The phosphodiesterase-4 inhibitor rolipram attenuates heroin-seeking behavior induced by cues or heroin priming in rats

International Journal of Neuropsychopharmacology

Volumn 17, Issue 9, 2014, Pages 1397-1407

  Lai, Miaojun ^a   Zhu, Huaqiang ^a   Sun, Anna ^a   Zhuang, Dingding ^a   Fu, Dan ^a   Chen, Weisheng ^a   Zhang, Han Ting ^b   Zhou, Wenhua ^a  

^a NINGBO UNIVERSITY   (China)

^b WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Addiction; cAMP; CREB; heroin; phosphodiesterase 4 (PDE4); rolipram

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIAMORPHINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; PHOSPHODIESTERASE IV; ROLIPRAM; SUCROSE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; NARCOTIC AGENT; PHOSPHODIESTERASE IV INHIBITOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; DRUG SEEKING BEHAVIOR; ENZYME INHIBITION; HEROIN DEPENDENCE; LOW DRUG DOSE; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PSYCHOPHARMACOTHERAPY; RAT; REINFORCEMENT; SIGNAL TRANSDUCTION; ANIMAL; ASSOCIATION; DOSE RESPONSE; DRUG EFFECTS; DRUG SELF ADMINISTRATION; INSTRUMENTAL CONDITIONING; METABOLISM; REWARD; SPRAGUE DAWLEY RAT;

ANIMALS; CONDITIONING, OPERANT; CREB-BINDING PROTEIN; CUES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-SEEKING BEHAVIOR; EXTINCTION, PSYCHOLOGICAL; HEROIN; HEROIN DEPENDENCE; MALE; NARCOTICS; PHOSPHODIESTERASE 4 INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; REINFORCEMENT SCHEDULE; REWARD; ROLIPRAM; SELF ADMINISTRATION;

EID: 84904960719     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145714000595     Document Type: Article

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