A therapeutic strategy to prevent morphine dependence and tolerance by coadministration of cAMP-related reagents with morphine

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 20, Issue 7, 1998, Pages 619-625

  Itoh, Akio ^a   Noda, Yukihiro ^a   Mamiya, Takayoshi ^a   Hasegawa, Takaaki ^a   Nabeshima, Toshitaka ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CAMP Dependence; Morphine; Nefiracetam; Rolipram; Tolerance; Xanthine derivatives

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; ENPROFYLLINE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MORPHINE; NALOXONE; NEFIRACETAM; ROLIPRAM; THEOPHYLLINE; XANTHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; BRAIN CORTEX; BRAIN LEVEL; CALCIUM CELL LEVEL; CONFERENCE PAPER; CONTROLLED STUDY; DRUG MECHANISM; DRUG TOLERANCE; INTRAPERITONEAL DRUG ADMINISTRATION; MORPHINE ADDICTION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PAIN; SUBCUTANEOUS DRUG ADMINISTRATION; TAIL FLICK TEST; THALAMUS; WITHDRAWAL SYNDROME;

2',3'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; ANALGESICS, OPIOID; ANIMALS; CYCLIC AMP; DRUG TOLERANCE; HUMANS; MICE; MORPHINE; MORPHINE DEPENDENCE;

EID: 0031763645     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.1998.20.7.485728     Document Type: Conference Paper

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