Ropivacaine attenuates endotoxin plus hyperinflation-mediated acute lung injury via inhibition of early-onset Src-dependent signaling

BMC Anesthesiology

Volumn 14, Issue , 2014, Pages

  Piegeler, Tobias ^a,c   Dull, Randal O ^a,b   Hu, Guochang ^a   Castellon, Maricela ^a   Chignalia, Andreia Z ^a   Koshy, Ruben G ^a   Votta Velis, E G ^a,e   Borgeat, Alain ^d   Schwartz, David E ^a   Beck Schimmer, Beatrice ^c   Minshall, Richard D ^a,b  

^a UNIVERSITY OF ILLINOIS HOSPITAL AND HEALTH SCIENCES SYSTEM   (United States)

^b University of Illinois at Chicago   (United States)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

^e JESSE BROWN VA MEDICAL CENTER   (United States)

Author keywords

Acute lung injury; ARDS; Caveolin 1; Endothelium; Local anesthetics; Src protein tyrosine kinase; Ventilator induced lung injury

Indexed keywords

CAVEOLIN 1; ENDOTOXIN; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; PROTEIN TYROSINE KINASE; ROPIVACAINE; SODIUM CHLORIDE; AMIDE; LOCAL ANESTHETIC AGENT;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPERINFLATION; LUNG FLUID; LUNG HOMOGENATE; MICROVASCULAR ENDOTHELIAL CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TIDAL VOLUME; VENTILATOR INDUCED LUNG INJURY; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; ENDOTHELIUM CELL; GENETICS; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PULMONARY EDEMA; SIGNAL TRANSDUCTION; VENTILATOR-INDUCED LUNG INJURY;

ACUTE LUNG INJURY; AMIDES; ANESTHETICS, LOCAL; ANIMALS; CAVEOLIN 1; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHORYLATION; PULMONARY EDEMA; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; VENTILATOR-INDUCED LUNG INJURY;

EID: 84904903305     PISSN: None     EISSN: 14712253     Source Type: Journal    
DOI: 10.1186/1471-2253-14-57     Document Type: Article

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