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Volumn 5, Issue , 2014, Pages

Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GALACTOSE; NEUTRALIZING ANTIBODY; VIRUS DNA; HOMEODOMAIN PROTEIN; RAG-1 PROTEIN;

EID: 84904908113     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms4075     Document Type: Article
Times cited : (112)

References (61)
  • 1
    • 33644820684 scopus 로고    scopus 로고
    • Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
    • Manno, C. S. et al. Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat. Med. 12, 342-347 (2006).
    • (2006) Nat. Med. , vol.12 , pp. 342-347
    • Manno, C.S.1
  • 2
    • 84855161388 scopus 로고    scopus 로고
    • Adenovirus-associated virus vector-mediated gene transfer in hemophilia B
    • Nathwani, A. C. et al. Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. N. Engl. J. Med. 365, 2357-2365 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 2357-2365
    • Nathwani, A.C.1
  • 3
    • 77954976233 scopus 로고    scopus 로고
    • Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: Implications for gene therapy using AAV vectors
    • Boutin, S. et al. Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: implications for gene therapy using AAV vectors. Hum. Gene Ther. 21, 704-712 (2010).
    • (2010) Hum. Gene Ther. , vol.21 , pp. 704-712
    • Boutin, S.1
  • 4
    • 58849086758 scopus 로고    scopus 로고
    • Worldwide epidemiology of neutralizing antibodies to adeno-associated viruses
    • Calcedo, R., Vandenberghe, L. H., Gao, G., Lin, J. & Wilson, J. M. Worldwide epidemiology of neutralizing antibodies to adeno-associated viruses. J. Infect. Dis. 199, 381-390 (2009).
    • (2009) J. Infect. Dis. , vol.199 , pp. 381-390
    • Calcedo, R.1    Vandenberghe, L.H.2    Gao, G.3    Lin, J.4    Wilson, J.M.5
  • 5
    • 84859440283 scopus 로고    scopus 로고
    • The AAV vector toolkit: Poised at the clinical crossroads
    • Asokan, A., Schaffer, D. V. & Samulski, R. J. The AAV vector toolkit: poised at the clinical crossroads. Mol. Ther. 20, 699-708 (2012).
    • (2012) Mol. Ther. , vol.20 , pp. 699-708
    • Asokan, A.1    Schaffer, D.V.2    Samulski, R.J.3
  • 6
    • 84869069238 scopus 로고    scopus 로고
    • Glycan binding avidity determines the systemic fate of adeno-associated virus type 9
    • Shen, S. et al. Glycan binding avidity determines the systemic fate of adeno-associated virus type 9. J. Virol. 86, 10408-10417 (2012).
    • (2012) J. Virol. , vol.86 , pp. 10408-10417
    • Shen, S.1
  • 7
    • 0038618725 scopus 로고    scopus 로고
    • Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding
    • Opie, S. R., Warrington, Jr. K. H., Agbandje-McKenna, M., Zolotukhin, S. & Muzyczka, N. Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding. J. Virol. 77, 6995-7006 (2003).
    • (2003) J. Virol. , vol.77 , pp. 6995-7006
    • Opie, S.R.1    Warrington, K.H.2    Agbandje-McKenna, M.3    Zolotukhin, S.4    Muzyczka, N.5
  • 8
    • 0141454787 scopus 로고    scopus 로고
    • Identification of a heparin-binding motif on adeno-associated virus type 2 capsids
    • Kern, A. et al. Identification of a heparin-binding motif on adeno-associated virus type 2 capsids. J. Virol. 77, 11072-11081 (2003).
    • (2003) J. Virol. , vol.77 , pp. 11072-11081
    • Kern, A.1
  • 9
    • 84864151821 scopus 로고    scopus 로고
    • Identification of the galactose binding domain of the adeno-associated virus serotype 9 capsid
    • Bell, C. L., Gurda, B. L., Van Vliet, K., Agbandje-McKenna, M. & Wilson, J. M. Identification of the galactose binding domain of the adeno-associated virus serotype 9 capsid. J. Virol. 86, 7326-7333 (2012).
