Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediated survival signals

Oncotarget

Volumn 5, Issue 13, 2014, Pages 4972-4989

  Kumar, Sushil ^a   Raina, Komal ^a,b   Agarwal, Chapla ^a,b   Agarwal, Rajesh ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

Cancer chemoprevention; Cancer stem cells; Colorectal cancer; Silibinin

Indexed keywords

INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; MOLECULAR MARKER; SILIBININ; TRANSCRIPTION FACTOR; ANTIOXIDANT; SILYMARIN;

ARTICLE; AUTOCRINE EFFECT; CANCER INHIBITION; CANCER STEM CELL; CELL DIFFERENTIATION; CELL DIVISION; CELL SURVIVAL; COLON CANCER; CONTROLLED STUDY; HUMAN; HUMAN CELL; PARACRINE SIGNALING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR SPHEROID; CELL PROLIFERATION; COLON TUMOR; CONFOCAL MICROSCOPY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HT 29 CELL LINE; KINETICS; METABOLISM; MULTICELLULAR SPHEROID; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ANTIOXIDANTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; HT29 CELLS; HUMANS; INTERLEUKIN-4; INTERLEUKIN-6; KINETICS; MICROSCOPY, CONFOCAL; NEOPLASTIC STEM CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SILYMARIN; SPHEROIDS, CELLULAR; TRANSCRIPTION FACTORS;

EID: 84905017619     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2068     Document Type: Article

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