific cross-reactivity between mimicking peptides of heat shock protein of Mycobacterium gordonae and dominant epitope of E2 subunit of pyruvate dehydrogenase is common in Spanish but not British patients with primary biliary cirrhosis. J Autoimmun 2004, 22(4):353-362. 10.1016/j.jaut.2004.03.002, 15120760.
    • (2004) J Autoimmun , vol.22 , Issue.4 , pp. 353-362
    • Bogdanos, D.P.1    Pares, A.2    Baum, H.3    Caballeria, L.4    Rigopoulou, E.I.5    Ma, Y.6    Burroughs, A.K.7    Rodes, J.8    Vergani, D.9
  • 129
    • 33745610428 scopus 로고    scopus 로고
    • Origin of cross-reactive autoimmunity in primary biliary cirrhosis
    • 10.1111/j.1478-3231.2006.01291.x, 16842317
    • Bogdanos DP, Vergani D. Origin of cross-reactive autoimmunity in primary biliary cirrhosis. Liver Int 2006, 26(6):633-635. 10.1111/j.1478-3231.2006.01291.x, 16842317.
    • (2006) Liver Int , vol.26 , Issue.6 , pp. 633-635
    • Bogdanos, D.P.1    Vergani, D.2
  • 130
    • 61949474897 scopus 로고    scopus 로고
    • Bacteria and primary biliary cirrhosis
    • 10.1007/s12016-008-8087-9, 18498061
    • Bogdanos DP, Vergani D. Bacteria and primary biliary cirrhosis. Clin Rev Allergy Immunol 2009, 36(1):30-39. 10.1007/s12016-008-8087-9, 18498061.
    • (2009) Clin Rev Allergy Immunol , vol.36 , Issue.1 , pp. 30-39
    • Bogdanos, D.P.1    Vergani, D.2
  • 131
    • 70349747358 scopus 로고    scopus 로고
    • Anti-Helicobacter pylori antibody responses specific for VacA do not trigger primary biliary cirrhosis-specific antimitochondrial antibodies
    • Koutsoumpas A, Mytilinaiou M, Polymeros D, Dalekos GN, Bogdanos DP. Anti-Helicobacter pylori antibody responses specific for VacA do not trigger primary biliary cirrhosis-specific antimitochondrial antibodies. Eur J Gastroenterol Hepatol 2009, 21(10):1220.
    • (2009) Eur J Gastroenterol Hepatol , vol.21 , Issue.10 , pp. 1220
    • Koutsoumpas, A.1    Mytilinaiou, M.2    Polymeros, D.3    Dalekos, G.N.4    Bogdanos, D.P.5
  • 132
    • 1442355473 scopus 로고    scopus 로고
    • Unusual suspects in primary biliary cirrhosis
    • 10.1002/hep.20028, 14752820
    • Vergani D, Bogdanos DP, Baum H. Unusual suspects in primary biliary cirrhosis. Hepatology 2004, 39(1):38-41. 10.1002/hep.20028, 14752820.
    • (2004) Hepatology , vol.39 , Issue.1 , pp. 38-41
    • Vergani, D.1    Bogdanos, D.P.2    Baum, H.3
  • 133
    • 78651064276 scopus 로고    scopus 로고
    • Infectious agents and xenobiotics in the etiology of primary biliary cirrhosis
    • Selmi C, De Santis M, Cavaciocchi F, Gershwin ME. Infectious agents and xenobiotics in the etiology of primary biliary cirrhosis. Dis Markers 2010, 29(6):287-299.
    • (2010) Dis Markers , vol.29 , Issue.6 , pp. 287-299
    • Selmi, C.1    De Santis, M.2    Cavaciocchi, F.3    Gershwin, M.E.4
  • 134
    • 68149119166 scopus 로고    scopus 로고
    • The role of environmental factors in primary biliary cirrhosis
    • 10.1016/j.it.2009.05.006, 19643668
    • Selmi C, Gershwin ME. The role of environmental factors in primary biliary cirrhosis. Trends Immunol 2009, 30(8):415-420. 10.1016/j.it.2009.05.006, 19643668.
    • (2009) Trends Immunol , vol.30 , Issue.8 , pp. 415-420
    • Selmi, C.1    Gershwin, M.E.2
  • 135
    • 61949237483 scopus 로고    scopus 로고
    • The chemical pathway to primary biliary cirrhosis
    • 10.1007/s12016-008-8089-7, 18509764
    • Selmi C, Cocchi CA, Zuin M, Gershwin ME. The chemical pathway to primary biliary cirrhosis. Clin Rev Allergy Immunol 2009, 36(1):23-29. 10.1007/s12016-008-8089-7, 18509764.
    • (2009) Clin Rev Allergy Immunol , vol.36 , Issue.1 , pp. 23-29
    • Selmi, C.1    Cocchi, C.A.2    Zuin, M.3    Gershwin, M.E.4
  • 136
    • 77649179578 scopus 로고    scopus 로고
    • Geoepidemiology of autoimmune liver diseases
    • 10.1016/j.jaut.2009.12.002, 20036105
    • Invernizzi P. Geoepidemiology of autoimmune liver diseases. J Autoimmun 2010, 34(3):J300-J306. 10.1016/j.jaut.2009.12.002, 20036105.
