Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle

Nature Biotechnology

Volumn 28, Issue 1, 2010, Pages 79-82

  Asokan, Aravind ^a   Conway, Julia C ^a   Phillips, Jana L ^a   Li, Chengwen ^a   Hegge, Julia ^c   Sinnott, Rebecca ^a   Yadav, Swati ^a   Diprimio, Nina ^a   Nam, Hyun Joo ^b   Agbandje Mckenna, Mavis ^b   McPhee, Scott ^d   Wolff, Jon ^c   Samulski, R Jude ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c Mirus Bio Corporation   (United States)

^d ASKLEPIOS BIOPHARMACEUTICAL INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENO-ASSOCIATED VIRUS; CLINICAL APPLICATION; HEPARAN SULFATES; HIGH EFFICIENCY; INTRAVENOUS ADMINISTRATION; MUSCULOSKELETAL DISORDERS; SEROTYPES; SKELETAL MUSCLE; VASCULATURE; WHOLE-BODY;

GENE TRANSFER; MUSCLE; REENGINEERING; VIRUSES;

GENE THERAPY;

HEPARAN SULFATE; HEXAPEPTIDE; PARVOVIRUS VECTOR;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANTIGENICITY; ARTICLE; CHIMERA; GENE TRANSFER; GENE VECTOR; GENETIC ENGINEERING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SEROTYPE; SKELETAL MUSCLE; VIRUS CAPSID; VIRUS STRAIN;

ANIMALS; DEPENDOVIRUS; GENE TRANSFER TECHNIQUES; GENETIC ENGINEERING; GENETIC VECTORS; MICE; MODELS, MOLECULAR; MUSCLES; ORGAN SPECIFICITY; RECEPTORS, VIRUS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL TROPISM;

ADENO-ASSOCIATED VIRUS; MIRIDAE; MUS;

EID: 74049120342     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1599     Document Type: Article

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