Fatness-associated FTO gene variant increases mortality independent of fatness - In cohorts of Danish men

PLoS ONE

Volumn 4, Issue 2, 2009, Pages

  Zimmermann, Esther ^a   Kring, Sofia I I ^a   Berentzen, Tina L ^a   Holst, Claus ^a   Pers, Tune H ^b   Hansen, Torben ^c   Pedersen, Oluf ^c   Sørensen, Thorkild I A ^a   Jess, Tine ^a  

^a The Capital Region   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c STENO DIABETES CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; PROTEIN FTO; UNCLASSIFIED DRUG;

ADULT; AGED; ARMY; ARTICLE; BODY FAT; BODY HEIGHT; BODY MASS; BODY WEIGHT; CAUSE OF DEATH; COHORT ANALYSIS; CONTROLLED STUDY; DENMARK; DNA DETERMINATION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HOSPITALIZATION; HUMAN; INCIDENCE; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; NUCLEOTIDE SEQUENCE; OBESITY; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; WAIST CIRCUMFERENCE;

EID: 84887212356     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004428     Document Type: Article

References (26)

1. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-94.
2. Dina C, Meyre D, Gallina S, Durand E, Korner A, et al. (2007) Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 39: 724-6.
3. Scuteri A, Sanna S, Chen WM, Uda M, Albai G, et al. (2007) Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits. PLoS Genet 3: e115.
4. Jess T, Zimmermann E, Kring SI, Berentzen T, Holst C, et al. (2008) Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study. Int J Obes 32: 1388-94.
5. Adams KF, Schatzkin A, Harris TB, Kipnis V, Mouw T, et al. (2006) Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med 355: 763-78.
6. Bigaard J, Tjonneland A, Thomsen BL, Overvad K, Heitmann BL, et al. (2003) Waist circumference, BMI, smoking, and mortality in middle-aged men and women. Obes Res 11: 895-903.
7. Bigaard J, Frederiksen K, Tjonneland A, Thomsen BL, Overvad K, et al. (2004) Body fat and fat-free mass and all-cause mortality. Obes Res 12: 1042-9.
8. Christensen U, Sonne-Holm S, Sørensen TIA (1981) Constant median body mass index of Danish young men, 1943-1977. Hum Biol 53: 403-10.
9. Sørensen TIA, Sonne-Holm S (1977) Mortality in extremely overweight young men. J Chronic Dis 30: 359-67.
10. Schnohr P, Jensen G, Lange P, Scharling H, Appleyard M (2001) The Copenhagen City Heart Study. Tables with data from the third examination 1991-1994. Journal of the European Society of Cardiology 3; Supplement H.
11. Heitmann BL (1994) Impedance: a valid method in assessment of body composition? Eur J Clin Nutr 48: 228-40.
12. Pedersen CB, Gotzsche H, Moller JO, Mortensen PB (2006) The Danish Civil Registration System. A cohort of eight million persons. Dan Med Bull 53: 441-9.
13. Andersen TF, Madsen M, Jorgensen J, Mellemkjoer L, Olsen JH (1999) The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull 46: 263-8.
14. Juel K, Helweg-Larsen K (1999) The Danish registers of causes of death. Dan Med Bull 46: 354-7.
15. Rothman K, Greenland S, Lash T (2008) Modern Epidemiology. Philadelphia, Lippincott: Williams & Wilkins. 758 p.
16. Andersen P, Borgan Ø, Gill R, Keiding N (1993) Statistical models based on counting processes. New York: Springer-Verlag. 767 p.
17. Greenland S (1995) Dose-response and trend analysis in epidemiology: alternatives to categorical analysis. Epidemiology 6: 356-65.
18. Doll R, Peto R, Boreham J, Sutherland I (2004) Mortality in relation to smoking: 50 years' observations on male British doctors. BMJ 328: 1519.
19. Andreasen CH, Stender-Petersen KL, Mogensen MS, Torekov SS, Wegner L, et al. (2008) Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 57: 95-101.
20. Peeters A, Beckers S, Verrijken A, Roevens P, Peeters P, et al. (2008) Variants in the FTO gene are associated with common obesity in the Belgian population. Mol Genet Metab 93: 481-4.
21. Fredriksson R, Hagglund M, Olszewski PK, Stephansson O, Jacobsson JA, et al. (2008) The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology 149: 2062-71.
22. Robbens S, Rouze P, Cock JM, Spring J, Worden AZ, et al. (2008) The FTO gene, implicated in human obesity, is found only in vertebrates and marine algae. J Mol Evol 66: 80-4.
23. Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, et al. (2007) The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318: 1469-72.
24. Tschritter O, Preissl H, Yokoyama Y, Machicao F, Haring HU, et al. (2007) Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans. Diabetologia 50: 2602-3.
25. Wahlen K, Sjolin E, Hoffstedt J (2008) The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis. J Lipid Res 49: 607-11.
26. The Danish National Board of Health (2006) New figures from the National Board of Health, No 18 [online]. Available: http://www.sst.dk/publ/ tidsskrifter/nyetal/pdf/2006/18_06.pdf. Accessed 19 Aug 2008.