Development of both methotrexate and mitomycin C loaded PEGylated chitosan nanoparticles for targeted drug codelivery and synergistic anticancer effect

ACS Applied Materials and Interfaces

Volumn 6, Issue 14, 2014, Pages 11413-11423

  Jia, Mengmeng ^a   Li, Yang ^a,b   Yang, Xiangrui ^a   Huang, Yuancan ^a   Wu, Hongjie ^b   Hueng, Yu ^a   Lin, Jinyan ^a,b   Li, Yanxiu ^a,c   Hou, Zhenqing ^a   Zhang, Qiqing ^d  

^a Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources   (China)

^b Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals   (China)

^c XIAMEN UNIVERSITY   (China)

^d INSTITUTE OF BIOMEDICAL ENGINEERING   (China)

Author keywords

drug delivery; methotrexate; mitomycin C; PEGylated chitosan; receptor mediated targeting

Indexed keywords

CHEMOTHERAPY; CHITOSAN; DISEASES; DRUG DELIVERY; DRUG PRODUCTS; MOLECULAR BIOLOGY; NANOPARTICLES; PARTICLE SIZE ANALYSIS; TUMORS;

CHITOSAN NANOPARTICLES; METHOTREXATE; MITOMYCIN C; PEGYLATED; RECEPTOR-MEDIATED ENDOCYTOSIS; RECEPTOR-MEDIATED TARGETING; SUSTAINED DRUG RELEASE; TARGETED DRUG DELIVERY;

C (PROGRAMMING LANGUAGE);

ANTINEOPLASTIC ANTIBIOTIC; ANTINEOPLASTIC ANTIMETABOLITE; CHITOSAN; MACROGOL DERIVATIVE; METHOTREXATE; MITOMYCIN; NANOPARTICLE;

ANIMAL; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG POTENTIATION; HELA CELL LINE; HUMAN; MOUSE; NEOPLASMS, EXPERIMENTAL; PROCEDURES;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIMETABOLITES, ANTINEOPLASTIC; CHITOSAN; DRUG DELIVERY SYSTEMS; DRUG SYNERGISM; HELA CELLS; HUMANS; METHOTREXATE; MICE; MITOMYCIN; NANOPARTICLES; NEOPLASMS, EXPERIMENTAL; POLYETHYLENE GLYCOLS;

EID: 84904989739     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/am501932s     Document Type: Article

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