    • (2010) J Autoimmun , vol.34 , Issue.3
    • Invernizzi, P.1
  • 137
    • 0035196753 scopus 로고    scopus 로고
    • Risk factors for primary biliary cirrhosis in a cohort of patients from the united states
    • 10.1053/jhep.2001.21165, 11124815
    • Parikh-Patel A, Gold EB, Worman H, Krivy KE, Gershwin ME. Risk factors for primary biliary cirrhosis in a cohort of patients from the united states. Hepatology 2001, 33(1):16-21. 10.1053/jhep.2001.21165, 11124815.
    • (2001) Hepatology , vol.33 , Issue.1 , pp. 16-21
    • Parikh-Patel, A.1    Gold, E.B.2    Worman, H.3    Krivy, K.E.4    Gershwin, M.E.5
  • 138
    • 77953284855 scopus 로고    scopus 로고
    • Demographic, lifestyle, medical and familial factors associated with primary biliary cirrhosis
    • 10.1016/j.jhep.2010.02.019, 20471130
    • Corpechot C, Chretien Y, Chazouilleres O, Poupon R. Demographic, lifestyle, medical and familial factors associated with primary biliary cirrhosis. J Hepatol 2010, 53(1):162-169. 10.1016/j.jhep.2010.02.019, 20471130.
    • (2010) J Hepatol , vol.53 , Issue.1 , pp. 162-169
    • Corpechot, C.1    Chretien, Y.2    Chazouilleres, O.3    Poupon, R.4
  • 139
    • 30944437302 scopus 로고    scopus 로고
    • Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview-based study of 1032 patients
    • 10.1002/hep.20907, 3150736, 16250040
    • Gershwin ME, Selmi C, Worman HJ, Gold EB, Watnik M, Utts J, Lindor KD, Kaplan MM, Vierling JM. Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview-based study of 1032 patients. Hepatology 2005, 42(5):1194-1202. 10.1002/hep.20907, 3150736, 16250040.
    • (2005) Hepatology , vol.42 , Issue.5 , pp. 1194-1202
    • Gershwin, M.E.1    Selmi, C.2    Worman, H.J.3    Gold, E.B.4    Watnik, M.5    Utts, J.6    Lindor, K.D.7    Kaplan, M.M.8    Vierling, J.M.9
  • 140
    • 77950833796 scopus 로고    scopus 로고
    • Case-control studies of risk factors for primary biliary cirrhosis in two United Kingdom populations
    • 10.1136/gut.2009.184218, 20332522
    • Prince MI, Ducker SJ, James OF. Case-control studies of risk factors for primary biliary cirrhosis in two United Kingdom populations. Gut 2010, 59(4):508-512. 10.1136/gut.2009.184218, 20332522.
    • (2010) Gut , vol.59 , Issue.4 , pp. 508-512
    • Prince, M.I.1    Ducker, S.J.2    James, O.F.3
  • 141
    • 34249886050 scopus 로고    scopus 로고
    • Interpreting serological tests in diagnosing autoimmune liver diseases
    • 10.1055/s-2007-979469, 17520516
    • Invernizzi P, Lleo A, Podda M. Interpreting serological tests in diagnosing autoimmune liver diseases. Semin Liver Dis 2007, 27(2):161-172. 10.1055/s-2007-979469, 17520516.
    • (2007) Semin Liver Dis , vol.27 , Issue.2 , pp. 161-172
    • Invernizzi, P.1    Lleo, A.2    Podda, M.3
  • 142
    • 54349118451 scopus 로고    scopus 로고
    • Autoimmune liver serology: current diagnostic and clinical challenges
    • 10.3748/wjg.14.3374, 2716592, 18528935
    • Bogdanos DP, Invernizzi P, Mackay IR, Vergani D. Autoimmune liver serology: current diagnostic and clinical challenges. World J Gastroenterol 2008, 14(21):3374-3387. 10.3748/wjg.14.3374, 2716592, 18528935.
    • (2008) World J Gastroenterol , vol.14 , Issue.21 , pp. 3374-3387
    • Bogdanos, D.P.1    Invernizzi, P.2    Mackay, I.R.3    Vergani, D.4
  • 146
    • 78049486376 scopus 로고    scopus 로고
    • Pathogenesis of cholestatic liver disease and therapeutic approaches
    • 10.1053/j.gastro.2010.09.004, 20849855
    • Hirschfield GM, Heathcote EJ, Gershwin ME. Pathogenesis of cholestatic liver disease and therapeutic approaches. Gastroenterology 2010, 139(5):1481-1496. 10.1053/j.gastro.2010.09.004, 20849855.
    • (2010) Gastroenterology , vol.139 , Issue.5 , pp. 1481-1496
    • Hirschfield, G.M.1    Heathcote, E.J.2    Gershwin, M.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.