Indicaxanthin from cactus pear fruit exerts anti-inflammatory effects in carrageenin-induced rat pleurisy

Journal of Nutrition

Volumn 144, Issue 2, 2014, Pages 185-192

  Allegra, Mario ^a   Ianaro, Angela ^b   Tersigni, Mariaroberta ^b   Panza, Elisabetta ^b   Tesoriere, Luisa ^a   Livrea, Maria Antonia ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARRAGEENAN; CYCLOOXYGENASE 2; INDICAXANTHIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MESSENGER RNA; NITRIC OXIDE; NUCLEAR FACTOR; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CHRONIC DISEASE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; EXUDATE; FRUIT; LEUKOCYTE; MALE; MEDICINAL PLANT; NONHUMAN; NUTRITIONAL DEFICIENCY; NUTRITIONAL SCIENCE; OPUNTIA FICUS INDICA; PEAR; PLEURA CAVITY; PLEURISY; PROPHYLAXIS; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BETAXANTHINS; CARRAGEENAN; DISEASE MODELS, ANIMAL; FRUIT; INFLAMMATION; INFLAMMATION MEDIATORS; LEUKOCYTES; MALE; OPUNTIA; PHYTOTHERAPY; PLANT EXTRACTS; PLEURAL CAVITY; PLEURISY; PYRIDINES; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 84892662851     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.113.183657     Document Type: Article

References (45)

