The role of FTO gene polymorphism in the pathogenesis of obesity;Rola polimorfizmu genu FTO w patogenezie otyłości

Pediatric Endocrinology, Diabetes and Metabolism

Volumn 16, Issue 2, 2010, Pages 109-113

  Tercjak, Magdalena ^a   Łuczyński, Włodzimierz ^b   Wawrusiewicz Kurylonek, Natalia ^c   Bossowski, Artur ^b  

^a Uniwersytetu Medycznego   (Poland)

^b Uniwersytetu Medycznego   (Poland)

^c Klinika Endokrynologii Diabetologii i Chorób Wewn trznych Uniwersytetu Medycznego   (Poland)

Author keywords

Genes; Obesity; Polymorphism

Indexed keywords

ALLELE; BODY MASS; BODY WEIGHT; CENTRAL NERVOUS SYSTEM; DNA REPAIR; ENERGY EXPENDITURE; FAT MASS AND OBESITY ASSOCIATED GENE; FOOD INTAKE; GENE; GENE EXPRESSION; GENE FUNCTION; GENETIC POLYMORPHISM; HUMAN; HYPOTHALAMUS; INSULIN RESISTANCE; METABOLIC REGULATION; OBESITY; PERIPHERAL NERVOUS SYSTEM; REVIEW; RNA REPAIR; WAIST CIRCUMFERENCE; ADULT; CHILD; EATING; ENERGY METABOLISM; GENETICS;

FTO PROTEIN, HUMAN; PROTEIN;

ADULT; CHILD; EATING; ENERGY METABOLISM; HUMANS; INSULIN RESISTANCE; OBESITY; POLYMORPHISM, GENETIC; PROTEINS;

EID: 84904841260     PISSN: 1234625X     EISSN: 20838441     Source Type: Journal    
DOI: None     Document Type: Review

References (43)