    • (2012) J. Virol. , vol.86 , pp. 7326-7333
    • Bell, C.L.1    Gurda, B.L.2    Van Vliet, K.3    Agbandje-McKenna, M.4    Wilson, J.M.5
  • 10
    • 33750722840 scopus 로고    scopus 로고
    • Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes
    • Wu, Z. et al. Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes. J. Virol. 80, 11393-11397 (2006).
    • (2006) J. Virol. , vol.80 , pp. 11393-11397
    • Wu, Z.1
  • 11
    • 0033851104 scopus 로고    scopus 로고
    • Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism
    • Wu, P. et al. Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism. J. Virol. 74, 8635-8647 (2000).
    • (2000) J. Virol. , vol.74 , pp. 8635-8647
    • Wu, P.1
  • 12
    • 84869060596 scopus 로고    scopus 로고
    • Evidence for pH-dependent protease activity in the adeno-associated virus capsid
    • Salganik, M. et al. Evidence for pH-dependent protease activity in the adeno-associated virus capsid. J. Virol. 86, 11877-11885 (2012).
    • (2012) J. Virol. , vol.86 , pp. 11877-11885
    • Salganik, M.1
  • 13
    • 84866169735 scopus 로고    scopus 로고
    • The threefold protrusions of adeno-associated virus type 8 are involved in cell surface targeting as well as postattachment processing
    • Raupp, C. et al. The threefold protrusions of adeno-associated virus type 8 are involved in cell surface targeting as well as postattachment processing. J. Virol. 86, 9396-9408 (2012).
    • (2012) J. Virol. , vol.86 , pp. 9396-9408
    • Raupp, C.1
  • 14
    • 84857602565 scopus 로고    scopus 로고
    • Intra- and intersubunit disulfide bond formation is nonessential in adeno-associated viral capsids
    • Pulicherla, N., Kota, P., Dokholyan, N. V. & Asokan, A. Intra- and intersubunit disulfide bond formation is nonessential in adeno-associated viral capsids. PLoS One 7, e32163 (2012).
    • (2012) PLoS One , vol.7
    • Pulicherla, N.1    Kota, P.2    Dokholyan, N.V.3    Asokan, A.4
  • 15
    • 79957890386 scopus 로고    scopus 로고
    • Engineering liver-detargeted AAV9 vectors for cardiac and musculoskeletal gene transfer
    • Pulicherla, N. et al. Engineering liver-detargeted AAV9 vectors for cardiac and musculoskeletal gene transfer. Mol. Ther. 19, 1070-1078 (2011).
    • (2011) Mol. Ther. , vol.19 , pp. 1070-1078
    • Pulicherla, N.1
  • 16
    • 30344450073 scopus 로고    scopus 로고
    • Mutations on the external surfaces of adeno-associated virus type 2 capsids that affect transduction and neutralization
    • Lochrie, M. A. et al. Mutations on the external surfaces of adeno-associated virus type 2 capsids that affect transduction and neutralization. J. Virol. 80, 821-834 (2006).
    • (2006) J. Virol. , vol.80 , pp. 821-834
    • Lochrie, M.A.1
  • 18
    • 33748494015 scopus 로고    scopus 로고
    • Adeno-associated virus type 2 contains an integrin α5β1 binding domain essential for viral cell entry
    • Asokan, A., Hamra, J. B., Govindasamy, L., Agbandje-McKenna, M. & Samulski, R. J. Adeno-associated virus type 2 contains an integrin α5β1 binding domain essential for viral cell entry. J. Virol. 80, 8961-8969 (2006).
    • (2006) J. Virol. , vol.80 , pp. 8961-8969
    • Asokan, A.1    Hamra, J.B.2    Govindasamy, L.3    Agbandje-McKenna, M.4    Samulski, R.J.5
  • 19
    • 0036678455 scopus 로고    scopus 로고
    • The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy
    • Xie, Q. et al. The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy. Proc. Natl Acad. Sci. USA 99, 10405-10410 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 10405-10410
    • Xie, Q.1
  • 20
    • 36049020398 scopus 로고    scopus 로고
    • Structure of adeno-associated virus serotype 8, a gene therapy vector
    • Nam, H. J. et al. Structure of adeno-associated virus serotype 8, a gene therapy vector. J. Virol. 81, 12260-12271 (2007).
