Anti-proliferative and pro-apoptotic activity of whole extract and isolated indicaxanthin from Opuntia ficus-indica associated with re-activation of the onco-suppressor p16INK4a gene in human colorectal carcinoma (Caco-2) cells

Biochemical and Biophysical Research Communications

Volumn 450, Issue 1, 2014, Pages 652-658

  Naselli, Flores ^a   Tesoriere, Luisa ^a   Caradonna, Fabio ^a   Bellavia, Daniele ^a   Attanzio, Alessandro ^a   Gentile, Carla ^a   Livrea, Maria A ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Cell cycle; Colorectal carcinoma; Epigenetic control; In vitro; Indicaxanthin

Indexed keywords

CYCLIN DEPENDENT KINASE 4; INDICAXANTHIN; MESSENGER RNA; PLANT EXTRACT; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BETAXANTHIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; PYRIDINE DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CACO 2 CELL LINE; CELL CYCLE REGULATION; CELL DIFFERENTIATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; DEMETHYLATION; DRUG ISOLATION; EPIGENETICS; FRUIT; G2 PHASE CELL CYCLE CHECKPOINT; GENE ACTIVATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IC 50; M PHASE CELL CYCLE CHECKPOINT; MEDICINAL PLANT; ONCOGENE; OPUNTIA FICUS INDICA; OXIDATIVE STRESS; P16 INK4A GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; CELL CYCLE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; EPIGENETIC CONTROL; IN VITRO STUDY; ISOLATION AND PURIFICATION; METABOLISM; OPUNTIA;

CACTACEAE; OPUNTIA FICUS-INDICA; PYRUS;

CELL CYCLE; COLORECTAL CARCINOMA; EPIGENETIC CONTROL; IN VITRO; INDICAXANTHIN;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BETAXANTHINS; CACO-2 CELLS; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; HUMANS; OPUNTIA; PLANT EXTRACTS; PYRIDINES;

EID: 84904719323     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.06.029     Document Type: Article

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