N-acetylcysteine in acute cardiology: 10 years later: What do we know and what would we like to know?!

Journal of the American College of Cardiology

Volumn 39, Issue 9, 2002, Pages 1422-1428

  Sochman, Jan ^a  

^a INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; OXYGEN RADICAL;

ACUTE HEART INFARCTION; CARDIOLOGY; CARDIOVASCULAR SYSTEM; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG MECHANISM; KIDNEY CLEARANCE; OXIDATIVE STRESS; PRIORITY JOURNAL; REPERFUSION INJURY; REVIEW;

ACETYLCYSTEINE; CARDIOLOGY; CLINICAL TRIALS; FREE RADICAL SCAVENGERS; HUMANS; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; VENTRICULAR FUNCTION, LEFT;

EID: 0036569113     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(02)01797-7     Document Type: Review

References (74)

1. Evidence that mitochondrial respiration is a source of potentially toxic free radicals in intact rabbit hearts subjected to ischemia and reflow
2. Regulation of intracellular calcium compartmentation: Studies with isolated hepatocytes and t-butyl hydroperoxide
3. Effects of ischemia and reperfusion on cardiac tolerance to oxidative stress
4. Oxidative stress: Damage to intact cells and organs
5. ++ATPase
6. +-ATPase activity induced by free radicals and ischemia of kidney
7. Oxidants and human disease: Some new concepts
8. Aging: A theory based on free radical and radiation chemistry
9. Prolongation of the normal life span by radiation protection chemicals
10. Oxygen radicals and cardiac aging
11. The effect of coronary occlusion on myocardial contraction
12. Reperfusion arrhythmias: A new marker of restoration of antegrade flow during intracoronary thrombolysis for acute myocardial infarction
13. Regional myocardial function and electrophysiological alterations after brief coronary artery occlusion in conscious dogs
14. The stunned myocardium: Prolonged postischemic ventricular dysfunction
15. Advances in the treatment of heart failure: Therapeutic targets for the new millennium
16. Oxidative stress after thrombolysis
17. Evidence for the role of oxidative stress in acute ischemic heart disease: A brief report
18. Evidence for free radical generation after primary percutaneous transluminal coronary angioplasty recanalization in acute myocardial infarction
19. The oxygen-free radical system: From equations through membrane protein interactions to a cardiovascular injury and protection
20. Phospholipases of the myocardium
21. Lysosomal lipolytic enzymes, lipid peroxidation and injury
22. Protection by verapamil of mitochondrial glutathione equilibrium and phospholipid changes during reperfusion of ischemic canine myocardium
23. Patterns of myocardial gene expression after cycles of brief coronary occlusion and reperfusion
24. Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion: Evidence that myocardial "stunning" is a manifestation of reperfusion injury
25. Cardioprotective effects of N-acetylcysteine: The reduction in the extent of infarction and occurrence of reperfusion arrhythmias in the dog
26. Experimental possibilities to reduce myocardial infarction
27. Hydrogen peroxide-induced oxidative stress to the mammalian heart-muscle cell (cardiomyocyte): Lethal peroxidative membrane injury
28. New insights on myocardial pyridine nucleotides and thiol redox state in ischemia and reperfusion damage
29. Attenuation of dysfunction in the postischemic "stunned" myocardium by dimethylthiourea
30. Canine myocardial reperfusion injury: Protection by a free radical scavenger, N-2-mercaptopropionyl glycine
31. Potentiation of nitroglycerin-induced coronary dilatation by N-acetylcysteine
32. The role of glutathione status in the protection against ischaemic and reperfusion damage: Effects of N-acetylcysteine
33. Glutathione redox pathway and reperfusion injury: Effects of N-acetylcysteine on infarct size and ventricular function
34. Myocardial glutathione depletion impairs recovery after short periods of ischemia
35. Myocardial glutathione depletion impairs recovery of isolated blood-perfused heart after global ischaemia
36. Oxygen free radicals and myocardial damage: Protective role of thiol-containing agents
37. Beneficial effects of N-acetylcysteine on acute myocardial infarction in open-chest dogs
