Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer

Gastroenterology

Volumn 147, Issue 2, 2014, Pages

  Luo, Yanxin ^a,b   Wong, Chao Jen ^b   Kaz, Andrew M ^b,c,d   Dzieciatkowski, Slavomir ^b   Carter, Kelly T ^b   Morris, Shelli M ^b   Wang, Jianping ^a   Willis, Joseph E ^e   Makar, Karen W ^b   Ulrich, Cornelia M ^b,f   Lutterbaugh, James D ^e   Shrubsole, Martha J ^g   Zheng, Wei ^g   Markowitz, Sanford D ^e   Grady, William M ^b,d  

^a SUN YAT SEN UNIVERSITY   (China)

^b Fred Hutchinson Cancer Research Center   (United States)

^c VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF HEIDELBERG   (Germany)

^g VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Colon Cancer; Epigenetic Modifications; Gene Regulation; Progression

Indexed keywords

K RAS PROTEIN;

ADENOMATOUS POLYP; ADULT; AGED; ARTICLE; CANCER GENETICS; CANCER GROWTH; COLON ADENOMA; COLORECTAL ADENOMA; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; DNA ISOLATION; DNA METHYLATION; EPIGENETICS; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PYROSEQUENCING;

COLON CANCER; EPIGENETIC MODIFICATIONS; GENE REGULATION; PROGRESSION;

ADENOMA; AGED; CASE-CONTROL STUDIES; CELL TRANSFORMATION, NEOPLASTIC; CLUSTER ANALYSIS; COLORECTAL NEOPLASMS; CPG ISLANDS; DISEASE PROGRESSION; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; EPIGENESIS, GENETIC; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MIDDLE AGED; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PROTO-ONCOGENE PROTEINS; RAS PROTEINS;

EID: 84904744663     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.04.039     Document Type: Article

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