Characterization of the ripoptosome and its components: Implications for anti-inflammatory and cancer therapy

Methods in Enzymology

Volumn 545, Issue , 2014, Pages 83-102

  Schilling, Ramon ^a   Geserick, Peter ^a   Leverkus, Martin ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Apoptosis; cFLIP isoforms; IAP antagonist; Immunoprecipitation; Necroptosis; RIP1; Ripoptosome

Indexed keywords

APOPTOSOME; CASPASE 8; CYTOCHROME C; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; DEATH RECEPTOR; HETERODIMER; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN; RIP1 PROTEIN; RIPOPTOSOME; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; AGFG1 PROTEIN, HUMAN; ANTIINFLAMMATORY AGENT; FADD PROTEIN, HUMAN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; MULTIPROTEIN COMPLEX; NUCLEOPORIN; RNA BINDING PROTEIN;

ANTIINFLAMMATORY THERAPY; APOPTOSIS; ARTICLE; CANCER THERAPY; CARCINOGENESIS; CELL DEATH; CELL STRESS; CELL STRUCTURE; CELL SURVIVAL; CHEMICAL ANALYSIS; DNA DAMAGE; EMBRYO DEVELOPMENT; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE MICROSCOPY; GEL FILTRATION; GENOTOXICITY; HUMAN; IMMUNE SYSTEM; IMMUNOPRECIPITATION; IN VIVO STUDY; INFLAMMATION; INTRACELLULAR SIGNALING; MASS SPECTROMETRY; NECROPTOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; STAINING; THERAPY; CHEMISTRY; GENE THERAPY; GENETICS; METABOLISM; NEOPLASMS; PROCEDURES; SIGNAL TRANSDUCTION;

ANTI-INFLAMMATORY AGENTS; CASPASE 8; CELL DEATH; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; GENETIC THERAPY; HUMANS; INFLAMMATION; INHIBITOR OF APOPTOSIS PROTEINS; MULTIPROTEIN COMPLEXES; NEOPLASMS; NUCLEAR PORE COMPLEX PROTEINS; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 84905021420     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-801430-1.00004-4     Document Type: Chapter

References (40)