38. Evidence implicating xanthine oxidase and neutrophils in reperfusion-induced microvascular dysfunction
39. Inhibition of nitric oxide production: Mechanisms of vascular albumin leakage
40. Fibrinolytic therapy and N-acetylcysteine in the treatment of patients with acute myocardial infarction: Its influence on authentic plasma hydroperoxlde levels and polymorphonuclear neutrophil oxygen metabolism
41. Blutgerinnungsbeeinflussung durch cystaminhomologe
42. N-acetylcysteine inhibits angiotensin converting enzyme in vivo
43. Pharmacokinetics of N-acetylcysteine in man
44. Improvement in renal function in hepatorenal syndrome with N-acetylcysteine
45. Prevention of radiographic-contrast-agent-induced reductions in renal functions by acetylcysteine
46. Acetylcysteine and nephrotoxic affects of radiographic contrast agents - A new use for an old drug
47. Combined use of nitroglycerin and N-acetylcysteine in the management of unstable angina pectoris
48. Effect of transdermal nitroglycerin or N-acetylcysteine, or both, in the long-term treatment of unstable angina pectoris
49. Nitrate therapy is an alternative to furosemide/morphine therapy in the management of acute cardiogenic pulmonary edema
50. Potentiation of isosorbide dinitrate effects with N-acetylcysteine in patients with chronic heart failure
51. Intravenous nitroglycerin infusion inhibits cyclic blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries
52. Total recovery of left ventricular function after acute myocardial infarction: Comprehensive therapy with streptokinase, N-acetylcysteine and percutaneous transluminal coronary angioplasty
53. Infarct Size Limitation: Acute N-acetylcysteine Defense (ISLAND) trial: Start of the study
54. Infarct Size Limitation: Acute N-acetylcysteine Defense (ISLAND) trial: Interim electrocardiographic analysis
55. N-acetylcysteine in combination with nitroglycerin and streptokinase for the treatment of evolving acute myocardial infarction: Safety and biochemical effects
56. Infarct size limitation: Acute N-acetylcysteine (ISLAND trial): Preliminary analysis and report after the first 30 patients
57. Infarct Size Limitation: Acute N-acetylcysteine Defense (ISLAND trial): A pilot study
58. Transient giant negative T wave in acute anterior myocardial infarction predicts R wave recovery and preservation of left ventricular function
59. Oxygen-derived free radical stress activates nonselective cation current in guinea pig ventricular myocytes: Role of sulfhydryl groups
60. Status of myocardial antioxidants in ischemia-reperfusion injury
61. Use of N-acetylcysteine in the management of coronary artery diseases
62. Effects of N-acetylcysteine in the rat heart reperfused after low-flow ischemia: Evidence for a direct scavenging of hydroxyl radicals and a nitric oxide-dependent increase in coronary flow
63. Maintenance of the myocardial thiol pool by N-acetylcysteine: An effective means of improving cardioplegic protection
64. The role of N-acetylcysteine administration on the oxidative response of neutrophils during cardiopulmonary bypass
65. Reduction of oxidative stress by oral N-acetyl-L-cysteine treatment decreases plasma soluble vascular adhesion molecule-1 concentrations in non-obese, nondyslipidaemic normotensive, patients with non-insulin-dependent diabetes
66. Nuclear factor-kappa B activation during cerebral reperfusion: Effect of attenuation with N-acetylcysteine treatment
67. N-acetylcysteine improves coronary and peripheral vascular function
68. N-acetylcysteine treatment lowers plasma homocysteine but not serum lipoprotein(a) levels
69. The effect of glutathione modulation on the concentration of homocysteine in plasma of rats
70. N-acetylcysteine enhances recovery from acute lung injury in man: A randomized, double-blind, placebo-controlled clinical study
71. The effect of prophylactically administered N-acetylcysteine on clinical indicators for tissue oxygenation during hyperoxic ventilation in cardiac risk patients
72. Influence of acetylcysteine on aggravation ofischemic damage in ex vivo hearts of rats exposed to hyperbaric oxygen
73. N-acetylcysteine infusion in viral myocarditis: A case report