Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd2+-induced apoptosis

Free Radical Biology and Medicine

Volumn 74, Issue , 2014, Pages 188-199

  Barajas Espinosa, Alma ^a   Basye, Ariel ^a   Jesse, Erin ^a   Yan, Haixu ^a   Quan, David ^a   Chen, Chun An ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

DUSP4; Endothelial dysfunction; Free radicals; MAP kinases; N acetylcysteine; Nitric oxide synthase; Phosphatase; Reactive oxygen species; Redox signaling

Indexed keywords

ACETYLCYSTEINE; BUTHIONINE SULFOXIMINE; DUAL SPECIFICITY PHOSPHATASE 4; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATASE; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG; CADMIUM; DUAL SPECIFICITY PHOSPHATASE; DUSP4 PROTEIN, RAT; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE; NITRIC OXIDE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL SURVIVAL; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ENDOTHELIUM CELL; ENZYME ACTIVATION; FEEDBACK SYSTEM; GENE EXPRESSION; GENE SILENCING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOBLOTTING; LONG TERM EXPOSURE; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; RAT; REDOX STRESS; SPIN TRAPPING; UPREGULATION; ANIMAL; BOVINE; CELL GROWTH; CELL LINE; CELL PROTECTION; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; SIGNAL TRANSDUCTION;

ACETYLCYSTEINE; ANIMALS; APOPTOSIS; CADMIUM; CATTLE; CELL GROWTH PROCESSES; CELL LINE; CELL SURVIVAL; CYTOPROTECTION; DUAL-SPECIFICITY PHOSPHATASES; ENDOTHELIAL CELLS; GLUTATHIONE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 84904959087     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.06.016     Document Type: Article

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