    • (2007) J. Virol. , vol.81 , pp. 12260-12271
    • Nam, H.J.1
  • 21
    • 84864003612 scopus 로고    scopus 로고
    • Structural insight into the unique properties of adeno-associated virus serotype 9
    • DiMattia, M. A. et al. Structural insight into the unique properties of adeno-associated virus serotype 9. J. Virol. 86, 6947-6958 (2012).
    • (2012) J. Virol. , vol.86 , pp. 6947-6958
    • DiMattia, M.A.1
  • 22
    • 33751210120 scopus 로고    scopus 로고
    • Structurally mapping the diverse phenotype of adeno-associated virus serotype 4
    • Govindasamy, L. et al. Structurally mapping the diverse phenotype of adeno-associated virus serotype 4. J. Virol. 80, 11556-11570 (2006).
    • (2006) J. Virol. , vol.80 , pp. 11556-11570
    • Govindasamy, L.1
  • 23
    • 77953285729 scopus 로고    scopus 로고
    • The structure of adeno-associated virus serotype 3B (AAV-3B): Insights into receptor binding and immune evasion
    • Lerch, T. F., Xie, Q. & Chapman, M. S. The structure of adeno-associated virus serotype 3B (AAV-3B): insights into receptor binding and immune evasion. Virology 403, 26-36 (2010).
    • (2010) Virology , vol.403 , pp. 26-36
    • Lerch, T.F.1    Xie, Q.2    Chapman, M.S.3
  • 24
    • 79957918498 scopus 로고    scopus 로고
    • The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice
    • Bell, C. L. et al. The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice. J. Clin. Invest. 121, 2427-2435 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 2427-2435
    • Bell, C.L.1
  • 25
    • 79953857433 scopus 로고    scopus 로고
    • Terminal N-linked galactose is the primary receptor for adeno-associated virus 9
    • Shen, S., Bryant, K. D., Brown, S. M., Randell, S. H. & Asokan, A. Terminal N-linked galactose is the primary receptor for adeno-associated virus 9. J. Biol. Chem. 286, 13532-13540 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 13532-13540
    • Shen, S.1    Bryant, K.D.2    Brown, S.M.3    Randell, S.H.4    Asokan, A.5
  • 26
    • 60949103263 scopus 로고    scopus 로고
    • Adeno-associated virus-2 and its primary cellular receptor-Cryo-EM structure of a heparin complex
    • O'Donnell, J., Taylor, K. A. & Chapman, M. S. Adeno-associated virus-2 and its primary cellular receptor-Cryo-EM structure of a heparin complex. Virology 385, 434-443 (2009).
    • (2009) Virology , vol.385 , pp. 434-443
    • O'Donnell, J.1    Taylor, K.A.2    Chapman, M.S.3
  • 27
    • 84864387256 scopus 로고    scopus 로고
    • Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8
    • Gurda, B. L. et al. Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8. J. Virol. 86, 7739-7751 (2012).
    • (2012) J. Virol. , vol.86 , pp. 7739-7751
    • Gurda, B.L.1
  • 28
    • 84862329652 scopus 로고    scopus 로고
    • Structure of adeno-associated virus-2 in complex with neutralizing monoclonal antibody A20
    • McCraw, D. M., O'Donnell, J. K., Taylor, K. A., Stagg, S. M. & Chapman, M. S. Structure of adeno-associated virus-2 in complex with neutralizing monoclonal antibody A20. Virology 431, 40-49 (2012).
    • (2012) Virology , vol.431 , pp. 40-49
    • McCraw, D.M.1    O'Donnell, J.K.2    Taylor, K.A.3    Stagg, S.M.4    Chapman, M.S.5
  • 29
    • 45549090635 scopus 로고    scopus 로고
    • Next generation of adeno-associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses
    • Zhong, L. et al. Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses. Proc. Natl Acad. Sci. USA 105, 7827-7832 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 7827-7832
    • Zhong, L.1
  • 30
    • 84856975718 scopus 로고    scopus 로고
    • Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9
    • Dalkara, D. et al. Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9. Gene Ther. 19, 176-181 (2012).