1. M.J. Bertrand, S. Lippens, A. Staes, B. Gilbert, R. Roelandt, and J. De Medts et al. cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4) PLoS One 6 2011 e22356
2. M.J. Bertrand, and P. Vandenabeele The Ripoptosome: Death decision in the cytosol Molecular Cell 43 2011 323 325
3. K. Cain, S.B. Bratton, C. Langlais, G. Walker, D.G. Brown, and X.M. Sun et al. Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes Journal of Biological Chemistry 275 2000 6067 6070
4. S.P. Cullen, C.M. Henry, C.J. Kearney, S.E. Logue, M. Feoktistova, and G.A. Tynan et al. Fas/CD95-induced chemokines can serve as "find-me" signals for apoptotic cells Molecular Cell 49 2013 1034 1048
5. W. Declercq, T. Vanden Berghe, and P. Vandenabeele RIP kinases at the crossroads of cell death and survival Cell 138 2009 229 232
6. L.S. Dickens, I.R. Powley, M.A. Hughes, and M. MacFarlane The 'complexities' of life and death: Death receptor signalling platforms Experimental Cell Research 318 2012 1269 1277
7. P. Diessenbacher, M. Hupe, M.R. Sprick, A. Kerstan, P. Geserick, and T.L. Haas et al. NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2 Journal of Investigative Dermatology 128 2008 1134 1147
8. C.P. Dillon, A. Oberst, R. Weinlich, L.J. Janke, T.B. Kang, and T. Ben-Moshe et al. Survival function of the FADD-CASPASE-8-cFLIP(L) complex Cell Reports 1 2012 401 407
9. Z. Dunai, P.I. Bauer, and R. Mihalik Necroptosis: Biochemical, physiological and pathological aspects Pathology and Oncology Research 17 2011 791 800
10. C.H. Emmerich, A.C. Schmukle, and H. Walczak The emerging role of linear ubiquitination in cell signaling Science Signaling 4 2011 re5
11. M. Feoktistova, P. Geserick, B. Kellert, D.P. Dimitrova, C. Langlais, and M. Hupe et al. cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms Molecular Cell 43 2011 449 463
12. M. Feoktistova, P. Geserick, D. Panayotova-Dimitrova, and M. Leverkus Pick your poison: The Ripoptosome, a cell death platform regulating apoptosis and necroptosis Cell Cycle 11 2012 460 467
13. P. Geserick, M. Hupe, M. Moulin, W.W. Wong, M. Feoktistova, and B. Kellert et al. Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment Journal of Cell Biology 187 2009 1037 1054
14. T.L. Haas, C.H. Emmerich, B. Gerlach, A.C. Schmukle, S.M. Cordier, and E. Rieser et al. Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction Molecular Cell 36 2009 831 844
15. M.O. Hengartner The biochemistry of apoptosis Nature 407 2000 770 776
16. T. Horn, and M. Boutros Design of RNAi reagents for invertebrate model organisms and human disease vectors Methods in Molecular Biology 942 2013 315 346
17. M.A. Hughes, C. Langlais, K. Cain, and M. MacFarlane Isolation, characterisation and reconstitution of cell death signalling complexes Methods 61 2013 98 104
18. W.J. Kaiser, J.W. Upton, A.B. Long, D. Livingston-Rosanoff, L.P. Daley-Bauer, and R. Hakem et al. RIP3 mediates the embryonic lethality of caspase-8-deficient mice Nature 471 2011 368 372
19. M.A. Kelliher, S. Grimm, Y. Ishida, F. Kuo, B.Z. Stanger, and P. Leder The death domain kinase RIP mediates the TNF-induced NF-kappaB signal Immunity 8 1998 297 303
20. J. Lu, D. McEachern, H. Sun, L. Bai, Y. Peng, and S. Qiu et al. Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment Molecular Cancer Therapeutics 10 2011 902 914
21. C. Maas, J.M. Tromp, J. Van Laar, R. Thijssen, J.A. Elias, and A. Malara et al. CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex Cell Death and Disease 4 2013 e782
22. M. Moulin, H. Anderton, A.K. Voss, T. Thomas, W.W. Wong, and A. Bankovacki et al. IAPs limit activation of RIP kinases by TNF receptor 1 during development EMBO Journal 31 2012 1679 1691
23. J.M. Murphy, P.E. Czabotar, J.M. Hildebrand, I.S. Lucet, J.G. Zhang, and S. Alvarez-Diaz et al. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism Immunity 39 2013 443 453
24. A. Oberst, C.P. Dillon, R. Weinlich, L.L. McCormick, P. Fitzgerald, and C. Pop et al. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis Nature 471 2011 363 367
25. D. Panayotova-Dimitrova, M. Feoktistova, M. Ploesser, B. Kellert, M. Hupe, and S. Horn et al. cFLIP regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis Cell Reports 5 2 2013 397 408
26. T.F. Reubold, and S. Eschenburg A molecular view on signal transduction by the apoptosome Cellular Signalling 24 2012 1420 1425
27. L. Sun, H. Wang, Z. Wang, S. He, S. Chen, and D. Liao et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase Cell 148 2012 213 227
28. T. Tenev, K. Bianchi, M. Darding, M. Broemer, C. Langlais, and F. Wallberg et al. The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs Molecular Cell 43 2011 432 448
29. E. Varfolomeev, J.W. Blankenship, S.M. Wayson, A.V. Fedorova, N. Kayagaki, and P. Garg et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis Cell 131 2007 669 681
30. E.E. Varfolomeev, M. Schuchmann, V. Luria, N. Chiannilkulchai, J.S. Beckmann, and I.L. Mett et al. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally Immunity 9 1998 267 276
31. J.E. Vince, W.W. Wong, N. Khan, R. Feltham, D. Chau, and A.U. Ahmed et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis Cell 131 2007 682 693
32. L. Wagner, V. Marschall, S. Karl, S. Cristofanon, K. Zobel, and K. Deshayes et al. Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner Oncogene 32 2013 988 997
33. F. Wallberg, T. Tenev, and P. Meier Time-lapse imaging of necrosis Methods in Molecular Biology 1004 2013 17 29
34. R. Weinlich, A. Oberst, C.P. Dillon, L.J. Janke, T.B. Kang, and S. Milasta et al. Protective roles for caspase-8 and cFLIP in adult homeostasis Cell Reports 5 2 2013 340 348
35. N. Wittkopf, C. Gunther, E. Martini, G. He, K. Amann, and Y.W. He et al. Cellular FLICE-like inhibitory protein secures intestinal epithelial cell survival and immune homeostasis by regulating caspase-8 Gastroenterology 145 2013 1369 1379
36. W.C. Yeh, A. Itie, A.J. Elia, M. Ng, H.B. Shu, and A. Wakeham et al. Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development Immunity 12 2000 633 642
37. J. Zhang, D. Cado, A. Chen, N.H. Kabra, and A. Winoto Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1 Nature 392 1998 296 300
38. H. Zhang, X. Zhou, T. McQuade, J. Li, F.K. Chan, and J. Zhang Functional complementation between FADD and RIP1 in embryos and lymphocytes Nature 471 2011 373 376
39. J. Zhao, S. Jitkaew, Z. Cai, S. Choksi, Q. Li, and J. Luo et al. Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis Proceedings of the National Academy of Sciences of the United States of America 109 2012 5322 5327
40. Z. Zhou, V. Han, and J. Han New components of the necroptotic pathway Protein & Cell 3 2012 811 817