A selective phosphodiesterase IV inhibitor, rolipram blocks both withdrawal behavioral manifestations, and c-Fos protein expression in morphine dependent mice

Behavioural Brain Research

Volumn 118, Issue 1, 2001, Pages 85-93

  Hamdy, Moustafa Mahmoud ^a,b   Mamiya, Takayoshi ^a   Noda, Yukihiro ^a   Sayed, Merfat ^a   Assi, Abdel Azim ^b   Gomaa, Adel ^b   Yamada, Kiyofumi ^a   Nabeshima, Toshitaka ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Assiut University Faculty of Medicine   (Egypt)

Author keywords

c Fos expression; cAMP pathway; Mice; Morphine dependence; Rolipram; Withdrawal manifestations

Indexed keywords

CYCLIC AMP; MORPHINE; NALOXONE; PHOSPHODIESTERASE IV INHIBITOR; PROTEIN C FOS; ROLIPRAM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG SELECTIVITY; IMMUNOHISTOCHEMISTRY; MALE; MORPHINE ADDICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROVOCATION TEST; WITHDRAWAL SYNDROME;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; GENE EXPRESSION REGULATION; MALE; MICE; MICE, INBRED C57BL; MORPHINE DEPENDENCE; NALOXONE; NARCOTIC ANTAGONISTS; PHOSPHODIESTERASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-FOS; ROLIPRAM; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0035825277     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(00)00315-6     Document Type: Article

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