Activation of calpains mediates early lung neutrophilic inflammation in ventilator-induced lung injury

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 302, Issue 4, 2012, Pages

  Liu, Dejie ^a,b   Yan, Zhibo ^a   Minshall, Richard D ^a   Schwartz, David E ^a   Chen, Yuguo ^b   Hu, Guochang ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Acute lung injury; Intercellular adhesion molecule; Neutrophils; Nitric oxide; Phosphorylation

Indexed keywords

ANTIINFLAMMATORY AGENT; CALPAIN 1; CALPAIN 2; CALPAIN INHIBITOR I; CALPASTATIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LIPOSOME; MYELOPEROXIDASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ARTIFICIAL VENTILATION; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG DOSE COMPARISON; ENZYME ACTIVATION; ENZYME INHIBITION; GENE SILENCING; IMMUNOPATHOGENESIS; IN VIVO STUDY; LIPOSOMAL GENE DELIVERY SYSTEM; LUNG BLOOD VESSEL; LUNG EDEMA; LUNG LAVAGE; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PNEUMONIA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; TIDAL VOLUME; VENTILATOR INDUCED LUNG INJURY;

ANIMALS; CALPAIN; ENZYME ACTIVATION; GENE KNOCKDOWN TECHNIQUES; GLYCOPROTEINS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; LUNG; MALE; MICE; MICE, INBRED C57BL; NEUTROPHIL INFILTRATION; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; RNA INTERFERENCE; VENTILATOR-INDUCED LUNG INJURY; VENTILATORS, MECHANICAL;

EID: 84863070087     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00349.2011     Document Type: Article

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