Transferrin-conjugated micelles: Enhanced accumulation and antitumor effect for transferrin-receptor-overexpressing cancer models

Molecular Pharmaceutics

Volumn 9, Issue 7, 2012, Pages 1919-1931

  Yue, Jun ^a,b   Liu, Shi ^a   Wang, Rui ^a,b   Hu, Xiuli ^a   Xie, Zhigang ^a   Huang, Yubin ^a   Jing, Xiabin ^a  

^a CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

antitumor effect; micelle; paclitaxel; TfR; transferrin

Indexed keywords

PACLITAXEL; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CARCINOMA; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG RELEASE; FEMALE; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MICELLE; MOUSE; NEAR INFRARED REFLECTANCE SPECTROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; FEMALE; HUMANS; MCF-7 CELLS; MICE; MICE, INBRED BALB C; MICE, NUDE; MICELLES; PACLITAXEL; POLYMERS; RECEPTORS, TRANSFERRIN; TISSUE DISTRIBUTION; TRANSFERRIN;

EID: 84863304628     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300213g     Document Type: Article

References (53)

1. Parren, P. W.; Winkel, J. An integrated science-based approach to drug development Curr. Opin. Immunol. 2008, 20, 426-430
2. Thorp, P. E. Vascular targeting agents as cancer therapeutics Clin. Cancer Res. 2004, 10, 415-427
3. Ojima, I. Modern molecular approaches to drug design and discovery Acc. Chem. Res. 2008, 41, 2-3
4. Persidis, A. Cancer multidrug resistance Nat. Biotechnol. 1999, 17, 94-95
5. Tsuruo, T.; Naito, M.; Tomida, A.; Fujita, N.; Mashima, T.; Sakamoto, H.; Haga, N. Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal Cancer Sci. 2003, 94, 15-21
6. Duncan, R.; Gaspar, R. Nanomedicine(s) under the Microscope Mol. Pharmacol. 2011, 8, 2101-2141
7. Minelli, C; Lowe, S. B.; Stevens, M. M. Engineering nanocomposite materials for cancer therapy Small 2010, 6, 2336-2357
8. Shi, J.; Votruba, A. R.; Farokhzad, O. C.; Langer, R. Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications Nano Lett. 2010, 10, 3223-30
9. Petros, R. A.; DeSimone, J. M. Strategies in the design of nanoparticles for therapeutic applications Nat. Rev. Drug Discovery 2010, 9, 615-627
10. Maeda, H. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting Adv. Enzyme Regul. 2001, 41, 189-207
11. Bel, S. J.; Fam, C. M.; Chlipala, E. A.; Carlson, S. J.; Lee, J. I.; Rosendahl, M. S.; Doherty, D. H.; Cox, G. N. Enhanced circulating half-life and antitumor activity of a site-specific PEGylated interferon-α protein therapeutic Bioconjugate Chem. 2008, 19, 299-305
12. Otsuka, H.; Nagasaki, Y.; Kataoka, K. PEGylated nanoparticles for biological and pharmaceutical applications Adv. Drug Delivery Rev. 2003, 55, 403-419
13. Danhier, F.; Feron, O.; Préat, V. To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery J. Controlled Release 2010, 148, 135-146
14. Rapoport, N. Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery Prog. Polym. Sci. 2007, 32, 962-990
15. Yu, H.; Zou, Y.; Wang, Y.; Huang, X.; Huang, G.; Sumer, B. D.; Boothman, D. A.; Gao, J. Overcoming endosomal barrier by amphotericin B-loaded dual pH-responsive PDMA-b-PDPA micelleplexes for siRNA delivery ACS Nano 2011, 5, 9246-9255
16. Chen, J.; Qiu, X.; Ouyang, J.; Kong, J.; Zhong, W.; Xing, M. pH and Reduction Dual-Sensitive Copolymeric Micelles for Intracellular Doxorubicin Delivery Biomacromolecules 2011, 12, 3601-3611
17. Quan, C. Y.; Chen, J. X.; Wang, H. Y.; Li, C.; Chang, C.; Zhang, X. Z.; Zhuo, R. X. Core-Shell Nanosized Assemblies Mediated by the Cyclodextrin Dimer with a Tumor-Triggered Targeting Property ACS Nano 2010, 4, 4211-4219
