Investigation of the flexibility of protein kinases implicated in the pathology of Alzheimer's disease

Molecules

Volumn 19, Issue 7, 2014, Pages 9134-9159

  Mazanetz, Michael P ^a   Laughton, Charles A ^b   Fischer, Peter M ^b  

^a EVOTEC UK LTD   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Active site pressurisation; Kinase; Molecular dynamics; Protein flexibility; Structure based drug design

Indexed keywords

ADENOSINE TRIPHOSPHATE; PROTEIN BINDING; PROTEIN KINASE; PROTEIN KINASE INHIBITOR;

ALZHEIMER DISEASE; CHEMISTRY; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME STABILITY; ENZYMOLOGY; HUMAN; MOLECULAR DYNAMICS; PRINCIPAL COMPONENT ANALYSIS; PROTEIN SECONDARY STRUCTURE;

ADENOSINE TRIPHOSPHATE; ALZHEIMER DISEASE; CATALYTIC DOMAIN; DRUG DESIGN; ENZYME STABILITY; HUMANS; MOLECULAR DYNAMICS SIMULATION; PRINCIPAL COMPONENT ANALYSIS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN STRUCTURE, SECONDARY;

EID: 84904822533     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules19079134     Document Type: Article

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