1. Virgili F, Marino M. Regulation of cellular signals from nutritional molecules: a specific role for phytochemicals, beyond antioxidant activity. Free Radic Biol Med. 2008;45:1205-16.
2. Halliwell B, Rafter J, Jenner A. Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not?. Am J Clin Nutr. 2005;81:268S-76S.
3. Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454:428-35.
4. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39:44-84.
5. Koutsilieri E, Scheller C, Grunblatt E, Nara K, Li J, Riederer P. Free radicals in Parkinsons disease. J Neurol. 2002;249(suppl 2):II1-5.
6. Closa D, Folch-Puy E. Oxygen free radicals and the systemic inflammatory response. IUBMB Life. 2004;56:185-91.
7. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 2006;160:1-40.
8. Wickens AP. Ageing and the free radical theory. Respir Physiol. 2001; 128:379-91.
9. Basu S. Bioactive eicosanoids: role of prostaglandin F(2alpha) and F-isoprostanes in inflammation and oxidative stress related pathology. Mol Cells. 30:383-91.
10. Leonarduzzi G, Sottero B, Poli G. Targeting tissue oxidative damage by means of cell signaling modulators: the antioxidant concept revisited. Pharmacol Ther. 128:336-74.
11. Butera D, Tesoriere L, Di Gaudio F, Bongiorno A, Allegra M, Pintaudi AM, Kohen R, Livrea MA. Antioxidant activities of sicilian prickly pear (Opuntia ficus indica) fruit extracts and reducing properties of its betalains: betanin and indicaxanthin. J Agric Food Chem. 2002;50: 6895-901.
12. Tesoriere L, Butera D, D'Arpa D, Di Gaudio F, Allegra M, Gentile C, Livrea MA. Increased resistance to oxidation of betalain-enriched human low density lipoproteins. Free Radic Res. 2003;37:689-96.
13. Allegra M, Furtmuller PG, Jantschko W, Zederbauer M, Tesoriere L, Livrea MA, Obinger C. Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid. Biochem Biophys Res Commun. 2005;332:837-44.
14. Tesoriere L, Allegra M, Butera D, Gentile C, Livrea MA. Cytoprotective effects of the antioxidant phytochemical indicaxanthin in betathalassemia red blood cells. Free Radic Res. 2006;40:753-61.
15. Tesoriere L, Allegra M, Butera D, Gentile C, Livrea MA. Kinetics of the lipoperoxyl radical-scavenging activity of indicaxanthin in solution and unilamellar liposomes. Free Radic Res. 2007;41:226-33.
16. Tesoriere L, Butera D, Allegra M, Fazzari M, Livrea MA. Distribution of betalain pigments in red blood cells after consumption of cactus pear fruits and increased resistance of the cells to ex vivo induced oxidative hemolysis in humans. J Agric Food Chem. 2005;53:1266-70.
17. Liveri ML, Sciascia L, Lombardo R, Tesoriere L, Passante E, Livrea MA. Spectrophotometric evidence for the solubilization site of betalain pigments in membrane biomimetic systems. J Agric Food Chem. 2007;55:2836-40.
18. Turco Liveri ML, Sciascia L, Allegra M, Tesoriere L, Livrea MA. Partition of indicaxanthin in membrane biomimetic systems. A kinetic and modeling approach. J Agric Food Chem. 2009;57:10959-63.
19. Gentile C, Tesoriere L, Allegra M, Livrea MA, DAlessio P. Antioxidant betalains from cactus pear (Opuntia ficus-indica) inhibit endothelial ICAM-1 expression. Ann N Y Acad Sci. 2004;1028:481-6.
20. Tesoriere L, Allegra M, Butera D, Livrea MA. Absorption, excretion, and distribution of dietary antioxidant betalains in LDLs: potential health effects of betalains in humans. Am J Clin Nutr. 2004;80:941-5.
21. Khoo KF, Tan HJ, Rosdinom R, Raymond AA, Norlinah MI, Shamsul A, Nafisah WY. Prevalence of depression in stroke patients with vascular dementia in universiti kebangsaan malaysia medical center. Med J Malaysia. 68:105-10.
22. Fraga CG. Plant polyphenols: how to translate their in vitro antioxidant actions to in vivo conditions. IUBMB Life. 2007;59:308-15.
23. Manach C, Williamson G, Morand C, Scalbert A, Remesy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr. 2005;81:230S-42S.
24. Di Rosa M, Willoughby DA. Screens for anti-inflammatory drugs. J Pharm Pharmacol. 1971;23:297-8.
25. Stintzing FC, Schieber A, Carle R. Identification of betalains from yellow beet (Beta vulgaris L.) and cactus pear [Opuntia ficus-indica (L.) Mill.] by high-performance liquid chromatography-electrospray ionization mass spectrometry. J Agric Food Chem. 2002;50:2302-7.
26. Ianaro A, Ialenti A, Maffia P, Pisano B, Di Rosa M. Role of cyclopentenone prostaglandins in rat carrageenin pleurisy. FEBS Lett. 2001;508:61-6.
27. Maffia P, Grassia G, Di Meglio P, Carnuccio R, Berrino L, Garside P, Ianaro A, Ialenti A. Neutralization of interleukin-18 inhibits neointimal formation in a rat model of vascular injury. Circulation. 2006;114:430-7.
28. Cuzzocrea S, Pisano B, Dugo L, Ianaro A, Maffia P, Patel NS, Di Paola R, Ialenti A, Genovese T, Chatterjee PK, et al. Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation. Eur J Pharmacol. 2004;483:79-93.
29. Panza E, Tersigni M, IorizziM, Zollo F, De Marino S, Festa C,Napolitano M, Castello G, Ialenti A, Ianaro A. Lauroside B, a megastigmane glycoside from Laurus nobilis (bay laurel) leaves, induces apoptosis in human melanoma cell lines by inhibiting NF-kappaB activation. J Nat Prod. 74:228-33.
30. Thomsen LL, Ching LM, Zhuang L, Gavin JB, Baguley BC. Tumordependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogues in mice. Cancer Res. 1991;51:77-81.
31. Kim H, Lee HS, Chang KT, Ko TH, Baek KJ, Kwon NS. Chloromethyl ketones block induction of nitric oxide synthase in murine macrophages by preventing activation of nuclear factor-kappa B. J Immunol. 1995;154:4741-8.
32. Gilroy DW, Colville-Nash PR, Willis D, Chivers J, Paul-Clark MJ, Willoughby DA. Inducible cyclooxygenase may have anti-inflammatory properties. Nat Med. 1999;5:698-701.
33. Liu SF, Malik AB. NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol. 2006;290:L622-45.
34. Visioli F, De La Lastra CA, Andres-Lacueva C, Aviram M, Calhau C, Cassano A, D'Archivio M, Faria A, Fave G, Fogliano V et al. Polyphenols and human health: a prospectus. Crit Rev Food Sci Nutr. 51:524-46.
35. Williamson G, Manach C. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr. 2005;81:243S-55S.
36. Rotelli AE, Aguilar CF, Pelzer LE. Structural basis of the antiinflammatory activity of quercetin: inhibition of the 5-hydroxytryptamine type 2 receptor. Eur Biophys J. 2009;38:865-71.
37. Ojewole JA. Antiinflammatory and analgesic effects of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rats and mice. Methods Find Exp Clin Pharmacol. 2006;28:441-6.
38. Kanner J, Harel S, Granit R. Betalains-a new class of dietary cationized antioxidants. J Agric Food Chem. 2001;49:5178-85.
39. Frank T, Stintzing FC, Carle R, Bitsch I, Quaas D, Strass G, Bitsch R, Netzel M. Urinary pharmacokinetics of betalains following consumption of red beet juice in healthy humans. Pharmacol Res. 2005;52:290-7.
40. Tesoriere L, Gentile C, Angileri F, Attanzio A, Tutone M, Allegra M, Livrea MA. Trans-epithelial transport of the betalain pigments indicaxanthin and betanin across Caco-2 cell monolayers and influence of food matrix. Eur J Nutr. 52:1077-87.
41. Tesoriere L, Fazzari M, Angileri F, Gentile C, Livrea MA. In vitro digestion of betalainic foods. Stability and bioaccessibility of betaxanthins and betacyanins and antioxidative potential of food digesta. J Agric Food Chem. 2008;56:10487-92.
42. Kitano A, Matsumoto T, Oshitani N, Nakagawa M, Yasuda K, Watanabe Y, Tomobuchi M, Obayashi M, Tabata A, Fukushima R, et al. Distribution and anti-inflammatory effect of mesalazine on carrageenaninduced colitis in the rabbit. Clin Exp Pharmacol Physiol. 1996;23:305-9.
43. Bhattacharyya S, Borthakur A, Anbazhagan AN, Katyal S, Dudeja PK, Tobacman JK. Specific effects of BCL10 Serine mutations on phosphorylations in canonical and noncanonical pathways of NF-kappaB activation following carrageenan. Am J Physiol Gastrointest Liver Physiol. 301:G475-86.
44. DAcquisto F, Ianaro A. From willow bark to peptides: the ever widening spectrum of NF-kappaB inhibitors. Curr Opin Pharmacol. 2006;6: 387-92.
45. Ben-Neriah Y, Karin M. Inflammation meets cancer, with NF-kappaB as the matchmaker. Nat Immunol. 12:715-23.