    • (2012) Gene Ther. , vol.19 , pp. 176-181
    • Dalkara, D.1
  • 31
    • 84872008658 scopus 로고    scopus 로고
    • Single tyrosine mutation in AAV8 and AAV9 capsids is insufficient to enhance gene delivery to skeletal muscle and heart
    • Qiao, C., Yuan, Z., Li, J., Tang, R. & Xiao, X. Single tyrosine mutation in AAV8 and AAV9 capsids is insufficient to enhance gene delivery to skeletal muscle and heart. Hum. Gene Ther. Methods 23, 29-37 (2012).
    • (2012) Hum. Gene Ther. Methods , vol.23 , pp. 29-37
    • Qiao, C.1    Yuan, Z.2    Li, J.3    Tang, R.4    Xiao, X.5
  • 32
    • 84859610928 scopus 로고    scopus 로고
    • Development of optimized AAV3 serotype vectors: Mechanism of high-efficiency transduction of human liver cancer cells
    • Cheng, B. et al. Development of optimized AAV3 serotype vectors: mechanism of high-efficiency transduction of human liver cancer cells. Gene Ther. 19, 375-384 (2012).
    • (2012) Gene Ther. , vol.19 , pp. 375-384
    • Cheng, B.1
  • 33
    • 74049120342 scopus 로고    scopus 로고
    • Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle
    • Asokan, A. et al. Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle. Nat. Biotechnol. 28, 79-82 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 79-82
    • Asokan, A.1
  • 34
    • 32344438754 scopus 로고    scopus 로고
    • Directed evolution of adeno-associated virus yields enhanced gene delivery vectors
    • Maheshri, N., Koerber, J. T., Kaspar, B. K. & Schaffer, D. V. Directed evolution of adeno-associated virus yields enhanced gene delivery vectors. Nat. Biotechnol. 24, 198-204 (2006).
    • (2006) Nat. Biotechnol. , vol.24 , pp. 198-204
    • Maheshri, N.1    Koerber, J.T.2    Kaspar, B.K.3    Schaffer, D.V.4
  • 35
    • 44949131860 scopus 로고    scopus 로고
    • In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses
    • Grimm, D. et al. In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses. J. Virol. 82, 5887-5911 (2008).
    • (2008) J. Virol. , vol.82 , pp. 5887-5911
    • Grimm, D.1
  • 36
    • 62649174755 scopus 로고    scopus 로고
    • Directed evolution of adeno-associated virus to an infectious respiratory virus
    • Excoffon, K. J. et al. Directed evolution of adeno-associated virus to an infectious respiratory virus. Proc. Natl Acad. Sci. USA 106, 3865-3870 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 3865-3870
    • Excoffon, K.J.1
  • 37
    • 62649151797 scopus 로고    scopus 로고
    • A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection
    • Yang, L. et al. A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection. Proc. Natl Acad. Sci. USA 106, 3946-3951 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 3946-3951
    • Yang, L.1
  • 38
    • 70349634435 scopus 로고    scopus 로고
    • Quantitative phenotyping via deep barcode sequencing
    • Smith, A. M. et al. Quantitative phenotyping via deep barcode sequencing. Genome Res. 19, 1836-1842 (2009).
    • (2009) Genome Res. , vol.19 , pp. 1836-1842
    • Smith, A.M.1
  • 39
    • 19644378907 scopus 로고    scopus 로고
    • Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart
    • Wang, Z. et al. Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart. Nat. Biotechnol. 23, 321-328 (2005).
    • (2005) Nat. Biotechnol. , vol.23 , pp. 321-328
    • Wang, Z.1
  • 40
    • 33745143956 scopus 로고    scopus 로고
    • Robust systemic transduction with AAV9 vectors in mice: Efficient global cardiac gene transfer superior to that of AAV8
    • Inagaki, K. et al. Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8. Mol. Ther. 14, 45-53 (2006).
    • (2006) Mol. Ther. , vol.14 , pp. 45-53
    • Inagaki, K.1
  • 41
    • 44349170706 scopus 로고    scopus 로고
    • Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection
    • Zincarelli, C., Soltys, S., Rengo, G. & Rabinowitz, J. E. Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection. Mol. Ther. 16, 1073-1080 (2008).