18. Ryu, J. H.; Chacko, R. T.; Jiwpanich, S.; Bickerton, S.; Babu, R. P.; Thayumanavan, S. Self-cross-linked polymer nanogels: a versatile nanoscopic drug delivery platform J. Am. Chem. Soc. 2010, 132, 17227-17235
19. Wang, H.; Zhao, Y.; Wu, Y.; Hu, Y. L.; Nan, K. H.; Nie, G. J.; Chen, H. Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles Biomaterials 2011, 32, 8281-8290
20. Chauhan, V. P.; Popovic, Z.; Chen, O.; Cui, J.; Fukumura, D.; Bawendi, M. G.; Jain, R. K. Fluorescent Nanorods and Nanospheres for Real-Time In Vivo Probing Angew. Chem., Int. Ed. 2011, 50, 1-5
21. Shen, Y. Q.; Jin, E. L.; Zhang, B.; Murphy, C. J.; Sui, M. H.; Zhao, J.; Wang, J. Q.; Tang, J. B.; Fan, M. H.; Kirk, E. V.; Murdoch, W. J. Prodrugs forming high drug loading multifunctional nanocapsules for intracellular cancer drug delivery J. Am. Chem. Soc. 2010, 132, 4259-4265
22. Schadlich, A.; Caysa, H.; Mueller, T.; Tenambergen, F.; Rose, C.; Gopferich, A.; Kuntsche, J.; Mäder, K. Tumor accumulation of NIR fluorescent PEG-PLA nanoparticles: impact of particle size and human xenograft tumor model ACS Nano 2011, 5, 8710-8720
23. Simone, E. A.; Dziubla, T. D.; Muzykantov, V. R. Polymeric carriers: role of geometry in drug delivery Expert. Opin. Drug Delivery 2008, 5, 1283-1300
24. Hatakeyama, H.; Akita, H.; Harashima, H. A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: A strategy for overcoming the PEG dilemma Adv. Drug Delivery Rev. 2011, 63, 152-160
25. Du, J. Z.; Sun, T. M.; Song, W. J.; Wu, J.; Wang, J. A tumor-acidity-activated charge-conversional nanogel as an intelligent vehicle for promoted tumoral-cell uptake and drug delivery Angew. Chem., Int. Ed. 2010, 49, 3621-3626
26. Du, J. Z.; Du, X. J.; Mao, C. Q.; Wang, J. Tailor-made dual pH-sensitive polymer-doxorubicin nano-particles for efficient anticancer drug delivery J. Am. Chem. Soc. 2011, 133, 17560-17563
27. Kuai, R.; Yuan, W. M.; Li, W. Y.; Qin, Y.; Tang, J.; Yuan, M. Q.; Fu, L.; Ran, R.; Zhang, Z. R.; He, Q. Targeted delivery of cargoes into a murine solid tumor by a cell-penetrating peptide and cleavable poly(ethylene glycol) comodified liposomal delivery system via systemic administration Mol. Pharmacol. 2011, 8, 2151-2161
28. Ma, P. A.; Liu, S.; Huang, Y. B.; Chen, X. S.; Zhang, L. P.; Jing, X. B. Lactose mediated liver-targeting effect observed by ex vivo imaging technology Biomaterials 2010, 31, 2646-2654
29. Hossen, M. N.; Kajimoto, K.; Akita, H.; Hyodo, M.; Ishitsuka, T.; Harashima, H. Ligand-based targeted delivery of a peptide modified nanocarrier to endothelial cells in adipose tissue J. Controlled Release 2010, 147, 261-268
30. Steinhauser, I.; Spankuch, B.; Strebhardt, K.; Langer, K. Trastuzumab-modified nanoparticles: optimization of preparation and uptake in cancer cells Biomaterials 2006, 27, 4975-4983
31. Gomme, P. T.; McCann, K. B. Transferrin: structure, function and potential therapeutic actions Drug Discovery Today 2005, 10, 267-273
32. Han, L.; Huang, R. Q.; Liu, S. H.; Huang, S. X.; Jiang, C. Peptide-conjugated PAMAM for targeted doxorubicin delivery to transferrin receptor overexpressed tumors Mol. Pharmaceutics 2010, 7, 2156-2165
33. Hu, K.; Li, J.; Shen, Y.; Lu, W.; Gao, X.; Zhang, Q.; Jiang, X. Lactoferrin-conjugated PEG-PLA nanoparticles with improved brain delivery: In vitro and in vivo evaluations J. Controlled Release 2009, 134, 55-61
34. Qian, Z. M.; Li, H.; Sun, H.; Ho, K. Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway Pharmacol. Rev. 2002, 54, 561-587
35. Sahoo, S. K.; Ma, W.; Labhasetwar, V. Efficacy of transferrin-conjugated paclitaxel-loaded nanoparticles in a murine model of prostate cancer Int. J. Cancer 2004, 112, 335-340