1. Ogden C.L., Carroll M.D., Curtin L.R. i wsp.: Prevalence of overweight and obesity in the United States, 1999-2004. JAMA, 2006, 295, 1549-1555.
2. Li T.Y., Rana J.S., Manson J.E. i wsp.: Obesity as compared with physical activity in predicting risk of coronary heart disease in women. Circulation, 2006, 113, 499-506.
3. Adams K.F., Schatzkin A., Harris T.B. i wsp.: Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. NEJM, 2006, 355, 763-778.
4. Wolf A.M., Colditz G.A.: Current estimates of the economic cost of obesity in the United States. Obes. Res., 1998, 6, 97-106.
5. Farooqi S., O'Rahilly S.: Genetics of obesity in humans. Endocr. Rev., 2006, 27, 710-718.
6. Zhao J., Bradfield J.P., Li M. i wsp.: The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. Obesity, 2009, 17, 2254-2257.
7. Frayling T.M., Timpson N.J., Weedon M.N. i wsp.: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 2007, 316, 889-894.
8. Scuteri A., Sanna S., Chen W.M. i wsp.: Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genetics, 2007, 3, e115.
9. Klein R.J., Zeiss C., Chew E.Y. i wsp.: Complement factor H polymorphism in age-related macular degeneration. Science, 2005, 308, 385-389.
10. Duerr R.H., Taylor K.D., Brant S.R. i wsp.: A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science, 2006, 314, 1461-1463.
11. Pearson T.A., Manolio T.A.: How to interpret a genome-wide association study. JAMA, 2008, 299, 1335-1344.
12. Collins F.S., Morgan M., Patrinos A.: The Human Genome Project: Lessons from Large-Scale Biology. Science, 2003, 300, 286-290.
13. Eberle M.A., Ng P.C., Kuhn K. i wsp.: Power to detect risk alleles using genome-wide tag SNP panels. PLoS Genetics, 2007, 3, 1827-1837.
14. Consortium I.H., Frazer K.A., Ballinger D.G. i wsp.: A second generation human haplotype map of over 3.1 million SNPs. Nature, 2008, 449, 851-861.
15. Consortium I.H.: The International HapMap Project. Nature, 2003, 426, 789-896.
16. Dina C., Meyre D., Gallina S. i wsp.: Variation in FTO contributes to childhood obesity and severe adult obesity. Nat. Genet., 2007, 39, 724-726.
17. Peters T., Ausmeier K., Ruthe U.: Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm. Genome, 1999, 10, 983-986.
18. Fischer J., Koch L., Emmerling C. i wsp.: Inactivation of the FTO gene protects from obesity. Nature, 2009, 458, 894-898.
19. Trewick S.C., Henshaw T.F., Hausinger R.P. i wsp.: Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature, 2002, 419, 174-178.
20. Aas P.A., Otterlei M., Falnes P.O. i wsp.: Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature, 2003, 421, 859-863.
21. Duncan T., Trewick S.C., Koivisto P. i wsp.: Reversal of DNA alkylation damage by two human dioxygenases. Proc. Natl. Acad. Sci. USA, 2002, 99, 16660-16665.
22. Fredriksson R., Hägglund M., Olszewski P.K. i wsp.: The obesity gene, FTO, is of ancient origin, upregulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinol., 2008, 149, 2062-2071.
23. Robbens S., Rouzé P., Cock J.M. i wsp.: The FTO gene, implicated in human obesity, is found only in vertebrates and marine algae. J. Mol. Evol., 2008, 66, 80-84.
24. Gerken T., Girard C.A., Tung Y.C. i wsp.: The obesity-associated FTO gene encodes a 2-oxoglutarate- dependent nucleic acid demethylase. Science, 2007, 318, 1469-1472.
25. Tung Y.C., Ayuso E., Shan X. i wsp.: Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS One, 2010, 5, e8771.
26. Klöting N., Schleinitz D., Ruschke K. i wsp.: Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans. Diabetologia, 2008, 51, 641-647.
27. Omori S., Tanaka Y., Takahashi A. i wsp.: Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes, 2008, 57, 791-795.
28. Liu Y., Liu Z., Song Y. i wsp.: Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population. Obesity, 2010 (w druku).
29. Karasawa S., Daimon M., Sasaki S. i wsp.: Association of the common fat mass and obesity associated (FTO) gene polymorphism with obesity in a Japanese population. Endocr. J., 2010 (w druku).
30. Jacobsson J.A., Riserus U., Axelsson T. i wsp.: The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924. BMC MED Genet., 2009, 10, 131.
31. Razquin C., Martinez J.A., Martinez-Gonzalez M.A. i wsp.: A 3-year intervention with a Mediterranean diet modified the associoation between the rs9939609 gene variant in FTO and body weight changes. Int. J. Obes. (Lond), 2010, 34, 266-272.
32. Hardy R., Wills A.K., Wong A. i wsp.: Life course variations in the associations between FTO and MC4R gene variants and body size. Hum. Mol. Genet., 2010, 19, 545-552.
33. Andreasen C.H., Andersen G.: Gene-environment interactions and obesity - further aspects of genomewide association studies. Nutrition, 2009, 25, 998-1003.
34. Tanofsky-Kraff M., Han J.C., Anandalingam K. i wsp.: The FTO gene rs9939609 obesity-risk allele and loss of control over eating. Am. J. Clin. Nutr., 2009, 90, 1483-1488.
35. Hasselbalch A.L., Angquist L., Christiansen L. i wsp.: A variant in the fat mass and obesity-associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) do not influence dietary intake. J. Nutr., 2010 (w druku).
36. Reinehr T., Hinney A., Toschke A.M., Hebebrand J.: Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention. Arch. Dis. Child., 2009, 94, 965-967.
37. Shimaoka I., Kamide K., Ohishi M. i wsp.: Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese. Hypertens. Res., 2010 (w druku).
38. Yajnik C.S., Janipalli C.S., Bhaskar S., Kulkarni S.R.: FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians. Diabetologia, 2009, 52, 247-252.
39. Attanoua R., Ait El Mkadem S., Lautier C. i wsp.: Association of the FTO gene with obesity and the metabolic syndrome is independent of the IRS-2 gene in the female population of Southern France. Diabet. Metab., 2009, 35, 476-483.
40. Pausova Z., Syme C., Abrahamowicz M. i wsp.: A common variant of the FTO gene is associated not only with increased adiposity but also elevated blood pressure in French Canadians. Circ. Cardiovasc. Genet., 2009, 2, 260-269.
41. Doney A.S., Dannfald J., Kimber C.H. i wsp.: The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study. Circ. Cardiovasc. Genet., 2009, 2, 255-259.
42. Zimmermann E., Kring S.I.I., Berentzen T.L. i wsp.: Fatness-associated FTO gene variant increases mortality independent of fatness - in cohorts of Danish Men. PLoS One, 2009, 4, e4428.
43. Tan S., Scherag A., Janssen O.E. i wsp.: Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variations in patients with polycystic ovary syndrome (PCOS). BMC MED Genet, 2010, 11, 12.