    • (2008) Mol. Ther. , vol.16 , pp. 1073-1080
    • Zincarelli, C.1    Soltys, S.2    Rengo, G.3    Rabinowitz, J.E.4
  • 42
    • 60149106907 scopus 로고    scopus 로고
    • Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes
    • Foust, K. D. et al. Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes. Nat. Biotechnol. 27, 59-65 (2009).
    • (2009) Nat. Biotechnol. , vol.27 , pp. 59-65
    • Foust, K.D.1
  • 43
    • 79961032418 scopus 로고    scopus 로고
    • Several rAAV vectors efficiently cross the blood-brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous system
    • Zhang, H. et al. Several rAAV vectors efficiently cross the blood-brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous system. Mol. Ther. 19, 1440-1448 (2011).
    • (2011) Mol. Ther. , vol.19 , pp. 1440-1448
    • Zhang, H.1
  • 44
    • 79957909371 scopus 로고    scopus 로고
    • A potential role of distinctively delayed blood clearance of recombinant adeno-associated virus serotype 9 in robust cardiac transduction
    • Kotchey, N. M. et al. A potential role of distinctively delayed blood clearance of recombinant adeno-associated virus serotype 9 in robust cardiac transduction. Mol. Ther. 19, 1079-1089 (2011).
    • (2011) Mol. Ther. , vol.19 , pp. 1079-1089
    • Kotchey, N.M.1
  • 45
    • 0021702358 scopus 로고
    • Translocation across Golgi vesicle membranes: A CHO glycosylation mutant deficient in CMP-sialic acid transport
    • Deutscher, S. L., Nuwayhid, N., Stanley, P., Briles, E. I. & Hirschberg, C. B. Translocation across Golgi vesicle membranes: a CHO glycosylation mutant deficient in CMP-sialic acid transport. Cell 39, 295-299 (1984).
    • (1984) Cell , vol.39 , pp. 295-299
    • Deutscher, S.L.1    Nuwayhid, N.2    Stanley, P.3    Briles, E.I.4    Hirschberg, C.B.5
  • 46
    • 33748501920 scopus 로고    scopus 로고
    • α2,3 and α2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6
    • Wu, Z., Miller, E., Agbandje-McKenna, M. & Samulski, R. J. α2,3 and α2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6. J. Virol. 80, 9093-9103 (2006).
    • (2006) J. Virol. , vol.80 , pp. 9093-9103
    • Wu, Z.1    Miller, E.2    Agbandje-McKenna, M.3    Samulski, R.J.4
  • 47
    • 0035827546 scopus 로고    scopus 로고
    • Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer
    • Walters, R. W. et al. Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer. J. Biol. Chem. 276, 20610-20616 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 20610-20616
    • Walters, R.W.1
  • 48
    • 2642512201 scopus 로고    scopus 로고
    • Clades of adeno-associated viruses are widely disseminated in human tissues
    • Gao, G. et al. Clades of adeno-associated viruses are widely disseminated in human tissues. J. Virol. 78, 6381-6388 (2004).
    • (2004) J. Virol. , vol.78 , pp. 6381-6388
    • Gao, G.1
  • 49
    • 84885171074 scopus 로고    scopus 로고
    • Engraftment of a galactose receptor footprint onto adeno-associated viral capsids improves transduction efficiency
    • Shen, S. et al. Engraftment of a galactose receptor footprint onto adeno-associated viral capsids improves transduction efficiency. J. Biol. Chem. 288, 28814-28823 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 28814-28823
    • Shen, S.1
  • 50
    • 80054719497 scopus 로고    scopus 로고
    • Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding
    • Lu, R., Neff, N. F., Quake, S. R. & Weissman, I. L. Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding. Nat. Biotechnol. 29, 928-933 (2011).
    • (2011) Nat. Biotechnol. , vol.29 , pp. 928-933
    • Lu, R.1    Neff, N.F.2    Quake, S.R.3    Weissman, I.L.4
  • 51
    • 84863230316 scopus 로고    scopus 로고
    • Massively parallel functional dissection of mammalian enhancers in vivo
    • Patwardhan, R. P. et al. Massively parallel functional dissection of mammalian enhancers in vivo. Nat. Biotechnol. 30, 265-270 (2012).