36. Li, J.; Wang, L.; Liu, X.; Zhang, Z.; Guo, H.; Liu, W.; Tang, S. In vitro cancer cell imaging and therapy using transferrin-conjugated gold nanoparticles Cancer Lett. 2009, 274, 319-326
37. Mendonca, L. S.; Firmino, F.; Moreira, J. N.; Pedroso de Lima, M. C.; Simoes, S. Transferrin receptor-targeted liposomes encapsulating anti-BCR-ABL siRNA or asODN for chronic myeloid leukemia treatment Bioconjugate Chem. 2010, 21, 157-168
38. Pang, Z.; Feng, L.; Hua, R.; Chen, J.; Gao, H.; Pan, S.; Jiang, X.; Zhang, P. Lactoferrin-conjugated biodegradable polymersome holding doxorubicin and tetrandrine for chemotherapy of glioma rats Mol. Pharmaceutics 2010, 7, 1995-2005
39. Gan, C. W.; Feng, S. S. Transferrin-conjugated nanoparticles of Poly(lactide)-D-a-Tocopheryl polyethylene glycol succinate diblock copolymer for targeted drug delivery across the blood-brain barrier Biomaterials 2010, 31, 7748-7757
40. Friden, P. M.; Walus, L. R.; Musso, G. F.; Taylor, M. A.; Malfroy, B.; Starzyk, R. M. Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier Proc. Natl. Acad. Sci. U.S.A. 1991, 88, 4771-4775
41. Kratz, F.; Roth, T.; Fichiner, I.; Schumacher, P.; Fiebig, H. H.; Unger, C. In vitro and in vivo efficacy of acid-sensitive transferrin and albumin doxorubicin conjugates in a human xenograft panel and in the MDR-MB-435 mamma carcinoma model J. Drug Targeting 2000, 8, 305-318
42. Hagihara, H.; Walbridge, S.; Olson, A. W.; Oldfield, E. H.; Youle, R. J. Vascular protection by chloroquine during brain tumor therapy with Tf-CRM107 Cancer Res. 2000, 60, 230-234
43. Lu, T.; Sun, J.; Chen, X.; Zhang, P.; Jing, X. Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis Macromol. Biosci. 2009, 9, 1059-1068
44. Wan, Y.; Zheng, Y.; Song, X.; Hu, X.; Liu, S.; Tong, T.; Jing, X. Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on Lewis Lung Cancer Mice Models J. Biomater. Sci., Polym. Ed. 2011, 22, 1131-1146
45. Yue, J.; Liu, S.; Mo, G.; Wang, R.; Jing, X. Active targeting and fluorescence-labeled micelles: Preparation, characterization and cellular uptake evaluation J. Controlled Release 2011, 152, e258-e260
46. Hu, X. L.; Chen, X. S.; Liu, S.; Shi, Q.; Jing, X. B. Novel aliphatic poly(ester-carbonate) with pendant allyl ester groups and its folic acid functionalization J. Polym. Sci., Polym. Chem. 2008, 46, 1852-1861
47. Cammas, S.; Nagasaki, Y.; Kataoka, K. Heterobifunctional poly(ethy1ene oxide): synthesis of α-methoxy-ω-amino and α-hydroxy-ω- amino PEOs with the same molecular weights Bioconjugate Chem. 1995, 6, 226-230
48. Hu, X. L.; Chen, X. S.; Xie, Z. G.; Liu, S.; Jing, X. B. Synthesis and characterization of amphiphilic block copolymers with allyl side-groups J. Polym. Sci., Polym. Chem. 2007, 45, 5518-5528
49. Nielsen, O.; Buchardt, O. Facile synthesis of reagents containing a terminal maleimido ligand linked to an active ester Synthesis 1991, 10, 819-821
50. Yue, J.; Li, X. Y.; Mo, G. J.; Wang, R.; Huang, Y. B.; Jing, X. B. Modular functionalization of amphiphilic block copolymers via radical-mediated thiol-ene reaction Macromolecules 2010, 43, 9645-9654
51. Storm, G.; Belliot, S. O.; Daemen, T.; Lasic, D. D. Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system Adv. Drug Delivery Rev. 1995, 17, 31-48
52. Juliano, R L. Factors affecting the clearance kinetics and tissue distribution of liposomes, microspheres and emulsions Adv. Drug Delivery Rev. 1988, 2, 31-54
53. Jones, A. R.; Shusta, E. V. Blood-Brain Barrier Transport of Therapeutics via Receptor-Mediation Pharm. Res. 2007, 24, 1759-1771