    • (2012) Nat. Biotechnol. , vol.30 , pp. 265-270
    • Patwardhan, R.P.1
  • 52
    • 84863229330 scopus 로고    scopus 로고
    • Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay
    • Melnikov, A. et al. Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay. Nat. Biotechnol. 30, 271-277 (2012).
    • (2012) Nat. Biotechnol. , vol.30 , pp. 271-277
    • Melnikov, A.1
  • 53
    • 0031875874 scopus 로고    scopus 로고
    • Adeno-associated virus vectors can be efficiently produced without helper virus
    • Matsushita, T. et al. Adeno-associated virus vectors can be efficiently produced without helper virus. Gene Ther. 5, 938-945 (1998).
    • (1998) Gene Ther. , vol.5 , pp. 938-945
    • Matsushita, T.1
  • 54
    • 2642642141 scopus 로고    scopus 로고
    • Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus
    • Xiao, X., Li, J. & Samulski, R. J. Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J. Virol. 72, 2224-2232 (1998).
    • (1998) J. Virol. , vol.72 , pp. 2224-2232
    • Xiao, X.1    Li, J.2    Samulski, R.J.3
  • 55
    • 0033607305 scopus 로고    scopus 로고
    • Coexpression of factor VIII heavy and light chain adeno-associated viral vectors produces biologically active protein
    • Burton, M. et al. Coexpression of factor VIII heavy and light chain adeno-associated viral vectors produces biologically active protein. Proc. Natl Acad. Sci. USA 96, 12725-12730 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 12725-12730
    • Burton, M.1
  • 56
    • 0141482003 scopus 로고    scopus 로고
    • Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors for liver gene therapy
    • Grimm, D. et al. Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors for liver gene therapy. Blood 102, 2412-2419 (2003).
    • (2003) Blood , vol.102 , pp. 2412-2419
    • Grimm, D.1
  • 57
    • 78149421208 scopus 로고    scopus 로고
    • A new recombinant adeno-associated virus (AAV)-based random peptide display library system: Infection-defective AAV1.9-3 as a novel detargeted platform for vector evolution
    • Adachi, K. & Nakai, H. A new recombinant adeno-associated virus (AAV)-based random peptide display library system: Infection-defective AAV1.9-3 as a novel detargeted platform for vector evolution. Gene Ther. Regul. 5, 31-55 (2010).
    • (2010) Gene Ther. Regul. , vol.5 , pp. 31-55
    • Adachi, K.1    Nakai, H.2
  • 58
    • 84879486500 scopus 로고    scopus 로고
    • An experimental and computational evolution-based method to study a mode of co-evolution of overlapping open reading frames in the AAV2 viral genome
    • Kawano, Y., Neeley, S., Adachi, K. & Nakai, H. An experimental and computational evolution-based method to study a mode of co-evolution of overlapping open reading frames in the AAV2 viral genome. PLoS One 8, e66211 (2013).
    • (2013) PLoS One , vol.8
    • Kawano, Y.1    Neeley, S.2    Adachi, K.3    Nakai, H.4
  • 59
    • 2542445427 scopus 로고    scopus 로고
    • ConSurf: Identification of functional regions in proteins by surface-mapping of phylogenetic information
    • Glaser, F. et al. ConSurf: identification of functional regions in proteins by surface-mapping of phylogenetic information. Bioinformatics 19, 163-164 (2003).
    • (2003) Bioinformatics , vol.19 , pp. 163-164
    • Glaser, F.1
  • 60
    • 58149182734 scopus 로고    scopus 로고
    • VIPERdb2: An enhanced and web API enabled relational database for structural virology
    • Carrillo-Tripp, M. et al. VIPERdb2: an enhanced and web API enabled relational database for structural virology. Nucleic Acids Res. 37, D436-D442 (2009).
    • (2009) Nucleic Acids Res. , vol.37 , pp. D436-D442
    • Carrillo-Tripp, M.1
  • 61
    • 84863304598 scopus 로고    scopus 로고
    • R Foundation for Statistical Computing
    • R Core Team. R: A Language and Environment for Statistical Computing (R Foundation for Statistical Computing. ISBN 3-900051-07-0, http://www.R-project.org/, 2012).
    • (2012) R: A Language and Environment for Statistical Computing


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.